Page last updated: 2024-08-07 15:58:12
Beta-3 adrenergic receptor
A beta-3 adrenergic receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:P13945]
Synonyms
Beta-3 adrenoreceptor;
Beta-3 adrenoceptor
Research
Bioassay Publications (62)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 7 (11.29) | 18.7374 |
| 1990's | 11 (17.74) | 18.2507 |
| 2000's | 26 (41.94) | 29.6817 |
| 2010's | 17 (27.42) | 24.3611 |
| 2020's | 1 (1.61) | 2.80 |
Compounds (79)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4-nonylphenol | Homo sapiens (human) | IC50 | 4.1900 | 1 | 0 |
| 4-nonylphenol | Homo sapiens (human) | Ki | 3.1420 | 1 | 0 |
| alprenolol | Homo sapiens (human) | IC50 | 0.0023 | 1 | 1 |
| amiodarone | Homo sapiens (human) | IC50 | 42.3490 | 1 | 0 |
| amiodarone | Homo sapiens (human) | Ki | 31.7610 | 1 | 0 |
| astemizole | Homo sapiens (human) | IC50 | 8.0600 | 1 | 0 |
| astemizole | Homo sapiens (human) | Ki | 6.0450 | 1 | 0 |
| candesartan | Homo sapiens (human) | IC50 | 4.3000 | 1 | 0 |
| candesartan | Homo sapiens (human) | Ki | 3.2000 | 1 | 0 |
| carvedilol | Homo sapiens (human) | IC50 | 0.0042 | 1 | 0 |
| carvedilol | Homo sapiens (human) | Ki | 0.0031 | 1 | 0 |
| celecoxib | Homo sapiens (human) | IC50 | 16.1240 | 1 | 0 |
| celecoxib | Homo sapiens (human) | Ki | 12.0930 | 1 | 0 |
| ciglitazone | Homo sapiens (human) | IC50 | 17.8710 | 1 | 0 |
| ciglitazone | Homo sapiens (human) | Ki | 13.4030 | 1 | 0 |
| cisapride | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| clotrimazole | Homo sapiens (human) | IC50 | 7.2080 | 1 | 0 |
| clotrimazole | Homo sapiens (human) | Ki | 5.4060 | 1 | 0 |
| ebastine | Homo sapiens (human) | IC50 | 2.5455 | 1 | 0 |
| ebastine | Homo sapiens (human) | Ki | 1.9091 | 1 | 0 |
| econazole | Homo sapiens (human) | IC50 | 6.1500 | 1 | 0 |
| econazole | Homo sapiens (human) | Ki | 4.6120 | 1 | 0 |
| fenofibrate | Homo sapiens (human) | IC50 | 123.9450 | 1 | 0 |
| fenofibrate | Homo sapiens (human) | Ki | 92.9590 | 1 | 0 |
| fluphenazine | Homo sapiens (human) | IC50 | 29.4880 | 1 | 0 |
| fluphenazine | Homo sapiens (human) | Ki | 22.1160 | 1 | 0 |
| isoproterenol | Homo sapiens (human) | Ki | 18.6209 | 1 | 1 |
| miconazole | Homo sapiens (human) | IC50 | 5.4820 | 1 | 0 |
| miconazole | Homo sapiens (human) | Ki | 4.1110 | 1 | 0 |
| pindolol | Homo sapiens (human) | IC50 | 0.0880 | 1 | 0 |
| pindolol | Homo sapiens (human) | Ki | 0.0660 | 1 | 0 |
| propafenone | Homo sapiens (human) | IC50 | 0.4240 | 1 | 0 |
| propafenone | Homo sapiens (human) | Ki | 0.3180 | 1 | 0 |
| propranolol | Homo sapiens (human) | IC50 | 0.0493 | 3 | 2 |
| propranolol | Homo sapiens (human) | Ki | 0.0990 | 1 | 0 |
| sotalol | Homo sapiens (human) | IC50 | 7.2000 | 1 | 1 |
| indopan | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| soterenol | Homo sapiens (human) | Ki | 4.1000 | 1 | 1 |
| danazol | Homo sapiens (human) | IC50 | 17.0200 | 1 | 0 |
| danazol | Homo sapiens (human) | Ki | 12.7650 | 1 | 0 |
| 1-(3-chloro-5-benzo[b][1]benzoxepinyl)-4-methylpiperazine | Homo sapiens (human) | Ki | 0.0030 | 1 | 1 |
| timolol | Homo sapiens (human) | IC50 | 0.4520 | 1 | 0 |
