Proteins > Cysteinyl leukotriene receptor 1
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Cysteinyl leukotriene receptor 1
A cysteinyl leukotriene receptor 1 that is encoded in the genome of guinea pig. [OMA:Q2NNR5, PRO:DNx]
Synonyms
CysLTR1;
Cysteinyl leukotriene D4 receptor;
LTD4 receptor
Research
Bioassay Publications (11)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 2 (18.18) | 18.7374 |
| 1990's | 5 (45.45) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 2 (18.18) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (17)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ono 1078 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0010 | 1 | 2 |
| pf 5901 | Cavia porcellus (domestic guinea pig) | Ki | 1.5000 | 1 | 1 |
| ici 204,219 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0020 | 1 | 1 |
| ici 204,219 | Cavia porcellus (domestic guinea pig) | Ki | 0.0003 | 2 | 2 |
| wy 48252 | Cavia porcellus (domestic guinea pig) | Ki | 0.0350 | 1 | 3 |
| fananserin | Cavia porcellus (domestic guinea pig) | Ki | 0.0001 | 1 | 1 |
| fpl 55712 | Cavia porcellus (domestic guinea pig) | Ki | 0.7250 | 2 | 2 |
| sr 2640 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0230 | 1 | 1 |
| rg 12525 | Cavia porcellus (domestic guinea pig) | Ki | 0.0030 | 1 | 1 |
| rg 6866 | Cavia porcellus (domestic guinea pig) | Ki | 100.0000 | 1 | 1 |
| 2-(1-piperazinyl)-4-amino-6,7-dimethoxyquinazoline | Cavia porcellus (domestic guinea pig) | IC50 | 1.0000 | 1 | 1 |
| montelukast | Cavia porcellus (domestic guinea pig) | Ki | 0.0005 | 1 | 1 |
| mdl 100907 | Cavia porcellus (domestic guinea pig) | Ki | 0.0001 | 1 | 1 |
| cinalukast | Cavia porcellus (domestic guinea pig) | Ki | 0.0064 | 1 | 1 |
| dcc-2701 | Cavia porcellus (domestic guinea pig) | IC50 | 0.0008 | 1 | 1 |
| bms 536924 | Cavia porcellus (domestic guinea pig) | IC50 | 0.5000 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| l 660,711 | Cavia porcellus (domestic guinea pig) | Kd | 0.0010 | 1 | 2 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| ly 171883 | Cavia porcellus (domestic guinea pig) | Kb | 0.1800 | 1 | 1 |
| fpl 55712 | Cavia porcellus (domestic guinea pig) | Kb | 0.4800 | 1 | 1 |
| rg 12525 | Cavia porcellus (domestic guinea pig) | Kb | 0.0030 | 1 | 1 |
Opportunities and Challenges for Fatty Acid Mimetics in Drug Discovery.Journal of medicinal chemistry, , 07-13, Volume: 60, Issue:13, 2017
N-carbamoyl analogs of Zafirlukast: potent receptor antagonists of leukotriene D4.Bioorganic & medicinal chemistry letters, , Sep-22, Volume: 8, Issue:18, 1998
Development of a three-dimensional CysLT1 (LTD4) antagonist model with an incorporated amino acid residue from the receptor.Journal of medicinal chemistry, , Apr-23, Volume: 41, Issue:9, 1998
Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene D4 receptor antagonists. 2. Effects of an additional phenyl ring on receptor affinity.Journal of medicinal chemistry, , Volume: 33, Issue:4, 1990
Development of a novel series of (2-quinolinylmethoxy)phenyl-containing compounds as high-affinity leukotriene receptor antagonists. 1. Initial structure-activity relationships.Journal of medicinal chemistry, , Volume: 33, Issue:4, 1990
Hydroxyacetophenone-derived antagonists of the peptidoleukotrienes.Journal of medicinal chemistry, , Volume: 32, Issue:4, 1989