Proteins > cGMP-inhibited 3',5'-cyclic phosphodiesterase B
Page last updated: 2024-08-07 17:05:28

cGMP-inhibited 3',5'-cyclic phosphodiesterase B

A cGMP-inhibited 3,5-cyclic phosphodiesterase 3B that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q13370]

Synonyms

EC 3.1.4.17;
CGIPDE1;
CGIP1;
Cyclic GMP-inhibited phosphodiesterase B;
CGI-PDE B

Research

Bioassay Publications (79)

TimeframeStudies on this Protein(%)All Drugs %
pre-199018 (22.78)18.7374
1990's19 (24.05)18.2507
2000's27 (34.18)29.6817
2010's14 (17.72)24.3611
2020's1 (1.27)2.80

Compounds (58)

Drugs with Inhibition Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
my 5445Homo sapiens (human)Ki16.000011
theophyllineHomo sapiens (human)IC50300.000022
cilostamideHomo sapiens (human)IC500.050256
cilostamideHomo sapiens (human)Ki0.012522
cilostazolHomo sapiens (human)IC500.436733
dipyridamoleHomo sapiens (human)IC5043.000011
etazolateHomo sapiens (human)Ki12.000011
amrinoneHomo sapiens (human)IC5052.875088
1-methyl-3-isobutylxanthineHomo sapiens (human)IC500.242022
losartanHomo sapiens (human)IC5013.000011
2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-oneHomo sapiens (human)IC50100.000011
milrinoneHomo sapiens (human)IC502.28962324
milrinoneHomo sapiens (human)Ki0.150011
papaverineHomo sapiens (human)IC501.030011
papaverineHomo sapiens (human)Ki0.282524
proxyphyllineHomo sapiens (human)Ki1,000.000011
4-(3-butoxy-4-methoxybenzyl)-2-imidazolidinoneHomo sapiens (human)IC50300.000011
rolipramHomo sapiens (human)IC50145.18351120
rolipramHomo sapiens (human)Ki200.000011
sulmazoleHomo sapiens (human)IC50383.333333
vesnarinoneHomo sapiens (human)IC5011.313333
zardaverineHomo sapiens (human)IC5071.4120514
9-benzyladenineHomo sapiens (human)IC50200.000011
eg 626Homo sapiens (human)Ki1.400011
enoximoneHomo sapiens (human)IC5011.450044
piroximoneHomo sapiens (human)IC5039.066733
2-(2-methoxy-4-(methylsulfinyl)phenyl)-1h-imidazo(4,5-c)pyridineHomo sapiens (human)IC5042.000011
imazodanHomo sapiens (human)IC5016.11821111
nitraquazoneHomo sapiens (human)IC50200.000011
tadalafilHomo sapiens (human)IC5065.9536717
y 590Homo sapiens (human)IC500.110022
9-(2-hydroxy-3-nonyl)adenineHomo sapiens (human)Ki200.000011
9-(2-hydroxy-3-nonyl)adenineHomo sapiens (human)IC5016.000011
cilomilastHomo sapiens (human)IC5041.1570414
rp 73401Homo sapiens (human)IC5036.7900110
8-methoxymethyl-3-isobutyl-1-methylxanthineHomo sapiens (human)IC50240.000011
vinpocetineHomo sapiens (human)IC50300.000011
rolipramHomo sapiens (human)IC503.162311
roflumilastHomo sapiens (human)IC50124.2002110
4,5-dihydro-6-(4-(imidazol-1-yl)phenyl)-5-methyl-3(2h)-pyridazinoneHomo sapiens (human)IC500.550088
indolidanHomo sapiens (human)IC503.540022
bemoradanHomo sapiens (human)IC500.300022
1,3-dihydro-7,8-dimethyl-2h-imidazo(4,5-b)quinolin-2-oneHomo sapiens (human)IC500.011033
ci 1044Homo sapiens (human)IC50100.000011
t 1032Homo sapiens (human)IC50100.000011
losartan potassiumHomo sapiens (human)IC5013.000011
pf 04217903Homo sapiens (human)IC503.330022
3-(2,5-dimethoxyphenyl)-6-(3,4-dimethoxyphenyl)-7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazineHomo sapiens (human)IC500.720011
pf-04418948Homo sapiens (human)IC503.500010
nitd 609Homo sapiens (human)IC5010.000011
an2728Homo sapiens (human)IC5029,403.200022
cc-115Homo sapiens (human)IC500.630011
chf6001Homo sapiens (human)IC501.000011
cyclic gmpHomo sapiens (human)IC502.400011
sildenafilHomo sapiens (human)IC5028.71061019
zaprinastHomo sapiens (human)IC50391.000022
vardenafilHomo sapiens (human)IC506.1984312
ImidazosagatriazinoneHomo sapiens (human)IC500.500011
bl 4162aHomo sapiens (human)IC500.232766
1,5-dihydro-7-(1-piperidinyl)-imidazo(2,1-b)quinazolin-2(3h)-oneHomo sapiens (human)IC500.150011
quazinoneHomo sapiens (human)IC500.240011
lixazinoneHomo sapiens (human)IC500.008344

