pilocarpine has been researched along with Necrosis in 16 studies
Pilocarpine: A slowly hydrolyzed muscarinic agonist with no nicotinic effects. Pilocarpine is used as a miotic and in the treatment of glaucoma.
(+)-pilocarpine : The (+)-enantiomer of pilocarpine.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "To investigate the spatiotemporal expression of cannabinoid receptor type 2 (CB2R) in the hippocampus of pilocarpine-treated rats experiencing a status epilepticus (SE)." | 7.88 | The spatiotemporal expression changes of CB2R in the hippocampus of rats following pilocarpine-induced status epilepticus. ( Wang, H; Wu, Q, 2018) |
| "Several domains of behavior were measured in rats (n = 465) 10 days to 100 days after induction of limbic seizures by a single subcutaneous injection of lithium and pilocarpine." | 7.68 | Behaviors of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine. ( Bureau, YR; Falter, H; Kostakos, M; Peredery, O; Persinger, MA, 1993) |
| "Hydrogen treatment downregulated the expression of necroptosis-related proteins, such as MLKL, phosphorylated-MLKL, and RIPK3 in hippocampus, and further protected neurons and astrocytes from necroptosis which was here first verified to occur in status epilepticus." | 5.51 | Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus. ( Gao, F; Jia, N; Jia, R; Jiang, W; Jiang, Y; Li, R; Liu, Z; Wang, L; Wu, S; Yang, F; Zhang, H; Zhang, S; Zhang, Z; Zhao, J, 2019) |
| "We tested the hypothesis that a single systemic injection of 380 mg/kg of the muscarinic agonist pilocarpine would produce more diffuse and severe seizure-induced brain damage than a single injection of lithium (3 mEq/kg) followed 4 h later by < 1/10 the dosage of pilocarpine." | 5.29 | Concordance of quantitative damage within the diencephalon and telencephalon following systemic pilocarpine (380 mg/kg) or lithium (3 mEq/kg)/pilocarpine (30 mg/kg) induced seizures. ( Bureau, YR; Peredery, O; Persinger, MA, 1994) |
| "To investigate the spatiotemporal expression of cannabinoid receptor type 2 (CB2R) in the hippocampus of pilocarpine-treated rats experiencing a status epilepticus (SE)." | 3.88 | The spatiotemporal expression changes of CB2R in the hippocampus of rats following pilocarpine-induced status epilepticus. ( Wang, H; Wu, Q, 2018) |
| " In this study, we analyzed the contribution of neuronal necrosis and caspase-3 activation to CA1 damage following lithium-pilocarpine SE in P14 rat pups." | 3.74 | Status epilepticus triggers caspase-3 activation and necrosis in the immature rat brain. ( Allen, S; Archie, M; Auvin, S; Niquet, J; Sankar, R; Seo, DW; Wasterlain, CG, 2007) |
| " We determined whether caspase-3 is activated by lithium-pilocarpine-induced status epilepticus in six brain regions with necrosis-induced DNA laddering." | 3.71 | Caspase-3 is not activated in seizure-induced neuronal necrosis with internucleosomal DNA cleavage. ( Fujikawa, DG; Ke, X; Shinmei, SS; Trinidad, RB; Wu, A, 2002) |
| "To determine definitively the morphology of neuronal death from lithium-pilocarpine (LPC)-and kainic acid (KA)-induced status epilepticus (SE), and to correlate this with markers of DNA fragmentation that have been associated with cellular apoptosis." | 3.70 | Seizure-induced neuronal necrosis: implications for programmed cell death mechanisms. ( Cai, B; Fujikawa, DG; Shinmei, SS, 2000) |
