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Prostaglandin G/H synthase 2
A prostaglandin G/H synthase 2 that is encoded in the genome of sheep. [OMA:P79208, PRO:DNx]
Synonyms
EC 1.14.99.1;
Cyclooxygenase-2;
COX-2;
PHS II;
Prostaglandin H2 synthase 2;
PGH synthase 2;
PGHS-2;
Prostaglandin-endoperoxide synthase 2
Research
Bioassay Publications (105)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (2.86) | 18.2507 |
| 2000's | 38 (36.19) | 29.6817 |
| 2010's | 62 (59.05) | 24.3611 |
| 2020's | 2 (1.90) | 2.80 |
Compounds (52)
Drugs with Inhibition Measurements
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| arachidonic acid | Ovis aries (sheep) | Km | 9.7000 | 1 | 1 |
Human disorders associated with inflammation and the evolving role of natural products to overcome.European journal of medicinal chemistry, , Oct-01, Volume: 179, 2019
Cyclooxygenase-2 and 15-lipoxygenase inhibition, synthesis, anti-inflammatory activity and ulcer liability of new celecoxib analogues: Determination of region-specific pyrazole ring formation by NOESY.Bioorganic & medicinal chemistry letters, , 06-15, Volume: 26, Issue:12, 2016
Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR.European journal of medicinal chemistry, , Aug-08, Volume: 118, 2016
Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 21, Issue:20, 2011
Ipomotaosides A-D, resin glycosides from the aerial parts of Ipomoea batatas and their inhibitory activity against COX-1 and COX-2.Journal of natural products, , Nov-29, Volume: 73, Issue:11, 2010
COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 19, Issue:24, 2009
Design, synthesis and evaluation of tetrahydropyran based COX-1/-2 inhibitors.European journal of medicinal chemistry, , Volume: 44, Issue:3, 2009
Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 19, Issue:3, 2009
Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 19, Issue:11, 2009
Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: synthesis, cyclooxygenase inhibition, and nitric oxide release studies.Bioorganic & medicinal chemistry, , Mar-15, Volume: 16, Issue:6, 2008
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry, , Nov-15, Volume: 16, Issue:22, 2008
Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers.Bioorganic & medicinal chemistry, , Feb-15, Volume: 16, Issue:4, 2008
O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.Bioorganic & medicinal chemistry, , Jul-15, Volume: 15, Issue:14, 2007
Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors.Bioorganic & medicinal chemistry, , Jan-15, Volume: 15, Issue:2, 2007
Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: design, synthesis, cyclooxygenase inhibition, and nitric oxide release studies.Bioorganic & medicinal chemistry, , Nov-01, Volume: 15, Issue:21, 2007
Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.Journal of medicinal chemistry, , Mar-09, Volume: 49, Issue:5, 2006
Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.Journal of medicinal chemistry, , Jun-16, Volume: 48, Issue:12, 2005
A new class of acyclic 2-alkyl-1,1,2-triaryl (Z)-olefins as selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004
Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.Journal of natural products, , Volume: 61, Issue:1, 1998
Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid.Journal of medicinal chemistry, , Feb-12, Volume: 41, Issue:4, 1998
Design, synthesis and biological evaluation of novel indanone containing spiroisoxazoline derivatives with selective COX-2 inhibition as anticancer agents.Bioorganic & medicinal chemistry, , 02-15, Volume: 32, 2021
[no title available]Bioorganic & medicinal chemistry letters, , 06-01, Volume: 30, Issue:11, 2020
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.European journal of medicinal chemistry, , Apr-01, Volume: 167, 2019
Novel benzenesulfonamide and 1,2-benzisothiazol-3(2H)-one-1,1-dioxide derivatives as potential selective COX-2 inhibitors.European journal of medicinal chemistry, , Jun-01, Volume: 171, 2019
Anti-inflammatory activity of triazine derivatives: A systematic review.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
[no title available]European journal of medicinal chemistry, , Oct-05, Volume: 158, 2018
