Page last updated: 2024-08-07 16:38:41
Glutamate receptor 1
A glutamate receptor 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P42261]
Synonyms
GluR-1;
AMPA-selective glutamate receptor 1;
GluR-A;
GluR-K1;
Glutamate receptor ionotropic, AMPA 1;
GluA1
Research
Bioassay Publications (21)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 5 (23.81) | 18.2507 |
| 2000's | 10 (47.62) | 29.6817 |
| 2010's | 5 (23.81) | 24.3611 |
| 2020's | 1 (4.76) | 2.80 |
Compounds (56)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| aminolevulinic acid | Homo sapiens (human) | Ki | 790.0000 | 1 | 1 |
| 5-aminovaleric acid | Homo sapiens (human) | Ki | 17,400.0000 | 1 | 1 |
| alanylalanine | Homo sapiens (human) | Ki | 120.0000 | 1 | 1 |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid | Homo sapiens (human) | IC50 | 0.1353 | 3 | 3 |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid | Homo sapiens (human) | Ki | 0.0220 | 1 | 1 |
| kainic acid | Homo sapiens (human) | Ki | 7.4663 | 3 | 3 |
| glycylglycine | Homo sapiens (human) | Ki | 1,000.0000 | 1 | 1 |
| glutamic acid | Homo sapiens (human) | IC50 | 0.6130 | 1 | 1 |
| glutamic acid | Homo sapiens (human) | Ki | 1.3607 | 3 | 3 |
| selfotel | Homo sapiens (human) | IC50 | 0.9670 | 1 | 1 |
| leucyl-alanine | Homo sapiens (human) | Ki | 120.0000 | 1 | 1 |
| alanylproline | Homo sapiens (human) | Ki | 150.0000 | 1 | 1 |
| glycylleucine | Homo sapiens (human) | Ki | 160.0000 | 1 | 1 |
| alanyltyrosine | Homo sapiens (human) | Ki | 150.0000 | 1 | 1 |
| glycylsarcosine | Homo sapiens (human) | Ki | 830.0000 | 1 | 1 |
| glycylaspartic acid | Homo sapiens (human) | Ki | 350.0000 | 1 | 1 |
| histidinoalanine | Homo sapiens (human) | Ki | 480.0000 | 1 | 1 |
| jstx-3 | Homo sapiens (human) | IC50 | 0.0400 | 1 | 1 |
| argiotoxin-636 | Homo sapiens (human) | IC50 | 61.9200 | 5 | 5 |
| 2-amino-3-(3-(carboxymethoxy)-5-methylisoxazol-4-yl)propionic acid | Homo sapiens (human) | IC50 | 93.0000 | 2 | 2 |
| 5-fluorowillardiine | Homo sapiens (human) | Ki | 0.0147 | 1 | 1 |
| ly 293558 | Homo sapiens (human) | IC50 | 3.0750 | 2 | 2 |
| ly 293558 | Homo sapiens (human) | Ki | 9.2000 | 2 | 2 |
| alanylglutamic acid | Homo sapiens (human) | Ki | 320.0000 | 1 | 1 |
| prolyl-tyrosine | Homo sapiens (human) | Ki | 730.0000 | 1 | 1 |
| alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid | Homo sapiens (human) | Ki | 0.0624 | 2 | 2 |
| 5-bromowillardiine | Homo sapiens (human) | Ki | 0.0920 | 1 | 1 |
| prolylglutamic acid | Homo sapiens (human) | Ki | 20,000.0000 | 1 | 1 |
| cysteinylglycine | Homo sapiens (human) | Ki | 200.0000 | 1 | 1 |
| willardiine | Homo sapiens (human) | Ki | 0.3860 | 1 | 1 |
| aspartyl-aspartic acid | Homo sapiens (human) | Ki | 410.0000 | 1 | 1 |
| 4-bromohomoibotenic acid, (rs)-isomer | Homo sapiens (human) | Ki | 0.1700 | 1 | 1 |
| glycylproline | Homo sapiens (human) | Ki | 300.0000 | 1 | 1 |
| 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline | Homo sapiens (human) | IC50 | 6.0000 | 1 | 1 |
| 2,3-dioxo-6-nitro-7-sulfamoylbenzo(f)quinoxaline | Homo sapiens (human) | Ki | 1.6000 | 1 | 1 |
| 6-cyano-7-nitroquinoxaline-2,3-dione | Homo sapiens (human) | IC50 | 1.0200 | 3 | 3 |
| fg 9041 | Homo sapiens (human) | IC50 | 1.5100 | 3 | 3 |
| fg 9041 | Homo sapiens (human) | Ki | 0.3600 | 1 | 1 |
| seryl-proline | Homo sapiens (human) | Ki | 130.0000 | 1 | 1 |
| lofepramine hydrochloride | Homo sapiens (human) | Ki | 13.0947 | 3 | 3 |
| phenylalanylalanine | Homo sapiens (human) | Ki | 110.0000 | 1 | 1 |
| acetylalanylalanine | Homo sapiens (human) | Ki | 30,000.0000 | 1 | 1 |
| alpha-aspartylalanine | Homo sapiens (human) | Ki | 320.0000 | 1 | 1 |
| alanyltyrosine | Homo sapiens (human) | Ki | 90.0000 | 1 | 1 |
| prolylglycine | Homo sapiens (human) | Ki | 22,000.0000 | 1 | 1 |
| glutamylalanine | Homo sapiens (human) | Ki | 250.0000 | 1 | 1 |
| phenylalanylphenylalanine | Homo sapiens (human) | Ki | 110.0000 | 1 | 1 |
| phenylalanyl-valine | Homo sapiens (human) | Ki | 50.0000 | 1 | 1 |
| alanylglycine | Homo sapiens (human) | Ki | 140.0000 | 1 | 1 |
| valyltyrosine | Homo sapiens (human) | Ki | 100.0000 | 1 | 1 |
| phenylalanylproline | Homo sapiens (human) | Ki | 130.0000 | 1 | 1 |
| glycylhistidine | Homo sapiens (human) | Ki | 1,000.0000 | 1 | 1 |
| prolyl-serine | Homo sapiens (human) | Ki | 14,000.0000 | 1 | 1 |