| "Several domains of behavior were measured in rats (n = 465) 10 days to 100 days after induction of limbic seizures by a single subcutaneous injection of lithium and pilocarpine." | 3.68 | Behaviors of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine. ( Bureau, YR; Falter, H; Kostakos, M; Peredery, O; Persinger, MA, 1993) |
| " The seizures, which induce insidious brain damage within a multitude of diencephalic and subcortical telencephalic structures, were induced by a single injection of lithium (3 mEq/kg sc) followed 24 hr later by pilocarpine (30 mg/kg sc)." | 3.68 | Radial maze learning deficits and mediodorsal thalamic damage in context of multifocal seizure-induced brain lesions. ( Harrigan, T; Peredery, O; Persinger, M, 1991) |
| "Hydrogen treatment downregulated the expression of necroptosis-related proteins, such as MLKL, phosphorylated-MLKL, and RIPK3 in hippocampus, and further protected neurons and astrocytes from necroptosis which was here first verified to occur in status epilepticus." | 1.51 | Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus. ( Gao, F; Jia, N; Jia, R; Jiang, W; Jiang, Y; Li, R; Liu, Z; Wang, L; Wu, S; Yang, F; Zhang, H; Zhang, S; Zhang, Z; Zhao, J, 2019) |
| "We tested the hypothesis that a single systemic injection of 380 mg/kg of the muscarinic agonist pilocarpine would produce more diffuse and severe seizure-induced brain damage than a single injection of lithium (3 mEq/kg) followed 4 h later by < 1/10 the dosage of pilocarpine." | 1.29 | Concordance of quantitative damage within the diencephalon and telencephalon following systemic pilocarpine (380 mg/kg) or lithium (3 mEq/kg)/pilocarpine (30 mg/kg) induced seizures. ( Bureau, YR; Peredery, O; Persinger, MA, 1994) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (12.50) | 18.7374 |
| 1990's | 4 (25.00) | 18.2507 |
| 2000's | 6 (37.50) | 29.6817 |
| 2010's | 4 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Cai, Q | 1 |
| Gan, J | 1 |
| Luo, R | 1 |
| Qu, Y | 1 |
| Li, S | 1 |
| Wan, C | 1 |
| Mu, D | 1 |
| Wu, Q | 1 |
| Wang, H | 1 |
| Jia, R | 1 |
| Jia, N | 1 |
| Yang, F | 1 |
| Liu, Z | 1 |
| Li, R | 1 |
| Jiang, Y | 1 |
| Zhao, J | 1 |
| Wang, L | 1 |
| Zhang, S | 1 |
| Zhang, Z | 1 |
| Zhang, H | 1 |
| Wu, S | 1 |
| Gao, F | 1 |
| Jiang, W | 1 |
| Yu, L | 1 |
| Zhou, Y | 1 |
| Wang, Y | 1 |
| Fujikawa, DG | 4 |
| Ke, X | 1 |
| Trinidad, RB | 1 |
| Shinmei, SS | 4 |
| Wu, A | 2 |
| MORRIS, RE | 1 |
| RAYNAUD, J | 1 |
| BLANC, G | 1 |
| Eidt, S | 1 |
| Kendall, EJ | 1 |
| Obenaus, A | 1 |
| Niquet, J | 1 |
| Auvin, S | 1 |
| Archie, M | 1 |
| Seo, DW | 1 |
| Allen, S | 1 |
| Sankar, R | 1 |
| Wasterlain, CG | 1 |
| Bureau, YR | 2 |
| Peredery, O | 3 |
| Persinger, MA | 2 |
| Kostakos, M | 1 |
| Falter, H | 1 |
| Cai, B | 2 |
| Itabashi, HH | 1 |
| Kubová, H | 1 |
| Druga, R | 1 |
| Lukasiuk, K | 1 |
| Suchomelová, L | 1 |
| Haugvicová, R | 1 |
| Jirmanová, I | 1 |
| Pitkänen, A | 1 |
| Harrigan, T | 1 |
| Persinger, M | 1 |
16 other studies available for pilocarpine and Necrosis
| Article | Year |
|---|---|
The role of necroptosis in status epilepticus-induced brain injury in juvenile rats.
Topics: Amygdala; Animals; Biomarkers; Brain Injuries; Cognitive Dysfunction; Lithium; Male; Necrosis; Neuro | 2017 |
The spatiotemporal expression changes of CB2R in the hippocampus of rats following pilocarpine-induced status epilepticus.
