fluorouracil has been researched along with Necrosis in 115 studies
Fluorouracil: A pyrimidine analog that is an antineoplastic antimetabolite. It interferes with DNA synthesis by blocking the THYMIDYLATE SYNTHETASE conversion of deoxyuridylic acid to thymidylic acid.
5-fluorouracil : A nucleobase analogue that is uracil in which the hydrogen at position 5 is replaced by fluorine. It is an antineoplastic agent which acts as an antimetabolite - following conversion to the active deoxynucleotide, it inhibits DNA synthesis (by blocking the conversion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase) and so slows tumour growth.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We describe a 47-year-old man who developed a linear serpentine erythematous eruption, overlying the superficial veins on both arms, after treatment with intravenous 5-fluorouracil." | 8.80 | Persistent supravenous erythematous eruption: a rare local complication of intravenous 5-fluorouracil therapy. ( Alomar, A; Lopez-Pousa, A; Pujol, RM; Rocamora, V; Taberner, R, 1998) |
| "To investigate the anticancer effects of warming and relieving cold phlegm formula (, WRCP), a Chinese medical mixture composed of the aqueous extracts of Aconitum carmichaeli, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginseng, and Gekko swinhonis Gūenther, combined with 5-fluorouracil (5-FU) on human breast cancer in vivo." | 7.78 | Anticancer effects of 5-fluorouracil combined with warming and relieving cold phlegm formula on human breast cancer. ( Ma, F; Wang, XL; Wu, XZ, 2012) |
| "To evaluate the antimitotic and toxic effects of 5-chlorouracil (5-CU) and 5-fluorouracil (5-FU) and study their potential to delay filtering bleb closure in the rabbit eye when released by poly(ortho esters) (POE)." | 7.74 | Controlled delivery of 5-chlorouracil using poly(ortho esters) in filtering surgery for glaucoma. ( Behar-Cohen, F; BenEzra, D; Bourges, JL; Felt, O; Gurny, R; Jeanny, JC; Polak, MB; Rat, P; Thomas-Doyle, A; Torriglia, A; Valamanesh, F, 2008) |
| "The apoptosis- and necrosis-inducing potential of the anticancer drugs cladribine (CDA), cytarabine (ARA-C), cisplatin (CDDP), and 5-fluorouracil (5FU) were studied in vitro in the human leukemia cell lines HSB2 and Jurkat using a flow-cytometry assay that permits the simultaneous quantification of vital, apoptotic, and necrotic cells by double-staining with fluorescein isothiocyanate (FITC)-labeled Annexin-V and propidium iodide." | 7.70 | Apoptosis- and necrosis-inducing potential of cladribine, cytarabine, cisplatin, and 5-fluorouracil in vitro: a quantitative pharmacodynamic model. ( Guchelaar, HJ; Haanen, C; Koopmans, RP; Reutelingsperger, CP; Vermes, I, 1998) |
| "5-Fluorouracil (5-FU) has been claimed to have beneficial effects in human pancreatitis because of its ability to inhibit protein synthesis and secretion." | 7.69 | Effect of 5-fluorouracil on secretion and synthesis of pancreatic digestive enzymes: studies in isolated pancreatic acini and perfused pancreas derived from normal rats and from rats with acute necrotizing pancreatitis. ( Bielecki, K; Kimura, W; Meyer, F; Mössner, J; Wiedmann, M, 1994) |
| "The article describes the morphological basis of the positive effect of the treatment of experimental pancreonecrosis, reproduced on dogs, by single endolymphatic injection of 5- fluorouracil." | 7.67 | [Pathomorphosis of experimental pancreatic necrosis treated by a single endolymphatic injection of 5-fluorouracil]. ( Magomedov, MK; Mezentsev, SS; Titova, GP, 1986) |
| "Histological and electron microscopic study of the pancreas and biochemical determination of pancreatic enzymes in blood serum were performed in animals with experimental pancreonecrosis and after the treatment with 5-fluorouracil." | 7.66 | [Morphology of experimental pancreonecrosis following treatment with 5-fluorouracil]. ( Nishanov, KhT; Pomelov, VS; Titova, GP, 1981) |
| "Application of 5-fluorouracil exerts a noticeable therapeutic effect in experimental pancreatitis induced according to the modified technique." | 7.66 | [Morphology of experimental acute pancreatitis during treatment with 5-fluorouracil]. ( Kaem, RI; Nishanov, KhT, 1980) |
| " The dosage should be reduced or therapeutic regimen changed." | 5.34 | [Unilateral acral necrosis as a minor form of hand-foot syndrome. Patient with unilateral acral necrosis secondary to capecitabine therapy for metastatic breast cancer]. ( Ockenfels, HM; Saborowski, A; Sauter, C, 2007) |
| "In the treatment group, cell cycle of hepatoma cells was mainly arrested at S phase, but in group D, G0/G1 phase cells were significantly decreased and S phase cells significantly increased." | 5.32 | [Influence of combined cyclosporine A and tacrolimus with 5-fluorouracil on hepatocellular carcinoma rats]. ( Jiang, GP; Li, MW; Xie, HY; Yang, FC; Zeng, QL; Zheng, SS, 2003) |
| "To evaluate, in a phase 2 study, whether induction docetaxel, cisplatin, and fluorouracil (TPF) followed by weekly docetaxel and cetuximab in concurrence with intensity modulated radiation therapy can improve the treatment outcome for patients with advanced locally recurrent nasopharyngeal carcinoma (rNPC)." | 5.27 | Prospective, Multicenter, Phase 2 Trial of Induction Chemotherapy Followed by Bio-Chemoradiotherapy for Locally Advanced Recurrent Nasopharyngeal Carcinoma. ( Chan, LLK; Kam, MKM; Kwong, DLW; Lee, AWM; Lung, ML; Ng, WT; Ngan, RKC; Sze, HCK; Tung, SY; Yiu, HHY; Yuen, KT, 2018) |
| "This study was designed to determine if histopathologic evaluation of patients with resectable colorectal cancer following preoperative chemotherapy with uracil and tegafur with a molar ratio of 4:1 (UFT) could predict chemosensitivity to postoperative fluoropyrimidines to prevent recurrence of disease." | 5.09 | Using preoperative UFT to predict sensitivity to fluoropyrimidines in colorectal cancer. ( Fujii, M, 1999) |
| " Here, we review the case of a 76-year-old male rectal cancer patient with liver metastasis who suffered extensive bowel necrosis after administration of 5-fluorouracil-based chemotherapy with bevacizumab, and required a subtotal colectomy and end-ileostomy." | 4.91 | Extensive bowel necrosis related to bevacizumab in metastatic rectal cancer patient: a case report and review of literature. ( Endo, K; Furukawa, J; Hoshino, Y; Ito, H; Kimata, M; Kobayashi, K; Masugi, Y; Ogata, Y; Shinozaki, H; Takada, S; Terauchi, T, 2015) |
