Page last updated: 2024-08-07 12:47:17
Neurotensin receptor type 2
A neurotensin receptor type 2 that is encoded in the genome of human. [PRO:WCB, UniProtKB:O95665]
Synonyms
NT-R-2;
NTR2;
Levocabastine-sensitive neurotensin receptor
Research
Bioassay Publications (12)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 4 (33.33) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| sr 48692 | Homo sapiens (human) | Ki | 0.4180 | 1 | 1 |
| neurotensin | Homo sapiens (human) | IC50 | 0.0075 | 1 | 1 |
| neurotensin | Homo sapiens (human) | Ki | 0.0019 | 6 | 6 |
| sr 142948 | Homo sapiens (human) | Ki | 0.0740 | 1 | 1 |
| neurotensin | Homo sapiens (human) | Ki | 0.0046 | 3 | 3 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| neurotensin | Homo sapiens (human) | EC50 | 0.1100 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| neurotensin | Homo sapiens (human) | Activity | 0.0011 | 1 | 1 |
Development of disulfide-functionalized peptides covalently binding G protein-coupled receptors.Bioorganic & medicinal chemistry, , 05-01, Volume: 61, 2022
Fluorescence Labeling of Neurotensin(8-13) via Arginine Residues Gives Molecular Tools with High Receptor Affinity.ACS medicinal chemistry letters, , Jan-09, Volume: 11, Issue:1, 2020
Optimized Opioid-Neurotensin Multitarget Peptides: From Design to Structure-Activity Relationship Studies.Journal of medicinal chemistry, , 11-12, Volume: 63, Issue:21, 2020
[no title available]Journal of medicinal chemistry, , 04-27, Volume: 60, Issue:8, 2017
NTS2-selective neurotensin mimetics with tetrahydrofuran amino acids.Bioorganic & medicinal chemistry, , 01-01, Volume: 25, Issue:1, 2017
Mimicking of Arginine by Functionalized N(ω)-Carbamoylated Arginine As a New Broadly Applicable Approach to Labeled Bioactive Peptides: High Affinity Angiotensin, Neuropeptide Y, Neuropeptide FF, and Neurotensin Receptor Ligands As Examples.Journal of medicinal chemistry, , Mar-10, Volume: 59, Issue:5, 2016
Synthesis and Characterization in Vitro and in Vivo of (l)-(Trimethylsilyl)alanine Containing Neurotensin Analogues.Journal of medicinal chemistry, , Oct-08, Volume: 58, Issue:19, 2015
[no title available]Journal of medicinal chemistry, , 02-25, Volume: 64, Issue:4, 2021
Synthesis and evaluation of a (18)F-labeled diarylpyrazole glycoconjugate for the imaging of NTS1-positive tumors.Journal of medicinal chemistry, , Nov-27, Volume: 56, Issue:22, 2013
Discovery of highly potent and neurotensin receptor 2 selective neurotensin mimetics.Journal of medicinal chemistry, , Apr-28, Volume: 54, Issue:8, 2011
Synthesis and biological effects of c(Lys-Lys-Pro-Tyr-Ile-Leu-Lys-Lys-Pro-Tyr-Ile-Leu) (JMV2012), a new analogue of neurotensin that crosses the blood-brain barrier.Journal of medicinal chemistry, , Mar-27, Volume: 51, Issue:6, 2008
Enables
This protein enables 2 target(s):
| Target | Category | Definition |
|---|
| G protein-coupled receptor activity | molecular function | Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR] |
| G protein-coupled neurotensin receptor activity | molecular function | Combining with the tridecapeptide neurotensin to initiate a G-protein mediated change in cell activity. A G-protein is a signal transduction molecule that alternates between an inactive GDP-bound and an active GTP-bound state. [PMID:10390649] |
Located In
This protein is located in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
Involved In
This protein is involved in 5 target(s):
| Target | Category | Definition |
|---|
| cell surface receptor signaling pathway | biological process | The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription. [GOC:signaling] |
| phospholipase C-activating G protein-coupled receptor signaling pathway | biological process | A G protein-coupled receptor signaling pathway in which the signal is transmitted via the activation of phospholipase C (PLC) and a subsequent increase in the intracellular concentration of inositol trisphosphate (IP3) and diacylglycerol (DAG). [GOC:dph, GOC:mah, GOC:signaling, GOC:tb, ISBN:0815316194] |
| sensory perception | biological process | The series of events required for an organism to receive a sensory stimulus, convert it to a molecular signal, and recognize and characterize the signal. This is a neurological process. [GOC:ai, GOC:dph] |
| regulation of membrane potential | biological process | Any process that modulates the establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:jl, GOC:mtg_cardio, GOC:tb, ISBN:0198506732] |
| neuropeptide signaling pathway | biological process | A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194] |