Topics: Animals; Apoptosis; Disease Models, Animal; Hippocampus; Male; Necrosis; Neurons; Pilocarpine; Rando | 2018 |
Hydrogen Alleviates Necroptosis and Cognitive Deficits in Lithium-Pilocarpine Model of Status Epilepticus.
Topics: Animals; Apoptosis; CA1 Region, Hippocampal; Cognition Disorders; Disease Models, Animal; Hydrogen; | 2019 |
Effect of mild hypothermia on glutamate receptor expression after status epilepticus.
Topics: Animals; Apoptosis; Blotting, Western; Cell Count; Diazepam; Electrodes, Implanted; Electroencephalo | 2012 |
Caspase-3 is not activated in seizure-induced neuronal necrosis with internucleosomal DNA cleavage.
Topics: Amino Acid Chloromethyl Ketones; Animals; Apoptosis; Brain; Caspase 3; Caspases; Disease Models, Ani | 2002 |
STUDIES ON THE DEVELOPMENT OF PANCREATIC NECROSIS IN THE LIVING MOUSE.
Topics: Amylases; Atropine; Blood Chemical Analysis; Hemorrhage; Meperidine; Mice; Morphine; Necrosis; Pancr | 1964 |
[ACTION OF CORTISONE AND PILOCARPINE ON THE DEVELOPMENT OF THE SALIVARY VIRUS IN THE FIELD-MOUSE (APODEMUS SYLVATICUS), THE GERBIL (MERIONES SHAWI) AND THE JERBOA (DIPODILLUS CAMPESTRIS)].
Topics: Adrenal Glands; Animals; Arvicolinae; Cortisone; Gerbillinae; Lung; Murinae; Necrosis; Pathology; Ph | 1964 |
Neuronal and glial cell populations in the piriform cortex distinguished by using an approximation of q-space imaging after status epilepticus.
Topics: Amygdala; Animals; Cell Death; Convulsants; Diffusion Magnetic Resonance Imaging; Disease Models, An | 2004 |
Status epilepticus triggers caspase-3 activation and necrosis in the immature rat brain.
Topics: Animals; Animals, Newborn; Autophagy; Brain; Caspase 3; Cell Death; Disease Models, Animal; Dizocilp | 2007 |
Concordance of quantitative damage within the diencephalon and telencephalon following systemic pilocarpine (380 mg/kg) or lithium (3 mEq/kg)/pilocarpine (30 mg/kg) induced seizures.
Topics: Acepromazine; Animals; Diencephalon; Lithium; Male; Muscarinic Agonists; Necrosis; Pilocarpine; Rats | 1994 |
Behaviors of rats with insidious, multifocal brain damage induced by seizures following single peripheral injections of lithium and pilocarpine.
Topics: Acetylcholine; Aggression; Animals; Association Learning; Avoidance Learning; Brain; Brain Damage, C | 1993 |
Lithium-pilocarpine-induced status epilepticus produces necrotic neurons with internucleosomal DNA fragmentation in adult rats.
Topics: Age Factors; Animals; Apoptosis; Cell Nucleolus; Dentate Gyrus; DNA Fragmentation; In Situ Nick-End | 1999 |
Status epilepticus-induced neuronal loss in humans without systemic complications or epilepsy.
Topics: Animals; Astrocytes; Brain; Cell Death; Electroencephalography; Entorhinal Cortex; Gliosis; Hippocam | 2000 |
Seizure-induced neuronal necrosis: implications for programmed cell death mechanisms.
Topics: Animals; Apoptosis; Brain; Cell Nucleolus; Coloring Agents; DNA Damage; In Situ Nick-End Labeling; K | 2000 |
Status epilepticus causes necrotic damage in the mediodorsal nucleus of the thalamus in immature rats.
Topics: Animals; Antigens, CD; Antigens, Neoplasm; Antigens, Surface; Apoptosis; Avian Proteins; Basigin; Bl | 2001 |
Radial maze learning deficits and mediodorsal thalamic damage in context of multifocal seizure-induced brain lesions.
Topics: Analysis of Variance; Animals; Brain; Humans; Infant; Learning; Lithium; Memory; Necrosis; Pilocarpi | 1991 |