A calpain-1 catalytic subunit that is encoded in the genome of human. [PRO:DNx, UniProtKB:P07384]
EC 3.4.22.52;
Calcium-activated neutral proteinase 1;
CANP 1;
Calpain mu-type;
Calpain-1 large subunit;
Cell proliferation-inducing gene 30 protein;
Micromolar-calpain;
muCANP
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 4 (14.29) | 18.2507 |
| 2000's | 16 (57.14) | 29.6817 |
| 2010's | 6 (21.43) | 24.3611 |
| 2020's | 2 (7.14) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| isoquinoline-1,3,4-trione | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| aloxistatin | Homo sapiens (human) | IC50 | 23.4200 | 3 | 3 |
| carbobenzoxyvalylphenylalanine aldehyde | Homo sapiens (human) | IC50 | 0.3000 | 1 | 1 |
| carbobenzoxyvalylphenylalanine aldehyde | Homo sapiens (human) | Ki | 0.0080 | 1 | 1 |
| calpeptin | Homo sapiens (human) | IC50 | 0.3472 | 4 | 4 |
| calpeptin | Homo sapiens (human) | Ki | 0.0070 | 1 | 1 |
| n-(n-(3-carboxyoxirane-2-carbonyl)leucyl)isoamylamine | Homo sapiens (human) | IC50 | 0.0400 | 1 | 1 |
| e 64 | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| acetylleucyl-leucyl-norleucinal | Homo sapiens (human) | IC50 | 4.0000 | 2 | 2 |
| benzyloxycarbonyl-phe-ala-fluormethylketone | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| 3-deoxysappanchalcone | Homo sapiens (human) | IC50 | 16.9200 | 1 | 1 |
| snj-1945 | Homo sapiens (human) | IC50 | 0.1700 | 1 | 1 |
| phenylalanyl-valine | Homo sapiens (human) | IC50 | 0.0110 | 1 | 1 |
| ca 074 | Homo sapiens (human) | IC50 | 100.0000 | 2 | 2 |
| a-705253 | Homo sapiens (human) | Ki | 0.0560 | 1 | 1 |
| sja 6017 | Homo sapiens (human) | IC50 | 0.0220 | 2 | 2 |
| phevalin | Homo sapiens (human) | IC50 | 1.2000 | 1 | 1 |
| calpain inhibitor iii | Homo sapiens (human) | IC50 | 0.1830 | 8 | 8 |
| calpain inhibitor iii | Homo sapiens (human) | Ki | 0.0139 | 4 | 4 |
| PF-00835231 | Homo sapiens (human) | IC50 | 0.4837 | 1 | 3 |
| grassystatin a | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| N-[(2S)-3-cyclohexyl-1-oxo-1-({(2S)-1-oxo-3-[(3S)-2-oxopyrrolidin-3-yl]propan-2-yl}amino)propan-2-yl]-1H-indole-2-carboxamide | Homo sapiens (human) | IC50 | 0.0041 | 1 | 2 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| calcium-dependent cysteine-type endopeptidase activity | molecular function | Catalysis of the hydrolysis of nonterminal peptide bonds in a polypeptide chain by a mechanism using a cysteine residue at the enzyme active center, and requiring the presence of calcium. [GOC:mah] |
| calcium ion binding | molecular function | Binding to a calcium ion (Ca2+). [GOC:ai] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| peptidase activity | molecular function | Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. [GOC:jl, ISBN:0815332181] |
This protein is located in 10 target(s):
| Target | Category | Definition |
|---|---|---|
| cornified envelope | cellular component | A type of plasma membrane that has been modified through addition of distinct intracellular and extracellular components, including ceramide, found in cornifying epithelial cells (corneocytes). [GOC:add, PMID:11112355, PMID:11590230, PMID:15803139] |
| extracellular region | cellular component | The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators] |
| mitochondrion | cellular component | A semiautonomous, self replicating organelle that occurs in varying numbers, shapes, and sizes in the cytoplasm of virtually all eukaryotic cells. It is notably the site of tissue respiration. [GOC:giardia, ISBN:0198506732] |
| lysosome | cellular component | A small lytic vacuole that has cell cycle-independent morphology found in most animal cells and that contains a variety of hydrolases, most of which have their maximal activities in the pH range 5-6. The contained enzymes display latency if properly isolated. About 40 different lysosomal hydrolases are known and lysosomes have a great variety of morphologies and functions. [GOC:mah, ISBN:0198506732] |
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| focal adhesion | cellular component | A cell-substrate junction that anchors the cell to the extracellular matrix and that forms a point of termination of actin filaments. In insects focal adhesion has also been referred to as hemi-adherens junction (HAJ). [GOC:aruk, GOC:bc, ISBN:0124325653, ISBN:0815316208, PMID:10419689, PMID:12191915, PMID:15246682, PMID:1643657, PMID:16805308, PMID:19197329, PMID:23033047, PMID:26923917, PMID:28796323, PMID:8314002] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
| ficolin-1-rich granule lumen | cellular component | Any membrane-enclosed lumen that is part of a ficolin-1-rich granule. [GO_REF:0000064, GOC:TermGenie, PMID:23650620] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytoplasm | cellular component | The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684] |
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|---|---|
| calpain complex | cellular component | A calcium-dependent protease complex that processes its substrate by limited proteolysis rather than degrading it. In some cases limited proteolysis is required for the activation of its substrate. [GOC:bhm, PMID:10639123] |
This protein is involved in 8 target(s):
| Target | Category | Definition |
|---|---|---|
| proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah] |
| positive regulation of cell population proliferation | biological process | Any process that activates or increases the rate or extent of cell proliferation. [GOC:go_curators] |
| regulation of macroautophagy | biological process | Any process that modulates the frequency, rate or extent of macroautophagy. [GOC:krc] |
| receptor catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function. [GOC:mah] |
| regulation of catalytic activity | biological process | Any process that modulates the activity of an enzyme. [GOC:ai, GOC:ebc, GOC:vw] |
| mammary gland involution | biological process | The tissue remodeling that removes differentiated mammary epithelia during weaning. [GOC:dph, PMID:15282149] |
| self proteolysis | biological process | The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds. [GOC:yaf, PMID:18676612, PMID:19144634] |
| regulation of NMDA receptor activity | biological process | Any process that modulates the frequency, rate or extent of N-methyl-D-aspartate selective glutamate receptor activity. [GOC:BHF] |