A protein that is a translation product of the PTR1 gene in Leishmania major. [PRO:DNx, UniProtKB:Q01782]
EC 1.5.1.33;
H region methotrexate resistance protein
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 4 (80.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 4-aminopyridine | Leishmania major | IC50 | 1,900.0000 | 1 | 1 |
| doxorubicin hydrochloride | Leishmania major | IC50 | 2.9500 | 1 | 1 |
| pyrimethamine | Leishmania major | IC50 | 13.6000 | 1 | 1 |
| riluzole | Leishmania major | IC50 | 72.0500 | 2 | 2 |
| riluzole | Leishmania major | Ki | 4.0000 | 1 | 1 |
| triamterene | Leishmania major | Ki | 3.4000 | 1 | 1 |
| 2-aminobenzothiazole | Leishmania major | IC50 | 1,800.0000 | 1 | 1 |
| 2-aminobenzothiazole | Leishmania major | Ki | 143.0000 | 1 | 1 |
| indole-3-carbaldehyde | Leishmania major | IC50 | 1,100.0000 | 1 | 1 |
| 2,4,6-triaminopyrimidine | Leishmania major | Ki | 27.0000 | 1 | 1 |
| 2-amino-1,3,4-thiadiazole | Leishmania major | IC50 | 5,600.0000 | 1 | 1 |
| 2-amino-1,3,4-thiadiazole | Leishmania major | Ki | 436.0000 | 1 | 1 |
| 4-amino-2-methylquinoline | Leishmania major | IC50 | 390.0000 | 1 | 1 |
| methotrexate | Leishmania major | Ki | 0.1095 | 2 | 2 |
| o 129 | Leishmania major | Ki | 0.2400 | 1 | 1 |