Proteins > cAMP-specific 3',5'-cyclic phosphodiesterase 4D
Page last updated: 2024-08-07 17:02:56

cAMP-specific 3',5'-cyclic phosphodiesterase 4D

A 3,5-cyclic-AMP phosphodiesterase 4D that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q08499]

Synonyms

EC 3.1.4.53;
DPDE3;
PDE43

Research

Bioassay Publications (139)

TimeframeStudies on this Protein(%)All Drugs %
pre-19907 (5.04)18.7374
1990's27 (19.42)18.2507
2000's44 (31.65)29.6817
2010's47 (33.81)24.3611
2020's14 (10.07)2.80

Compounds (92)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
theophyllineHomo sapiens (human)IC50637.000033
theophyllineHomo sapiens (human)Ki530.000011
cilostamideHomo sapiens (human)IC5050.002512
5,7-dimethoxycoumarinHomo sapiens (human)IC5010.000011
clioquinolHomo sapiens (human)IC5010.000022
denbufyllineHomo sapiens (human)IC500.085122
dipyridamoleHomo sapiens (human)IC502.100024
donepezilHomo sapiens (human)IC5036.000011
9-(2-hydroxy-3-nonyl)adenineHomo sapiens (human)IC5066.933313
etazolateHomo sapiens (human)IC500.390011
fluoxetineHomo sapiens (human)Ki1.560011
ibudilastHomo sapiens (human)IC500.166022
amrinoneHomo sapiens (human)IC50113.600045
1-methyl-3-isobutylxanthineHomo sapiens (human)IC5045.666733
losartanHomo sapiens (human)IC5026.000011
milrinoneHomo sapiens (human)IC5035.433323
nimodipineHomo sapiens (human)IC507.150011
papaverineHomo sapiens (human)IC5013.200022
pentoxifyllineHomo sapiens (human)IC50100.000011
4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinoneHomo sapiens (human)IC5018.933323
rolipramHomo sapiens (human)IC5015.8851101113
rolipramHomo sapiens (human)Ki1.44181822
streptonigrinHomo sapiens (human)IC501.870011
thalidomideHomo sapiens (human)IC50500.000011
tofisopamHomo sapiens (human)IC500.900010
trequinsinHomo sapiens (human)IC501.433423
zardaverineHomo sapiens (human)IC5050.19851121
9-benzyladenineHomo sapiens (human)IC50160.000011
8-bromo cyclic adenosine monophosphateHomo sapiens (human)IC5018.466723
enoximoneHomo sapiens (human)IC5052.633333
imazodanHomo sapiens (human)IC506.000011
tolafentrineHomo sapiens (human)IC500.030010
nitraquazoneHomo sapiens (human)IC500.050011
cipamfyllineHomo sapiens (human)IC501.900011
cipamfyllineHomo sapiens (human)Ki21.000011
ethyl 3-amino-1h-pyrazole-4-carboxylateHomo sapiens (human)IC50200.000012
8-((4-chlorophenyl)thio)cyclic-3',5'-ampHomo sapiens (human)IC5081.333323
8-thio-benzyl cyclic ampHomo sapiens (human)IC5029.000023
8-chloro-cyclic adenosine monophosphateHomo sapiens (human)IC5034.333323
tadalafilHomo sapiens (human)IC5068.0274515
4-phenylpyrrolidone-2Homo sapiens (human)IC501,000.000012
cdp 840Homo sapiens (human)IC500.102977
7-benzylamino-6-chloro-2-piperazino-4-pyrrolidinopteridineHomo sapiens (human)IC500.016011
9-(2-hydroxy-3-nonyl)adenineHomo sapiens (human)Ki200.000011
9-(2-hydroxy-3-nonyl)adenineHomo sapiens (human)IC5016.000011
cilomilastHomo sapiens (human)IC5014.73492537
cilomilastHomo sapiens (human)Ki0.038022
rp 73401Homo sapiens (human)IC5011.86922030
rp 73401Homo sapiens (human)Ki0.001166
moracin cHomo sapiens (human)IC5026.000011
(+)-rolipramHomo sapiens (human)IC501.190544
n(6)-benzyl-cyclic adenosine 5'-monophosphateHomo sapiens (human)IC5068.000023
moracin mHomo sapiens (human)IC502.905022
cocaineHomo sapiens (human)Ki1.115011
rolipramHomo sapiens (human)IC500.442266
mesopramHomo sapiens (human)IC501.100010
roflumilastHomo sapiens (human)IC5044.39111927
cyclic nucleotide phosphodiesterases, type 4Homo sapiens (human)IC500.025023
eggmanoneHomo sapiens (human)IC500.380011
3-(n,n-dimethylsulfonamido)-4-methyl-nitrobenzeneHomo sapiens (human)IC501.280011
4,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2h)-pyridazinoneHomo sapiens (human)Ki50.000048
tetomilastHomo sapiens (human)IC500.072021
mangostinHomo sapiens (human)IC501.310011
morusinHomo sapiens (human)IC500.900011
indolidanHomo sapiens (human)IC500.150011
cudraflavone cHomo sapiens (human)IC500.260011
fosbretabulinHomo sapiens (human)IC5010.000011
9-HydroxycalabaxanthoneHomo sapiens (human)IC500.420022
sch 351591Homo sapiens (human)IC500.060022
rs 14203Homo sapiens (human)IC500.005022
gsk 256066Homo sapiens (human)IC500.000022
ci 1044Homo sapiens (human)IC500.270011
l-454,560Homo sapiens (human)IC500.001077
t 1032Homo sapiens (human)IC503.300011
l-826,141Homo sapiens (human)IC500.002410
4-n-butyl-1-(4-(2-methylphenyl)-4-oxo-1-butyl)-piperidine hydrogen chlorideHomo sapiens (human)Ki1.000011
8-(methylthio)cyclic 3',5'-adenosine monophosphateHomo sapiens (human)IC5039.000023
licoflavone cHomo sapiens (human)IC500.630011
oglemilastHomo sapiens (human)IC500.166010
apremilastHomo sapiens (human)IC500.123488
f-amidineHomo sapiens (human)IC50110.800022
8-benzylthio-n(6)-n-butyladenosine cyclic-3,5'-monophosphateHomo sapiens (human)IC5040.000023
lyonisideHomo sapiens (human)IC5020.000011
pf 04217903Homo sapiens (human)IC5010.000011
3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineHomo sapiens (human)IC505.024622
n-alpha-benzoyl-n5-(2-chloro-1-iminoethyl)-l-ornithine amideHomo sapiens (human)IC505.900011
nitd 609Homo sapiens (human)IC5010.000011
an2728Homo sapiens (human)IC500.327055
bms-911543Homo sapiens (human)IC505.600011
d159687Homo sapiens (human)IC500.027011
chf6001Homo sapiens (human)IC500.000033
sildenafilHomo sapiens (human)IC5021.43211222
zaprinastHomo sapiens (human)IC5024.333333
zaprinastHomo sapiens (human)Ki39.690048
vardenafilHomo sapiens (human)IC506.6668312
ImidazosagatriazinoneHomo sapiens (human)IC500.500011
pelrinoneHomo sapiens (human)IC504.000011
lixazinoneHomo sapiens (human)IC500.006011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
rolipramHomo sapiens (human)EC501.100011

