Page last updated: 2024-08-07 10:07:16

UDP-glucuronosyltransferase 1A8

A UDP-glucuronosyltransferase 1A8 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q9HAW9]

Synonyms

UGT1A8;
EC 2.4.1.17;
UDP-glucuronosyltransferase 1-8;
UDPGT 1-8;
UGT1*8;
UGT1-08;
UGT1.8;
UDP-glucuronosyltransferase 1-H;
UGT-1H;
UGT1H

Research

Bioassay Publications (4)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (25.00)29.6817
2010's2 (50.00)24.3611
2020's1 (25.00)2.80

Compounds (9)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
iriloneHomo sapiens (human)Ki23.000022

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
ezogabineHomo sapiens (human)EC503.900011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
propofolHomo sapiens (human)Km412.000011
scutellarinHomo sapiens (human)Km198.000011
mycophenolic acidHomo sapiens (human)Km298.000011
scutellareinHomo sapiens (human)Km19.000011
iriloneHomo sapiens (human)Km79.200022
naloxoneHomo sapiens (human)Km450.000011
naltrexoneHomo sapiens (human)Km1,550.000011
morphine-3-glucuronideHomo sapiens (human)Km26,000.000011

Enables

This protein enables 8 target(s):

TargetCategoryDefinition
retinoic acid bindingmolecular functionBinding to retinoic acid, 3,7-dimethyl-9-(2,6,-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoic acid. [GOC:hjd]
enzyme inhibitor activitymolecular functionBinds to and stops, prevents or reduces the activity of an enzyme. [GOC:ai, GOC:ebc]
steroid bindingmolecular functionBinding to a steroid, any of a large group of substances that have in common a ring system based on 1,2-cyclopentanoperhydrophenanthrene. [GOC:jl, ISBN:0198506732]
fatty acid bindingmolecular functionBinding to a fatty acid, an aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198506732]
glucuronosyltransferase activitymolecular functionCatalysis of the reaction: UDP-glucuronate + acceptor = UDP + acceptor beta-D-glucuronoside. [RHEA:21032]
enzyme bindingmolecular functionBinding to an enzyme, a protein with catalytic activity. [GOC:jl]
protein homodimerization activitymolecular functionBinding to an identical protein to form a homodimer. [GOC:jl]
protein heterodimerization activitymolecular functionBinding to a nonidentical protein to form a heterodimer. [GOC:ai]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
endoplasmic reticulumcellular componentThe irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
endoplasmic reticulum membranecellular componentThe lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
endoplasmic reticulumcellular componentThe irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]

Involved In

This protein is involved in 11 target(s):

TargetCategoryDefinition
fatty acid metabolic processbiological processThe chemical reactions and pathways involving fatty acids, aliphatic monocarboxylic acids liberated from naturally occurring fats and oils by hydrolysis. [ISBN:0198547684]
steroid metabolic processbiological processThe chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus. [ISBN:0198547684]
coumarin metabolic processbiological processThe chemical reactions and pathways involving coumarins, compounds derived from the phenylacrylic skeleton of cinnamic acids. [GOC:lr, GOC:yl]
retinoic acid metabolic processbiological processThe chemical reactions and pathways involving retinoic acid, one of the three components that makes up vitamin A. [GOC:jl, http://www.indstate.edu/thcme/mwking/vitamins.html]
negative regulation of fatty acid metabolic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving fatty acids. [GOC:go_curators]
negative regulation of steroid metabolic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving steroids. [GOC:go_curators]
flavone metabolic processbiological processThe chemical reactions and pathways involving flavones, a class of pigmented plant compounds based on 2-phenyl-4H-1-benzopyran-4-one (2-phenylchromone). [PMID:18567791]
flavonoid glucuronidationbiological processThe modification of a flavonoid by the conjugation of glucuronic acid. The resultant flavonoid glucuronosides are often much more water-soluble than the precursor. [GOC:BHF, PMID:20056724]
xenobiotic glucuronidationbiological processThe modification of a xenobiotic substance by the conjugation of glucuronic acid. The resultant glucuronosides are often much more water-soluble than the xenobiotic precursor, enabling efficient excretion. [GOC:BHF, PMID:20056724]
liver developmentbiological processThe process whose specific outcome is the progression of the liver over time, from its formation to the mature structure. The liver is an exocrine gland which secretes bile and functions in metabolism of protein and carbohydrate and fat, synthesizes substances involved in the clotting of the blood, synthesizes vitamin A, detoxifies poisonous substances, stores glycogen, and breaks down worn-out erythrocytes. [GOC:add, ISBN:068340007X]
cellular glucuronidationbiological processThe modification of an organic chemical by the conjugation of glucuronic acid. The substances resulting from glucuronidation are known as glucuronosides (or glucuronides) and are often much more water-soluble than the non-glucuronic acid-containing precursor. [GOC:BHF]