Proteins > Purine nucleoside phosphorylase
Page last updated: 2024-08-07 16:51:49
Purine nucleoside phosphorylase
[no definition available]
Synonyms
PNP;
EC 2.4.2.1;
Inosine phosphorylase;
Inosine-guanosine phosphorylase
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (11)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| guanine | Bos taurus (cattle) | Kd | 0.9350 | 4 | 4 |
| hypoxanthine | Bos taurus (cattle) | Kd | 0.9650 | 2 | 2 |
| forodesine | Bos taurus (cattle) | Kd | 0.0000 | 1 | 1 |
| 9-deazaguanine | Bos taurus (cattle) | Kd | 0.1650 | 2 | 2 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| guanine | Bos taurus (cattle) | Kieq | 4.0000 | 1 | 1 |
| hypoxanthine | Bos taurus (cattle) | Kieq | 2.5000 | 1 | 1 |
| forodesine | Bos taurus (cattle) | Kieq | 0.0000 | 1 | 1 |
| 9-deazaguanine | Bos taurus (cattle) | Kieq | 7.4000 | 1 | 1 |
The transition to magic bullets - transition state analogue drug design.MedChemComm, , Dec-01, Volume: 9, Issue:12, 2018
Trimeric purine nucleoside phosphorylase: exploring postulated one-third-of-the-sites binding in the transition state.Bioorganic & medicinal chemistry, , Nov-15, Volume: 20, Issue:22, 2012
8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases.Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003
The transition to magic bullets - transition state analogue drug design.MedChemComm, , Dec-01, Volume: 9, Issue:12, 2018
8-Aza-immucillins as transition-state analogue inhibitors of purine nucleoside phosphorylase and nucleoside hydrolases.Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003