disulfiram has been researched along with Necrosis in 16 studies
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Disulfiram (DSF) is an FDA-proved drug with potential therapeutic effects on inflammatory diseases." | 5.91 | Disulfiram reduces the severity of mouse acute pancreatitis by inhibiting RIPK1-dependent acinar cell necrosis. ( Dai, C; Huang, KL; Huang, QY; Lin, ZH; Liu, YY; Shen, Y; Yu, XY; Yuan, L; Zhang, QY; Zhang, R, 2023) |
| "Pancreatic cancer cell lines with mutated ras underwent an alternative form of cell death (aponecrosis) when treated concomitantly with clinically achievable concentrations of arsenic trioxide, ascorbic acid, and disulfiram (Antabuse; AAA)." | 3.79 | Redirecting apoptosis to aponecrosis induces selective cytotoxicity to pancreatic cancer cells through increased ROS, decline in ATP levels, and VDAC. ( Brandt-Rauf, P; Cassai, N; Dinnen, RD; Fine, RL; Mao, Y; Nichols, G; Qiu, W; Slavkovich, VN; Su, GH, 2013) |
| "After undergoing withdrawal treatment for alcoholism as an in-patient for one year a 49-year-old woman was started on disulfiram, 250 mg daily, her liver function tests being normal." | 3.68 | [Fulminant hepatitis caused by disulfiram]. ( Bühler, H; Schmid, M; Zala, G, 1993) |
| "Disulfiram is used commonly as reinforcement in the treatment of chronic alcoholism." | 3.66 | Fulminant hepatitis associated with disulfiram. Report of a case. ( Dekker, A; Gray, JA; Schade, RR; Shaffer, RD; Van Thiel, DH; Varma, RR, 1983) |
| "Disulfiram (DSF) is an FDA-proved drug with potential therapeutic effects on inflammatory diseases." | 1.91 | Disulfiram reduces the severity of mouse acute pancreatitis by inhibiting RIPK1-dependent acinar cell necrosis. ( Dai, C; Huang, KL; Huang, QY; Lin, ZH; Liu, YY; Shen, Y; Yu, XY; Yuan, L; Zhang, QY; Zhang, R, 2023) |
| " A synergistic treatment with drug supporting activity could maximize the cytotoxic effects of chemotherapeutic agents on tumor cells while decreasing the dosage of each drug to potentially reduce toxicity." | 1.72 | Blockade of ALDH in Cisplatin-Resistant Ovarian Cancer Stem Cells In Vitro Synergistically Enhances Chemotherapy-Induced Cell Death. ( Guo, F; Kaufmann, AM; Sehouli, J; Yang, Z, 2022) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 11 (68.75) | 18.7374 |
| 1990's | 1 (6.25) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (6.25) | 24.3611 |
| 2020's | 3 (18.75) | 2.80 |
| Authors | Studies |
|---|---|
| Guo, F | 1 |
| Yang, Z | 1 |
| Sehouli, J | 1 |
| Kaufmann, AM | 1 |
| Huang, QY | 1 |
| Zhang, R | 1 |
| Zhang, QY | 1 |
| Dai, C | 1 |
| Yu, XY | 1 |
| Yuan, L | 1 |
| Liu, YY | 1 |
| Shen, Y | 1 |
| Huang, KL | 1 |
| Lin, ZH | 1 |
| Rudresha, GV | 1 |
| Urs, AP | 1 |
| Manjuprasanna, VN | 1 |
| Milan Gowda, MD | 1 |
| Jayachandra, K | 1 |
| Rajaiah, R | 1 |
| Vishwanath, BS | 1 |
| Dinnen, RD | 1 |
| Mao, Y | 1 |
| Qiu, W | 1 |
| Cassai, N | 1 |
| Slavkovich, VN | 1 |
| Nichols, G | 1 |
| Su, GH | 1 |
| Brandt-Rauf, P | 1 |
| Fine, RL | 1 |
| Zabirova, IG | 1 |
| Schade, RR | 1 |
| Gray, JA | 1 |
| Dekker, A | 1 |
| Varma, RR | 1 |
| Shaffer, RD | 1 |
| Van Thiel, DH | 1 |
| Wysor, MS | 1 |
| Zwelling, LA | 1 |
| Sanders, JE | 1 |
| Grenan, MM | 1 |
| Zala, G | 1 |
| Schmid, M | 1 |
| Bühler, H | 1 |
| Krüger, FW | 1 |
| Osterholm, JL | 1 |
| Mathews, GJ | 1 |
| Irvin, JD | 1 |
| Calesnick, B | 1 |
| Kendrey, G | 1 |
| Sziza, M | 1 |
| Scholler, KL | 3 |
| Müller, E | 1 |
| von Plehwe, U | 1 |
| Althoff, H | 2 |
1 review available for disulfiram and Necrosis
| Article | Year |
|---|---|
[The biochemical mechanism of action of carcinogenic N-nitroso compounds].
