Proteins > 3-hydroxy-3-methylglutaryl-coenzyme A reductase
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3-hydroxy-3-methylglutaryl-coenzyme A reductase
A 3-hydroxy-3-methylglutaryl-coenzyme A reductase that is encoded in the genome of rat. [OMA:P51639, PRO:DNx]
Synonyms
HMG-CoA reductase;
EC 1.1.1.34
Research
Bioassay Publications (26)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 3 (11.54) | 18.7374 |
| 1990's | 13 (50.00) | 18.2507 |
| 2000's | 8 (30.77) | 29.6817 |
| 2010's | 2 (7.69) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (22)
Drugs with Inhibition Measurements
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010
Synthesis and biological activity of bile acid-derived HMG-CoA reductase inhibitors. The role of 21-methyl in recognition of HMG-CoA reductase and the ileal bile acid transport system.Journal of medicinal chemistry, , Sep-30, Volume: 37, Issue:20, 1994
Inhibitors of cholesterol biosynthesis. 2. 3,5-Dihydroxy-7-(N-pyrrolyl)-6-heptenoates, a novel series of HMG-CoA reductase inhibitors.Journal of medicinal chemistry, , Nov-12, Volume: 36, Issue:23, 1993
HMG-CoA reductase inhibitors: design, synthesis, and biological activity of tetrahydroindazole-substituted 3,5-dihydroxy-6-heptenoic acid sodium salts.Journal of medicinal chemistry, , Nov-12, Volume: 36, Issue:23, 1993
Inhibitors of cholesterol biosynthesis. 4. trans-6-[2-(substituted-quinolinyl)ethenyl/ethyl]tetrahydro-4-hydroxy-2 H-pyran-2-ones, a novel series of HMG-CoA reductase inhibitors.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids.Journal of medicinal chemistry, , Volume: 34, Issue:10, 1991
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 1. Lactones of pyridine- and pyrimidine-substituted 3,5-dihydroxy-6-heptenoic (-heptanoic) acids.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
Synthesis, biological profile, and quantitative structure-activity relationship of a series of novel 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors.Journal of medicinal chemistry, , Volume: 33, Issue:11, 1990
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 2. Derivatives of 7-(1H-pyrrol-3-yl)-substituted-3,5-dihydroxyhept-6(E)-enoic (-heptanoic) acids.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor withJournal of medicinal chemistry, , May-08, Volume: 51, Issue:9, 2008
Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase.Bioorganic & medicinal chemistry, , Aug-15, Volume: 15, Issue:16, 2007
Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hyperJournal of medicinal chemistry, , Jan-10, Volume: 51, Issue:1, 2008
(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor withJournal of medicinal chemistry, , May-08, Volume: 51, Issue:9, 2008
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010
Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor withJournal of medicinal chemistry, , May-08, Volume: 51, Issue:9, 2008
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010
Application of a 3,3-diphenylpentane skeleton as a multi-template for creation of HMG-CoA reductase inhibitors.Bioorganic & medicinal chemistry letters, , Aug-01, Volume: 19, Issue:15, 2009
Inhibitors of cholesterol biosynthesis. 3. Tetrahydro-4-hydroxy-6-[2-(1H-pyrrol-1-yl)ethyl]-2H-pyran-2-one inhibitors of HMG-CoA reductase. 2. Effects of introducing substituents at positions three and four of the pyrrole nucleus.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
Inhibitors of cholesterol biosynthesis. 4. trans-6-[2-(substituted-quinolinyl)ethenyl/ethyl]tetrahydro-4-hydroxy-2 H-pyran-2-ones, a novel series of HMG-CoA reductase inhibitors.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
Inhibitors of cholesterol biosynthesis. 1. trans-6-(2-pyrrol-1-ylethyl)-4-hydroxypyran-2-ones, a novel series of HMG-CoA reductase inhibitors. 1. Effects of structural modifications at the 2- and 5-positions of the pyrrole nucleus.Journal of medicinal chemistry, , Volume: 33, Issue:1, 1990
3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors. 1. Structural modification of 5-substituted 3,5-dihydroxypentanoic acids and their lactone derivatives.Journal of medicinal chemistry, , Volume: 28, Issue:3, 1985
