Cyclin-dependent kinase 5 activator 1

A cyclin-dependent kinase 5 activator 1 that is encoded in the genome of human. [PRO:DNx]

Synonyms

CDK5 activator 1;
Cyclin-dependent kinase 5 regulatory subunit 1;
TPKII regulatory subunit

Research

Bioassay Publications (76)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	2 (2.63)	18.2507
2000's	24 (31.58)	29.6817
2010's	43 (56.58)	24.3611
2020's	7 (9.21)	2.80

Compounds (77)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tacrine	Homo sapiens (human)	IC50	10.0000	1	1
gw8510	Homo sapiens (human)	IC50	0.0070	1	1
indirubin-3'-monoxime	Homo sapiens (human)	IC50	0.1000	6	6
indirubin-5-sulfonate	Homo sapiens (human)	IC50	0.0650	1	1
nsc 664704	Homo sapiens (human)	IC50	0.6314	7	11
nu6102	Homo sapiens (human)	IC50	0.1170	1	1
olomoucine	Homo sapiens (human)	IC50	5.6667	2	3
indirubin	Homo sapiens (human)	IC50	7.4444	7	9
indigo	Homo sapiens (human)	IC50	100.0000	1	1
2-phenylindole	Homo sapiens (human)	IC50	100.0000	1	1
staurosporine	Homo sapiens (human)	IC50	0.0141	9	9
cercosporamide	Homo sapiens (human)	IC50	5.6000	1	1
birb 796	Homo sapiens (human)	IC50	30.0000	2	2
cyc 202	Homo sapiens (human)	IC50	65.4440	21	35
paullone	Homo sapiens (human)	IC50	6.4025	3	5
meridianin g	Homo sapiens (human)	IC50	186.4286	3	7
5-iodoindirubin-3'-monoxime	Homo sapiens (human)	IC50	0.0200	2	2
2H-pyrazolo[4,3-b]quinoxalin-3-amine	Homo sapiens (human)	IC50	7.0500	2	2
n-(4-methoxybenzyl)-n'-(5-nitro-1,3-thiazol-2-yl)urea	Homo sapiens (human)	IC50	50,050.0000	2	2
7-n-butyl-6-(4'-hydroxyphenyl)-5h-pyrrolo(2,3b)pyrazine	Homo sapiens (human)	IC50	0.2450	6	8
6-bromoindirubin-3'-oxime	Homo sapiens (human)	IC50	0.0746	5	5
purvalanol b	Homo sapiens (human)	IC50	0.0060	2	2
purvalanol a	Homo sapiens (human)	IC50	0.0623	4	6
2-methyl-5-(4-methylanilino)-1,3-benzothiazole-4,7-dione	Homo sapiens (human)	IC50	20.0000	1	1
cgp 60474	Homo sapiens (human)	IC50	0.0100	1	1
cgp 74514a	Homo sapiens (human)	IC50	0.0260	1	1
1,4-dimethoxy-10H-acridine-9-thione	Homo sapiens (human)	IC50	20.0000	1	1
bms 387032	Homo sapiens (human)	IC50	0.3400	2	2
7-butyl-6-(4-methoxyphenyl)-5H-pyrrolo[2,3-b]pyrazine	Homo sapiens (human)	IC50	1.1550	2	4
alsterpaullone	Homo sapiens (human)	IC50	0.0815	4	6
quercetin	Homo sapiens (human)	IC50	29.6200	2	5
apigenin	Homo sapiens (human)	IC50	2.0600	2	5
