Proteins > Neuronal acetylcholine receptor subunit alpha-4
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Neuronal acetylcholine receptor subunit alpha-4
A neuronal acetylcholine receptor subunit alpha-4 that is encoded in the genome of mouse. [OMA:O70174, PRO:DNx]
Synonyms
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (20.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (8)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| nicotine | Mus musculus (house mouse) | EC50 | 0.7222 | 1 | 2 |
Conformationally restrained carbamoylcholine homologues. Synthesis, pharmacology at neuronal nicotinic acetylcholine receptors and biostructural considerations.European journal of medicinal chemistry, , Sep-18, Volume: 102, 2015
(-)6-n-Propylnicotine antagonizes the antinociceptive effects of (-)nicotine.Bioorganic & medicinal chemistry letters, , Oct-21, Volume: 12, Issue:20, 2002
Neonicotinoid insecticides: molecular features conferring selectivity for insect versus mammalian nicotinic receptors.Journal of agricultural and food chemistry, , Volume: 48, Issue:12, 2000
(S)-(-)-5-ethynyl-3-(1-methyl-2-pyrrolidinyl)pyridine maleate (SIB-1508Y): a novel anti-parkinsonian agent with selectivity for neuronal nicotinic acetylcholine receptors.Journal of medicinal chemistry, , Aug-16, Volume: 39, Issue:17, 1996