Proteins > Transient receptor potential cation channel subfamily V member 2
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Transient receptor potential cation channel subfamily V member 2
A transient receptor potential cation channel TRPV2 that is encoded in the genome of rat. [OMA:Q9WUD2, PRO:DNx]
Synonyms
TrpV2;
Osm-9-like TRP channel 2;
OTRPC2;
Stretch-activated channel 2B;
Vanilloid receptor-like protein 1;
VRL-1
Research
Bioassay Publications (13)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 3 (23.08) | 18.2507 |
| 2000's | 5 (38.46) | 29.6817 |
| 2010's | 4 (30.77) | 24.3611 |
| 2020's | 1 (7.69) | 2.80 |
Compounds (30)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| cannabinol | Rattus norvegicus (Norway rat) | EC50 | 19.0000 | 1 | 1 |
| nonivamide | Rattus norvegicus (Norway rat) | EC50 | 0.5500 | 2 | 2 |
| dihydrocapsaicin | Rattus norvegicus (Norway rat) | EC50 | 0.1900 | 1 | 1 |
| cannabidiol | Rattus norvegicus (Norway rat) | EC50 | 1.2000 | 1 | 1 |
| capsaicin | Rattus norvegicus (Norway rat) | EC50 | 0.2460 | 4 | 5 |
| capsazepine | Rattus norvegicus (Norway rat) | EC50 | 100.0000 | 1 | 1 |
| N-octylhomovanillamide | Rattus norvegicus (Norway rat) | EC50 | 0.3000 | 1 | 1 |
| olvanil | Rattus norvegicus (Norway rat) | EC50 | 0.1700 | 2 | 2 |
| cannabigerol | Rattus norvegicus (Norway rat) | EC50 | 1.7000 | 1 | 1 |
| ne 21610 | Rattus norvegicus (Norway rat) | EC50 | 0.2500 | 1 | 1 |
Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 3. The hydrophobic side-chain "C-region".Journal of medicinal chemistry, , Aug-06, Volume: 36, Issue:16, 1993
Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 2. The amide bond "B-region".Journal of medicinal chemistry, , Aug-06, Volume: 36, Issue:16, 1993
N-4-Substituted-benzyl-N'-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity.Bioorganic & medicinal chemistry letters, , Feb-09, Volume: 14, Issue:3, 2004
Analogues of capsaicin with agonist activity as novel analgesic agents: structure-activity studies. 4. Potent, orally active analgesics.Journal of medicinal chemistry, , Dec-06, Volume: 39, Issue:25, 1996
Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 2. The amide bond "B-region".Journal of medicinal chemistry, , Aug-06, Volume: 36, Issue:16, 1993
Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 3. The hydrophobic side-chain "C-region".Journal of medicinal chemistry, , Aug-06, Volume: 36, Issue:16, 1993
N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands.Bioorganic & medicinal chemistry letters, , Apr-05, Volume: 14, Issue:7, 2004
N-4-Substituted-benzyl-N'-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity.Bioorganic & medicinal chemistry letters, , Feb-09, Volume: 14, Issue:3, 2004
Chain-branched acyclic phenethylthiocarbamates as vanilloid receptor antagonists.Bioorganic & medicinal chemistry letters, , May-05, Volume: 13, Issue:9, 2003
Synthesis of N,N',N"-trisubstituted thiourea derivatives and their antagonist effect on the vanilloid receptor.Bioorganic & medicinal chemistry letters, , Feb-24, Volume: 13, Issue:4, 2003
Elongation of the Hydrophobic Chain as a Molecular Switch: Discovery of Capsaicin Derivatives and Endogenous Lipids as Potent Transient Receptor Potential Vanilloid Channel 2 Antagonists.Journal of medicinal chemistry, , 09-27, Volume: 61, Issue:18, 2018
Analogues of capsaicin with agonist activity as novel analgesic agents: structure-activity studies. 4. Potent, orally active analgesics.Journal of medicinal chemistry, , Dec-06, Volume: 39, Issue:25, 1996
Analogues of capsaicin with agonist activity as novel analgesic agents; structure-activity studies. 3. The hydrophobic side-chain "C-region".Journal of medicinal chemistry, , Aug-06, Volume: 36, Issue:16, 1993
N-4-methansulfonamidobenzyl-N'-2-substituted-4-tert-butyl-benzyl thioureas as potent vanilloid receptor antagonistic ligands.Bioorganic & medicinal chemistry letters, , Apr-05, Volume: 14, Issue:7, 2004
N-4-Substituted-benzyl-N'-tert-butylbenzyl thioureas as vanilloid receptor ligands: investigation on the role of methanesulfonamido group in antagonistic activity.Bioorganic & medicinal chemistry letters, , Feb-09, Volume: 14, Issue:3, 2004