Synthesis and biological properties of aryl methyl sulfones.Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Design & synthesis of novel oxazolone & triazinone derivatives and their biological evaluation as COX-2 inhibitors.Bioorganic chemistry, , Volume: 72, 2017
[no title available]Bioorganic chemistry, , Volume: 70, 2017
Structure-activity relationships for the synthesis of selective cyclooxygenase 2 inhibitors: an overview (2009-2016).MedChemComm, , Mar-01, Volume: 8, Issue:3, 2017
Synthesis, potential anti-inflammatory and analgesic activities study of (S)-N-substituted-1-phenyl-3,4-dihydroisoquinoline-2(1H)-carboxamides.Bioorganic & medicinal chemistry letters, , 08-01, Volume: 27, Issue:15, 2017
New hybrid molecules combining benzothiophene or benzofuran with rhodanine as dual COX-1/2 and 5-LOX inhibitors: Synthesis, biological evaluation and docking study.Bioorganic chemistry, , Volume: 72, 2017
Cyclooxygenase-2 and 15-lipoxygenase inhibition, synthesis, anti-inflammatory activity and ulcer liability of new celecoxib analogues: Determination of region-specific pyrazole ring formation by NOESY.Bioorganic & medicinal chemistry letters, , 06-15, Volume: 26, Issue:12, 2016
Synthesis of phenylpiperazine derivatives of 1,4-benzodioxan as selective COX-2 inhibitors and anti-inflammatory agents.Bioorganic & medicinal chemistry, , 11-01, Volume: 24, Issue:21, 2016
Design, synthesis of 2,3-disubstitued 4(3H)-quinazolinone derivatives as anti-inflammatory and analgesic agents: COX-1/2 inhibitory activities and molecular docking studies.Bioorganic & medicinal chemistry, , 08-15, Volume: 24, Issue:16, 2016
Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibition activities and molecular docking study of pyrazoline derivatives.Bioorganic & medicinal chemistry, , May-01, Volume: 24, Issue:9, 2016
Synthesis of new thiazolo-celecoxib analogues as dual cyclooxygenase-2/15-lipoxygenase inhibitors: Determination of regio-specific different pyrazole cyclization by 2D NMR.European journal of medicinal chemistry, , Aug-08, Volume: 118, 2016
Synthesis, anti-inflammatory, analgesic, COX-1/2 inhibitory activities and molecular docking studies of substituted 2-mercapto-4(3H)-quinazolinones.European journal of medicinal chemistry, , Oct-04, Volume: 121, 2016
Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study.European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Synthesis, anti-inflammatory, analgesic and COX-1/2 inhibition activities of anilides based on 5,5-diphenylimidazolidine-2,4-dione scaffold: Molecular docking studies.European journal of medicinal chemistry, , Jun-10, Volume: 115, 2016
Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach.Bioorganic chemistry, , Volume: 69, 2016
Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 (COX-2)-targeted imaging agents: Synthesis, in vitro COX-2-inhibitory potency, and cellular transport properties.Bioorganic & medicinal chemistry, , Nov-01, Volume: 23, Issue:21, 2015
Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: anti-inflammatory and analgesic activities.European journal of medicinal chemistry, , Mar-06, Volume: 92, 2015
Synthesis, molecular docking, and biological evaluation of some novel hydrazones and pyrazole derivatives as anti-inflammatory agents.Chemical biology & drug design, , Volume: 84, Issue:4, 2014
Synthesis and biologic evaluation of substituted 5-methyl-2-phenyl-1H-pyrazol-3(2H)-one derivatives as selective COX-2 inhibitors: molecular docking study.Chemical biology & drug design, , Volume: 84, Issue:4, 2014
Synthesis, docking simulation, biological evaluations and 3D-QSAR study of 5-Aryl-6-(4-methylsulfonyl)-3-(metylthio)-1,2,4-triazine as selective cyclooxygenase-2 inhibitors.Bioorganic & medicinal chemistry, , Jan-15, Volume: 22, Issue:2, 2014
Part I. Synthesis, biological evaluation and docking studies of new 2-furylbenzimidazoles as antiangiogenic agents.European journal of medicinal chemistry, , Nov-24, Volume: 87, 2014
Synthesis and biological evaluation of new pyrazolone-pyridazine conjugates as anti-inflammatory and analgesic agents.Bioorganic & medicinal chemistry, , Apr-01, Volume: 22, Issue:7, 2014
Design, synthesis and molecular docking study of novel quinoxalin-2(1H)-ones as anti-tumor active agents with inhibition of tyrosine kinase receptor and studying their cyclooxygenase-2 activity.European journal of medicinal chemistry, , Oct-30, Volume: 86, 2014