| prolylvaline | Homo sapiens (human) | Ki | 60.0000 | 1 | 1 |
| tqx 173 | Homo sapiens (human) | IC50 | 6.9500 | 2 | 2 |
| tqx 173 | Homo sapiens (human) | Ki | 16.8200 | 2 | 2 |
| perampanel | Homo sapiens (human) | IC50 | 1.8082 | 5 | 5 |
Drugs with Activation Measurements
Drugs with Other Measurements
Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands.Bioorganic & medicinal chemistry, , Feb-15, Volume: 18, Issue:4, 2010
Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Heteroaryl analogues of AMPA. Synthesis and quantitative structure-activity relationships.Journal of medicinal chemistry, , Aug-29, Volume: 40, Issue:18, 1997
Novel class of amino acid antagonists at non-N-methyl-D-aspartic acid excitatory amino acid receptors. Synthesis, in vitro and in vivo pharmacology, and neuroprotection.Journal of medicinal chemistry, , Volume: 34, Issue:1, 1991
Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands.Bioorganic & medicinal chemistry, , Feb-15, Volume: 18, Issue:4, 2010
4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists.Bioorganic & medicinal chemistry letters, , Aug-21, Volume: 10, Issue:16, 2000
4-Alkyl- and 4-cinnamylglutamic acid analogues are potent GluR5 kainate receptor agonists.Journal of medicinal chemistry, , May-18, Volume: 43, Issue:10, 2000
Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Use of the 4-Hydroxytriazole Moiety as a Bioisosteric Tool in the Development of Ionotropic Glutamate Receptor Ligands.Journal of medicinal chemistry, , 05-09, Volume: 62, Issue:9, 2019
Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands.Bioorganic & medicinal chemistry, , Feb-15, Volume: 18, Issue:4, 2010
Functional characterization of Tet-AMPA [tetrazolyl-2-amino-3-(3-hydroxy-5-methyl- 4-isoxazolyl)propionic acid] analogues at ionotropic glutamate receptors GluR1-GluR4. The molecular basis for the functional selectivity profile of 2-Bn-Tet-AMPA.Journal of medicinal chemistry, , Aug-23, Volume: 50, Issue:17, 2007
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.Journal of medicinal chemistry, , Nov-03, Volume: 48, Issue:22, 2005
4-Alkylidenyl glutamic acids, potent and selective GluR5 agonists.Bioorganic & medicinal chemistry letters, , Aug-21, Volume: 10, Issue:16, 2000
4-Alkyl- and 4-cinnamylglutamic acid analogues are potent GluR5 kainate receptor agonists.Journal of medicinal chemistry, , May-18, Volume: 43, Issue:10, 2000
Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands.Bioorganic & medicinal chemistry, , Feb-15, Volume: 18, Issue:4, 2010
Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
alpha-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) antagonists: from bench to bedside.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.Journal of medicinal chemistry, , Sep-26, Volume: 45, Issue:20, 2002
(3SR,4aRS,6SR,8aRS)-6-(1H-tetrazol-5-yl)decahydroisoquinoline-3-carboxylic acid, a novel, competitive, systemically active NMDA and AMPA receptor antagonist.Journal of medicinal chemistry, , Dec-08, Volume: 38, Issue:25, 1995
(3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3 - carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist.Journal of medicinal chemistry, , Jul-09, Volume: 36, Issue:14, 1993
Convergent synthesis and pharmacology of substituted tetrazolyl-2-amino-3-(3-hydroxy-5-methyl-4-isoxazolyl)propionic acid analogues.Journal of medicinal chemistry, , May-05, Volume: 48, Issue:9, 2005
Synthesis of willardiine and 6-azawillardiine analogs: pharmacological characterization on cloned homomeric human AMPA and kainate receptor subtypes.Journal of medicinal chemistry, , Oct-24, Volume: 40, Issue:22, 1997
Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands.Bioorganic & medicinal chemistry, , Feb-15, Volume: 18, Issue:4, 2010
Design, synthesis, and pharmacology of a highly subtype-selective GluR1/2 agonist, (RS)-2-amino-3-(4-chloro-3-hydroxy-5-isoxazolyl)propionic acid (Cl-HIBO).Journal of medicinal chemistry, , May-22, Volume: 46, Issue:11, 2003
Developing a complete pharmacology for AMPA receptors: a perspective on subtype-selective ligands.Bioorganic & medicinal chemistry, , Feb-15, Volume: 18, Issue:4, 2010
Structure-activity relationship studies on N3-substituted willardiine derivatives acting as AMPA or kainate receptor antagonists.Journal of medicinal chemistry, , Apr-20, Volume: 49, Issue:8, 2006