| timolol | Homo sapiens (human) | Ki | 0.3390 | 1 | 0 |
| penfluridol | Homo sapiens (human) | Ki | 0.5150 | 1 | 1 |
| levobunolol | Homo sapiens (human) | IC50 | 0.3400 | 1 | 0 |
| levobunolol | Homo sapiens (human) | Ki | 0.2550 | 1 | 0 |
| bopindolol | Homo sapiens (human) | IC50 | 0.4580 | 1 | 0 |
| bopindolol | Homo sapiens (human) | Ki | 0.3440 | 1 | 0 |
| sematilide | Homo sapiens (human) | IC50 | 7,000.0000 | 1 | 1 |
| nelfinavir | Homo sapiens (human) | IC50 | 34.0800 | 1 | 0 |
| nelfinavir | Homo sapiens (human) | Ki | 25.5660 | 1 | 0 |
| sotalol hydrochloride | Homo sapiens (human) | IC50 | 7.2000 | 1 | 1 |
| pramipexole | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| sc 53116 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| alpha-ergocryptine | Homo sapiens (human) | IC50 | 2.4960 | 1 | 0 |
| alpha-ergocryptine | Homo sapiens (human) | Ki | 1.8720 | 1 | 0 |
| nantenine, (+-)-isomer | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| dihydroergocristine monomesylate | Homo sapiens (human) | IC50 | 3.3080 | 1 | 0 |
| dihydroergocristine monomesylate | Homo sapiens (human) | Ki | 2.4810 | 1 | 0 |
| (1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol | Homo sapiens (human) | IC50 | 4.9963 | 1 | 0 |
| (1S,2R)-2-(octylamino)-1-[4-(propan-2-ylthio)phenyl]-1-propanol | Homo sapiens (human) | Ki | 3.7472 | 1 | 0 |
| (S)-(-)-pindolol | Homo sapiens (human) | IC50 | 0.0480 | 1 | 0 |
| (S)-(-)-pindolol | Homo sapiens (human) | Ki | 0.0360 | 1 | 0 |
| enclomiphene | Homo sapiens (human) | IC50 | 5.6730 | 1 | 0 |
| enclomiphene | Homo sapiens (human) | Ki | 4.2540 | 1 | 0 |
| tamoxifen | Homo sapiens (human) | IC50 | 7.7030 | 1 | 0 |
| tamoxifen | Homo sapiens (human) | Ki | 5.7780 | 1 | 0 |
| montelukast | Homo sapiens (human) | IC50 | 4.3000 | 1 | 0 |
| montelukast | Homo sapiens (human) | Ki | 3.2000 | 1 | 0 |
| cl 316243 | Homo sapiens (human) | Ki | 20.0000 | 1 | 1 |
| oxiconazole | Homo sapiens (human) | IC50 | 4.7449 | 1 | 0 |
| oxiconazole | Homo sapiens (human) | Ki | 3.5587 | 1 | 0 |
| gw 1929 | Homo sapiens (human) | IC50 | 22.0800 | 1 | 0 |
| gw 1929 | Homo sapiens (human) | Ki | 16.5640 | 1 | 0 |
| brl 37344 | Homo sapiens (human) | Ki | 0.6600 | 1 | 1 |
| naluzotan | Homo sapiens (human) | Ki | 2.0000 | 1 | 1 |
| nitd 609 | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| n,n-diallyl-5-methoxytryptamine | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| acebutolol | Homo sapiens (human) | Kd | 13.3613 | 1 | 3 |
| albuterol | Homo sapiens (human) | Kd | 23.1370 | 1 | 3 |
| alprenolol | Homo sapiens (human) | Kd | 0.0694 | 3 | 5 |
| atenolol | Homo sapiens (human) | Kd | 26.2890 | 1 | 3 |
| bisoprolol | Homo sapiens (human) | Kd | 0.7843 | 1 | 3 |
| bupranolol | Homo sapiens (human) | Kd | 0.0314 | 1 | 3 |
| carvedilol | Homo sapiens (human) | Kd | 0.0024 | 1 | 3 |
| cgp 20712a | Homo sapiens (human) | Kd | 3.1825 | 2 | 4 |
| cgp 12177 | Homo sapiens (human) | Kd | 0.0343 | 1 | 3 |
| cimaterol | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| formoterol fumarate | Homo sapiens (human) | EC50 | 0.0251 | 4 | 4 |
| ici 118551 | Homo sapiens (human) | Kd | 0.2218 | 1 | 3 |
