Indoleamine 2,3-dioxygenase 2

An indoleamine 2,3-dioxygenase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6ZQW0]

IDO-2;
EC 1.13.11.-;
Indoleamine 2,3-dioxygenase-like protein 1;
Indoleamine-pyrrole 2,3-dioxygenase-like protein 1

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
tryptanthrine	Homo sapiens (human)	IC50	11.1550	4	2
tryptanthrine	Homo sapiens (human)	Ki	15.1900	2	1
indoximod	Homo sapiens (human)	IC50	205.8125	4	2
indoximod	Homo sapiens (human)	Ki	3,600.0000	2	1
tenatoprazole	Homo sapiens (human)	IC50	1.8000	1	1
1-methyltryptophan	Homo sapiens (human)	IC50	62.7780	5	3
1-methyltryptophan	Homo sapiens (human)	Ki	383.3333	3	2

This protein enables 4 target(s):

Target	Category	Definition
heme binding	molecular function	Binding to a heme, a compound composed of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:ai]
indoleamine 2,3-dioxygenase activity	molecular function	Catalysis of the reaction: tryptophan + O2 = N-formylkynurenine. The product of the reaction depends on the substrate; D-tryptophan produces N-formyl-D-kynurenine, and L-tryptophan produces N-formyl-L-kynurenine. [EC:1.13.11.52]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
tryptophan 2,3-dioxygenase activity	molecular function	Catalysis of the reaction: L-tryptophan + O2 = N-formyl-L-kynurenine. [EC:1.13.11.11]

This protein is located in 2 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is active in 1 target(s):

Target	Category	Definition
cytoplasm	cellular component	The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. [ISBN:0198547684]

This protein is involved in 3 target(s):

Target	Category	Definition
immune system process	biological process	Any process involved in the development or functioning of the immune system, an organismal system for calibrated responses to potential internal or invasive threats. [GO_REF:0000022, GOC:add]
tryptophan catabolic process to kynurenine	biological process	The chemical reactions and pathways resulting in the breakdown of tryptophan into other compounds, including kynurenine. [GOC:go_curators]
'de novo' NAD biosynthetic process from tryptophan	biological process	The chemical reactions and pathways resulting in the formation of nicotinamide adenine dinucleotide (NAD), beginning with the synthesis of tryptophan from simpler precursors; biosynthesis may be of either the oxidized form, NAD, or the reduced form, NADH. [PMID:17161604]