Lysine-specific demethylase 4B

A lysine-specific demethylase 4B that is encoded in the genome of human. [PRO:DNx, UniProtKB:O94953]

Synonyms

EC 1.14.11.66;
JmjC domain-containing histone demethylation protein 3B;
Jumonji domain-containing protein 2B;
[histone H3]-trimethyl-L-lysine(9) demethylase 4B

Research

Bioassay Publications (2)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	2 (100.00)	2.80

Compounds (5)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ciclopirox	Homo sapiens (human)	IC50	3.8000	1	1
5-carboxy-8-hydroxyquinoline	Homo sapiens (human)	IC50	0.2000	1	1
geldanamycin	Homo sapiens (human)	IC50	0.7000	1	1
17-(dimethylaminoethylamino)-17-demethoxygeldanamycin	Homo sapiens (human)	IC50	0.7000	1	1
tanespimycin	Homo sapiens (human)	IC50	0.7000	1	1

Enables

This protein enables 5 target(s):

Target	Category	Definition
histone demethylase activity	molecular function	Catalysis of the removal of a methyl group from a histone. [GOC:mah]
histone H3K9 demethylase activity	molecular function	Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein. [PMID:16362057]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
histone H3K36 demethylase activity	molecular function	Catalysis of the removal of a methyl group from a modified lysine residue at position 36 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:16362057]
histone H3K9me2/H3K9me3 demethylase activity	molecular function	Catalysis of the removal of a methyl group from a tri or a dimethyl-lysine residue at position 9 of the histone H3 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate. [PMID:20208542, PMID:20531378]

Located In

This protein is located in 1 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
nucleus	cellular component	A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]

Part Of

This protein is part of 1 target(s):

Target	Category	Definition
chromatin	cellular component	The ordered and organized complex of DNA, protein, and sometimes RNA, that forms the chromosome. [GOC:elh, PMID:20404130]

Involved In

This protein is involved in 3 target(s):

Target	Category	Definition
brain development	biological process	The process whose specific outcome is the progression of the brain over time, from its formation to the mature structure. Brain development begins with patterning events in the neural tube and ends with the mature structure that is the center of thought and emotion. The brain is responsible for the coordination and control of bodily activities and the interpretation of information from the senses (sight, hearing, smell, etc.). [GOC:dph, GOC:jid, GOC:tb, UBERON:0000955]
chromatin remodeling	biological process	A dynamic process of chromatin reorganization resulting in changes to chromatin structure. These changes allow DNA metabolic processes such as transcriptional regulation, DNA recombination, DNA repair, and DNA replication. [GOC:jid, GOC:vw, PMID:12042764, PMID:12697820]
regulation of gene expression	biological process	Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018]

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