Synaptojanin-2

A synaptojanin-2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15056]

Synonyms

EC 3.1.3.36;
Synaptic inositol 1,4,5-trisphosphate 5-phosphatase 2

Research

Bioassay Publications (0)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0)	18.7374
1990's	0 (0)	18.2507
2000's	0 (0)	29.6817
2010's	0 (0)	24.3611
2020's	0 (0)	2.80

Compounds (7)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)
epicatechin gallate	Homo sapiens (human)	IC50	2.8800	3
ampelopsin	Homo sapiens (human)	IC50	3.1700	3
epiafzelechin	Homo sapiens (human)	IC50	15.9000	3
pyrvinium	Homo sapiens (human)	IC50	1.2500	3
trans-2,3',4,5'-tetrahydroxystilbene	Homo sapiens (human)	IC50	6.6500	3
chlorhexidine	Homo sapiens (human)	IC50	10.0000	3
eriodictyol 7-O-beta-D-glucopyranoside	Homo sapiens (human)	IC50	0.8740	3

Enables

This protein enables 8 target(s):

Target	Category	Definition
RNA binding	molecular function	Binding to an RNA molecule or a portion thereof. [GOC:jl, GOC:mah]
phosphatidylinositol-3-phosphate phosphatase activity	molecular function	Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3-phosphate + H2O = 1-phosphatidyl-1D-myo-inositol + phosphate. [EC:3.1.3.64]
phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity	molecular function	Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 4-phosphate + phosphate. [RHEA:22764]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
phosphatidylinositol phosphate 4-phosphatase activity	molecular function	Catalysis of the removal of the 4-phosphate group of a phosphatidylinositol phosphate. [GOC:mah]
phosphatidylinositol-3,5-bisphosphate 5-phosphatase activity	molecular function	Catalysis of the reaction: phosphatidylinositol-3,5-bisphosphate + H2O = phosphatidylinositol-3-phosphate + orthophosphate. [PMID:10806194, PMID:16607019, RHEA:32955]
phosphatidylinositol-3,5-bisphosphate 3-phosphatase activity	molecular function	Catalysis of the reaction: 1-phosphatidyl-1D-myo-inositol 3,5-bisphosphate + H2O = 1-phosphatidyl-1D-myo-inositol 5-phosphate + phosphate + 2 H+. [PMID:19901554, RHEA:39019]
SH3 domain binding	molecular function	Binding to a SH3 domain (Src homology 3) of a protein, small protein modules containing approximately 50 amino acid residues found in a great variety of intracellular or membrane-associated proteins. [GOC:go_curators, Pfam:PF00018]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
cytoskeleton	cellular component	A cellular structure that forms the internal framework of eukaryotic and prokaryotic cells. The cytoskeleton includes intermediate filaments, microfilaments, microtubules, the microtrabecular lattice, and other structures characterized by a polymeric filamentous nature and long-range order within the cell. The various elements of the cytoskeleton not only serve in the maintenance of cellular shape but also have roles in other cellular functions, including cellular movement, cell division, endocytosis, and movement of organelles. [GOC:mah, PMID:16959967, PMID:27419875]
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
cell projection	cellular component	A prolongation or process extending from a cell, e.g. a flagellum or axon. [GOC:jl, http://www.cogsci.princeton.edu/~wn/]
membrane raft	cellular component	Any of the small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes. Small rafts can sometimes be stabilized to form larger platforms through protein-protein and protein-lipid interactions. [PMID:16645198, PMID:20044567]

Active In

This protein is active in 2 target(s):

Target	Category	Definition
perinuclear region of cytoplasm	cellular component	Cytoplasm situated near, or occurring around, the nucleus. [GOC:jid]
presynapse	cellular component	The part of a synapse that is part of the presynaptic cell. [GOC:dos]

Involved In

This protein is involved in 5 target(s):

Target	Category	Definition
phosphatidylinositol biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of phosphatidylinositol, any glycophospholipid in which the sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol. [ISBN:0198506732]
phosphatidylinositol-3-phosphate biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position. [GOC:al, GOC:vw]
synaptic vesicle endocytosis	biological process	A vesicle-mediated transport process, in which the synaptic vesicle membrane constituents are retrieved from the presynaptic membrane on the axon terminal after neurotransmitter secretion by exocytosis. Synaptic vesicle endocytosis can occur via clathrin-dependent and clathrin-independent mechanisms. [GOC:aruk, GOC:bc, GOC:jid, GOC:lmg, GOC:mah, PMID:20448150, PMID:26430111]
membrane organization	biological process	A process which results in the assembly, arrangement of constituent parts, or disassembly of a membrane. A membrane is a double layer of lipid molecules that encloses all cells, and, in eukaryotes, many organelles; may be a single or double lipid bilayer; also includes associated proteins. [GOC:dph, GOC:tb]
phosphatidylinositol dephosphorylation	biological process	The process of removing one or more phosphate groups from a phosphatidylinositol. [ISBN:0198506732]