Kinesin-like protein KIF11

A kinesin-like protein KIF11 that is encoded in the genome of human. [PRO:DNx]

Synonyms

Kinesin-like protein 1;
Kinesin-like spindle protein HKSP;
Kinesin-related motor protein Eg5;
Thyroid receptor-interacting protein 5;
TR-interacting protein 5;
TRIP-5

Research

Bioassay Publications (32)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (21.88)	29.6817
2010's	25 (78.13)	24.3611
2020's	0 (0.00)	2.80

Compounds (22)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
gossypol	Homo sapiens (human)	IC50	17.9000	2	2
cysteine	Homo sapiens (human)	IC50	63.0000	1	1
s-methylcysteine	Homo sapiens (human)	IC50	63.0000	1	1
3-tritylthio-l-alanine	Homo sapiens (human)	IC50	0.8227	12	12
3-tritylthio-l-alanine	Homo sapiens (human)	Ki	0.0892	8	8
s-2-aminoethyl cysteine	Homo sapiens (human)	IC50	63.0000	1	1
docetaxel anhydrous	Homo sapiens (human)	IC50	0.0014	8	8
s-benzylcysteine	Homo sapiens (human)	IC50	63.0000	1	1
carbocysteine	Homo sapiens (human)	IC50	63.0000	1	1
1-acetyl-3,5-diphenyl-4,5-dihydro-(1h)-pyrazole	Homo sapiens (human)	IC50	50.0000	1	1
(S)-monastrol	Homo sapiens (human)	IC50	10.0000	2	2
k 858	Homo sapiens (human)	IC50	1.0686	7	7
monastrol	Homo sapiens (human)	IC50	12.8247	9	9
ispinesib	Homo sapiens (human)	IC50	0.0260	2	2
ispinesib	Homo sapiens (human)	Ki	0.0024	3	3
3-tritylthio-l-alanine, (d)-isomer	Homo sapiens (human)	IC50	0.6531	2	2
3-tritylthio-l-alanine, (d)-isomer	Homo sapiens (human)	Ki	0.0986	1	1
sb 743921	Homo sapiens (human)	IC50	0.3637	6	6
sb 743921	Homo sapiens (human)	Ki	0.0005	1	1
adociasulfate-2	Homo sapiens (human)	IC50	7.5000	4	4
terpendole e	Homo sapiens (human)	IC50	26.9000	3	3
ck0106023	Homo sapiens (human)	IC50	0.0437	3	3
dimethylenastron	Homo sapiens (human)	IC50	0.2000	3	3
emd 534085	Homo sapiens (human)	IC50	0.0080	1	1
litronesib	Homo sapiens (human)	IC50	0.0165	2	2
arry 520	Homo sapiens (human)	IC50	0.0090	4	4

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
3-tritylthio-l-alanine	Homo sapiens (human)	EC50	1.7200	1	1
k 858	Homo sapiens (human)	Kd	0.6645	1	1
sb 743921	Homo sapiens (human)	Kd	7.8371	8	8

Enables

This protein enables 6 target(s):

Target	Category	Definition
microtubule motor activity	molecular function	A motor activity that generates movement along a microtubule, driven by ATP hydrolysis. [PMID:19686686, PMID:32684327, PMID:32842864]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
ATP binding	molecular function	Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732]
microtubule binding	molecular function	Binding to a microtubule, a filament composed of tubulin monomers. [GOC:krc]
protein kinase binding	molecular function	Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl]
plus-end-directed microtubule motor activity	molecular function	A motor activity that generates movement along a microtubule toward the plus end, driven by ATP hydrolysis. [GOC:vw, PMID:32842864]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
spindle	cellular component	The array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during mitosis or meiosis and serves to move the duplicated chromosomes apart. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
microtubule	cellular component	Any of the long, generally straight, hollow tubes of internal diameter 12-15 nm and external diameter 24 nm found in a wide variety of eukaryotic cells; each consists (usually) of 13 protofilaments of polymeric tubulin, staggered in such a manner that the tubulin monomers are arranged in a helical pattern on the microtubular surface, and with the alpha/beta axes of the tubulin subunits parallel to the long axis of the tubule; exist in equilibrium with pool of tubulin monomers and can be rapidly assembled or disassembled in response to physiological stimuli; concerned with force generation, e.g. in the spindle. [ISBN:0879693568]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]
mitotic spindle	cellular component	A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
mitotic spindle	cellular component	A spindle that forms as part of mitosis. Mitotic and meiotic spindles contain distinctive complements of proteins associated with microtubules. [GOC:mah, GOC:vw, PMID:11408572, PMID:18367542, PMID:8027178]

Part Of

This protein is part of 2 target(s):

Target	Category	Definition
kinesin complex	cellular component	Any complex that includes a dimer of molecules from the kinesin superfamily, a group of related proteins that contain an extended region of predicted alpha-helical coiled coil in the main chain that likely produces dimerization. The native complexes of several kinesin family members have also been shown to contain additional peptides, often designated light chains as all of the noncatalytic subunits that are currently known are smaller than the chain that contains the motor unit. Kinesin complexes generally possess a force-generating enzymatic activity, or motor, which converts the free energy of the gamma phosphate bond of ATP into mechanical work. [GOC:mah, http://www.proweb.org/kinesin//KinesinMotility.html, http://www.proweb.org/kinesin//KinesinStructure.html]
protein-containing complex	cellular component	A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together. [GOC:dos, GOC:mah]

Involved In

This protein is involved in 9 target(s):

Target	Category	Definition
mitotic cell cycle	biological process	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent. [GOC:mah, ISBN:0815316194, Reactome:69278]
microtubule-based movement	biological process	A microtubule-based process that results in the movement of organelles, other microtubules, or other cellular components. Examples include motor-driven movement along microtubules and movement driven by polymerization or depolymerization of microtubules. [GOC:cjm, ISBN:0815316194]
spindle organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the spindle, the array of microtubules and associated molecules that forms between opposite poles of a eukaryotic cell during DNA segregation and serves to move the duplicated chromosomes apart. [GOC:go_curators, GOC:mah]
mitotic spindle organization	biological process	A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle during a mitotic cell cycle. [GOC:go_curators, GOC:mah]
mitotic centrosome separation	biological process	Separation of duplicated centrosome components at the beginning of mitosis. The centriole pair within each centrosome becomes part of a separate microtubule organizing center that nucleates a radial array of microtubules called an aster. The two asters move to opposite sides of the nucleus to form the two poles of the mitotic spindle. [ISBN:0815316194]
regulation of mitotic centrosome separation	biological process	Any process that modulates the frequency, rate or extent of the separation of duplicated centrosome components at the beginning of mitosis. [GOC:ai]
cell division	biological process	The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. [GOC:di, GOC:go_curators, GOC:pr]
mitotic spindle assembly	biological process	Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied. [GOC:tb, GOC:vw]
spindle elongation	biological process	The cell cycle process in which the distance is lengthened between poles of the spindle. [GOC:ai]

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