| "We describe a 47-year-old man who developed a linear serpentine erythematous eruption, overlying the superficial veins on both arms, after treatment with intravenous 5-fluorouracil." | 4.80 | Persistent supravenous erythematous eruption: a rare local complication of intravenous 5-fluorouracil therapy. ( Alomar, A; Lopez-Pousa, A; Pujol, RM; Rocamora, V; Taberner, R, 1998) |
| "During a regular MR control, the patient developed anaphylactic reaction to Gadolinium, and after that a rectosigmoid ischemia with total necrosis of the posterior rectal wall was diagnosed and surgically treated with Hartmann procedure." | 3.91 | Hypovolemic shock after pelvic radiotherapy. A rare combination leading to a devastating complication. ( Calvisi, G; Carlei, F; Di Sibio, A; Di Staso, M; Giuliani, A; Lombardi, L; Marchese, M; Romano, L; Romanzi, F; Schietroma, M, 2019) |
| "To investigate the anticancer effects of warming and relieving cold phlegm formula (, WRCP), a Chinese medical mixture composed of the aqueous extracts of Aconitum carmichaeli, Rhizoma bolbostemmatis, Phytolacca acinosa, Panax notoginseng, and Gekko swinhonis Gūenther, combined with 5-fluorouracil (5-FU) on human breast cancer in vivo." | 3.78 | Anticancer effects of 5-fluorouracil combined with warming and relieving cold phlegm formula on human breast cancer. ( Ma, F; Wang, XL; Wu, XZ, 2012) |
| "Human adenocarcinoma cells, colonic (Caco-2) and ovarian (59 M) cells, were incubated with 5-fluorouracil (1-300 µg·mL(-1) ) or paclitaxel (1-200 µg·mL(-1) ) in the presence or absence of platelets (1." | 3.78 | Platelets increase survival of adenocarcinoma cells challenged with anticancer drugs: mechanisms and implications for chemoresistance. ( Bazou, D; Inkielewicz-Stepniak, I; Jow, H; Medina, C; O'Driscoll, L; Radomski, A; Radomski, MW; Radziwon-Balicka, A; Treumann, A, 2012) |
| " In this study, we examined the chemoresistance to 5-Fluorouracil (5-FU) using MCF-7 breast cancer MTS." | 3.76 | Implication of necrosis-linked p53 aggregation in acquired apoptotic resistance to 5-FU in MCF-7 multicellular tumour spheroids. ( Jeon, HM; Jeong, EK; Kang, HS; Kim, CH; Lee, SY, 2010) |
| "To evaluate the antimitotic and toxic effects of 5-chlorouracil (5-CU) and 5-fluorouracil (5-FU) and study their potential to delay filtering bleb closure in the rabbit eye when released by poly(ortho esters) (POE)." | 3.74 | Controlled delivery of 5-chlorouracil using poly(ortho esters) in filtering surgery for glaucoma. ( Behar-Cohen, F; BenEzra, D; Bourges, JL; Felt, O; Gurny, R; Jeanny, JC; Polak, MB; Rat, P; Thomas-Doyle, A; Torriglia, A; Valamanesh, F, 2008) |
| "Radiological and clinical evidence of acute necrosis in a meningioma following one cycle of chemotherapy with 5-fluorouracil, folinic acid, and levamisole was observed in a patient being treated for invasive rectal carcinoma." | 3.69 | Necrosis in a meningioma following systemic chemotherapy. Case report. ( Bernstein, M; Davidson, G; Erlichman, C; Villamil, A, 1994) |
| "5-Fluorouracil (5-FU) has been claimed to have beneficial effects in human pancreatitis because of its ability to inhibit protein synthesis and secretion." | 3.69 | Effect of 5-fluorouracil on secretion and synthesis of pancreatic digestive enzymes: studies in isolated pancreatic acini and perfused pancreas derived from normal rats and from rats with acute necrotizing pancreatitis. ( Bielecki, K; Kimura, W; Meyer, F; Mössner, J; Wiedmann, M, 1994) |
| " Regarding HAI, transcatheter hepatic arterial embolization (TAE) was applied in two cases (hepatocellular carcinoma: 1; metastasis: 1) and 5-fluorouracil (continuous) combined with leucovorin (one shot) therapy (LV + 5-FU) was given to one metastatic case." | 3.68 | [Bile duct necrosis and hepatic necrosis following hepatic arterial infusion chemotherapy]. ( Arai, K; Iwasaki, Y; Kitamura, M; Miyashita, K; Mori, T; Okamoto, A, 1991) |
| "Application of 5-fluorouracil exerts a noticeable therapeutic effect in experimental pancreatitis induced according to the modified technique." | 3.66 | [Morphology of experimental acute pancreatitis during treatment with 5-fluorouracil]. ( Kaem, RI; Nishanov, KhT, 1980) |
| "Histological and electron microscopic study of the pancreas and biochemical determination of pancreatic enzymes in blood serum were performed in animals with experimental pancreonecrosis and after the treatment with 5-fluorouracil." | 3.66 | [Morphology of experimental pancreonecrosis following treatment with 5-fluorouracil]. ( Nishanov, KhT; Pomelov, VS; Titova, GP, 1981) |
| "5 mg/kg of mitomycin-C (Mit-C) resulted in 70% (n = 20) and 71% (n = 14) mortality, respectively, from 2 to 7 days after perfusion, with extensive, patchy necrosis and infarction seen on histologic examination and markedly elevated levels of serum glutamic oxaloacetic transaminase (SGOT) and serum glutamic pyruvic transaminase (SGPT) at 6 and 24 hours after perfusion." | 3.66 | Reversal of lethal, chemotherapeutically induced acute hepatic necrosis in rats by regenerating liver cytosol. ( Falk, JA; Falk, RE; Falk, W; Makowka, L; Miyazaki, M; Venturi, D, 1983) |
| "A minority of early invasive breast cancers show a pattern of central necrosis and fibrosis (CNF)." | 2.75 | Prognostic and predictive impact of central necrosis and fibrosis in early breast cancer: results from two International Breast Cancer Study Group randomized trials of chemoendocrine adjuvant therapy. ( Castiglione-Gertsch, M; Coates, AS; Colleoni, M; Gelber, RD; Goldhirsch, A; Maiorano, E; Mastropasqua, MG; Price, KN; Regan, MM; Viale, G, 2010) |
| "route, in various types of cancer disease such as non-small cell lung cancer and advanced breast cancer." | 2.67 | Experimental studies and preliminary clinical trial of vinorelbine-loaded polymeric bioresorbable implants for the local treatment of solid tumors. ( Bouffard, P; Caty, A; Fournier, C; Hecquet, B; Krikorian, A; Lefebvre, JL; Merle, S; Vanseymortier, L; Vert, M; Vilain, MO, 1991) |
| "Mitoxantrone (Novantrone), is an anthracenedione which in preclinical studies demonstrated a spectrum of antitumor activity similar to the anthracyclines, but with less cardiotoxicity." | 2.66 | Mitoxantrone: an overview of safety and toxicity. ( Bernstein, T; Cartwright, K; Dukart, G; Goldberg, J; Posner, LE, 1985) |
| "Therapies for patients with scirrhous gastric cancer remain ineffective." | 1.46 | Effects of 5-fluorouracil, adriamycin and irinotecan on HSC-39, a human scirrhous gastric cancer cell line. ( Amano, F; Kanai-Mori, A; Koike, A; Morishige, Y; Tamaki, R; Yanagihara, K, 2017) |