Ethyl (3S,4aR,6S,8aR)-6-(4-ethoxycar- bonylimidazol-1-ylmethyl)decahydroiso-quinoline-3-carboxylic ester: a prodrug of a GluR5 kainate receptor antagonist active in two animal models of acute migraine.Journal of medicinal chemistry, , Sep-26, Volume: 45, Issue:20, 2002
Functionalized quinoxalinones as privileged structures with broad-ranging pharmacological activities.European journal of medicinal chemistry, , Feb-05, Volume: 229, 2022
(3SR,4aRS,6SR,8aRS)-6-(1H-tetrazol-5-yl)decahydroisoquinoline-3-carboxylic acid, a novel, competitive, systemically active NMDA and AMPA receptor antagonist.Journal of medicinal chemistry, , Dec-08, Volume: 38, Issue:25, 1995
Enables
This protein enables 21 target(s):
| Target | Category | Definition |
|---|
| amyloid-beta binding | molecular function | Binding to an amyloid-beta peptide/protein. [GOC:hjd] |
| G-protein alpha-subunit binding | molecular function | Binding to a G-protein alpha subunit. The alpha subunit binds a guanine nucleotide. [GOC:hjd] |
| AMPA glutamate receptor activity | molecular function | An ionotropic glutamate receptor activity that exhibits fast gating by glutamate and acts by opening a cation channel permeable to sodium, potassium, and, in the absence of a GluR2 subunit, calcium. [GOC:mah, PMID:10049997, PMID:8804111] |
| protein binding | molecular function | Binding to a protein. [GOC:go_curators] |
| glutamate receptor activity | molecular function | Combining with glutamate and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. [GOC:ai, GOC:signaling] |
| adenylate cyclase binding | molecular function | Binding to an adenylate cyclase. [GOC:jl] |
| immunoglobulin binding | molecular function | Binding to an immunoglobulin. [GOC:ma] |
| protein kinase binding | molecular function | Binding to a protein kinase, any enzyme that catalyzes the transfer of a phosphate group, usually from ATP, to a protein substrate. [GOC:jl] |
| glutamate-gated calcium ion channel activity | molecular function | Enables the transmembrane transfer of a calcium ion by a channel that opens when glutamate has been bound by the channel complex or one of its constituent parts. [GOC:mtg_transport, ISBN:0815340729] |
| PDZ domain binding | molecular function | Binding to a PDZ domain of a protein, a domain found in diverse signaling proteins. [GOC:go_curators, Pfam:PF00595] |
| small GTPase binding | molecular function | Binding to a small monomeric GTPase. [GOC:mah, PMID:27218782] |
| myosin V binding | molecular function | Binding to a class V myosin; myosin V is a dimeric molecule involved in intracellular transport. [GOC:mah, http://www.mrc-lmb.cam.ac.uk/myosin/Review/Reviewframeset.html] |
| G-protein beta-subunit binding | molecular function | Binding to a G-protein beta subunit. [GOC:mah] |
| beta-2 adrenergic receptor binding | molecular function | Binding to a beta-2 adrenergic receptor. [GOC:mah, GOC:nln] |
| glutamate receptor binding | molecular function | Binding to a glutamate receptor. [GOC:bf] |
| identical protein binding | molecular function | Binding to an identical protein or proteins. [GOC:jl] |
| protein kinase A binding | molecular function | Binding to a protein kinase A. [GOC:ai] |
| scaffold protein binding | molecular function | Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes. [GOC:BHF, GOC:sjp, PMID:10433269, Wikipedia:Scaffold_protein] |
| ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential | molecular function | Any ligand-gated ion channel activity, occurring in the presynaptic membrane, that is involved in regulation of presynaptic membrane potential. [GOC:dos, PMID:15145529, PMID:19558451] |
| transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential | molecular function | Any transmitter-gated ion channel activity that is involved in regulation of postsynaptic membrane potential. [GO_REF:0000061, GOC:TermGenie, PMID:20200227] |
| neurotransmitter receptor activity involved in regulation of postsynaptic cytosolic calcium ion concentration | molecular function | Any neurotransmitter receptor activity that is involved in regulating the concentration of calcium in the postsynaptic cytosol. [GOC:dos] |
Located In
This protein is located in 30 target(s):
| Target | Category | Definition |
|---|
