Page last updated: 2024-08-07 20:17:53
Arylacetamide deacetylase
An arylacetamide deacetylase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P22760]
Synonyms
EC 3.1.1.3
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (5)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| t-tucb | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| osteum | Homo sapiens (human) | Ki | 16.7000 | 1 | 2 |
| rifampin | Homo sapiens (human) | Ki | 300.0000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| flutamide | Homo sapiens (human) | Km | 500.0000 | 2 | 3 |
| phenacetin | Homo sapiens (human) | Km | 2.3509 | 2 | 4 |
| rifampin | Homo sapiens (human) | Km | 200.0000 | 1 | 2 |
Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 40, Issue:4, 2012
Contributions of arylacetamide deacetylase and carboxylesterase 2 to flutamide hydrolysis in human liver.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 40, Issue:6, 2012
Species differences in tissue distribution and enzyme activities of arylacetamide deacetylase in human, rat, and mouse.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 40, Issue:4, 2012
Effect of albumin on human liver microsomal and recombinant CYP1A2 activities: impact on in vitro-in vivo extrapolation of drug clearance.Drug metabolism and disposition: the biological fate of chemicals, , Volume: 40, Issue:5, 2012
Enables
This protein enables 6 target(s):
| Target | Category | Definition |
|---|
| catalytic activity | molecular function | Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. [GOC:vw, ISBN:0198506732] |
| triglyceride lipase activity | molecular function | Catalysis of the reaction: triacylglycerol + H2O = diacylglycerol + a carboxylate. [EC:3.1.1.3] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| lipase activity | molecular function | Catalysis of the hydrolysis of a lipid or phospholipid. [GOC:mah, ISBN:0198506732] |
| serine hydrolase activity | molecular function | Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [Wikipedia:Serine_hydrolase] |
| deacetylase activity | molecular function | Catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule. [GOC:jl] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
Involved In
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|
| lipid metabolic process | biological process | The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. [GOC:ma] |
| xenobiotic metabolic process | biological process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc] |
| positive regulation of triglyceride catabolic process | biological process | Any process that increases the frequency, rate, or extent of the chemical reactions and pathways resulting in the breakdown of triglyceride. [GOC:rn, GOC:tb] |