Proteins > Trace amine-associated receptor 1
Page last updated: 2024-08-08 00:11:06

Trace amine-associated receptor 1

A trace amine-associated receptor 1 that is encoded in the genome of human. [PRO:WCB, UniProtKB:Q96RJ0]

Synonyms

TaR-1;
Trace amine receptor 1

Research

Bioassay Publications (8)

TimeframeStudies on this Protein(%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's1 (12.50)29.6817
2010's5 (62.50)24.3611
2020's2 (25.00)2.80

Compounds (28)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
tolazolineHomo sapiens (human)Ki1.640011
st 1913Homo sapiens (human)Ki0.500011

Drugs with Activation Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
norepinephrine, (+,-)-isomerHomo sapiens (human)EC5012.200011
phenethylamineHomo sapiens (human)EC500.095044
tryptamineHomo sapiens (human)EC502.210011
3-methoxytyramineHomo sapiens (human)EC500.308011
o-methyltyramineHomo sapiens (human)EC505.980011
phentermineHomo sapiens (human)EC505.470011
tyramineHomo sapiens (human)EC500.599033
dextroamphetamineHomo sapiens (human)EC500.666244
methamphetamineHomo sapiens (human)EC501.400022
3-tyramineHomo sapiens (human)EC501.039522
n-methylphenethylamineHomo sapiens (human)EC500.262733
tranylcypromineHomo sapiens (human)EC501.510011
4-chlorophenylbiguanideHomo sapiens (human)EC5010.000011
n,n-dimethylphenylethylamineHomo sapiens (human)EC5050.745022
l-amphetamineHomo sapiens (human)EC501.042544
4-chlorophenethylamineHomo sapiens (human)EC502.860011
3,4-methylenedioxyphenethylamineHomo sapiens (human)EC505.030011
3-methoxy-4-hydroxyphenylethylamineHomo sapiens (human)EC501.444011
2-(2,5-dimethoxyphenyl)ethanamineHomo sapiens (human)EC502.010011
2-chloro-2-phenethylamineHomo sapiens (human)EC500.077011
2-(4-bromo-2,5-dimethoxyphenyl)ethylamineHomo sapiens (human)EC507.190011
proguanilHomo sapiens (human)EC5010.000011
3-iodothyronamineHomo sapiens (human)EC501.141733
2,5-dimethoxy-4-bromoamphetamine, (r)-isomerHomo sapiens (human)EC5031.940011
2,5-dimethoxy-4-bromoamphetamine, (s)-isomerHomo sapiens (human)EC5015.340011
ro5166017Homo sapiens (human)EC500.059011

Enables

This protein enables 2 target(s):

TargetCategoryDefinition
G protein-coupled receptor activitymolecular functionCombining with an extracellular signal and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex. [GOC:bf, http://www.iuphar-db.org, Wikipedia:GPCR]
trace-amine receptor activitymolecular functionCombining with a trace amine to initiate a change in cell activity. Trace amines are biogenic amines that are synthesized from aromatic amino acids and are substrates for monoamine oxidase, and are therefore detectable only at trace levels in mammals. [GOC:mah, PMID:19325074]

Located In

This protein is located in 1 target(s):

TargetCategoryDefinition
plasma membranecellular componentThe membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363]

Involved In

This protein is involved in 1 target(s):

TargetCategoryDefinition
G protein-coupled receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
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