| " 5-FU alone, BLTA alone or BLTA in combination with 5-FU were used to treat tumor-bearing mice." | 1.42 | Cooperative effect of Bifidobacteria lipoteichoic acid combined with 5-fluorouracil on hepatoma-22 cells growth and apoptosis. ( Guo, B; Wang, Y; Xie, N, 2015) |
| "Mitochondrial Bcl-2, Bax, cytochrome c and cytoplasmic caspase-3 expression, as well as toxic effect patterns, mitosis and cellular reactions due to α-tocopherol alone or combined with paclitaxel, mitomycin C and 5-flurouracil (5-FU), was studied in series obtained from human endothelial and primary Tenon's fibroblast cell cultures." | 1.42 | The evaluation of human tenon's fibroblasts and endothelial cell responses to antifibrotics alone and in combination with α-tocopherol. ( Akgün-Dar, K; Arslan, M; Bilgiç, S; Çetin, B; Engin, KN; Erdem-Kuruca, S; Gürel, E; Karadenizli, S; Yemisci, B, 2015) |
| "Head and neck squamous cell carcinoma (HNSCC) is the sixth most common cancer worldwide." | 1.40 | INF-γ sensitizes head and neck squamous cell carcinoma cells to chemotherapy-induced apoptosis and necroptosis through up-regulation of Egr-1. ( Liu, P; Shu, Y; Xu, B, 2014) |
| "A 57-year-old woman with invasive breast cancer was referred for adjuvant chemotherapy after undergoing breast conservative therapy and axillary dissection." | 1.39 | Massive breast necrosis after extravasation of a full anthracycline cycle. ( Schoenegg, W; Vasconcelos, I, 2013) |
| "The treatment of anal cancer is based on concomitant radiotherapy and chemotherapy and is associated with a nonnegligible rate of local severe toxicities that can strongly impair the quality of life." | 1.39 | Predictive factors for early and late local toxicities in anal cancer treated by radiotherapy in combination with or without chemotherapy. ( Benezery, K; Doyen, J; Follana, P; Francois, E; Gal, J; Gérard, JP; Hannoun-Levi, JM; Ortholan, C, 2013) |
| "p53-null colon cancer cell lines with different sets of mutations were used to validate the role of GSK3B in sustaining resistance and to characterize cell death mechanisms triggered by chemotherapy when GSK3B is silenced." | 1.39 | Inhibition of GSK3B bypass drug resistance of p53-null colon carcinomas by enabling necroptosis in response to chemotherapy. ( Bonin, S; Donada, M; Federzoni, E; Giovannoni, R; Grassilli, E; Helin, K; Ianzano, L; Lavitrano, M; Leone, BE; Masiero, L; Narloch, R; Pisano, F; Romano, G; Stanta, G, 2013) |
| "In cases of triple-negative breast cancer involving clear intratumoral necrosis with an irregular mass shape, it is predicted that the effects of neoadjuvant chemotherapy will likely be poor, and therefore, the presence of such image findings may be useful for determining the optimal application of neoadjuvant chemotherapy." | 1.37 | Triple-negative breast cancer: are the imaging findings different between responders and nonresponders to neoadjuvant chemotherapy? ( Furukawa, H; Inokuchi, M; Kawashima, H; Kitamura, S, 2011) |
| "Pemphigus is an autoimmune intraepidermal blistering disease mediated by autoantibodies targeting desmosomes." | 1.37 | Radiotherapy-induced pemphigus vulgaris with autoantibodies targeting a 110 kDa epidermal antigen. ( Badri, T; Benmously-Mlika, R; Fenniche, S; Hammami, H; Lachkham, A; Mokhtar, I, 2011) |
| "Recent advances in chemotherapy for colorectal cancer prolonged survival." | 1.36 | [Roles of hepatectomy for colorectal liver metastases with necrotic foci caused by prior anti-cancer therapies]. ( Inoue, T; Ishikawa, H; Ko, S; Kunishige, T; Mukogawa, T; Nakamoto, T; Nishiwada, T; Watanabe, A, 2010) |
| "Human pancreatic cancer cells such as PANC-1 are known to exhibit marked tolerance to nutrition starvation that enables them to survive for prolonged period of time even under extremely nutrient-deprived conditions." | 1.35 | Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition. ( Awale, S; Esumi, H; Kadota, S; Li, F; Onozuka, H; Tezuka, Y, 2008) |
| "Capecitabine is a tumor selective pro-drug of 5-fluorouracil, indicated for the therapy of colorectal cancer." | 1.34 | Histological evaluation of colonic anastomotic healing, during perioperative Capecitabine administration. Experimental study in rats. ( Demertzidis, CI; Economou, LD; Konstantinidis, HD; Mpallas, KD; Pissanidou, TT; Sioga, AC, 2007) |
| " The dosage should be reduced or therapeutic regimen changed." | 1.34 | [Unilateral acral necrosis as a minor form of hand-foot syndrome. Patient with unilateral acral necrosis secondary to capecitabine therapy for metastatic breast cancer]. ( Ockenfels, HM; Saborowski, A; Sauter, C, 2007) |
| "In the treatment group, cell cycle of hepatoma cells was mainly arrested at S phase, but in group D, G0/G1 phase cells were significantly decreased and S phase cells significantly increased." | 1.32 | [Influence of combined cyclosporine A and tacrolimus with 5-fluorouracil on hepatocellular carcinoma rats]. ( Jiang, GP; Li, MW; Xie, HY; Yang, FC; Zeng, QL; Zheng, SS, 2003) |
| " We conclude that there is greater risk of toxic anterior segment effects when mitomycin C is used as adjunctive therapy following filtration or pterygium surgery." | 1.29 | Ocular toxicity of mitomycin C and 5-fluorouracil in the rabbit. ( Feldman, F; Heathcote, JG; Ikeda-Douglas, JV; Morrow, GL; Stein, RM, 1994) |
| "In a patient with akinetic mutism, extensive circumscribed bilateral lesions in the precentral part of the centrum semiovale, due to delayed necrotizing leucoencephalopathy after combined intravenous polychemotherapy and radiation, were found at autopsy." | 1.28 | Akinetic mutism in bilateral necrotizing leucoencephalopathy after radiation and chemotherapy: electrophysiological and autopsy findings. ( Gütling, E; Kleihues, P; Landis, T, 1992) |
| "Tegafur was administered for 24 weeks at respective doses of 90 mg, 120 mg and 150 mg/kg/day." | 1.27 | [Maximum tolerated dose of tegafur in rats]. ( Aoki, N; Hamada, S; Hirayama, R; Matsumura, J; Mishima, Y; Miyanaga, T; Takagi, Y, 1984) |
| "Cardionecrosis is the irreversible consequence of cardiotoxicity." | 1.27 | Drug-induced cardionecrosis. ( Godfraind, T, 1984) |
| "The anti-tumor activity of partially purified tumor necrosis factor (TNF) was analysed in combination with chemotherapeutic drugs against intradermally transplanted Meth A sarcoma." | 1.27 | Anti-tumor effects of tumor necrosis factor in combination with chemotherapeutic agents. ( Curschellas, E; Matter, A; Müller, M; Regenass, U, 1987) |
