Proteins > Cytochrome P450 11B2, mitochondrial
Page last updated: 2024-08-07 18:31:11

Cytochrome P450 11B2, mitochondrial

A cytochrome P450 11B that is a translation product of the CYP11B2 gene in human. [PRO:DNx, UniProtKB:P19099]

Synonyms

Aldosterone synthase;
ALDOS;
Aldosterone-synthesizing enzyme;
CYPXIB2;
Corticosterone 18-monooxygenase, CYP11B2;
1.14.15.5;
Cytochrome P-450Aldo;
Cytochrome P-450C18;
Steroid 11-beta-hydroxylase, CYP11B2;
1.14.15.4;

Research

Bioassay Publications (35)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's8 (22.86)29.6817
2010's26 (74.29)24.3611
2020's1 (2.86)2.80

Compounds (16)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
fluconazoleHomo sapiens (human)IC5013.000011
ketoconazoleHomo sapiens (human)IC500.517999
letrozoleHomo sapiens (human)IC501.420011
metyraponeHomo sapiens (human)IC500.083899
staurosporineHomo sapiens (human)IC500.011011
fadrozoleHomo sapiens (human)IC500.00452226
1-benzylimidazoleHomo sapiens (human)IC501.358223
abirateroneHomo sapiens (human)IC501.722045
ketoconazoleHomo sapiens (human)IC500.127236
posaconazoleHomo sapiens (human)IC500.021011
1-(phenylmethyl)benzimidazoleHomo sapiens (human)IC500.865011
etomidateHomo sapiens (human)IC500.000944
1-[(3-methylphenyl)methyl]benzimidazoleHomo sapiens (human)IC500.309011
4-fluoro-N-(3-pyridinyl)benzamideHomo sapiens (human)IC500.082011
4-(1H-imidazol-1-ylmethyl)benzonitrileHomo sapiens (human)IC500.371812
osilodrostatHomo sapiens (human)IC500.00141212

Enables

This protein enables 5 target(s):

TargetCategoryDefinition
steroid 11-beta-monooxygenase activitymolecular functionCatalysis of the reaction: a steroid + reduced adrenal ferredoxin + O2 = an 11-beta-hydroxysteroid + oxidized adrenal ferredoxin + H2O. [EC:1.14.15.4]
iron ion bindingmolecular functionBinding to an iron (Fe) ion. [GOC:ai]
steroid hydroxylase activitymolecular functionCatalysis of the formation of a hydroxyl group on a steroid by incorporation of oxygen from O2. [ISBN:0721662544]
heme bindingmolecular functionBinding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai]
corticosterone 18-monooxygenase activitymolecular functionCatalysis of the reaction: corticosterone + reduced adrenal ferredoxin + O2 = 18-hydroxycorticosterone + oxidized adrenal ferredoxin + H2O. [EC:1.14.15.5]

Located In

This protein is located in 2 target(s):

TargetCategoryDefinition
mitochondrioncellular componentA semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732]
mitochondrial inner membranecellular componentThe inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]

Active In

This protein is active in 1 target(s):

TargetCategoryDefinition
mitochondrial inner membranecellular componentThe inner, i.e. lumen-facing, lipid bilayer of the mitochondrial envelope. It is highly folded to form cristae. [GOC:ai]

Involved In

This protein is involved in 15 target(s):

TargetCategoryDefinition
regulation of blood volume by renal aldosteronebiological processThe process in which the hormone aldosterone decreases the rate of diuresis and natriuresis resulting in increased blood volume. [GOC:dph, GOC:tb, ISBN:0721643949]
renal water homeostasisbiological processRenal process involved in the maintenance of an internal steady state of water in the body. [GOC:mtg_cardio]
C21-steroid hormone biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of C21-steroid hormones, steroid compounds containing 21 carbons which function as hormones. [GOC:ai]
mineralocorticoid biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of mineralocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. [ISBN:0198506732]
sterol metabolic processbiological processThe chemical reactions and pathways involving sterols, steroids with one or more hydroxyl groups and a hydrocarbon side-chain in the molecule. [ISBN:0198547684]
aldosterone biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance. [PMID:16527843]
cellular response to hormone stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus. [GOC:mah]
cortisol biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties. [GOC:BHF, GOC:mah, GOC:rl]
cellular response to potassium ionbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus. [GOC:yaf]
potassium ion homeostasisbiological processAny process involved in the maintenance of an internal steady state of potassium ions within an organism or cell. [GOC:jid, GOC:mah]
sodium ion homeostasisbiological processAny process involved in the maintenance of an internal steady state of sodium ions within an organism or cell. [GOC:ai, GOC:jid, GOC:mah]
glucocorticoid biosynthetic processbiological processThe chemical reactions and pathways resulting in the formation of glucocorticoids, hormonal C21 corticosteroids synthesized from cholesterol. [ISBN:0198506732]
cortisol metabolic processbiological processThe chemical reactions and pathways involving cortisol, the steroid hormone 11-beta-17,21-trihydroxypregn-4-ene-3,20-dione. Cortisol is synthesized from cholesterol in the adrenal gland and controls carbohydrate, fat and protein metabolism and has anti-inflammatory properties. [GOC:BHF, GOC:mah, GOC:rl]
cellular response to peptide hormone stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. [GOC:mah]
cholesterol metabolic processbiological processThe chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones. It is a component of the plasma membrane lipid bilayer and of plasma lipoproteins and can be found in all animal tissues. [ISBN:0198506732]