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
rolipramHomo sapiens (human)Log IC500.006411

Enables

This protein enables 14 target(s):

TargetCategoryDefinition
3',5'-cyclic-nucleotide phosphodiesterase activitymolecular functionCatalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate. [RHEA:14653]
3',5'-cyclic-AMP phosphodiesterase activitymolecular functionCatalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+. [GOC:ai, RHEA:25277]
calcium channel regulator activitymolecular functionModulates the activity of a calcium channel. [GOC:mah]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
enzyme bindingmolecular functionBinding to an enzyme, a protein with catalytic activity. [GOC:jl]
signaling receptor regulator activitymolecular functionBinds to and modulates the activity of a receptor. [GOC:ceb]
cAMP bindingmolecular functionBinding to cAMP, the nucleotide cyclic AMP (adenosine 3',5'-cyclophosphate). [GOC:ai]
beta-2 adrenergic receptor bindingmolecular functionBinding to a beta-2 adrenergic receptor. [GOC:mah, GOC:nln]
transmembrane transporter bindingmolecular functionBinding to a transmembrane transporter, a protein or protein complex that enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. [GOC:BHF, GOC:jl, PMID:33199372]
metal ion bindingmolecular functionBinding to a metal ion. [GOC:ai]
ATPase bindingmolecular functionBinding to an ATPase, any enzyme that catalyzes the hydrolysis of ATP. [GOC:ai]
scaffold protein bindingmolecular functionBinding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. [GOC:BHF, GOC:sjp, PMID:10433269, Wikipedia:Scaffold_protein]
heterocyclic compound bindingmolecular functionBinding to heterocyclic compound. [GOC:TermGenie]
3',5'-cyclic-GMP phosphodiesterase activitymolecular functionCatalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+. [RHEA:16957]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
centrosomecellular componentA structure comprised of a core structure (in most organisms, a pair of centrioles) and peripheral material from which a microtubule-based structure, such as a spindle apparatus, is organized. Centrosomes occur close to the nucleus during interphase in many eukaryotic cells, though in animal cells it changes continually during the cell-division cycle. [GOC:mah, ISBN:0198547684]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
apical plasma membranecellular componentThe region of the plasma membrane located at the apical end of the cell. [GOC:curators]