| isoproterenol | Homo sapiens (human) | EC50 | 0.0730 | 25 | 25 |
| labetalol | Homo sapiens (human) | Kd | 0.2313 | 1 | 3 |
| metoprolol | Homo sapiens (human) | Kd | 2.3667 | 1 | 3 |
| pindolol | Homo sapiens (human) | Kd | 0.5830 | 2 | 2 |
| practolol | Homo sapiens (human) | Kd | 18.8532 | 3 | 6 |
| pronethalol | Homo sapiens (human) | Kd | 0.5650 | 1 | 3 |
| propranolol | Homo sapiens (human) | Kd | 0.0514 | 6 | 10 |
| salmeterol xinafoate | Homo sapiens (human) | EC50 | 1.1850 | 7 | 7 |
| salmeterol xinafoate | Homo sapiens (human) | Kd | 2.0108 | 1 | 3 |
| sotalol | Homo sapiens (human) | Kd | 3.5840 | 1 | 3 |
| terbutaline | Homo sapiens (human) | Kd | 101.3852 | 1 | 4 |
| phenylephrine | Homo sapiens (human) | EC50 | 6.0000 | 1 | 1 |
| sq-11725 | Homo sapiens (human) | Kd | 0.2408 | 1 | 3 |
| flestolol | Homo sapiens (human) | Kd | 0.0079 | 1 | 2 |
| (S)-betaxolol | Homo sapiens (human) | Kd | 0.3734 | 1 | 3 |
| propranolol hydrochloride | Homo sapiens (human) | Kd | 0.0013 | 1 | 1 |
| labetalol hydrochloride | Homo sapiens (human) | Kd | 0.0079 | 1 | 1 |
| ici 89406 | Homo sapiens (human) | Kd | 0.7094 | 1 | 3 |
| xamoterol | Homo sapiens (human) | EC50 | 100.0000 | 1 | 1 |
| xamoterol | Homo sapiens (human) | Kd | 19.9526 | 1 | 1 |
| L-isoprenaline | Homo sapiens (human) | EC50 | 0.0398 | 1 | 1 |
| cl 316243 | Homo sapiens (human) | EC50 | 0.6850 | 2 | 2 |
| phentolamine | Homo sapiens (human) | Kd | 10.0000 | 1 | 1 |
| ici 215001 | Homo sapiens (human) | Kd | 0.6803 | 1 | 3 |
| l 755507 | Homo sapiens (human) | EC50 | 0.0005 | 5 | 5 |
| brl 37344 | Homo sapiens (human) | EC50 | 0.1059 | 9 | 9 |
| solabegron | Homo sapiens (human) | EC50 | 0.0040 | 1 | 1 |
| l 748,337 | Homo sapiens (human) | EC50 | 0.0119 | 1 | 1 |
| l 764646 | Homo sapiens (human) | EC50 | 10,113.5263 | 7 | 7 |
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| beta-adrenergic receptor activity | molecular function | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta-adrenergic receptors; the activity involves transmitting the signal to the Gs alpha subunit of a heterotrimeric G protein. [GOC:cb, GOC:mah, IUPHAR_GPCR:1274] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| beta3-adrenergic receptor activity | molecular function | Combining with epinephrine or norepinephrine to initiate a change in cell activity via activation of a G protein, with pharmacological characteristics of beta3-adrenergic receptors. [GOC:mah, IUPHAR_GPCR:1274] |
| beta-3 adrenergic receptor binding | molecular function | Binding to a beta-3 adrenergic receptor. [GOC:mah, GOC:nln] |
| protein homodimerization activity | molecular function | Binding to an identical protein to form a homodimer. [GOC:jl] |
| epinephrine binding | molecular function | Binding to epinephrine, a hormone produced by the medulla of the adrenal glands that increases heart activity, improves the power and prolongs the action of muscles, and increases the rate and depth of breathing. It is synthesized by the methylation of norepinephrine. [GOC:ai] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| receptor complex | cellular component | Any protein complex that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:go_curators] |