| "A 45-year-old man with hepatocellular carcinoma who developed intravascular coagulation following complete tumor regression by chemotherapy is described." | 1.26 | Complete necrotization of hepatocellular carcinoma by chemotherapy and subsequent intravascular coagulation: a case report. ( Harada, T; Makisaka, Y; Nishimura, H; Okuda, K, 1978) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 37 (32.17) | 18.7374 |
| 1990's | 20 (17.39) | 18.2507 |
| 2000's | 20 (17.39) | 29.6817 |
| 2010's | 36 (31.30) | 24.3611 |
| 2020's | 2 (1.74) | 2.80 |
| Authors | Studies |
|---|---|
| Awale, S | 1 |
| Li, F | 1 |
| Onozuka, H | 1 |
| Esumi, H | 1 |
| Tezuka, Y | 1 |
| Kadota, S | 1 |
| Yu, QQ | 1 |
| Zhang, H | 1 |
| Guo, Y | 1 |
| Han, B | 1 |
| Jiang, P | 1 |
| Ng, WT | 1 |
| Ngan, RKC | 1 |
| Kwong, DLW | 1 |
| Tung, SY | 1 |
| Yuen, KT | 1 |
| Kam, MKM | 1 |
| Sze, HCK | 1 |
| Yiu, HHY | 1 |
| Chan, LLK | 1 |
| Lung, ML | 1 |
| Lee, AWM | 1 |
| Zheng, W | 1 |
| Zhou, CY | 1 |
| Zhu, XQ | 1 |
| Wang, XJ | 1 |
| Li, ZY | 1 |
| Chen, XC | 1 |
| Chen, F | 1 |
| Che, XY | 1 |
| Xie, X | 1 |
| Lu, L | 1 |
| Sheng, Y | 1 |
| Zhang, G | 1 |
| Li, Y | 1 |
| OuYang, PY | 1 |
| Ge, Y | 1 |
| Xie, T | 1 |
| Chang, H | 1 |
| Deng, X | 1 |
| Wu, JQ | 1 |
| Wu, L | 1 |
| Chung, YL | 1 |
| Tomlinson, KR | 1 |
| Pablo-Rodriguez, JL | 1 |
| Bunawan, H | 1 |
| Nanyiti, S | 1 |
| Green, P | 1 |
| Miller, J | 1 |
| Alicai, T | 1 |
| Seal, SE | 1 |
| Bailey, AM | 1 |
| Foster, GD | 1 |
| Gupta, R | 1 |
| Bhatt, LK | 1 |
| Momin, M | 1 |
| Güçlü, O | 1 |
| Doğanlar, O | 1 |
| Yüksel, V | 1 |
| Doğanlar, ZB | 1 |
| Giuliani, A | 1 |
| Romanzi, F | 1 |
| Di Sibio, A | 1 |
| Calvisi, G | 1 |
| Lombardi, L | 1 |
| Marchese, M | 1 |
| Di Staso, M | 1 |
| Schietroma, M | 1 |
| Carlei, F | 1 |
| Romano, L | 1 |
| Grassilli, E | 1 |
| Narloch, R | 1 |
| Federzoni, E | 1 |
| Ianzano, L | 1 |
| Pisano, F | 1 |
| Giovannoni, R | 1 |
| Romano, G | 1 |
| Masiero, L | 1 |
| Leone, BE | 1 |
| Bonin, S | 1 |
| Donada, M | 1 |
| Stanta, G | 1 |
| Helin, K | 1 |
| Lavitrano, M | 1 |
| Doyen, J | 1 |
| Benezery, K | 1 |
| Follana, P | 1 |
| Ortholan, C | 1 |
| Gérard, JP | 1 |
| Hannoun-Levi, JM | 1 |
| Gal, J | 1 |
| Francois, E | 1 |
| Welling, TH | 1 |
| Feng, M | 1 |
| Wan, S | 1 |
| Hwang, SY | 1 |
| Volk, ML | 1 |
| Lawrence, TS | 1 |
| Zalupski, MM | 1 |
| Sonnenday, CJ | 1 |
| Vasconcelos, I | 1 |
| Schoenegg, W | 1 |
| Wang, H | 1 |
| Bastian, SE | 1 |
| Cheah, KY | 1 |
| Lawrence, A | 1 |
| Howarth, GS | 1 |
| Engin, KN | 1 |
| Erdem-Kuruca, S | 1 |
| Akgün-Dar, K | 1 |
| Çetin, B | 1 |
| Karadenizli, S | 1 |
| Gürel, E | 1 |
| Yemisci, B | 1 |
| Bilgiç, S | 1 |
| Arslan, M | 1 |
| Xu, B | 1 |
| Shu, Y | 1 |
| Liu, P | 1 |
| Su, J | 1 |
| Cheng, H | 1 |
| Zhang, D | 1 |
| Wang, M | 1 |
| Xie, C | 1 |
| Hu, Y | 1 |
| Chang, HC | 1 |
| Li, Q | 1 |
| Poornima, K | 1 |
| Chella Perumal, P | 1 |
| Gopalakrishnan, VK | 1 |
| Takada, S | 1 |
| Hoshino, Y | 1 |
| Ito, H | 1 |
| Masugi, Y | 1 |
| Terauchi, T | 1 |
| Endo, K | 1 |
| Kimata, M | 1 |
| Furukawa, J | 1 |
| Shinozaki, H | 1 |
| Kobayashi, K | 1 |
| Ogata, Y | 1 |
| Guo, B | 1 |
| Xie, N | 1 |
| Wang, Y | 2 |
| Stremitzer, S | 1 |
| Stift, J | 1 |
| Singh, J | 1 |
| Starlinger, P | 1 |
| Gruenberger, B | 1 |
| Tamandl, D | 1 |
| Gruenberger, T | 1 |
| Oliver Metzig, M | 1 |
| Fuchs, D | 1 |
| Tagscherer, KE | 1 |
| Gröne, HJ | 1 |
| Schirmacher, P | 1 |
| Roth, W | 1 |
| Serrablo, A | 1 |
| Paliogiannis, P | 1 |
| Pulighe, F | 1 |
| Moro, SS | 1 |
| Borrego-Estella, V | 1 |
| Attene, F | 1 |
| Scognamillo, F | 1 |
| Hörndler, C | 1 |
| Song, XL | 1 |
| Kang, HK | 1 |
| Jeong, GW | 1 |
| Ahn, KY | 1 |
| Jeong, YY | 1 |
| Kang, YJ | 1 |
| Cho, HJ | 1 |
| Moon, CM | 1 |
| Däster, S | 1 |
| Amatruda, N | 1 |
| Calabrese, D | 1 |
| Ivanek, R | 1 |
| Turrini, E | 1 |
| Droeser, RA | 1 |
| Zajac, P | 1 |
| Fimognari, C | 1 |
| Spagnoli, GC | 1 |
| Iezzi, G | 1 |
| Mele, V | 1 |
| Muraro, MG | 1 |
| Tamaki, R | 1 |
| Kanai-Mori, A | 1 |
| Morishige, Y | 1 |
| Koike, A | 1 |
| Yanagihara, K | 1 |
| Amano, F | 1 |
| Polak, MB | 1 |
| Valamanesh, F | 1 |
| Felt, O | 1 |
| Torriglia, A | 1 |
| Jeanny, JC | 1 |
| Bourges, JL | 1 |
| Rat, P | 1 |
| Thomas-Doyle, A | 1 |
| BenEzra, D | 1 |
| Gurny, R | 1 |
| Behar-Cohen, F | 1 |
| Bijnsdorp, IV | 2 |
| Kruyt, F | 1 |
| Fukushima, M | 2 |
| Peters, GJ | 2 |
| Maiorano, E | 1 |
| Regan, MM | 1 |
| Viale, G | 1 |
| Mastropasqua, MG | 1 |
| Colleoni, M | 1 |
| Castiglione-Gertsch, M | 1 |
| Price, KN | 1 |
| Gelber, RD | 2 |
| Goldhirsch, A | 1 |
| Coates, AS | 1 |
| Le Pivert, PJ | 1 |
| Morrison, DR | 1 |
| Haddad, RS | 1 |
| Renard, M | 1 |
| Aller, A | 1 |
| Titus, K | 1 |
| Doulat, J | 1 |
| Temmink, OH | 1 |
| Kruyt, FA | 1 |
| Bercovitz, RS | 1 |
| Greffe, BS | 1 |
| Hunger, SP | 1 |
| Lee, SY | 1 |
| Jeong, EK | 1 |
| Jeon, HM | 1 |
| Kim, CH | 1 |
| Kang, HS | 1 |
| Benoit, A | 1 |
| Ducray, F | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Treatment of Liver Metastases With Electrochemotherapy[NCT01264952] | Phase 1/Phase 2 | 16 participants (Actual) | Interventional | 2008-11-30 | Completed | ||
| Treatment of Liver Metastases With Electrochemotherapy (ECTJ) Phase II[NCT02352259] | Phase 2 | 23 participants (Actual) | Interventional | 2013-09-30 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
(NCT01264952)
Timeframe: After operation on day 7
| Intervention | events (Number) |
|---|---|
| Group I | 0 |
| Group II | 0 |
| Group III | 0 |
(NCT01264952)
Timeframe: After operation on tha days 2, 7, 30, monthly
| Intervention | patients with non-severe adverse events (Number) |
|---|---|
| Group I | 3 |
| Group II | 2 |
| Group III | 7 |
"Response Evaluation Criteria In Solid Tumors Criteria (RECIST v1.0) for target lesions and assessed by MRI:~Complete Response (CR), Disappearance of all target lesions; Partial Response (PR), >=30% decrease in the sum of the longest diameter of target lesions; Overall Response (OR) = CR + PR" (NCT01264952)
Timeframe: After operation or 1st day after operation, 7th day, 30th day, monthly
| Intervention | metastases (Number) |
|---|---|
| Group I | 10 |
| Group II | 1 |
| Group III | 10 |
6 reviews available for fluorouracil and Necrosis
| Article | Year |
|---|---|
The Intestinal Redox System and Its Significance in Chemotherapy-Induced Intestinal Mucositis.
