Dehydrogenase/reductase SDR family member 9

A dehydrogenase/reductase SDR family member 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BPW9]

Synonyms

EC 1.1.1.209;
EC 1.1.1.53;
3-alpha hydroxysteroid dehydrogenase;
3-alpha-HSD;
NADP-dependent retinol dehydrogenase/reductase;
RDH-E2;
RDHL;
Retinol dehydrogenase 15;
1.1.1.105;
Short chain dehydrogenase/reductase famil

Research

Bioassay Publications (1)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (100.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80

Compounds (2)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
indomethacin	Homo sapiens (human)	IC50	14.0000	1	1
6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid	Homo sapiens (human)	IC50	1,000.0000	1	1

Enables

This protein enables 6 target(s):

Target	Category	Definition
alcohol dehydrogenase (NAD+) activity	molecular function	Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. [EC:1.1.1.1]
all-trans-retinol dehydrogenase (NAD+) activity	molecular function	Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. [RHEA:21284]
racemase and epimerase activity	molecular function	Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. [GOC:mah, ISBN:0198506732]
androsterone dehydrogenase activity	molecular function	Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. [EC:1.1.1.209, MetaCyc:1.1.1.209-RXN]
testosterone dehydrogenase (NAD+) activity	molecular function	Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH. [EC:1.1.1.239]
androstan-3-alpha,17-beta-diol dehydrogenase activity	molecular function	Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+. [EC:1.1.1.53, MetaCyc:1.1.1.53-RXN]

Located In

This protein is located in 1 target(s):

Target	Category	Definition
endoplasmic reticulum membrane	cellular component	The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]

Involved In

This protein is involved in 6 target(s):

Target	Category	Definition
androgen metabolic process	biological process	The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. [ISBN:0198506732]
epithelial cell differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. [GOC:ecd, PMID:11839751]
progesterone metabolic process	biological process	The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. [GOC:jl, http://www.cogsci.princeton.edu/]
retinol metabolic process	biological process	The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551]
9-cis-retinoic acid biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative. [GOC:jl, PMID:11279029]
steroid metabolic process	biological process	The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684]

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