Urotensin-2 receptor

A urotensin-2 receptor that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q9UKP6]

Synonyms

UR-2-R;
G-protein coupled receptor 14;
Urotensin II receptor;
UR-II-R

Research

Bioassay Publications (12)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	7 (58.33)	29.6817
2010's	5 (41.67)	24.3611
2020's	0 (0.00)	2.80

Compounds (6)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ici 199441	Homo sapiens (human)	Ki	4.0000	1	1
act 058362	Homo sapiens (human)	IC50	0.1213	3	3
act 058362	Homo sapiens (human)	Ki	0.0410	1	1
sb 657510	Homo sapiens (human)	IC50	0.0330	2	2
sb-706375	Homo sapiens (human)	IC50	0.0093	3	3
sb-706375	Homo sapiens (human)	Ki	0.0067	2	2
urotensin ii	Homo sapiens (human)	Ki	0.0043	2	2

Drugs with Activation Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
ac 7954	Homo sapiens (human)	EC50	0.7832	5	5
urotensin ii	Homo sapiens (human)	EC50	0.0035	2	2

Enables

This protein enables 2 target(s):

Target	Category	Definition
G protein-coupled receptor activity	molecular function	Combining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
urotensin II receptor activity	molecular function	Combining with urotensin II to initiate a change in cell activity. [GOC:mah, PMID:15102493]

Located In

This protein is located in 2 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]
membrane	cellular component	A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
plasma membrane	cellular component	The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 5 target(s):

Target	Category	Definition
signal transduction	biological process	The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11]
blood circulation	biological process	The flow of blood through the body of an animal, enabling the transport of nutrients to the tissues and the removal of waste products. [GOC:mtg_heart, ISBN:0192800825]
regulation of blood pressure	biological process	Any process that modulates the force with which blood travels through the circulatory system. The process is controlled by a balance of processes that increase pressure and decrease pressure. [GOC:dph, GOC:mtg_cardio, ISBN:0721643949]
blood vessel diameter maintenance	biological process	Any process that modulates the diameter of blood vessels. [GOC:pr]
neuropeptide signaling pathway	biological process	A G protein-coupled receptor signaling pathway initiated by a neuropeptide binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process. [GOC:mah, ISBN:0815316194]

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