Synthesis of novel pyrazole–thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 24, Issue:22, 2014
Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors.European journal of medicinal chemistry, , Jun-10, Volume: 80, 2014
Synthesis, biological evaluation and docking analysis of 3-methyl-1-phenylchromeno[4,3-c]pyrazol-4(1H)-ones as potential cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 24, Issue:19, 2014
Synthesis, pharmacological screening and in silico studies of new class of Diclofenac analogues as a promising anti-inflammatory agents.Bioorganic & medicinal chemistry, , May-15, Volume: 22, Issue:10, 2014
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles.European journal of medicinal chemistry, , Mar-03, Volume: 74, 2014
Synthesis of novel celecoxib analogues by bioisosteric replacement of sulfonamide as potent anti-inflammatory agents and cyclooxygenase inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Molecular design, synthesis and biological evaluation of cyclic imides bearing benzenesulfonamide fragment as potential COX-2 inhibitors. Part 2.Bioorganic & medicinal chemistry letters, , May-01, Volume: 23, Issue:9, 2013
Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.Bioorganic & medicinal chemistry, , May-15, Volume: 20, Issue:10, 2012
Synthesis and biological evaluation of 2,5-disubstituted 1,3,4-oxadiazole derivatives with both COX and LOX inhibitory activity.Journal of enzyme inhibition and medicinal chemistry, , Volume: 26, Issue:6, 2011
Synthesis and biological evaluation of some new 2-pyrazolines bearing benzene sulfonamide moiety as potential anti-inflammatory and anti-cancer agents.European journal of medicinal chemistry, , Volume: 46, Issue:12, 2011
Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 21, Issue:20, 2011
Synthesis, anti-inflammatory activity and COX-1/COX-2 inhibition of novel substituted cyclic imides. Part 1: Molecular docking study.European journal of medicinal chemistry, , Volume: 46, Issue:5, 2011
Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011
Mono-, di-, and triaryl substituted tetrahydropyrans as cyclooxygenase-2 and tumor growth inhibitors. Synthesis and biological evaluation.Journal of medicinal chemistry, , May-13, Volume: 53, Issue:9, 2010
Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones.Journal of medicinal chemistry, , Sep-23, Volume: 53, Issue:18, 2010
Design, synthesis and biological evaluation of new (E)- and (Z)-1,2,3-triaryl-2-propen-1-ones as selective COX-2 inhibitors.European journal of medicinal chemistry, , Volume: 45, Issue:9, 2010
Design, synthesis and biological evaluation of new 2,3-diarylquinoline derivatives as selective cyclooxygenase-2 inhibitors.Bioorganic & medicinal chemistry, , Volume: 18, Issue:3, 2010
Synthesis and biological evaluation of new 4-carboxyl quinoline derivatives as cyclooxygenase-2 inhibitors.Bioorganic & medicinal chemistry, , Jul-15, Volume: 17, Issue:14, 2009
COX, LOX and platelet aggregation inhibitory properties of Lauraceae neolignans.Bioorganic & medicinal chemistry letters, , Dec-15, Volume: 19, Issue:24, 2009
Design and synthesis of new 1,3-benzthiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 17, Issue:15, 2009
Design and synthesis of 3-alkyl-2-aryl-1,3-thiazinan-4-one derivatives as selective cyclooxygenase (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 19, Issue:12, 2009
Fenbufen based 3-[5-(substituted aryl)-1,3,4-oxadiazol-2-yl]-1-(biphenyl-4-yl)propan-1-ones as safer antiinflammatory and analgesic agents.European journal of medicinal chemistry, , Volume: 44, Issue:9, 2009
Design, synthesis, and biological evaluation of 1-(4-sulfamylphenyl)-3-trifluoromethyl-5-indolyl pyrazolines as cyclooxygenase-2 (COX-2) and lipoxygenase (LOX) inhibitors.Bioorganic & medicinal chemistry, , Apr-01, Volume: 16, Issue:7, 2008
Diazen-1-ium-1,2-diolated and nitrooxyethyl nitric oxide donor ester prodrugs of anti-inflammatory (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic acids: synthesis, cyclooxygenase inhibition, and nitric oxide release studies.Bioorganic & medicinal chemistry, , Mar-15, Volume: 16, Issue:6, 2008
Synthesis and biological evaluation of 2-trifluoromethyl/sulfonamido-5,6-diaryl substituted imidazo[2,1-b]-1,3,4-thiadiazoles: a novel class of cyclooxygenase-2 inhibitors.Bioorganic & medicinal chemistry, , Jan-01, Volume: 16, Issue:1, 2008
