Page last updated: 2024-12-11

tylvalosin

Description

3-acetyl-4''-isovaleryltylosin: structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID6441094
CHEMBL ID2103834
MeSH IDM0541553

Synonyms (31)

Synonym
einecs 264-132-2
D10032
tylvalosin (usan/inn)
unii-9t02s42wqo
aiv-tylosin
(4r,5s,6s,7r,9r,11e,13e,15r,16r)-15-(((6-deoxy-2,3-di-o-methyl-beta-d-allopyranosyl)oxy)methyl)-6-((3,6-dideoxy-4-o-(2,6-dideoxy-3-c-methyl-4-o-(3-methylbutanoyl)-alpha-l-ribo-hexopyranosyl)-3-(dimethylamino)-beta-d-glucopyranosyl)oxy)-16-ethyl-5,9,13-tri
3-acetyl-4''-isovaleryltylosin
tylvalosin
9t02s42wqo ,
tylvalosin [usan:inn]
tylosin acetate isovalerate
tylvalosin (ema epar: veterinary)
tylosin acetate isovalerte
CHEMBL2103834
tylosin 3-acetate 4b-(3-methylbutanoate)
tylvalosin [usan]
tylvalosin [mi]
tylvalosin [green book]
tylvalosin [inn]
tylosin acetate isovalerte [jan]
KCJJINQANFZSAM-HZDSEHBESA-N
3-acetyl-4-isovaleryltylosin
DB11554
DTXSID901016510 ,
NCGC00510884-01
Q27273124
aivlosin 17%
tylvalosinum
tylvalosine
tilvalosina
dtxcid301474699

Research Excerpts

Overview

Tylvalosin (TVN) is a water soluble macrolide used in swine production to treat enteric, respiratory, and arthritic pathogens. It is supposed to possess an immunosuppressive effect.

ExcerptReferenceRelevance
"Tylvalosin (TVN) is a water soluble macrolide used in swine production to treat enteric, respiratory, and arthritic pathogens. "( Variation in water disappearance, daily dose, and synovial fluid concentrations of tylvalosin and 3-O-acetyltylosin in commerical pigs during five day water medication with tylvalosin under field conditions.
Bates, J; Canning, P; Coetzee, J; Gauger, P; Karriker, L; Rajewski, S; Ramirez, A; Skoland, K; Wang, C; Wulf, L, 2018
)
2.15
"Tylvalosin is a broad-spectrum antibiotic with an immunomodulatory function."( Tylvalosin administration in pregnant sows attenuates the enlargement and bluish coloration of inguinal lymph nodes in newborn piglets.
Deng, X; Li, J; Li, T; Li, Z; Lv, Y; Zhang, L, 2019
)
2.68
"Tylvalosin (TVS) is a third-generation macrolide drug used for prophylaxis and treatment of mycoplasma, however; it is supposed to possess an immunosuppressive effect. "( Investigating the potential role of vitamin E in modulating the immunosuppressive effects of tylvalosin and florfenicol in broiler chickens.
El-Banna, HA; El-Deen, MB; El-Ela, FI; El-Gendy, AA; Hendy, K; Shany, SA; Tohamy, MA, 2016
)
2.1

Actions

Tylvalosin tartrate can inhibit PRRSV proliferation in a dose-dependent manner, causing more than 90% proliferation reduction at 40 µg/mL.

ExcerptReferenceRelevance
"Tylvalosin tartrate can inhibit PRRSV proliferation in a dose-dependent manner, causing more than 90% proliferation reduction at 40 µg/mL."( Evaluating anti-viral effect of Tylvalosin tartrate on porcine reproductive and respiratory syndrome virus and analyzing the related gene regulation by transcriptomics.
Dai, Y; Ma, N; Ma, X; Sun, S; Sun, W; Tang, X; Wan, J; Wang, C; Wu, W; Xu, R; Yang, Q; Zhou, L; Zhu, G, 2023
)
1.92
"Tylvalosin tartrate can inhibit PRRSV proliferation in vitro in a dose-dependent manner. "( Evaluating anti-viral effect of Tylvalosin tartrate on porcine reproductive and respiratory syndrome virus and analyzing the related gene regulation by transcriptomics.
Dai, Y; Ma, N; Ma, X; Sun, S; Sun, W; Tang, X; Wan, J; Wang, C; Wu, W; Xu, R; Yang, Q; Zhou, L; Zhu, G, 2023
)
2.64

Treatment

Tylvalosin treatment significantly reduced the level of L intracellularis infection. Almost half of the treated pigs were IHC-negative compared with 3.3 per cent of the untreated pigs.

ExcerptReferenceRelevance
"Tylvalosin treatment markedly decreased IL-8, IL-6, IL-1β, PGE2, TNF-α and NO levels in vitro and in vivo."( Tylvalosin exhibits anti-inflammatory property and attenuates acute lung injury in different models possibly through suppression of NF-κB activation.
Chen, W; Fu, L; Gao, J; Hou, S; Jia, H; Lai, Z; Liang, L; Shi, L; Tang, X; Yuan, W; Zhang, H; Zhang, K; Zhang, M; Zhang, W; Zhao, X; Zhao, Z, 2014
)
2.57
"The tylvalosin treatment significantly reduced the level of L intracellularis infection; almost half of the treated pigs were IHC-negative compared with 3.3 per cent of the untreated pigs."( Use of tylvalosin-medicated feed to control porcine proliferative enteropathy.
Blumer, MA; da Costa Cruz, EC; França, SA; Guedes, RM; Machado, GS, 2009
)
1.29
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (22)

TimeframeStudies, This Drug (%)All Drugs %
pre-19903 (13.64)18.7374
1990's2 (9.09)18.2507
2000's1 (4.55)29.6817
2010's13 (59.09)24.3611
2020's3 (13.64)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 43.25

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index43.25 (24.57)
Research Supply Index3.40 (2.92)
Research Growth Index5.34 (4.65)
Search Engine Demand Index59.70 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (43.25)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials6 (26.09%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other17 (73.91%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
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