luteolin	Homo sapiens (human)	IC50	62.9200	2	5
kaempferol	Homo sapiens (human)	IC50	33.7000	2	5
harmine	Homo sapiens (human)	IC50	11.4000	5	5
aureusidin	Homo sapiens (human)	IC50	4.1550	2	2
sulfuretin	Homo sapiens (human)	IC50	37.0300	1	1
chrysin	Homo sapiens (human)	IC50	5.3000	2	5
cupressuflavone	Homo sapiens (human)	IC50	9.2900	1	1
fisetin	Homo sapiens (human)	IC50	0.6400	2	5
demethylbellidifolin	Homo sapiens (human)	IC50	0.2000	1	1
hyperoside	Homo sapiens (human)	IC50	10.2800	1	1
alvocidib	Homo sapiens (human)	IC50	0.1765	5	8
aftin-4	Homo sapiens (human)	IC50	556.6667	1	6
su 9516	Homo sapiens (human)	IC50	0.0220	1	1
arcyriaflavin a	Homo sapiens (human)	IC50	0.9360	1	1
palbociclib	Homo sapiens (human)	IC50	10.0000	2	2
olomoucine ii	Homo sapiens (human)	IC50	0.2700	1	1
manzamine a	Homo sapiens (human)	IC50	1.5000	1	1
1-azakenpaullone	Homo sapiens (human)	IC50	2.9236	3	5
cvt 313	Homo sapiens (human)	IC50	0.4190	1	1
leucettamine b	Homo sapiens (human)	IC50	40.0000	3	3
nu 6140	Homo sapiens (human)	IC50	8.8000	1	1
meridianin a	Homo sapiens (human)	IC50	36.8000	2	6
rgb 286638	Homo sapiens (human)	IC50	0.0020	1	1
at 7519	Homo sapiens (human)	IC50	2.6360	4	4
at 7519	Homo sapiens (human)	Ki	0.0180	1	1
pha 848125	Homo sapiens (human)	IC50	0.3468	4	8
14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene	Homo sapiens (human)	IC50	0.0040	1	1
meriolin 3	Homo sapiens (human)	IC50	0.1700	2	2
amg 458	Homo sapiens (human)	IC50	100.0000	1	1
cink4	Homo sapiens (human)	IC50	10.0000	1	1
ldc067	Homo sapiens (human)	IC50	4.9600	1	1
(R)-DRF053	Homo sapiens (human)	IC50	0.1475	2	2
ribociclib	Homo sapiens (human)	IC50	20.0000	1	1
bay 1000394	Homo sapiens (human)	IC50	0.0100	2	2
pha 793887	Homo sapiens (human)	IC50	0.0050	1	1
abemaciclib	Homo sapiens (human)	IC50	0.4050	2	2
dinaciclib	Homo sapiens (human)	IC50	0.0219	6	6
nms p937	Homo sapiens (human)	IC50	10.0000	1	1
bs-181	Homo sapiens (human)	IC50	3.7000	1	1
on123300	Homo sapiens (human)	IC50	0.2720	1	1
chr-6494	Homo sapiens (human)	IC50	0.0410	1	1
((5z)5-(1,3-benzodioxol-5-yl)methylene-2-phenylamino-3,5-dihydro-4h-imidazol-4-one)	Homo sapiens (human)	IC50	13.4700	3	3
ro 3306	Homo sapiens (human)	IC50	2.4800	1	1
hymenialdisine	Homo sapiens (human)	IC50	0.0383	3	7
7-bromoindirubin-3'-oxime	Homo sapiens (human)	IC50	33.0000	2	2
debromohymenialdisine	Homo sapiens (human)	IC50	0.1577	1	3