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry, , Nov-15, Volume: 16, Issue:22, 2008
Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.Bioorganic & medicinal chemistry letters, , Dec-01, Volume: 18, Issue:23, 2008
Synthesis and cyclooxygenase inhibitory activities of linear 1-(methanesulfonylphenyl or benzenesulfonamido)-2-(pyridyl)acetylene regioisomers.Bioorganic & medicinal chemistry, , Feb-15, Volume: 16, Issue:4, 2008
Design and synthesis of 1,3-diarylurea derivatives as selective cyclooxygenase (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Feb-15, Volume: 18, Issue:4, 2008
Novel (E)-2-(aryl)-3-(4-methanesulfonylphenyl)acrylic ester prodrugs possessing a diazen-1-ium-1,2-diolate moiety: design, synthesis, cyclooxygenase inhibition, and nitric oxide release studies.Bioorganic & medicinal chemistry, , Nov-01, Volume: 15, Issue:21, 2007
Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.Journal of medicinal chemistry, , Mar-09, Volume: 49, Issue:5, 2006
Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 16, Issue:17, 2006
Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 15, Issue:7, 2005
Design and synthesis of (E)-1,1,2-triarylethenes: novel inhibitors of the cyclooxygenase-2 (COX-2) isozyme.Bioorganic & medicinal chemistry letters, , Jan-17, Volume: 15, Issue:2, 2005
A new class of acyclic 2-alkyl-1,2-diaryl (E)-olefins as selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Oct-04, Volume: 14, Issue:19, 2004
A new class of acyclic 2-alkyl-1,1,2-triaryl (Z)-olefins as selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , Nov-18, Volume: 47, Issue:24, 2004
Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , Jul-29, Volume: 47, Issue:16, 2004
Design of acyclic triaryl olefins: a new class of potent and selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Apr-19, Volume: 14, Issue:8, 2004
6-Alkyl, alkoxy, or alkylthio-substituted 3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones: a novel class of diarylheterocyclic selective cyclooxygenase-2 inhibitors.Bioorganic & medicinal chemistry letters, , Jul-07, Volume: 13, Issue:13, 2003
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.European journal of medicinal chemistry, , Apr-01, Volume: 167, 2019
Structure-based design of phthalimide derivatives as potential cyclooxygenase-2 (COX-2) inhibitors: anti-inflammatory and analgesic activities.European journal of medicinal chemistry, , Mar-06, Volume: 92, 2015
Synthesis, pharmacological screening and in silico studies of new class of Diclofenac analogues as a promising anti-inflammatory agents.Bioorganic & medicinal chemistry, , May-15, Volume: 22, Issue:10, 2014
Binding of ibuprofen, ketorolac, and diclofenac to COX-1 and COX-2 studied by saturation transfer difference NMR.Journal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011
Synthesis and biological properties of aryl methyl sulfones.Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Binding of ibuprofen, ketorolac, and diclofenac to COX-1 and COX-2 studied by saturation transfer difference NMR.Journal of medicinal chemistry, , Dec-22, Volume: 54, Issue:24, 2011
Isomeric acetoxy analogs of celecoxib and their evaluation as cyclooxygenase inhibitors.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 21, Issue:20, 2011
Phenylacetic acid regioisomers possessing a N-difluoromethyl-1,2-dihydropyrid-2-one pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 20, Issue:3, 2010
Synthesis of 1-(methanesulfonyl- and aminosulfonylphenyl)acetylenes that possess a 2-(N-difluoromethyl-1,2-dihydropyridin-2-one) pharmacophore: evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 19, Issue:3, 2009
Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 19, Issue:11, 2009
Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry, , Nov-15, Volume: 16, Issue:22, 2008
O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.Bioorganic & medicinal chemistry, , Jul-15, Volume: 15, Issue:14, 2007
Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.Journal of medicinal chemistry, , Jun-16, Volume: 48, Issue:12, 2005
Design, synthesis, biological evaluation and molecular docking of curcumin analogues as antioxidant, cyclooxygenase inhibitory and anti-inflammatory agents.Bioorganic & medicinal chemistry letters, , Apr-01, Volume: 15, Issue:7, 2005
Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.Journal of natural products, , Volume: 61, Issue:1, 1998
Tackling neuroinflammation and cholinergic deficit in Alzheimer's disease: Multi-target inhibitors of cholinesterases, cyclooxygenase-2 and 15-lipoxygenase.European journal of medicinal chemistry, , Apr-01, Volume: 167, 2019
Anti-inflammatory activity of triazine derivatives: A systematic review.European journal of medicinal chemistry, , Jan-15, Volume: 162, 2019
Synthesis and biological properties of aryl methyl sulfones.Bioorganic & medicinal chemistry, , 08-07, Volume: 26, Issue:14, 2018
Design, synthesis, evaluation and molecular modelling studies of some novel 5,6-diphenyl-1,2,4-triazin-3(2H)-ones bearing five-member heterocyclic moieties as potential COX-2 inhibitors: A hybrid pharmacophore approach.Bioorganic chemistry, , Volume: 69, 2016
Novel N-substituted indole Schiff bases as dual inhibitors of cyclooxygenase-2 and 5-lipoxygenase enzymes: Synthesis, biological activities in vitro and docking study.European journal of medicinal chemistry, , Nov-10, Volume: 123, 2016
Synthesis, characterization, evaluation and molecular dynamics studies of 5, 6-diphenyl-1,2,4-triazin-3(2H)-one derivatives bearing 5-substituted 1,3,4-oxadiazole as potential anti-inflammatory and analgesic agents.European journal of medicinal chemistry, , Aug-28, Volume: 101, 2015
Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 (COX-2)-targeted imaging agents: Synthesis, in vitro COX-2-inhibitory potency, and cellular transport properties.Bioorganic & medicinal chemistry, , Nov-01, Volume: 23, Issue:21, 2015
Synthesis of novel pyrazole–thiadiazole hybrid as potential potent and selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Nov-15, Volume: 24, Issue:22, 2014
Synthesis, biological evaluation, molecular docking and theoretical evaluation of ADMET properties of nepodin and chrysophanol derivatives as potential cyclooxygenase (COX-1, COX-2) inhibitors.European journal of medicinal chemistry, , Jun-10, Volume: 80, 2014
Selective COX-1 inhibition as a target of theranostic novel diarylisoxazoles.European journal of medicinal chemistry, , Mar-03, Volume: 74, 2014
Synthesis of novel celecoxib analogues by bioisosteric replacement of sulfonamide as potent anti-inflammatory agents and cyclooxygenase inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 21, Issue:15, 2013
Synthesis of some novel chalcones, flavanones and flavones and evaluation of their anti-inflammatory activity.European journal of medicinal chemistry, , Volume: 65, 2013
Design and synthesis of indomethacin analogues that inhibit P-glycoprotein and/or multidrug resistant protein without COX inhibitory activity.Journal of medicinal chemistry, , Sep-27, Volume: 55, Issue:18, 2012
Design of novel N-phenylnicotinamides as selective cyclooxygenase-1 inhibitors.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 21, Issue:1, 2011
Synthesis, biological evaluation, and docking studies of novel heterocyclic diaryl compounds as selective COX-2 inhibitors.Bioorganic & medicinal chemistry, , Sep-01, Volume: 18, Issue:17, 2010
Synthesis and biological evaluation of indomethacin analogs possessing a N-difluoromethyl-1,2-dihydropyrid-2-one ring system: a search for novel cyclooxygenase and lipoxygenase inhibitors.Bioorganic & medicinal chemistry letters, , Oct-01, Volume: 20, Issue:19, 2010
Synthesis and biological evaluation of 4,5-diphenyloxazolone derivatives on route towards selective COX-2 inhibitors.European journal of medicinal chemistry, , Volume: 44, Issue:5, 2009
Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.Bioorganic & medicinal chemistry letters, , Jun-01, Volume: 19, Issue:11, 2009
1-Toluene-sulfonyl-3-[(3'-hydroxy-5'-substituted)-gamma-butyrolactone]-indoles: synthesis, COX-2 inhibition and anti-cancer activities.Bioorganic & medicinal chemistry letters, , Jan-01, Volume: 18, Issue:1, 2008
O2-acetoxymethyl-protected diazeniumdiolate-based NSAIDs (NONO-NSAIDs): synthesis, nitric oxide release, and biological evaluation studies.Bioorganic & medicinal chemistry, , Jul-15, Volume: 15, Issue:14, 2007
Analgesic agents without gastric damage: design and synthesis of structurally simple benzenesulfonanilide-type cyclooxygenase-1-selective inhibitors.Bioorganic & medicinal chemistry, , Jan-15, Volume: 15, Issue:2, 2007
