A dehydrogenase/reductase SDR family member 9 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9BPW9]
EC 1.1.1.209;
EC 1.1.1.53;
3-alpha hydroxysteroid dehydrogenase;
3-alpha-HSD;
NADP-dependent retinol dehydrogenase/reductase;
RDH-E2;
RDHL;
Retinol dehydrogenase 15;
1.1.1.105;
Short chain dehydrogenase/reductase famil
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| indomethacin | Homo sapiens (human) | IC50 | 14.0000 | 1 | 1 |
| 6-hydroxy-2,5,7,8-tetramethylchroman-2-carboxylic acid | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 1 |
This protein enables 6 target(s):
| Target | Category | Definition |
|---|---|---|
| alcohol dehydrogenase (NAD+) activity | molecular function | Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+. [EC:1.1.1.1] |
| all-trans-retinol dehydrogenase (NAD+) activity | molecular function | Catalysis of the reaction: retinol + NAD+ = retinal + NADH + H+. [RHEA:21284] |
| racemase and epimerase activity | molecular function | Catalysis of a reaction that alters the configuration of one or more chiral centers in a molecule. [GOC:mah, ISBN:0198506732] |
| androsterone dehydrogenase activity | molecular function | Catalysis of the reaction: NAD(P)+ + androsterone = NAD(P)H + H+ + 5-alpha-androstane-3,17-dione. [EC:1.1.1.209, MetaCyc:1.1.1.209-RXN] |
| testosterone dehydrogenase (NAD+) activity | molecular function | Catalysis of the reaction: testosterone + NAD+ = androst-4-ene-3,17-dione + NADH. [EC:1.1.1.239] |
| androstan-3-alpha,17-beta-diol dehydrogenase activity | molecular function | Catalysis of the reaction: NAD+ + androstan-3-alpha,17-beta-diol = 17-beta-hydroxyandrostan-3-one + NADH + H+. [EC:1.1.1.53, MetaCyc:1.1.1.53-RXN] |
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| intracellular membrane-bounded organelle | cellular component | Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators] |
This protein is involved in 6 target(s):
| Target | Category | Definition |
|---|---|---|
| androgen metabolic process | biological process | The chemical reactions and pathways involving androgens, C19 steroid hormones that can stimulate the development of male sexual characteristics. [ISBN:0198506732] |
| epithelial cell differentiation | biological process | The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium. [GOC:ecd, PMID:11839751] |
| progesterone metabolic process | biological process | The chemical reactions and pathways involving progesterone, a steroid hormone produced in the ovary which prepares and maintains the uterus for pregnancy. Also found in plants. [GOC:jl, http://www.cogsci.princeton.edu/] |
| retinol metabolic process | biological process | The chemical reactions and pathways involving retinol, one of the three compounds that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html, PMID:1924551] |
| 9-cis-retinoic acid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of 9-cis-retinoic acid, a metabolically active vitamin A derivative. [GOC:jl, PMID:11279029] |
| steroid metabolic process | biological process | The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684] |