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| cell-cell junction | cellular component | A cell junction that forms a connection between two or more cells of an organism; excludes direct cytoplasmic intercellular bridges, such as ring canals in insects. [GOC:aruk, GOC:bc, GOC:dgh, GOC:hb, GOC:mah, PMID:21422226, PMID:28096264] |
| cell surface | cellular component | The external part of the cell wall and/or plasma membrane. [GOC:jl, GOC:mtg_sensu, GOC:sm] |
| ER to Golgi transport vesicle membrane | cellular component | The lipid bilayer surrounding a vesicle transporting substances from the endoplasmic reticulum to the Golgi. [GOC:ai, GOC:ascb_2009, GOC:dph, GOC:tb] |
| postsynaptic density | cellular component | An electron dense network of proteins within and adjacent to the postsynaptic membrane of an asymmetric, neuron-neuron synapse. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize them such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:BHF, GOC:dos, GOC:ef, GOC:jid, GOC:pr, GOC:sjp, http://molneuro.kaist.ac.kr/psd, PMID:14532281, Wikipedia:Postsynaptic_density] |
| dendrite | cellular component | A neuron projection that has a short, tapering, morphology. Dendrites receive and integrate signals from other neurons or from sensory stimuli, and conduct nerve impulses towards the axon or the cell body. In most neurons, the impulse is conveyed from dendrites to axon via the cell body, but in some types of unipolar neuron, the impulse does not travel via the cell body. [GOC:aruk, GOC:bc, GOC:dos, GOC:mah, GOC:nln, ISBN:0198506732] |
| endocytic vesicle membrane | cellular component | The lipid bilayer surrounding an endocytic vesicle. [GOC:mah] |
| synaptic vesicle membrane | cellular component | The lipid bilayer surrounding a synaptic vesicle. [GOC:mah] |
| neuromuscular junction | cellular component | The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential. [GOC:nln] |
| early endosome membrane | cellular component | The lipid bilayer surrounding an early endosome. [GOC:pz] |
| dendritic spine membrane | cellular component | The portion of the plasma membrane surrounding a dendritic spine. [GOC:mah] |
| neuronal cell body membrane | cellular component | The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites. [GOC:jl] |
| endoplasmic reticulum-Golgi intermediate compartment membrane | cellular component | The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system. [GOC:mah, GOC:pr, PMID:16723730] |
| neuronal cell body | cellular component | The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators] |
| dendritic spine | cellular component | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. [GOC:nln] |
| dendritic shaft | cellular component | Cylindric portion of the dendrite, directly stemming from the perikaryon, and carrying the dendritic spines. [GOC:nln] |
| axonal spine | cellular component | A spine that originates from the axon, usually from the initial segment. [NIF_Subcellular:sao18239917] |
| neuron spine | cellular component | A small membranous protrusion, often ending in a bulbous head and attached to the neuron by a narrow stalk or neck. [ISBN:0198504888, NIF_Subcellular:sao1145756102] |
| postsynaptic membrane | cellular component | A specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters cross the synaptic cleft and transmit the signal to the postsynaptic membrane. [ISBN:0198506732] |
| presynaptic active zone membrane | cellular component | The membrane portion of the presynaptic active zone; it is the site where docking and fusion of synaptic vesicles occurs for the release of neurotransmitters. [PMID:12812759, PMID:12923177, PMID:3152289] |
| recycling endosome | cellular component | An organelle consisting of a network of tubules that functions in targeting molecules, such as receptors transporters and lipids, to the plasma membrane. [GOC:dph, GOC:jid, GOC:kmv, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101, PMID:21556374, PMID:21562044] |
| recycling endosome membrane | cellular component | The lipid bilayer surrounding a recycling endosome. [GOC:jid, GOC:rph, PMID:10930469, PMID:15601896, PMID:16246101] |
| excitatory synapse | cellular component | A synapse in which an action potential in the presynaptic cell increases the probability of an action potential occurring in the postsynaptic cell. [GOC:dph, GOC:ef] |
