Page last updated: 2024-08-07 17:28:43
Cysteinyl leukotriene receptor 2
A cysteinyl leukotriene receptor 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9NS75]
Synonyms
CysLTR2;
G-protein coupled receptor GPCR21;
hGPCR21;
G-protein coupled receptor HG57;
HPN321
Research
Bioassay Publications (9)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (55.56) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 3 (33.33) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
Compounds (22)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| ly 171883 | Homo sapiens (human) | Ki | 0.6000 | 1 | 1 |
| ono 1078 | Homo sapiens (human) | IC50 | 2.2070 | 3 | 3 |
| pf 5901 | Homo sapiens (human) | Ki | 0.7000 | 1 | 1 |
| ici 204,219 | Homo sapiens (human) | IC50 | 22.1323 | 3 | 3 |
| ici 204,219 | Homo sapiens (human) | Ki | 0.0003 | 1 | 1 |
| zileuton | Homo sapiens (human) | IC50 | 0.4200 | 1 | 1 |
| wy 48252 | Homo sapiens (human) | Ki | 0.0350 | 1 | 1 |
| pobilukast | Homo sapiens (human) | Ki | 0.0050 | 1 | 1 |
| fpl 55712 | Homo sapiens (human) | IC50 | 0.5100 | 1 | 1 |
| l 648051 | Homo sapiens (human) | Ki | 6.2000 | 1 | 1 |
| rg 12525 | Homo sapiens (human) | Ki | 0.0030 | 1 | 1 |
| montelukast | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| l 735821 | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| bay u9773 | Homo sapiens (human) | IC50 | 0.3000 | 1 | 1 |
| l 365260 | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| cp 105696 | Homo sapiens (human) | IC50 | 0.0084 | 1 | 1 |
| l 365260 | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| mk 0571 | Homo sapiens (human) | Ki | 0.0002 | 1 | 1 |
| montelukast sodium | Homo sapiens (human) | IC50 | 27.0000 | 1 | 1 |
| 3-(((3-carboxycyclohexyl)amino)carbonyl)-4-(3-(4-(4-phenoxybutoxy)phenyl)propoxy)benzoic acid | Homo sapiens (human) | IC50 | 0.0530 | 2 | 2 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| leukotriene c4 | Homo sapiens (human) | EC50 | 0.0089 | 1 | 1 |
| leukotriene d4 | Homo sapiens (human) | EC50 | 0.0044 | 1 | 1 |
| leukotriene e4 | Homo sapiens (human) | EC50 | 0.2930 | 1 | 1 |
Enables
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| leukotriene receptor activity | molecular function | Combining with a leukotriene to initiate a change in cell activity. Leukotrienes are pharmacologically active substances with a set of three conjugated double bonds; some contain a peptide group based on cysteine. [GOC:ai, ISBN:0198506732] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| cysteinyl leukotriene receptor activity | molecular function | Combining with a cysteinyl leukotriene to initiate a change in cell activity. Cysteinyl leukotrienes are leukotrienes that contain a peptide group based on cysteine. [GOC:ai, ISBN:0198506732] |
| G protein-coupled peptide receptor activity | molecular function | Combining with a peptide and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:dph, GOC:tb] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Active In
This protein is active in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cellular_component | cellular component | A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex). [GOC:pdt] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| immune response | biological process | Any immune system process that functions in the calibrated response of an organism to a potential internal or invasive threat. [GO_REF:0000022, GOC:add] |
| leukotriene signaling pathway | biological process | A G protein-coupled receptor signaling pathway initiated by leukotriene binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:dph, PMID:21771892] |
| neuropeptide signaling pathway | biological process | A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194] |