Page last updated: 2024-12-11

tylvalosin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

3-acetyl-4''-isovaleryltylosin: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	6441094
CHEMBL ID	2103834
MeSH ID	M0541553

Synonyms (31)

Synonym
einecs 264-132-2
D10032
tylvalosin (usan/inn)
unii-9t02s42wqo
aiv-tylosin
(4r,5s,6s,7r,9r,11e,13e,15r,16r)-15-(((6-deoxy-2,3-di-o-methyl-beta-d-allopyranosyl)oxy)methyl)-6-((3,6-dideoxy-4-o-(2,6-dideoxy-3-c-methyl-4-o-(3-methylbutanoyl)-alpha-l-ribo-hexopyranosyl)-3-(dimethylamino)-beta-d-glucopyranosyl)oxy)-16-ethyl-5,9,13-tri
3-acetyl-4''-isovaleryltylosin
tylvalosin
9t02s42wqo ,
tylvalosin [usan:inn]
tylosin acetate isovalerate
tylvalosin (ema epar: veterinary)
tylosin acetate isovalerte
CHEMBL2103834
tylosin 3-acetate 4b-(3-methylbutanoate)
tylvalosin [usan]
tylvalosin [mi]
tylvalosin [green book]
tylvalosin [inn]
tylosin acetate isovalerte [jan]
KCJJINQANFZSAM-HZDSEHBESA-N
3-acetyl-4-isovaleryltylosin
DB11554
DTXSID901016510 ,
NCGC00510884-01
Q27273124
aivlosin 17%
tylvalosinum
tylvalosine
tilvalosina
dtxcid301474699

Research Excerpts

Overview

Tylvalosin (TVN) is a water soluble macrolide used in swine production to treat enteric, respiratory, and arthritic pathogens. It is supposed to possess an immunosuppressive effect.

Excerpt	Reference	Relevance
"Tylvalosin (TVN) is a water soluble macrolide used in swine production to treat enteric, respiratory, and arthritic pathogens. "	( Variation in water disappearance, daily dose, and synovial fluid concentrations of tylvalosin and 3-O-acetyltylosin in commerical pigs during five day water medication with tylvalosin under field conditions. Bates, J; Canning, P; Coetzee, J; Gauger, P; Karriker, L; Rajewski, S; Ramirez, A; Skoland, K; Wang, C; Wulf, L, 2018)	2.15
"Tylvalosin is a broad-spectrum antibiotic with an immunomodulatory function."	( Tylvalosin administration in pregnant sows attenuates the enlargement and bluish coloration of inguinal lymph nodes in newborn piglets. Deng, X; Li, J; Li, T; Li, Z; Lv, Y; Zhang, L, 2019)	2.68
"Tylvalosin (TVS) is a third-generation macrolide drug used for prophylaxis and treatment of mycoplasma, however; it is supposed to possess an immunosuppressive effect. "	( Investigating the potential role of vitamin E in modulating the immunosuppressive effects of tylvalosin and florfenicol in broiler chickens. El-Banna, HA; El-Deen, MB; El-Ela, FI; El-Gendy, AA; Hendy, K; Shany, SA; Tohamy, MA, 2016)	2.1

Actions

Tylvalosin tartrate can inhibit PRRSV proliferation in a dose-dependent manner, causing more than 90% proliferation reduction at 40 µg/mL.

Excerpt	Reference	Relevance
"Tylvalosin tartrate can inhibit PRRSV proliferation in a dose-dependent manner, causing more than 90% proliferation reduction at 40 µg/mL."	( Evaluating anti-viral effect of Tylvalosin tartrate on porcine reproductive and respiratory syndrome virus and analyzing the related gene regulation by transcriptomics. Dai, Y; Ma, N; Ma, X; Sun, S; Sun, W; Tang, X; Wan, J; Wang, C; Wu, W; Xu, R; Yang, Q; Zhou, L; Zhu, G, 2023)	1.92
"Tylvalosin tartrate can inhibit PRRSV proliferation in vitro in a dose-dependent manner. "	( Evaluating anti-viral effect of Tylvalosin tartrate on porcine reproductive and respiratory syndrome virus and analyzing the related gene regulation by transcriptomics. Dai, Y; Ma, N; Ma, X; Sun, S; Sun, W; Tang, X; Wan, J; Wang, C; Wu, W; Xu, R; Yang, Q; Zhou, L; Zhu, G, 2023)	2.64

Treatment

Tylvalosin treatment significantly reduced the level of L intracellularis infection. Almost half of the treated pigs were IHC-negative compared with 3.3 per cent of the untreated pigs.