Enables

This protein enables 15 target(s):

Target	Category	Definition
protease binding	molecular function	Binding to a protease or a peptidase. [GOC:hjd]
protein kinase activity	molecular function	Catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP. [PMID:25399640]
calcium ion binding	molecular function	Binding to a calcium ion (Ca2+). [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
kinase activity	molecular function	Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. [ISBN:0198506732]
protein kinase binding	molecular function	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
protein kinase activator activity	molecular function	Binds to and increases the activity of a protein kinase, an enzyme which phosphorylates a protein. [GOC:ai]
ionotropic glutamate receptor binding	molecular function	Binding to an ionotropic glutamate receptor. Ionotropic glutamate receptors bind glutamate and exert an effect through the regulation of ion channels. [GOC:bf, ISBN:0198506732]
alpha-tubulin binding	molecular function	Binding to the microtubule constituent protein alpha-tubulin. [GOC:jl]
protein serine/threonine kinase activator activity	molecular function	Binds to and increases the activity of a protein serine/threonine kinase. [GOC:go_curators]
cadherin binding	molecular function	Binding to cadherin, a type I membrane protein involved in cell adhesion. [GOC:bf]
ephrin receptor binding	molecular function	Binding to an ephrin receptor. [GOC:ai]
beta-tubulin binding	molecular function	Binding to the microtubule constituent protein beta-tubulin. [GOC:krc]
actin filament binding	molecular function	Binding to an actin filament, also known as F-actin, a helical filamentous polymer of globular G-actin subunits. [ISBN:0198506732]
cyclin-dependent protein serine/threonine kinase activator activity	molecular function	Binds to and increases the activity of a cyclin-dependent protein serine/threonine kinase. [GOC:dph, PMID:2569363, PMID:3322810]

Located In

This protein is located in 19 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
postsynaptic density	cellular component	An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
axon	cellular component	The long process of a neuron that conducts nerve impulses, usually away from the cell body to the terminals and varicosities, which are sites of storage and release of neurotransmitter. [GOC:nln, ISBN:0198506732]
dendrite	cellular component	A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732]
growth cone	cellular component	The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]
neuromuscular junction	cellular component	The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. [GOC:nln]
neuron projection	cellular component	A prolongation or process extending from a nerve cell, e.g. an axon or dendrite. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
neuronal cell body	cellular component	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]
dendritic spine	cellular component	A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. [GOC:nln]
perikaryon	cellular component	The portion of the cell soma (neuronal cell body) that excludes the nucleus. [GOC:jl]
intracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane. [GOC:go_curators]
contractile muscle fiber	cellular component	Fibers, composed of actin, myosin, and associated proteins, found in cells of smooth or striated muscle. [GOC:go_curators, ISBN:0815316194]
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
presynapse	cellular component	The part of a synapse that is part of the presynaptic cell. [GOC:dos]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
growth cone	cellular component	The migrating motile tip of a growing neuron projection, where actin accumulates, and the actin cytoskeleton is the most dynamic. [GOC:aruk, GOC:bc, ISBN:0815316194, PMID:10082468]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
cyclin-dependent protein kinase holoenzyme complex	cellular component	Cyclin-dependent protein kinases (CDKs) are enzyme complexes that contain a kinase catalytic subunit associated with a regulatory cyclin partner. [GOC:krc, PMID:11602261]
protein kinase 5 complex	cellular component	A protein complex that has protein serine/threonine kinase activity; in mammals composed of catalytic subunit CDK5 and regulatory subunits CDK5R1 or CDK5R2. Contrary to its gene symbol, CDK5 is not cyclin-dependent. [PMID:15689152]

Involved In

This protein is involved in 30 target(s):