Involved In
This protein is involved in 15 target(s):
| Target | Category | Definition |
|---|---|---|
| diet induced thermogenesis | biological process | The process that results in increased metabolic rate in tissues of an organism. It is triggered by the detection of dietary excess. This process is achieved via signaling in the sympathetic nervous system. [PMID:12161655] |
| carbohydrate metabolic process | biological process | The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. [GOC:mah, ISBN:0198506732] |
| generation of precursor metabolites and energy | biological process | The chemical reactions and pathways resulting in the formation of precursor metabolites, substances from which energy is derived, and any process involved in the liberation of energy from these substances. [GOC:jl] |
| energy reserve metabolic process | biological process | The chemical reactions and pathways by which a cell derives energy from stored compounds such as fats or glycogen. [GOC:mah] |
| G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of a nucleotide cyclase activity and a subsequent change in the concentration of a cyclic nucleotide. [GOC:mah, GOC:signaling, ISBN:0815316194] |
| adenylate cyclase-modulating G protein-coupled receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation or inhibition of adenylyl cyclase activity and a subsequent change in the intracellular concentration of cyclic AMP (cAMP). [GOC:mah, GOC:signaling, ISBN:0815316194] |
| response to cold | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cold stimulus, a temperature stimulus below the optimal temperature for that organism. [GOC:lr] |
| heat generation | biological process | Any homeostatic process in which an organism produces heat, thereby raising its internal temperature. [GOC:mah] |
| negative regulation of multicellular organism growth | biological process | Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size. [GOC:dph, GOC:ems, GOC:tb] |
| eating behavior | biological process | The specific behavior of an organism relating to the intake of food, any substance (usually solid) that can be metabolized by an organism to give energy and build tissue. [GOC:jl, GOC:pr, PMID:19361967] |
| positive regulation of MAPK cascade | biological process | Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the MAPK cascade. [GOC:go_curators] |
| brown fat cell differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria. [PMID:12588810] |
| adenylate cyclase-activating adrenergic receptor signaling pathway | biological process | An adenylate cyclase-activating G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process. [GOC:BHF, GOC:mah, GOC:signaling] |
| positive regulation of cold-induced thermogenesis | biological process | Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809] |
| norepinephrine-epinephrine-mediated vasodilation involved in regulation of systemic arterial blood pressure | biological process | A process that results in an increase in the diameter of an artery during the norepinephrine-epinephrine response to blood pressure change. [GOC:mtg_cardio, PMID:10358008] |