Active In

This protein is active in 3 target(s):

TargetCategoryDefinition
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
nucleuscellular componentA membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent. [GOC:go_curators]
perinuclear region of cytoplasmcellular componentCytoplasm situated near, or occurring around, the nucleus. [GOC:jid]

Part Of

This protein is part of 2 target(s):

TargetCategoryDefinition
voltage-gated calcium channel complexcellular componentA protein complex that forms a transmembrane channel through which calcium ions may pass in response to changes in membrane potential. [GOC:mah]
calcium channel complexcellular componentAn ion channel complex through which calcium ions pass. [GOC:mah]

Involved In

This protein is involved in 18 target(s):

TargetCategoryDefinition
regulation of heart ratebiological processAny process that modulates the frequency or rate of heart contraction. [GOC:dph, GOC:tb, PMID:10358008]
cAMP catabolic processbiological processThe chemical reactions and pathways resulting in the breakdown of the nucleotide cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate). [ISBN:0198506732]
positive regulation of heart ratebiological processAny process that activates or increases the frequency or rate of heart contraction. [GOC:dph, GOC:tb]
regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulumbiological processAny process that modulates the rate, frequency or extent of release of sequestered calcium ion into cytosol by the sarcoplasmic reticulum, the process in which the release of sequestered calcium ion by sarcoplasmic reticulum into cytosol occurs via calcium release channels. [GOC:BHF, GOC:dph, GOC:tb]
positive regulation of type II interferon productionbiological processAny process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon. [GOC:add, GOC:mah, PMID:15546383]
positive regulation of interleukin-2 productionbiological processAny process that activates or increases the frequency, rate, or extent of interleukin-2 production. [GOC:mah]
positive regulation of interleukin-5 productionbiological processAny process that activates or increases the frequency, rate, or extent of interleukin-5 production. [GOC:mah]
negative regulation of peptidyl-serine phosphorylationbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine. [GOC:mah]
negative regulation of heart contractionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of heart contraction. [GOC:go_curators]
T cell receptor signaling pathwaybiological processThe series of molecular signals initiated by the cross-linking of an antigen receptor on a T cell. [GOC:add]
establishment of endothelial barrierbiological processThe establishment of a barrier between endothelial cell layers, such as those in the brain, lung or intestine, to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition. [GOC:dph]
adrenergic receptor signaling pathwaybiological processA G protein-coupled receptor signaling pathway initiated by a ligand binding to an adrenergic receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:BHF]
regulation of cardiac muscle cell contractionbiological processAny process that modulates the frequency, rate or extent of cardiac muscle cell contraction. [GOC:BHF, GOC:mtg_cardiac_conduct_nov11]
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwaybiological processAny process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway. [GOC:hjd, PMID:19246489]
regulation of cell communication by electrical coupling involved in cardiac conductionbiological processAny process that modulates the frequency, rate or extent of cell communication by electrical coupling involved in cardiac conduction. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:17130302]
negative regulation of relaxation of cardiac musclebiological processAny process that stops, prevents or reduces the frequency, rate or extent of relaxation of cardiac muscle. [GOC:BHF, GOC:rl, GOC:TermGenie, PMID:19708671]
regulation of calcium ion transmembrane transport via high voltage-gated calcium channelbiological processAny process that modulates the frequency, rate or extent of generation of calcium ion transmembrane transport via high voltage-gated calcium channel. [GOC:dph, GOC:pg, GOC:TermGenie, PMID:1611048]
cAMP-mediated signalingbiological processAn intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell. [GOC:signaling]