Topics: Alkanes; Alkylation; Animals; Carcinogens; Diazomethane; Disulfiram; Iodides; Kidney; Lethal Dose 50 | 1972 |
15 other studies available for disulfiram and Necrosis
| Article | Year |
|---|---|
Blockade of ALDH in Cisplatin-Resistant Ovarian Cancer Stem Cells In Vitro Synergistically Enhances Chemotherapy-Induced Cell Death.
Topics: Antineoplastic Agents; Apoptosis; Cisplatin; Disulfiram; Female; Humans; Necrosis; Neoplastic Stem C | 2022 |
Disulfiram reduces the severity of mouse acute pancreatitis by inhibiting RIPK1-dependent acinar cell necrosis.
Topics: Acinar Cells; Acute Disease; Animals; Ceruletide; Disulfiram; Mice; Molecular Docking Simulation; Ne | 2023 |
Echis carinatus snake venom metalloprotease-induced toxicities in mice: Therapeutic intervention by a repurposed drug, Tetraethyl thiuram disulfide (Disulfiram).
Topics: Animals; Antivenins; Disulfiram; Extracellular Traps; Female; Hemorrhage; Humans; Metalloproteases; | 2021 |
Redirecting apoptosis to aponecrosis induces selective cytotoxicity to pancreatic cancer cells through increased ROS, decline in ATP levels, and VDAC.
Topics: Adenosine Triphosphate; Animals; Antineoplastic Agents; Apoptosis; Arsenic Trioxide; Arsenicals; Asc | 2013 |
[Cardionecrotic effect of ethanol, acetaldehyde and teturam in acute experiments on rats].
Topics: Acetaldehyde; Acute Disease; Animals; Disulfiram; Endomyocardial Fibrosis; Ethanol; Male; Myocardium | 1983 |
Fulminant hepatitis associated with disulfiram. Report of a case.
Topics: Acute Disease; Adult; Alcoholism; Chemical and Drug Induced Liver Injury; Disulfiram; Humans; Liver; | 1983 |
Cure of mice infected with Trypanosoma rhodesiense by cis-diamminedichloroplatinum (II) and disulfiram rescue.
Topics: Animals; Cisplatin; Disulfiram; Kidney; Male; Mice; Mice, Inbred ICR; Necrosis; Rats; Sodium Chlorid | 1982 |
[Fulminant hepatitis caused by disulfiram].
Topics: Alcoholism; Biopsy; Combined Modality Therapy; Critical Care; Disulfiram; Fatal Outcome; Female; Hep | 1993 |
Chapter 29. Anti-norepinephrine therapy against traumatic hemorrhagic necrosis of the spinal cord: preliminary report.
Topics: Animals; Bretylium Compounds; Cats; Dihydroxyphenylalanine; Disease Models, Animal; Disulfiram; Guan | 1973 |
[Adrenal cortex necrosis in laboratory rats treated with Thiuram (tetramethyl-thiuram-disulfide)].
Topics: Adrenal Glands; Animals; Disulfiram; Necrosis; Rats | 1971 |
Modification of the effects of chloroform on the rat liver.
Topics: Animals; Chemical and Drug Induced Liver Injury; Chloroform; Disulfiram; Enzyme Induction; Microsome | 1970 |
[Stimulation and depression of toxicity of chloroform for the liver by drugs].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chemical and Drug Induced Liver Injury; | 1970 |
[Potentiation and inhibition of chloroform liver toxicity by drugs].
Topics: Alanine Transaminase; Animals; Aspartate Aminotransferases; Chloroform; Disulfiram; Drug Antagonism; | 1971 |
[Multiple hemorrhagic necroses of the brain as complications of disulfiram (Antabuse) therapy].
Topics: Adult; Alcoholism; Cerebral Hemorrhage; Chromatography, Thin Layer; Disulfiram; Drug Incompatibility | 1968 |
Multiple haemorrhage necroses of the brain as a complication of disulfiram (antabuse) therapy.
Topics: Adult; Alcoholism; Cerebral Hemorrhage; Disulfiram; Humans; Male; Necrosis | 1968 |