Selective COX-2 inhibitors. Part 1: synthesis and biological evaluation of phenylazobenzenesulfonamides.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 16, Issue:17, 2006
Novel nonsteroidal antiinflammatory drugs possessing a nitric oxide donor diazen-1-ium-1,2-diolate moiety: design, synthesis, biological evaluation, and nitric oxide release studies.Journal of medicinal chemistry, , Jun-16, Volume: 48, Issue:12, 2005
Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.Journal of natural products, , Volume: 61, Issue:1, 1998
Design, synthesis, and biological evaluation of conformationally constrained aci-reductone mimics of arachidonic acid.Journal of medicinal chemistry, , Feb-12, Volume: 41, Issue:4, 1998
Structural basis for selective inhibition of Cyclooxygenase-1 (COX-1) by diarylisoxazoles mofezolac and 3-(5-chlorofuran-2-yl)-5-methyl-4-phenylisoxazole (P6).European journal of medicinal chemistry, , Sep-29, Volume: 138, 2017
General role of the amino and methylsulfamoyl groups in selective cyclooxygenase(COX)-1 inhibition by 1,4-diaryl-1,2,3-triazoles and validation of a predictive pharmacometric PLS model.European journal of medicinal chemistry, , Apr-13, Volume: 94, 2015
Isomeric methoxy analogs of nimesulide for development of brain cyclooxygense-2 (COX-2)-targeted imaging agents: Synthesis, in vitro COX-2-inhibitory potency, and cellular transport properties.Bioorganic & medicinal chemistry, , Nov-01, Volume: 23, Issue:21, 2015
Syntheses and characterization of nimesulide derivatives for dual enzyme inhibitors of both cyclooxygenase-1/2 and 5-lipoxygenase.Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
Lignan derivatives from Krameria lappacea roots inhibit acute inflammation in vivo and pro-inflammatory mediators in vitro.Journal of natural products, , Aug-26, Volume: 74, Issue:8, 2011
Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones.Journal of medicinal chemistry, , Sep-23, Volume: 53, Issue:18, 2010
Derivatives of schisandrin with increased inhibitory potential on prostaglandin E(2) and leukotriene B(4) formation in vitro.Bioorganic & medicinal chemistry, , Apr-01, Volume: 18, Issue:7, 2010
Design and synthesis of ten biphenyl-neolignan derivatives and their in vitro inhibitory potency against cyclooxygenase-1/2 activity and 5-lipoxygenase-mediated LTB4-formation.Bioorganic & medicinal chemistry, , Jul-01, Volume: 17, Issue:13, 2009
Development of a radiochemical cyclooxygenase-1 and -2 in vitro assay for identification of natural products as inhibitors of prostaglandin biosynthesis.Journal of natural products, , Volume: 61, Issue:1, 1998
Stereoselective synthesis and anti-proliferative effects on prostate cancer evaluation of 5-substituted-3,4-diphenylfuran-2-ones.European journal of medicinal chemistry, , Volume: 65, 2013
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Sulfonamido, azidosulfonyl and N-acetylsulfonamido analogues of rofecoxib: 4-[4-(N-acetylsulfonamido)phenyl]-3-(4-methanesulfonylphenyl)-2(5H)furanone is a potent and selective cyclooxygenase-2 inhibitor.Bioorganic & medicinal chemistry letters, , Apr-19, Volume: 14, Issue:8, 2004
Design, synthesis, and structure-activity relationship studies of 3,4,6-triphenylpyran-2-ones as selective cyclooxygenase-2 inhibitors.Journal of medicinal chemistry, , Jul-29, Volume: 47, Issue:16, 2004
Design of acyclic triaryl olefins: a new class of potent and selective cyclooxygenase-2 (COX-2) inhibitors.Bioorganic & medicinal chemistry letters, , Apr-19, Volume: 14, Issue:8, 2004
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Synthesis, anti-inflammatory activity, and in vitro antitumor effect of a novel class of cyclooxygenase inhibitors: 4-(aryloyl)phenyl methyl sulfones.Journal of medicinal chemistry, , Sep-23, Volume: 53, Issue:18, 2010
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Synthesis, biological evaluation and molecular modeling study of pyrazole and pyrazoline derivatives as selective COX-2 inhibitors and anti-inflammatory agents. Part 2.Bioorganic & medicinal chemistry, , May-15, Volume: 20, Issue:10, 2012
Design, synthesis, and biological evaluation of substituted hydrazone and pyrazole derivatives as selective COX-2 inhibitors: Molecular docking study.Bioorganic & medicinal chemistry, , Jun-01, Volume: 19, Issue:11, 2011