Topics: Antineoplastic Agents; Fluorouracil; Humans; Intestinal Mucosa; Intestines; Mucositis; Necrosis; Oxi | 2022 |
Extensive bowel necrosis related to bevacizumab in metastatic rectal cancer patient: a case report and review of literature.
Topics: Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemothera | 2015 |
[5-fluorouracil in the treatment and prevention of acute pancreatitis].
Topics: Acute Disease; Animals; Depression, Chemical; DNA; Fluorouracil; Humans; Infusions, Intra-Arterial; | 1982 |
Persistent supravenous erythematous eruption: a rare local complication of intravenous 5-fluorouracil therapy.
Topics: Antimetabolites, Antineoplastic; Dermis; Drug Eruptions; Erythema; Fluorouracil; Follow-Up Studies; | 1998 |
[Ligation of the hepatic artery in the treatment of liver tumors (review of the literature)].
Topics: Adult; Anti-Bacterial Agents; Fluorouracil; Hemangioma; Hepatic Artery; Humans; Ligation; Liver Cirr | 1975 |
[Raynaud's phenomenon and finger necrosis after treatment of ovarian seminoma with bleomycin, vinblastine and 5-fluorouracil].
Topics: Adult; Antineoplastic Combined Chemotherapy Protocols; Bleomycin; Dysgerminoma; Female; Fingers; Flu | 1987 |
13 trials available for fluorouracil and Necrosis
| Article | Year |
|---|---|
Prospective, Multicenter, Phase 2 Trial of Induction Chemotherapy Followed by Bio-Chemoradiotherapy for Locally Advanced Recurrent Nasopharyngeal Carcinoma.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Cause of Death; Cetuximab; Chemoradioth | 2018 |
Histological response, pattern of tumor destruction and clinical outcome after neoadjuvant chemotherapy including bevacizumab or cetuximab in patients undergoing liver resection for colorectal liver metastases.
Topics: Adult; Aged; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy Protocols; Beva | 2015 |
Prognostic and predictive impact of central necrosis and fibrosis in early breast cancer: results from two International Breast Cancer Study Group randomized trials of chemoendocrine adjuvant therapy.
Topics: Antineoplastic Agents, Hormonal; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; C | 2010 |
Electrochemotherapy: a new technological approach in treatment of metastases in the liver.
Topics: Antibiotics, Antineoplastic; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy | 2011 |
Electrochemotherapy: a new technological approach in treatment of metastases in the liver.
Topics: Antibiotics, Antineoplastic; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy | 2011 |
Electrochemotherapy: a new technological approach in treatment of metastases in the liver.
Topics: Antibiotics, Antineoplastic; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy | 2011 |
Electrochemotherapy: a new technological approach in treatment of metastases in the liver.
Topics: Antibiotics, Antineoplastic; Antibodies, Monoclonal, Humanized; Antineoplastic Combined Chemotherapy | 2011 |
Single-cycle induction chemotherapy selects patients with advanced laryngeal cancer for combined chemoradiation: a new treatment paradigm.
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, Adjuvant; Cisplatin; Dise | 2006 |
Combined transarterial targeting locoregional immunotherapy-chemotherapy for patients with unresectable hepatocellular carcinoma: a new alternative for an old problem.
Topics: Aged; alpha-Fetoproteins; Antineoplastic Combined Chemotherapy Protocols; Carboplatin; Carcinoma, He | 1995 |
[Local arterial infusion of 5-FU in treatment of acute necrotic pancreatitis].
Topics: Acute Disease; Adolescent; Adult; Aged; Double-Blind Method; Female; Fluorouracil; Humans; Infusions | 1995 |
Using preoperative UFT to predict sensitivity to fluoropyrimidines in colorectal cancer.
Topics: Aged; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Chemotherapy, | 1999 |
E1B-deleted adenovirus (dl1520) gene therapy for patients with primary and secondary liver tumors.
Topics: Adenoviridae; Adenovirus E1B Proteins; Adult; Aged; Aged, 80 and over; Antimetabolites, Antineoplast | 2001 |
Experimental studies and preliminary clinical trial of vinorelbine-loaded polymeric bioresorbable implants for the local treatment of solid tumors.
Topics: Adult; Animals; Antineoplastic Agents; Delayed-Action Preparations; Dogs; Dose-Response Relationship | 1991 |
Mitoxantrone: an overview of safety and toxicity.
Topics: Anthraquinones; Antineoplastic Combined Chemotherapy Protocols; Bone Marrow; Breast Neoplasms; Clini | 1985 |
Radiation therapy alone or in combination with chemotherapy in the treatment of residual or inoperable carcinoma of the rectum and rectosigmoid or pelvic recurrence following colorectal surgery. Radiation Therapy Oncology Group study (76-16).
Topics: Abscess; Actuarial Analysis; Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Clinical T | 1985 |
Complications and toxic manifestations of surgical adjuvant chemotherapy for breast cancer.
Topics: Adult; Aged; Blood Cell Count; Blood Platelets; Blood Transfusion; Breast Neoplasms; Clinical Trials | 1968 |
96 other studies available for fluorouracil and Necrosis
| Article | Year |
|---|---|
Constituents of Brazilian red propolis and their preferential cytotoxic activity against human pancreatic PANC-1 cancer cell line in nutrient-deprived condition.
Topics: Antineoplastic Agents; Cell Line, Tumor; Drug Screening Assays, Antitumor; Humans; Necrosis; Nutriti | 2008 |
Oridonin enhances the cytotoxicity of 5-FU in renal carcinoma cells by inducting necroptotic death.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Renal Cell; Cell Line | 2018 |
Temporal lobe injury patterns following intensity modulated radiotherapy in a large cohort of nasopharyngeal carcinoma patients.
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Brain Edema; Cisplatin; Docetaxel; Female; Flu | 2018 |
Tumor-Infiltrating T Cell Receptor-Beta Repertoires are Linked to the Risk of Late Chemoradiation-Induced Temporal Lobe Necrosis in Locally Advanced Nasopharyngeal Carcinoma.
Topics: Analysis of Variance; Antineoplastic Agents; Chemoradiotherapy; Cisplatin; Fluorouracil; Humans; Leu | 2019 |
Cassava brown streak virus Ham1 protein hydrolyses mutagenic nucleotides and is a necrosis determinant.