Excerpt	Reference	Relevance
"Tylvalosin treatment markedly decreased IL-8, IL-6, IL-1β, PGE2, TNF-α and NO levels in vitro and in vivo."	( Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through suppression of NF-κB activation. Chen, W; Fu, L; Gao, J; Hou, S; Jia, H; Lai, Z; Liang, L; Shi, L; Tang, X; Yuan, W; Zhang, H; Zhang, K; Zhang, M; Zhang, W; Zhao, X; Zhao, Z, 2014)	2.57
"The tylvalosin treatment significantly reduced the level of L intracellularis infection; almost half of the treated pigs were IHC-negative compared with 3.3 per cent of the untreated pigs."	( Use of tylvalosin-medicated feed to control porcine proliferative enteropathy. Blumer, MA; da Costa Cruz, EC; França, SA; Guedes, RM; Machado, GS, 2009)	1.29

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (22)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	3 (13.64)	18.7374
1990's	2 (9.09)	18.2507
2000's	1 (4.55)	29.6817
2010's	13 (59.09)	24.3611
2020's	3 (13.64)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 43.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	43.25 (24.57)
Research Supply Index	3.40 (2.92)
Research Growth Index	5.34 (4.65)
Search Engine Demand Index	59.70 (26.88)
Search Engine Supply Index	2.00 (0.95)

This Compound (43.25)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	6 (26.09%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	17 (73.91%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Trials	Classes	Roles
d-alpha tocopherol Vitamin E: A generic descriptor for all TOCOPHEROLS and TOCOTRIENOLS that exhibit ALPHA-TOCOPHEROL activity. By virtue of the phenolic hydrogen on the 2H-1-benzopyran-6-ol nucleus, these compounds exhibit varying degree of antioxidant activity, depending on the site and number of methyl groups and the type of ISOPRENOIDS.. tocopherol : A collective name for a group of closely related lipids that contain a chroman-6-ol nucleus substituted at position 2 by a methyl group and by a saturated hydrocarbon chain consisting of three isoprenoid units. They are designated as alpha-, beta-, gamma-, and delta-tocopherol depending on the number and position of additional methyl substituents on the aromatic ring. Tocopherols occur in vegetable oils and vegetable oil products, almost exclusively with R,R,R configuration. Tocotrienols differ from tocopherols only in having three double bonds in the hydrocarbon chain.. vitamin E : Any member of a group of fat-soluble chromanols that exhibit biological activity against vitamin E deficiency. The vitamers in this class consists of a chroman-6-ol core which is substituted at position 2 by a methyl group and (also at position 2) either a saturated or a triply-unsaturated hydrocarbon chain consisting of three isoprenoid units. The major function of vitamin E is to act as a natural antioxidant by scavenging free radicals and molecular oxygen.. (R,R,R)-alpha-tocopherol : An alpha-tocopherol that has R,R,R configuration. The naturally occurring stereoisomer of alpha-tocopherol, it is found particularly in sunflower and olive oils.	2.13	1	0	alpha-tocopherol	algal metabolite; antiatherogenic agent; anticoagulant; antioxidant; antiviral agent; EC 2.7.11.13 (protein kinase C) inhibitor; immunomodulator; micronutrient; nutraceutical; plant metabolite
thiamphenicol [no description available]	2.13	1	0	monocarboxylic acid amide; sulfone	antimicrobial agent; immunosuppressive agent
danofloxacin [no description available]	7.15	1	0	quinolines
florfenicol florfenicol: structure given in first source. florfenicol : A carboxamide that is the N-dichloroacetyl derivative of (1R,2S)-2-amino-3-fluoro-1-[4-(methanesulfonyl)phenyl]propan-1-ol. A synthetic veterinary antibiotic that is used for treatment of bovine respiratory disease and foot rot; also used in aquaculture.	7.13	1	0	organochlorine compound; organofluorine compound; secondary alcohol; secondary carboxamide; sulfone	antimicrobial agent
tartaric acid tartaric acid: RN given refers to cpd with unspecified isomeric designation. D-tartaric acid : The D-enantiomer of tartaric acid.	2.6	1	0	tartaric acid	Escherichia coli metabolite
valnemulin valnemulin: a pleuromutilin derivative	7.5	2	0	carbotricyclic compound; carboxylic ester; cyclic ketone
tiamulin tiamulin: 81723 HFU and tiamutin are for fumarate salt; prevents senescence in ascomycete; pleuromutilin derivative; RN given refers to ((3aS-(3aalpha,4beta,5alpha,6alpha,8beta,9alpha,9abeta,10S*))-isomer. tiamulin : A carbotricyclic compound that is pleuromutilin in which the hydroxyacetate group is replaced by a 2-{[2-(diethylamino)ethyl]sulfanyl}acetate group. An antibacterial drug, tiamulin is used in veterinary medicine (generally as its hydrogen fumarate salt) for the treatment of swine dysentery caused by Serpulina hyodysenteriae.	2.06	1	0	carbotricyclic compound; carboxylic ester; cyclic ketone; organic sulfide; secondary alcohol; semisynthetic derivative; tertiary amino compound; tetracyclic diterpenoid	antibacterial drug
lincomycin Lincomycin: An antibiotic produced by Streptomyces lincolnensis var. lincolnensis. It has been used in the treatment of staphylococcal, streptococcal, and Bacteroides fragilis infections.. lincomycin : A carbohydrate-containing antibiotic produced by the actinomyces Streptomyces lincolnensis.	2.48	2	0	carbohydrate-containing antibiotic; L-proline derivative; monocarboxylic acid amide; pyrrolidinecarboxamide; S-glycosyl compound	antimicrobial agent; bacterial metabolite
carbomycin carbomycin: from Streptomyces halstedii	1.98	1	0
interleukin-8 Interleukin-8: A member of the CXC chemokine family that plays a role in the regulation of the acute inflammatory response. It is secreted by variety of cell types and induces CHEMOTAXIS of NEUTROPHILS and other inflammatory cells.	2.6	1	0
tilmicosin tilmicosin: semi-synthetic antibiotic. tilmicosin : A macrolide antibiotic with formula C46H80N2O13. It is used for the treatment of respiratory disease in cattle at high risk of developing bovine respiratory disease associated with Mannheimia haemolytica.	7.15	1	0
tylosin [no description available]	7.33	20	6
carbadox Carbadox: An antibacterial agent that has been used in veterinary practice for treating swine dysentery and enteritis and for promoting growth. However, its use has been prohibited in the UK following reports of carcinogenicity and mutagenicity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p125)	1.96	1	0	quinoxaline derivative

