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Beta-lactamase OXA-1
A protein that is a translation product of any of the plasmid-encoded copies of the bla gene in Escherichia coli. [PRO:DAN, UniProtKB:P13661]
Synonyms
EC 3.5.2.6;
Penicillinase
Research
Bioassay Publications (4)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (25.00) | 18.7374 |
| 1990's | 1 (25.00) | 18.2507 |
| 2000's | 2 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| tazobactam | Escherichia coli | IC50 | 4.8000 | 1 | 1 |
| sulbactam | Escherichia coli | IC50 | 22.0000 | 1 | 1 |
| clavulanic acid | Escherichia coli | IC50 | 3.2000 | 1 | 1 |
Drugs with Other Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| cephalothin | Escherichia coli | Km | 10.0000 | 1 | 1 |
| tazobactam | Escherichia coli | Kinact | 380.0000 | 1 | 1 |
Efficient inhibition of class A and class D beta-lactamases by Michaelis complexes.The Journal of biological chemistry, , Jul-27, Volume: 282, Issue:30, 2007
Design, synthesis, and evaluation of 2 beta-alkenyl penam sulfone acids as inhibitors of beta-lactamases.Journal of medicinal chemistry, , Sep-13, Volume: 39, Issue:19, 1996