Vitamin K-dependent protein C

A vitamin K-dependent protein C that is encoded in the genome of human. [PRO:DNx, UniProtKB:P04070]

Synonyms

EC 3.4.21.69;
Anticoagulant protein C;
Autoprothrombin IIA;
Blood coagulation factor XIV

Research

Bioassay Publications (13)

Timeframe	Studies on this Protein(%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	1 (7.69)	18.2507
2000's	8 (61.54)	29.6817
2010's	4 (30.77)	24.3611
2020's	0 (0.00)	2.80

Compounds (14)

Drugs with Inhibition Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
5-(n,n-hexamethylene)amiloride	Homo sapiens (human)	IC50	50.0000	1	1
amiloride	Homo sapiens (human)	IC50	50.0000	1	1
cyc 202	Homo sapiens (human)	IC50	2.6900	1	6
melagatran	Homo sapiens (human)	IC50	1.3000	1	1
razaxaban	Homo sapiens (human)	Ki	11.1500	2	2
dabigatran	Homo sapiens (human)	Ki	20.9300	1	1
bms 387032	Homo sapiens (human)	IC50	0.2640	2	12
alvocidib	Homo sapiens (human)	IC50	0.1429	3	14
bms 740808	Homo sapiens (human)	Ki	2.8000	1	1
dpc 423	Homo sapiens (human)	Ki	1.8000	1	1
gw 813893	Homo sapiens (human)	IC50	20.0000	1	1
betrixaban	Homo sapiens (human)	IC50	10.0000	1	1
rpr 120844	Homo sapiens (human)	Ki	2.4000	1	1
grassystatin a	Homo sapiens (human)	IC50	50.0000	1	1

Drugs with Other Measurements

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
dpc 423	Homo sapiens (human)	Activity	1,800.0000	1	1

Enables

This protein enables 3 target(s):

Target	Category	Definition
serine-type endopeptidase activity	molecular function	Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [GOC:mah, https://www.ebi.ac.uk/merops/about/glossary.shtml#CATTYPE]
calcium ion binding	molecular function	Binding to a calcium ion (Ca2+). [GOC:ai]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]

Located In

This protein is located in 5 target(s):

Target	Category	Definition
extracellular region	cellular component	The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. [GOC:go_curators]
endoplasmic reticulum	cellular component	The irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
endoplasmic reticulum lumen	cellular component	The volume enclosed by the membranes of the endoplasmic reticulum. [ISBN:0198547684]
Golgi apparatus	cellular component	A membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
Golgi lumen	cellular component	The volume enclosed by the membranes of any cisterna or subcompartment of the Golgi apparatus, including the cis- and trans-Golgi networks. [GOC:mah]

Active In

This protein is active in 1 target(s):

Target	Category	Definition
extracellular space	cellular component	That part of a multicellular organism outside the cells proper, usually taken to be outside the plasma membranes, and occupied by fluid. [ISBN:0198547684]

Involved In

This protein is involved in 7 target(s):

Target	Category	Definition
proteolysis	biological process	The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. [GOC:bf, GOC:mah]
blood coagulation	biological process	The sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot; it may be divided into three stages: stage 1, the formation of intrinsic and extrinsic prothrombin converting principle; stage 2, the formation of thrombin; stage 3, the formation of stable fibrin polymers. [PMID:30700128]
negative regulation of blood coagulation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of blood coagulation. [GOC:mah]
negative regulation of apoptotic process	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of cell death by apoptotic process. [GOC:jl, GOC:mtg_apoptosis]
negative regulation of inflammatory response	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of the inflammatory response. [GOC:ai]
negative regulation of coagulation	biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of coagulation. [GOC:ai]
positive regulation of establishment of endothelial barrier	biological process	Any process that activates or increases the frequency, rate or extent of establishment of endothelial barrier. [GO_REF:0000058, GOC:als, GOC:TermGenie, PMID:24851274]