Compactin (ML-236B) and related compounds as potential cholesterol-lowering agents that inhibit HMG-CoA reductase.Journal of medicinal chemistry, , Volume: 28, Issue:4, 1985
3-Alkyl-3-hydroxyglutaric acids: a new class of hypocholesterolemic HMG CoA reductase inhibitors. 1.Journal of medicinal chemistry, , Volume: 28, Issue:5, 1985
(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor withJournal of medicinal chemistry, , May-08, Volume: 51, Issue:9, 2008
Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase.Bioorganic & medicinal chemistry, , Aug-15, Volume: 15, Issue:16, 2007
Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hyperJournal of medicinal chemistry, , Jan-10, Volume: 51, Issue:1, 2008
(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor withJournal of medicinal chemistry, , May-08, Volume: 51, Issue:9, 2008
Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase.Bioorganic & medicinal chemistry, , Aug-15, Volume: 15, Issue:16, 2007
Hepatoselectivity of statins: design and synthesis of 4-sulfamoyl pyrroles as HMG-CoA reductase inhibitors.Bioorganic & medicinal chemistry letters, , Feb-01, Volume: 18, Issue:3, 2008
Substituted pyrazoles as hepatoselective HMG-CoA reductase inhibitors: discovery of (3R,5R)-7-[2-(4-fluoro-phenyl)-4-isopropyl-5-(4-methyl-benzylcarbamoyl)-2H-pyrazol-3-yl]-3,5-dihydroxyheptanoic acid (PF-3052334) as a candidate for the treatment of hyperJournal of medicinal chemistry, , Jan-10, Volume: 51, Issue:1, 2008
(3R,5S,E)-7-(4-(4-fluorophenyl)-6-isopropyl-2-(methyl(1-methyl-1h-1,2,4-triazol-5-yl)amino)pyrimidin-5-yl)-3,5-dihydroxyhept-6-enoic acid (BMS-644950): a rationally designed orally efficacious 3-hydroxy-3-methylglutaryl coenzyme-a reductase inhibitor withJournal of medicinal chemistry, , May-08, Volume: 51, Issue:9, 2008
Pyrazole inhibitors of HMG-CoA reductase: an attempt to dramatically reduce synthetic complexity through minimal analog re-design.Bioorganic & medicinal chemistry letters, , Oct-15, Volume: 17, Issue:20, 2007
Discovery of pyrrole-based hepatoselective ligands as potent inhibitors of HMG-CoA reductase.Bioorganic & medicinal chemistry, , Aug-15, Volume: 15, Issue:16, 2007
Synthesis and biological evaluations of condensed pyridine and condensed pyrimidine-based HMG-CoA reductase inhibitors.Bioorganic & medicinal chemistry letters, , May-21, Volume: 11, Issue:10, 2001
Inhibitors of cholesterol biosynthesis. 2. 3,5-Dihydroxy-7-(N-pyrrolyl)-6-heptenoates, a novel series of HMG-CoA reductase inhibitors.Journal of medicinal chemistry, , Nov-12, Volume: 36, Issue:23, 1993
Phosphorus-containing inhibitors of HMG-CoA reductase. 2. Synthesis and biological activities of a series of substituted pyridines containing a hydroxyphosphinyl moiety.Journal of medicinal chemistry, , Volume: 34, Issue:9, 1991
Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
Phosphorus-containing inhibitors of HMG-CoA reductase. 1. 4-[(2-arylethyl)hydroxyphosphinyl]-3-hydroxy-butanoic acids: a new class of cell-selective inhibitors of cholesterol biosynthesis.Journal of medicinal chemistry, , Volume: 33, Issue:11, 1990
Synthesis and HMG CoA reductase inhibition of 4-thiophenyl quinolines as potential hypocholesterolemic agents.Bioorganic & medicinal chemistry, , Dec-15, Volume: 15, Issue:24, 2007
HMG-CoA reductase inhibitors: design, synthesis, and biological activity of tetrahydroindazole-substituted 3,5-dihydroxy-6-heptenoic acid sodium salts.Journal of medicinal chemistry, , Nov-12, Volume: 36, Issue:23, 1993
Relationship between tissue selectivity and lipophilicity for inhibitors of HMG-CoA reductase.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
Synthesis and biological activity of new HMG-CoA reductase inhibitors. 3. Lactones of 6-phenoxy-3,5-dihydroxyhexanoic acids.Journal of medicinal chemistry, , Volume: 34, Issue:10, 1991
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010
Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands.Bioorganic & medicinal chemistry letters, , Sep-15, Volume: 20, Issue:18, 2010