Condition	Relationship Strength	Studies	Trials
Dysentery Acute inflammation of the intestine associated with infectious DIARRHEA of various etiologies, generally acquired by eating contaminated food containing TOXINS, BIOLOGICAL derived from BACTERIA or other microorganisms. Dysentery is characterized initially by watery FECES then by bloody mucoid stools. It is often associated with ABDOMINAL PAIN; FEVER; and DEHYDRATION.	1.96	1	0
Swine Diseases Diseases of domestic swine and of the wild boar of the genus Sus.	4.53	5	1
Bejel [description not available]	2.4	2	0
Lung Injury, Acute [description not available]	2.58	2	0
Brain Disorders [description not available]	2.41	1	0
Infection, Toxoplasma gondii [description not available]	2.41	1	0
Brain Diseases Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM.	2.41	1	0
Toxoplasmosis The acquired form of infection by Toxoplasma gondii in animals and man.	7.41	1	0
Acute Lung Injury A condition of lung damage that is characterized by bilateral pulmonary infiltrates (PULMONARY EDEMA) rich in NEUTROPHILS, and in the absence of clinical HEART FAILURE. This can represent a spectrum of pulmonary lesions, endothelial and epithelial, due to numerous factors (physical, chemical, or biological).	7.58	2	0
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	3.97	2	1
Blue-Eared Pig Disease [description not available]	2.94	3	0
Viremia The presence of viruses in the blood.	2.6	1	0
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	4.11	2	1
Clostridioides difficile Infection [description not available]	3.47	1	1
Besnoitiasis [description not available]	3.47	1	1
Poultry Diseases Diseases of birds which are raised as a source of meat or eggs for human consumption and are usually found in barnyards, hatcheries, etc. The concept is differentiated from BIRD DISEASES which is for diseases of birds not considered poultry and usually found in zoos, parks, and the wild.	4.42	2	2
Clostridium Infections Infections with bacteria of the genus CLOSTRIDIUM and closely related CLOSTRIDIOIDES species.	3.47	1	1
Intestinal Diseases Pathological processes in any segment of the INTESTINE from DUODENUM to RECTUM.	3.47	1	1
Necrosis The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.	2.08	1	0
Ulcer A lesion on the surface of the skin or a mucous surface, produced by the sloughing of inflammatory necrotic tissue.	2.08	1	0
Acute Liver Injury, Drug-Induced [description not available]	2.1	1	0
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2.1	1	0
Weight Gain Increase in BODY WEIGHT over existing weight.	2.1	1	0
Chemical and Drug Induced Liver Injury A spectrum of clinical liver diseases ranging from mild biochemical abnormalities to ACUTE LIVER FAILURE, caused by drugs, drug metabolites, herbal and dietary supplements and chemicals from the environment.	2.1	1	0
Ileitis Inflammation of any segment of the ILEUM and the ILEOCECAL VALVE.	3.43	1	1
Bilophila Infections [description not available]	3.43	1	1
Eperythrozoonosis [description not available]	3.45	1	1
Sinus Infections [description not available]	3.45	1	1
Sinusitis Inflammation of the NASAL MUCOSA in one or more of the PARANASAL SINUSES.	3.45	1	1

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