Topics: Amino Acid Motifs; Amino Acid Sequence; Conserved Sequence; Fluorouracil; Hydrolysis; Mutagens; Muta | 2019 |
Potent antitumor activity of Laccaic acid and Phenethyl isothiocyanate combination in colorectal cancer via dual inhibition of DNA methyltransferase-1 and Histone deacetylase-1.
Topics: Animals; Antimetabolites, Antineoplastic; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; | 2019 |
FOLFIRI-Mediated Toxicity in Human Aortic Smooth Muscle Cells and Possible Amelioration with Curcumin and Quercetin.
Topics: Antineoplastic Combined Chemotherapy Protocols; Aorta; Apoptosis; Apoptosis Regulatory Proteins; Cam | 2020 |
Hypovolemic shock after pelvic radiotherapy. A rare combination leading to a devastating complication.
Topics: Aged; Anaphylaxis; Anus Neoplasms; Carcinoma; Carcinoma, Squamous Cell; Chemoradiotherapy; Colon, Si | 2019 |
Inhibition of GSK3B bypass drug resistance of p53-null colon carcinomas by enabling necroptosis in response to chemotherapy.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Colonic Neoplasms; DNA Damage; Drug Resistance, | 2013 |
Predictive factors for early and late local toxicities in anal cancer treated by radiotherapy in combination with or without chemotherapy.
Topics: Adult; Aged; Aged, 80 and over; Antineoplastic Combined Chemotherapy Protocols; Anus Neoplasms; Brac | 2013 |
Neoadjuvant stereotactic body radiation therapy, capecitabine, and liver transplantation for unresectable hilar cholangiocarcinoma.
Topics: Aged; Antineoplastic Agents; Capecitabine; Chemoradiotherapy; Cholangiocarcinoma; Cholangitis, Scler | 2014 |
Massive breast necrosis after extravasation of a full anthracycline cycle.
Topics: Breast; Breast Neoplasms; Cyclophosphamide; Epirubicin; Extravasation of Diagnostic and Therapeutic | 2013 |
Escherichia coli Nissle 1917-derived factors reduce cell death and late apoptosis and increase transepithelial electrical resistance in a model of 5-fluorouracil-induced intestinal epithelial cell damage.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Biological Products; Cell Death; Cell Line; Cel | 2014 |
The evaluation of human tenon's fibroblasts and endothelial cell responses to antifibrotics alone and in combination with α-tocopherol.
Topics: Alkylating Agents; alpha-Tocopherol; Antioxidants; Apoptosis; bcl-2-Associated X Protein; Caspase 3; | 2015 |
INF-γ sensitizes head and neck squamous cell carcinoma cells to chemotherapy-induced apoptosis and necroptosis through up-regulation of Egr-1.
Topics: Antineoplastic Agents; Apoptosis; Carcinoma, Squamous Cell; Cell Line, Tumor; Cisplatin; Drug Synerg | 2014 |
Synergistic effects of 5-fluorouracil and gambogenic acid on A549 cells: activation of cell death caused by apoptotic and necroptotic mechanisms via the ROS-mitochondria pathway.
Topics: Antineoplastic Agents; Apoptosis; Caspase 3; Caspase 9; Cell Line, Tumor; Cell Survival; Drug Synerg | 2014 |
Protective effect of ethanolic extract of Tabernaemontana divaricata (L.) R. Br. against DEN and Fe NTA induced liver necrosis in Wistar Albino rats.
Topics: Alkylating Agents; Animals; Antimetabolites; Antioxidants; Bilirubin; Biomarkers; Carcinogens; Chemi | 2014 |
Cooperative effect of Bifidobacteria lipoteichoic acid combined with 5-fluorouracil on hepatoma-22 cells growth and apoptosis.
Topics: Animals; Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Bifidobacterium; Carcinoma, H | 2015 |
Inhibition of caspases primes colon cancer cells for 5-fluorouracil-induced TNF-α-dependent necroptosis driven by RIP1 kinase and NF-κB.
Topics: Animals; Antimetabolites, Antineoplastic; Apoptosis; Caspases; Cell Line, Tumor; Colonic Neoplasms; | 2016 |
Impact of novel histopathological factors on the outcomes of liver surgery for colorectal cancer metastases.
Topics: Antibodies, Monoclonal; Antineoplastic Combined Chemotherapy Protocols; Bevacizumab; Capecitabine; C | 2016 |
Intravoxel incoherent motion diffusion-weighted imaging for monitoring chemotherapeutic efficacy in gastric cancer.
Topics: Adenocarcinoma; Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Diffusion Magnet | 2016 |
Induction of hypoxia and necrosis in multicellular tumor spheroids is associated with resistance to chemotherapy treatment.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Hypoxia; Colorectal Neoplasms; Drug Resistance, Neopl | 2017 |
Effects of 5-fluorouracil, adriamycin and irinotecan on HSC-39, a human scirrhous gastric cancer cell line.
Topics: Adenocarcinoma, Scirrhous; Apoptosis; Camptothecin; Cell Line; Cell Proliferation; Cell Survival; Do | 2017 |
Controlled delivery of 5-chlorouracil using poly(ortho esters) in filtering surgery for glaucoma.
Topics: Animals; Antimitotic Agents; Apoptosis; Blister; Cell Death; Cell Proliferation; Cell Survival; Cell | 2008 |
Novel cell death mechanisms of trifluorothymidine.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Cell Line, Tumor; Fluorouracil; Humans; Necrosis; Triflu | 2008 |
Percutaneous tumor ablation: microencapsulated echo-guided interstitial chemotherapy combined with cryosurgery increases necrosis in prostate cancer.
Topics: Animals; Antimetabolites, Antineoplastic; Cell Line, Tumor; Combined Modality Therapy; Cryosurgery; | 2009 |
Differential activation of cell death and autophagy results in an increased cytotoxic potential for trifluorothymidine compared to 5-fluorouracil in colon cancer cells.
Topics: Antimetabolites, Antineoplastic; Apoptosis; Autophagy; Blotting, Western; Caspases; Cathepsin B; Cel | 2010 |
Acute tumor lysis syndrome in a 7-month-old with hepatoblastoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Cisplatin; Disseminated Intravascular Coagulation; F | 2010 |
Implication of necrosis-linked p53 aggregation in acquired apoptotic resistance to 5-FU in MCF-7 multicellular tumour spheroids.
Topics: Adenocarcinoma; Apoptosis; Breast Neoplasms; Cell Line, Tumor; Chemical Precipitation; Drug Resistan | 2010 |
Favorable outcome with bevacizumab after poor outcome with steroids in a patient with temporal lobe and brainstem radiation necrosis.
Topics: Adult; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Agents; Bevacizumab | 2011 |
[Roles of hepatectomy for colorectal liver metastases with necrotic foci caused by prior anti-cancer therapies].
Topics: Aged; Angiogenesis Inhibitors; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineopla | 2010 |
Mediastinal infusion with tracheal necrosis: an unusual complication of Port-a-cath devices.
Topics: Adenocarcinoma; Antibodies, Monoclonal; Antibodies, Monoclonal, Humanized; Antineoplastic Combined C | 2011 |
Triple-negative breast cancer: are the imaging findings different between responders and nonresponders to neoadjuvant chemotherapy?
Topics: Adult; Aged; Antineoplastic Combined Chemotherapy Protocols; Biopsy, Fine-Needle; Breast Neoplasms; | 2011 |
Radiotherapy-induced pemphigus vulgaris with autoantibodies targeting a 110 kDa epidermal antigen.
