An alkaline phosphatase, tissue-nonspecific isozyme that is encoded in the genome of human. [PRO:DNx, UniProtKB:P05186]
| Target | Category | Definition |
|---|
| alkaline phosphatase activity | molecular function | Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an alkaline pH optimum. [EC:3.1.3.1] |
| inorganic diphosphate phosphatase activity | molecular function | Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate. [EC:3.6.1.1, RHEA:24576] |
| calcium ion binding | molecular function | Binding to a calcium ion (Ca2+). [GOC:ai] |
| pyrophosphatase activity | molecular function | Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups. [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase] |
| ATP hydrolysis activity | molecular function | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. [RHEA:13065] |
| pyridoxal phosphatase activity | molecular function | Catalysis of the reaction: pyridoxal 5'-phosphate + H2O = pyridoxal + phosphate. [EC:3.1.3.74] |
| ADP phosphatase activity | molecular function | Catalysis of the reaction: ADP + H2O = AMP + phosphate + H+. [PMID:1470606, RHEA:61436] |
| phosphoamidase activity | molecular function | Catalysis of the reaction: N-phosphocreatine + H2O = creatine + phosphate. [EC:3.9.1.1, RHEA:12977] |
| phosphoethanolamine phosphatase activity | molecular function | Catalysis of the reaction: O-phosphoethanolamine + H2O = ethanolamine + phosphate. [EC:3.1.3.75] |
| Target | Category | Definition |
|---|
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| extracellular matrix | cellular component | A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| side of membrane | cellular component | A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface. [GOC:dos] |
| Target | Category | Definition |
|---|
| skeletal system development | biological process | The process whose specific outcome is the progression of the skeleton over time, from its formation to the mature structure. The skeleton is the bony framework of the body in vertebrates (endoskeleton) or the hard outer envelope of insects (exoskeleton or dermoskeleton). [GOC:dph, GOC:jid, GOC:tb] |
| osteoblast differentiation | biological process | The process whereby a relatively unspecialized cell acquires the specialized features of an osteoblast, a mesodermal or neural crest cell that gives rise to bone. [CL:0000062, GO_REF:0000034, GOC:jid] |
| endochondral ossification | biological process | Replacement ossification wherein bone tissue replaces cartilage. [GO_REF:0000034, ISBN:0878932437] |
| developmental process involved in reproduction | biological process | A developmental process in which a progressive change in the state of some part of an organism, germline or somatic, specifically contributes to its ability to form offspring. [GOC:dph, GOC:isa_complete] |
| cellular homeostasis | biological process | Any process involved in the maintenance of an internal steady state at the level of the cell. [GOC:isa_complete, GOC:jl, ISBN:0395825172] |
| bone mineralization | biological process | The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. [GOC:mah, PMID:22936354] |
| response to lipopolysaccharide | biological process | Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria. [GOC:add, ISBN:0721601464] |
| response to insulin | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732] |
| response to vitamin D | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin D stimulus. [GOC:sl] |
| response to vitamin B6 | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin B6 stimulus. Vitamin B6 encompasses pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate. [GOC:mah, GOC:rph] |
| response to macrophage colony-stimulating factor | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus. [GOC:yaf, PMID:14687666] |
| pyridoxal phosphate metabolic process | biological process | The chemical reactions and pathways involving pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6. [GOC:jl] |
| response to antibiotic | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. [GOC:ai, GOC:ef] |
| response to glucocorticoid | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glucocorticoid stimulus. Glucocorticoids are hormonal C21 corticosteroids synthesized from cholesterol with the ability to bind with the cortisol receptor and trigger similar effects. Glucocorticoids act primarily on carbohydrate and protein metabolism, and have anti-inflammatory effects. [GOC:ai, PMID:9884123] |
| phosphate ion homeostasis | biological process | Any process involved in the maintenance of an internal steady state of phosphate ions within an organism or cell. [GOC:jid, GOC:mah] |
| calcium ion homeostasis | biological process | Any process involved in the maintenance of an internal steady state of calcium ions within an organism or cell. [GOC:ceb, GOC:jid, GOC:mah] |
| cellular response to organic cyclic compound | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an organic cyclic compound stimulus. [GOC:mah] |
| cementum mineralization | biological process | The process in which calcium salts, mainly carbonated hydroxyapatite, are deposited into the initial acellular cementum. [GOC:sl, PMID:17043865] |
| positive regulation of cold-induced thermogenesis | biological process | Any process that activates or increases the frequency, rate or extent of cold-induced thermogenesis. [PMID:27876809] |
| futile creatine cycle | biological process | The phosphorylation and dephosphorylation of creatine in a futile cycle, which dissipates the high energy charge of phosphocreatine as heat without performing any mechanical or chemical work. The futile creatine cycle takes place in thermogenic fat cells and is part of adaptive thermogenesis. [PMID:33597756, PMID:33981039] |
| inhibition of non-skeletal tissue mineralization | biological process | A homeostatic process involved in the maintenance of non-mineral tissue, by preventing mineralization of non-skeletal tissue. [PMID:21490328, PMID:30030150] |
| response to sodium phosphate | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sodium phosphate stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:24625659] |
| dephosphorylation | biological process | The process of removing one or more phosphoric (ester or anhydride) residues from a molecule. [ISBN:0198506732] |