Drugs with Other Measurements

DrugTaxonomyMeasurementAverage (mM)Bioassay(s)Publication(s)
rolipramHomo sapiens (human)Log IC500.004011

Enables

This protein enables 7 target(s):

TargetCategoryDefinition
3',5'-cyclic-nucleotide phosphodiesterase activitymolecular functionCatalysis of the reaction: a nucleoside 3',5'-cyclic phosphate + H2O = a nucleoside 5'-phosphate. [RHEA:14653]
3',5'-cyclic-AMP phosphodiesterase activitymolecular functionCatalysis of the reaction: 3',5'-cyclic AMP + H2O = AMP + H+. [GOC:ai, RHEA:25277]
cGMP-inhibited cyclic-nucleotide phosphodiesterase activitymolecular functionCatalysis of the reaction: nucleoside 3',5'-cyclic phosphate + H2O = nucleoside 5'-phosphate; catalytic activity is decreased in the presence of cGMP. [GOC:mah]
protein bindingmolecular functionBinding to a protein. [GOC:go_curators]
protein kinase B bindingmolecular functionBinding to protein kinase B, an intracellular kinase that is important in regulating glucose metabolism. [GOC:jl, http://www.heartandmetabolism.org/]
metal ion bindingmolecular functionBinding to a metal ion. [GOC:ai]
3',5'-cyclic-GMP phosphodiesterase activitymolecular functionCatalysis of the reaction: 3',5'-cyclic GMP + H2O = GMP + H+. [RHEA:16957]

Located In

This protein is located in 4 target(s):

TargetCategoryDefinition
endoplasmic reticulumcellular componentThe irregular network of unit membranes, visible only by electron microscopy, that occurs in the cytoplasm of many eukaryotic cells. The membranes form a complex meshwork of tubular channels, which are often expanded into slitlike cavities called cisternae. The ER takes two forms, rough (or granular), with ribosomes adhering to the outer surface, and smooth (with no ribosomes attached). [ISBN:0198506732]
Golgi apparatuscellular componentA membrane-bound cytoplasmic organelle of the endomembrane system that further processes the core oligosaccharides (e.g. N-glycans) added to proteins in the endoplasmic reticulum and packages them into membrane-bound vesicles. The Golgi apparatus operates at the intersection of the secretory, lysosomal, and endocytic pathways. [ISBN:0198506732]
cytosolcellular componentThe part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
membranecellular componentA lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194]

Part Of

This protein is part of 1 target(s):

TargetCategoryDefinition
guanyl-nucleotide exchange factor complexcellular componentA protein complex that stimulates the exchange of guanyl nucleotides associated with a GTPase. [GOC:mah]

Involved In

This protein is involved in 9 target(s):

TargetCategoryDefinition
angiogenesisbiological processBlood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels. [ISBN:0878932453]
negative regulation of cell adhesionbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of cell adhesion. [GOC:go_curators]
G protein-coupled receptor signaling pathwaybiological processThe series of molecular signals initiated by a ligand binding to its receptor, in which the activated receptor promotes the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex. The GTP-bound activated alpha-G-protein then dissociates from the beta- and gamma-subunits to further transmit the signal within the cell. The pathway begins with receptor-ligand interaction, and ends with regulation of a downstream cellular process. The pathway can start from the plasma membrane, Golgi or nuclear membrane. [GOC:bf, GOC:mah, PMID:16902576, PMID:24568158, Wikipedia:G_protein-coupled_receptor]
negative regulation of angiogenesisbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of angiogenesis. [GOC:go_curators]
cellular response to insulin stimulusbiological processAny process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms. [GOC:mah, ISBN:0198506732]
negative regulation of cell adhesion mediated by integrinbiological processAny process that stops, prevents, or reduces the frequency, rate, or extent of cell adhesion mediated by integrin. [GOC:add]
negative regulation of lipid catabolic processbiological processAny process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of lipids. [GOC:ai]
negative regulation of adenylate cyclase-activating G protein-coupled receptor signaling pathwaybiological processAny process that stops, prevents or reduces the frequency, rate or extent of an adenylate cyclase-activating G protein-coupled receptor signaling pathway. [GOC:hjd, PMID:19246489]
cAMP-mediated signalingbiological processAn intracellular signaling cassette that starts with production of cyclic AMP (cAMP), and ends with activation of downstream effectors that further transmit the signal within the cell. [GOC:signaling]