Topics: Acantholysis; Adrenal Cortex Hormones; Antigens; Antineoplastic Agents; Autoantibodies; Carcinoma; C | 2011 |
Anticancer effects of 5-fluorouracil combined with warming and relieving cold phlegm formula on human breast cancer.
Topics: Animals; Antineoplastic Agents; Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Ce | 2012 |
Platelets increase survival of adenocarcinoma cells challenged with anticancer drugs: mechanisms and implications for chemoresistance.
Topics: Adenocarcinoma; Antineoplastic Agents; Apoptosis; Blood Platelets; Caco-2 Cells; Cell Cycle; Cell Pr | 2012 |
[Influence of combined cyclosporine A and tacrolimus with 5-fluorouracil on hepatocellular carcinoma rats].
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Apoptosis; Carcinoma, Hepatocellular; Cyclo | 2003 |
[Method for improving results of local operations for pyo-necrotic disease of the foot associated with diabetes mellitus].
Topics: Adult; Aged; Aged, 80 and over; Antimetabolites; Combined Modality Therapy; Diabetic Foot; Fluoroura | 2003 |
Cryosurgery--a putative approach to molecular-based optimization.
Topics: Antineoplastic Agents; Apoptosis; Caspase Inhibitors; Caspases; Cell Death; Cell Line, Tumor; Cell S | 2004 |
Addition of anticancer agents enhances freezing-induced prostate cancer cell death: implications of mitochondrial involvement.
Topics: Antineoplastic Agents; Apoptosis; bcl-2-Associated X Protein; Cell Death; Cell Line, Tumor; Chemothe | 2004 |
Combined radiofrequency ablation and adjuvant liposomal chemotherapy: effect of chemotherapeutic agent, nanoparticle size, and circulation time.
Topics: Adenocarcinoma; Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Antineoplasti | 2005 |
[Unilateral acral necrosis as a minor form of hand-foot syndrome. Patient with unilateral acral necrosis secondary to capecitabine therapy for metastatic breast cancer].
Topics: Aged; Antimetabolites, Antineoplastic; Breast Neoplasms; Capecitabine; Deoxycytidine; Erythema; Fema | 2007 |
Macroscopic and microscopic effects of GaAIAs diode laser and dexamethasone therapies on oral mucositis induced by fluorouracil in rats.
Topics: Aluminum; Animals; Anti-Inflammatory Agents; Antimetabolites; Arsenicals; Biofilms; Dexamethasone; D | 2007 |
Histological evaluation of colonic anastomotic healing, during perioperative Capecitabine administration. Experimental study in rats.
Topics: Anastomosis, Surgical; Animals; Antimetabolites, Antineoplastic; Capecitabine; Chemotherapy, Adjuvan | 2007 |
Reversal of lethal, chemotherapeutically induced acute hepatic necrosis in rats by regenerating liver cytosol.
Topics: Acute Disease; Animals; Chemical and Drug Induced Liver Injury; Cytosol; Fluorouracil; Hyperthermia, | 1983 |
[Maximum tolerated dose of tegafur in rats].
Topics: Administration, Oral; Animals; Body Weight; Drug Administration Schedule; Drug Tolerance; Fluorourac | 1984 |
Drug-induced cardionecrosis.
Topics: Anesthetics; Antibiotics, Antineoplastic; Antidepressive Agents; Antineoplastic Agents; Calcium; Cyc | 1984 |
[Results of the treatment of pancreonecrosis].
Topics: Acute Disease; Fluorouracil; Humans; Hypothermia, Induced; Infusions, Intra-Arterial; Necrosis; Panc | 1983 |
[Unsolved problems of the treatment of pancreatic necrosis].
Topics: Acute Disease; Anti-Bacterial Agents; Drug Therapy, Combination; Fluorouracil; Humans; Necrosis; Pan | 1983 |
Death of intestinal crypts and of their constituent cells after treatment by chemotherapeutic drugs.
Topics: Animals; Antineoplastic Agents; Carmustine; Cell Survival; Cyclophosphamide; Dactinomycin; Doxorubic | 1984 |
Protection of thermochemotherapeutic-induced lethal acute hepatic necrosis in the rat by 16,16-dimethyl prostaglandin E2.
Topics: 16,16-Dimethylprostaglandin E2; Alanine Transaminase; Animals; Aspartate Aminotransferases; Fluorour | 1983 |
[Morphology of experimental pancreonecrosis following treatment with 5-fluorouracil].
Topics: Acute Disease; alpha-Amylases; Amidinotransferases; Animals; Fluorouracil; Male; Microscopy, Electro | 1981 |
Nasal cartilage necrosis following high-dose 5-FU: a case report.
Topics: Adenocarcinoma; Cartilage; Female; Fluorouracil; Humans; Middle Aged; Necrosis; Nose; Pelvic Neoplas | 1982 |
[Morphology of experimental acute pancreatitis during treatment with 5-fluorouracil].
Topics: Acute Disease; Animals; Fluorouracil; Male; Necrosis; Pancreas; Pancreatitis; Rats | 1980 |
Effect of 5-fluorouracil on secretion and synthesis of pancreatic digestive enzymes: studies in isolated pancreatic acini and perfused pancreas derived from normal rats and from rats with acute necrotizing pancreatitis.
Topics: Acute Disease; Amylases; Animals; Autoradiography; Fluorouracil; Male; Necrosis; Pancreas; Pancreati | 1994 |
Effect of diets on 5-fluorouracil and cyclophosphamide toxicity.
Topics: Animals; Caseins; Cyclophosphamide; Dietary Proteins; Fluorouracil; Intestinal Diseases; Intestines; | 1995 |
Ocular toxicity of mitomycin C and 5-fluorouracil in the rabbit.
Topics: Animals; Corneal Edema; Corneal Neovascularization; Eye; Eyelids; Fluorouracil; Mitomycin; Necrosis; | 1994 |
[Cardiac toxicity of 5-fluorouracil].
Topics: Adenocarcinoma; Angina Pectoris; Cardiomyopathies; Cecal Neoplasms; Colonic Neoplasms; Death, Sudden | 1994 |
Necrosis in a meningioma following systemic chemotherapy. Case report.
Topics: Adenocarcinoma; Antineoplastic Combined Chemotherapy Protocols; Combined Modality Therapy; Embolizat | 1994 |
5-Fluorouracil metabolite patterns in viable and necrotic tumor areas of murine colon carcinoma determined by 19F NMR spectroscopy.
Topics: Animals; Colonic Neoplasms; Female; Fluorine; Fluorouracil; Humans; Magnetic Resonance Spectroscopy; | 1996 |
[Morphological changes in human colon carcinoma after chemotherapy with 5-fluorouracil--a study in the nude mouse model].
Topics: Adenocarcinoma, Papillary; Animals; Antimetabolites, Antineoplastic; Cell Survival; Colonic Neoplasm | 1997 |
Apoptosis- and necrosis-inducing potential of cladribine, cytarabine, cisplatin, and 5-fluorouracil in vitro: a quantitative pharmacodynamic model.
Topics: Antineoplastic Agents; Apoptosis; Cisplatin; Cladribine; Combined Modality Therapy; Cytarabine; Dose | 1998 |
Nonselective debridement and antimicrobial cleansing of a venting ductal breast carcinoma.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Carcinoma, Ductal, Breast; Cycloph | 1999 |
Fluorouracil cream: don't forget to wash your hands.
Topics: Aged; Aged, 80 and over; Antimetabolites; Fluorouracil; Hand Disinfection; Humans; Keratosis; Male; | 2000 |
Direct in vivo observation of 5-fluorouracil release from a prodrug in human tumors heterotransplanted in nude mice: a magnetic resonance study.