Target	Category	Definition
regulation of cyclin-dependent protein serine/threonine kinase activity	biological process	Any process that modulates the frequency, rate or extent of cyclin-dependent protein serine/threonine kinase activity. [GOC:go_curators, GOC:pr]
microtubule cytoskeleton organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins. [GOC:mah]
neuron migration	biological process	The characteristic movement of an immature neuron from germinal zones to specific positions where they will reside as they mature. [CL:0000540, GOC:go_curators]
neuron cell-cell adhesion	biological process	The attachment of a neuron to another cell via adhesion molecules. [GOC:go_curators]
G protein-coupled acetylcholine receptor signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by a ligand binding to an acetylcholine receptor on the surface of a target cell, and ends with regulation of a downstream cellular process, e.g. transcription. [GOC:mah, ISBN:0815316194]
axon guidance	biological process	The chemotaxis process that directs the migration of an axon growth cone to a specific target site in response to a combination of attractive and repulsive cues. [ISBN:0878932437]
axonal fasciculation	biological process	The collection of axons into a bundle of rods, known as a fascicle. [GOC:dgh]
brain development	biological process	The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
embryo development ending in birth or egg hatching	biological process	The process whose specific outcome is the progression of an embryo over time, from zygote formation until the end of the embryonic life stage. The end of the embryonic life stage is organism-specific and may be somewhat arbitrary; for mammals it is usually considered to be birth, for insects the hatching of the first instar larva from the eggshell. [GOC:go_curators, GOC:isa_complete, GOC:mtg_sensu]
regulation of macroautophagy	biological process	Any process that modulates the frequency, rate or extent of macroautophagy. [GOC:krc]
peptidyl-serine phosphorylation	biological process	The phosphorylation of peptidyl-serine to form peptidyl-O-phospho-L-serine. [RESID:AA0037]
peptidyl-threonine phosphorylation	biological process	The phosphorylation of peptidyl-threonine to form peptidyl-O-phospho-L-threonine. [RESID:AA0038]
cerebellum development	biological process	The process whose specific outcome is the progression of the cerebellum over time, from its formation to the mature structure. The cerebellum is the portion of the brain in the back of the head between the cerebrum and the pons. In mice, the cerebellum controls balance for walking and standing, modulates the force and range of movement and is involved in the learning of motor skills. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
superior olivary nucleus maturation	biological process	A developmental process, independent of morphogenetic (shape) change, that is required for the superior olivary nucleus to attain its fully functional state. The superior olivary nucleus is a small cylindrical mass on the dorsal surface of the lateral part of the trapezoid body of the pons, and it is situated immediately above the inferior olivary nucleus. It receives projections from the cochlear nucleus and thus is involved in the perception of sound. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0838580343]
hippocampus development	biological process	The progression of the hippocampus over time from its initial formation until its mature state. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, ISBN:0878937420, UBERON:0002421]
layer formation in cerebral cortex	biological process	The detachment of cells from radial glial fibers at the appropriate time when they cease to migrate and form distinct layer in the cerebral cortex. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid, PMID:12626695]
neuron differentiation	biological process	The process in which a relatively unspecialized cell acquires specialized features of a neuron. [GOC:mah]
positive regulation of microtubule polymerization	biological process	Any process that activates or increases the frequency, rate or extent of microtubule polymerization. [GOC:mah]
neuron projection development	biological process	The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites). [GOC:mah]
regulation of actin cytoskeleton organization	biological process	Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins. [GOC:mah]
ionotropic glutamate receptor signaling pathway	biological process	The series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, ISBN:0198506732]
positive regulation of neuron apoptotic process	biological process	Any process that activates or increases the frequency, rate or extent of cell death of neurons by apoptotic process. [GOC:go_curators, GOC:mtg_apoptosis]
regulation of neuron differentiation	biological process	Any process that modulates the frequency, rate or extent of neuron differentiation. [GOC:go_curators]
negative regulation of DNA-templated transcription	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cellular DNA-templated transcription. [GOC:go_curators, GOC:txnOH]
ephrin receptor signaling pathway	biological process	The series of molecular signals initiated by ephrin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:ceb]
rhythmic process	biological process	Any process pertinent to the generation and maintenance of rhythms in the physiology of an organism. [GOC:jid]
regulation of dendritic spine morphogenesis	biological process	Any process that modulates the rate, frequency, or extent of dendritic spine morphogenesis, the process in which the anatomical structures of a dendritic spine are generated and organized. A dendritic spine is a protrusion from a dendrite and a specialized subcellular compartment involved in synaptic transmission. [GOC:dph]
G1 to G0 transition involved in cell differentiation	biological process	A cell cycle arrest process that results in arrest during G1 phase, whereupon the cell enters G0 phase, in the context of cell differentiation. [GOC:mah, ISBN:0815316194]
positive regulation of protein targeting to membrane	biological process	Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein. [GOC:tb]
regulation of synaptic vesicle cycle	biological process	Any process that modulates the frequency, rate or extent of the synaptic vesicle cycle. [GOC:dos]