Page last updated: 2024-12-06

ubiquinone-o

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Ubiquinone-O (UQ-O) is a unique form of ubiquinone with an oxygen atom attached to the quinone ring. Its synthesis and biological function are not fully understood. Research suggests UQ-O may be involved in various metabolic pathways, possibly acting as an antioxidant or playing a role in electron transport. The presence of UQ-O in specific tissues and its potential role in diseases like cancer are being actively investigated. Its distinct structure and potential biological activity make it a subject of ongoing research to understand its function and importance in cellular processes.'

2,3-dimethoxy-5-methyl-p-benzoquinone: from solid-cultured Antrodia camphorata; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ubiquinone-0 : A derivative of benzoquinone carrying a 5-methyl substituent; and methoxy substituents at positions 2 and 3. The core structure of the ubiquinone group of compounds. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID69068
CHEMBL ID1812772
CHEBI ID27906
SCHEMBL ID49420
MeSH IDM0285013

Synonyms (58)

Synonym
AC-4353
p-benzoquinone, 2,3-dimethoxy-5-methyl-
2,5-cyclohexadiene-1,4-dione, 2,3-dimethoxy-5-methyl-
2,3-dimethoxy-5-methylbenzo-1,4-quinone
inchi=1/c9h10o4/c1-5-4-6(10)8(12-2)9(13-3)7(5)11/h4h,1-3h
2,3-dimethoxy-5-methyl-p-benzoquinone, apoptosis inducer
coenzyme q0
ubiquinone-0
2-methyl-4,5-dimethoxy-p-quinone
605-94-7
q0
2,3-dimethoxy-5-methyl-p-benzoquinone
2,3-dimethoxy-5-methylcyclohexa-2,5-diene-1,4-dione
ubiquinone 0
2-methyl-5,6-dimethoxybenzoquinone
CHEBI:27906 ,
2,3-dimethoxy-5-methylbenzoquinone
2,3-dimethoxy-5-methyl-1,4-benzoquinone
coq0
ubiquinone q0
ubiquinone-q0
ubiquinone-o
coenzyme qo
D1956
CHEMBL1812772
ubiquinone qo
2,3-dimethoxy-5-methyl-2,5-cyclohexadiene-1,4-dione
einecs 210-100-8
ccris 7153
uq(0) cpd
AKOS006227783
FT-0609676
2,3-dimethoxy 5-methyl-1,4-benzoquinone
2,3dimethoxy-5-methyl 1,4 benzoquinone
2,3-dimethoxy-5- methyl-[1,4]benzoquinone
2,3 dimethoxy 5-methyl 1,4 benzoquinone
2,3-dimethoxy-5-methyl-[1,4]benzoquinone
2,3-dimethoxy-5 methyl-[1,4]benzoquinone
SCHEMBL49420
bdbm15346
2,3-dimethoxy-5-methyl-cyclohexa-2,5-diene-1,4-dione
ubiquinone-0 (coq0)
2,3-dimethoxy-6-methyl-p-benzoquinone
2,3-dimethoxy-5-methylbenzo-1,4-quinone #
W-105244
DS-1644
DTXSID90209242
mfcd00001595
2,3-dimethoxy-5-methyl-[1,4]-benzoquinone
CS-W017128
Q27103400
EN300-112639
STL570273
2-methyl-4,5-dimethoxy-p-benzoquinone
HY-W016412
fumigatin methylether
SY047043
Z1201617041
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
Escherichia coli metaboliteAny bacterial metabolite produced during a metabolic reaction in Escherichia coli.
human metaboliteAny mammalian metabolite produced during a metabolic reaction in humans (Homo sapiens).
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (1)

ClassDescription
ubiquinonesAny benzoquinone derived from 2,3-dimethoxy-5-methylbenzoquinone; one of a group of naturally occurring homologues. The redox-active quinoid moiety usually carries a polyprenoid side chain at position 6, the number of isoprenoid units in which is species-specific. Ubiquinones are involved in the control of mitochondrial electron transport, and are also potent anti-oxidants.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (4)

PathwayProteinsCompounds
TCA cycle (ubiquinol-0)1825
Pyruvate to Cytochrome bd Terminal Oxidase Electron Transfer48
TCA Cycle (Ubiquinol-0)425
superpathway of glycol metabolism and degradation1035
glycolate and glyoxylate degradation I726

Bioassays (9)

Assay IDTitleYearJournalArticle
AID1091120Antifeedant activity against Coptotermes formosanus placed on 1 % wt/wt compound treated filter paper assessed as filter paper consumption measured 21 days post compound exposure (Rvb = 42.4 +/- 4.3 mg)2008Journal of agricultural and food chemistry, Jun-11, Volume: 56, Issue:11
Activity of 1,4-benzoquinones against formosan subterranean termites (Coptotermes formosanus).
AID610714Activity of Rhodobacter capsulatus NADH-ubiquinone oxidoreductase2010Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10
Photolabile ubiquinone analogues for identification and characterization of quinone binding sites in proteins.
AID1091095Termiticidal activity against Coptotermes formosanus placed on 1 % wt/wt compound treated filter paper assessed as termite mortality measured 11 days post compound exposure2008Journal of agricultural and food chemistry, Jun-11, Volume: 56, Issue:11
Activity of 1,4-benzoquinones against formosan subterranean termites (Coptotermes formosanus).
AID610713Activity of Bacillus subtilis Succinate-ubiquinone oxidoreductase2010Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10
Photolabile ubiquinone analogues for identification and characterization of quinone binding sites in proteins.
AID610712Activity of Escherichia coli WrbA2010Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10
Photolabile ubiquinone analogues for identification and characterization of quinone binding sites in proteins.
AID1091094Termiticidal activity against Coptotermes formosanus placed on 1 % wt/wt compound treated filter paper assessed as termite mortality measured 21 days post compound exposure2008Journal of agricultural and food chemistry, Jun-11, Volume: 56, Issue:11
Activity of 1,4-benzoquinones against formosan subterranean termites (Coptotermes formosanus).
AID1091096Termiticidal activity against Coptotermes formosanus placed on 1 % wt/wt compound treated filter paper assessed as termite mortality measured 3 days post compound exposure2008Journal of agricultural and food chemistry, Jun-11, Volume: 56, Issue:11
Activity of 1,4-benzoquinones against formosan subterranean termites (Coptotermes formosanus).
AID610721Inhibition of Bacillus subtilis Succinate-ubiquinone oxidoreductase using Q0 as substrate2010Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10
Photolabile ubiquinone analogues for identification and characterization of quinone binding sites in proteins.
AID610718Inhibition of photo labeled detergent solubilized succinate:ubiquinone oxidoreductase activity in Bacillus subtilis measured in dark2010Bioorganic & medicinal chemistry, May-15, Volume: 18, Issue:10
Photolabile ubiquinone analogues for identification and characterization of quinone binding sites in proteins.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (37)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (2.70)18.7374
1990's5 (13.51)18.2507
2000's15 (40.54)29.6817
2010's16 (43.24)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 17.72

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be moderate demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index17.72 (24.57)
Research Supply Index3.66 (2.92)
Research Growth Index5.29 (4.65)
Search Engine Demand Index18.60 (26.88)
Search Engine Supply Index4.00 (0.95)

This Compound (17.72)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews1 (2.63%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other37 (97.37%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]