Topics: Animals; Antimetabolites, Antineoplastic; Colonic Neoplasms; Female; Fluorouracil; Glucuronidase; Hu | 2000 |
A simple method for classification of cell death by use of thin layer collagen gel for the detection of apoptosis and/or necrosis after cancer chemotherapy.
Topics: Antineoplastic Agents; Apoptosis; Bisbenzimidazole; Cisplatin; Collagen; Eosine Yellowish-(YS); Fluo | 2001 |
The preferential induction of apoptosis in multidrug-resistant KB cells by 5-fluorouracil.
Topics: Apoptosis; Cell Survival; Dose-Response Relationship, Drug; Drug Resistance, Multiple; Fluorouracil; | 2002 |
Activity of boanmycin against colorectal cancer.
Topics: Animals; Antibiotics, Antineoplastic; Antimetabolites, Antineoplastic; Bleomycin; Colorectal Neoplas | 2001 |
Anticancer efficacy of systemically delivered anaerobic bacteria as gene therapy vectors targeting tumor hypoxia/necrosis.
Topics: Animals; Carcinoma, Squamous Cell; Cell Hypoxia; Clostridium; Cytosine Deaminase; Flucytosine; Fluor | 2002 |
Complete necrotization of hepatocellular carcinoma by chemotherapy and subsequent intravascular coagulation: a case report.
Topics: Acute Kidney Injury; Antineoplastic Agents; Carcinoma, Hepatocellular; Disseminated Intravascular Co | 1978 |
The acute effects of various cytotoxic compounds injected into the prostate glands of dogs.
Topics: Animals; Antineoplastic Agents; Dactinomycin; Dogs; Ethoglucid; Fluorouracil; Inflammation; Injectio | 1978 |
Delayed complications in colo-rectal carcinoma treated by combination radiotherapy and 5-fluorouracil--Eastern Cooperative Oncology Group (E.C.O.G.) pilot study.
Topics: Aged; Colonic Diseases; Colonic Neoplasms; Connective Tissue; Constriction, Pathologic; Female; Fluo | 1979 |
Intrathecal 5-fluorouracil in the rhesus monkey.
Topics: Animals; Cerebral Ventricles; Fluorouracil; Injections, Spinal; Macaca mulatta; Male; Necrosis; Para | 1992 |
Akinetic mutism in bilateral necrotizing leucoencephalopathy after radiation and chemotherapy: electrophysiological and autopsy findings.
Topics: Adult; Afferent Pathways; Akinetic Mutism; Alpha Rhythm; Antineoplastic Combined Chemotherapy Protoc | 1992 |
Necrotizing pneumonitis caused by 5-fluorouracil infusion. A complication of a Hickman catheter.
Topics: Aged; Brachiocephalic Veins; Catheters, Indwelling; Fluorouracil; Foreign-Body Migration; Humans; In | 1992 |
[Bile duct necrosis and hepatic necrosis following hepatic arterial infusion chemotherapy].
Topics: Aged; Antineoplastic Combined Chemotherapy Protocols; Bile Ducts, Intrahepatic; Carcinoma, Hepatocel | 1991 |
[Chemotherapeutic pathomorphosis of breast cancer].
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast; Breast Neoplasms; Carcinoma; Carcinoma, Intr | 1990 |
Effect of preoperative chemotherapy on mastectomy for locally advanced breast cancer.
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Combined Modality Therapy; Cycloph | 1990 |
[Pathomorphosis of bladder cancer after endolymphatic polychemotherapy].
Topics: Antineoplastic Combined Chemotherapy Protocols; Carcinoma, Transitional Cell; Chemotherapy, Cancer, | 1986 |
Drug extravasation as a complication of venous access ports.
Topics: Adolescent; Adult; Aged; Dobutamine; Extravasation of Diagnostic and Therapeutic Materials; Floxurid | 1985 |
Experience with an annular phased array hyperthermia system in the treatment of advanced recurrences of the pelvis.
Topics: Combined Modality Therapy; Evaluation Studies as Topic; Female; Fluorouracil; Humans; Hyperthermia, | 1988 |
A warning on antimetabolites and cryosurgery in the reconstruction of eyelids. Case report.
Topics: Aged; Antimetabolites, Antineoplastic; Cryosurgery; Eyelid Diseases; Eyelids; Female; Fluorouracil; | 1987 |
[Mechanisms of the pathogenetic prevention of acute pancreatitis in an experiment].
Topics: Acute Disease; Animals; Drug Evaluation, Preclinical; Drug Therapy, Combination; Fat Emulsions, Intr | 1987 |
[Pathomorphosis of experimental pancreatic necrosis treated by a single endolymphatic injection of 5-fluorouracil].
Topics: Animals; Biopsy; Dogs; Drug Evaluation, Preclinical; Fluorouracil; Injections, Intralymphatic; Micro | 1986 |
Skin necrosis due to antiblastics (procedures of prevention and therapy).
Topics: Antineoplastic Combined Chemotherapy Protocols; Breast Neoplasms; Cyclophosphamide; Doxorubicin; Ext | 1986 |
Anti-tumor effects of tumor necrosis factor in combination with chemotherapeutic agents.
Topics: Animals; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dose-Response Relationshi | 1987 |
[Therapy-induced tumor regression. Morphological findings in malignant primary and secondary liver tumors following intensive regional cytostatic treatment].
Topics: Adenocarcinoma; Carcinoid Tumor; Chemotherapy, Cancer, Regional Perfusion; Colonic Neoplasms; Doxoru | 1985 |
Treatment of secondary hepatic tumours by ligation of hepatic artery and infusion of cytotoxic drugs.
Topics: Adenocarcinoma; Aged; Angiography; Aortography; Carcinoid Tumor; Chemotherapy, Cancer, Regional Perf | 1970 |
Arterial infusion of 5-fluorouracil as a treatment for carcinoma of the prostate.
Topics: Aged; Catheterization; Fluorouracil; Humans; Iliac Artery; Injections, Intra-Arterial; Male; Middle | 1974 |
[Treatment of cancer of the liver by regional perfusion].
Topics: Adult; Aged; Angiography; Carcinoma, Hepatocellular; Catheterization; Colonic Neoplasms; Fluorouraci | 1968 |
Pathologic changes in the gastroduodenal mucosa after intra-arterial infusion of 5-fluorouracil.
Topics: Animals; Arteries; Catheterization; Dogs; Duodenum; Fluorouracil; Gastric Mucosa; Gastrointestinal H | 1973 |
Cecal necrosis and perforation with systemic chemotherapy.
Topics: Adult; Asparaginase; Breast Neoplasms; Cecal Diseases; Child; Cytarabine; Daunorubicin; Female; Fluo | 1973 |
Effects of topically applied 5-fluorouracil in the Syrian hamster.
Topics: Administration, Topical; Animals; Cheek; Cricetinae; Erythema; Fluorouracil; Mouth Mucosa; Necrosis; | 1974 |
[Diffuse liver necrosis in treatment with 5-fluorouracil].
Topics: Adult; Chemical and Drug Induced Liver Injury; Fluorouracil; Humans; Liver; Male; Mesothelioma; Necr | 1972 |
Tumor hyperthermia in the treatment of malignant gliomas of the brain.
Topics: Animals; Blood-Brain Barrier; Brain Edema; Brain Neoplasms; Dogs; Fluorouracil; Glioma; Hot Temperat | 1971 |
The place of chemotherapy with 5 per cent 5-fluorouracil ointment in the treatment of malignant disease of the skin.
Topics: Carcinoma, Squamous Cell; Female; Fluorouracil; Humans; Male; Necrosis; Ointments; Skin Neoplasms; T | 1970 |