| synaptic membrane | cellular component | A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell. [GOC:BHF, PMID:20410104] |
| presynapse | cellular component | The part of a synapse that is part of the presynaptic cell. [GOC:dos] |
| postsynaptic density membrane | cellular component | The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos] |
| glutamatergic synapse | cellular component | A synapse that uses glutamate as a neurotransmitter. [GOC:dos] |
| postsynaptic density, intracellular component | cellular component | A network of proteins adjacent to the postsynaptic membrane forming an electron dense disc. Its major components include neurotransmitter receptors and the proteins that spatially and functionally organize neurotransmitter receptors in the adjacent membrane, such as anchoring and scaffolding molecules, signaling enzymes and cytoskeletal components. [GOC:dos] |
| perisynaptic space | cellular component | The extracellular region immediately adjacent to to a synapse. [GOC:dos] |
Active In
This protein is active in 3 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| dendritic spine | cellular component | A small, membranous protrusion from a dendrite that forms a postsynaptic compartment, typically receiving input from a single presynapse. They function as partially isolated biochemical and an electrical compartments. Spine morphology is variable:they can be thin, stubby, mushroom, or branched, with a continuum of intermediate morphologies. They typically terminate in a bulb shape, linked to the dendritic shaft by a restriction. Spine remodeling is though to be involved in synaptic plasticity. [GOC:nln] |
| postsynaptic density membrane | cellular component | The membrane component of the postsynaptic density. This is the region of the postsynaptic membrane in which the population of neurotransmitter receptors involved in synaptic transmission are concentrated. [GOC:dos] |
Part Of
This protein is part of 1 target(s):
| Target | Category | Definition |
|---|
| AMPA glutamate receptor complex | cellular component | An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus. [GOC:ef] |
Involved In
This protein is involved in 34 target(s):
| Target | Category | Definition |
|---|
| regulation of receptor recycling | biological process | Any process that modulates the frequency, rate, or extent of receptor recycling. [GOC:add] |
| signal transduction | biological process | The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell. [GOC:go_curators, GOC:mtg_signaling_feb11] |
| chemical synaptic transmission | biological process | The vesicular release of classical neurotransmitter molecules from a presynapse, across a chemical synapse, the subsequent activation of neurotransmitter receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:jl, MeSH:D009435] |
| synapse assembly | biological process | The aggregation, arrangement and bonding together of a set of components to form a synapse. This process ends when the synapse is mature (functional). [GOC:mah] |
| long-term memory | biological process | The memory process that deals with the storage, retrieval and modification of information a long time (typically weeks, months or years) after receiving that information. This type of memory is typically dependent on gene transcription regulated by second messenger activation. [http://hebb.mit.edu/courses/9.03/lecture4.html, ISBN:0582227089] |
| response to xenobiotic stimulus | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc] |
| response to lithium ion | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lithium (Li+) ion stimulus. [GOC:tb] |
| positive regulation of gene expression | biological process | Any process that increases the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). [GOC:txnOH-2018] |
| neuronal action potential | biological process | An action potential that occurs in a neuron. [GOC:dph, GOC:isa_complete, GOC:tb] |
| calcium-mediated signaling | biological process | Any intracellular signal transduction in which the signal is passed on within the cell via calcium ions. [GOC:signaling] |
| spinal cord development | biological process | The process whose specific outcome is the progression of the spinal cord over time, from its formation to the mature structure. The spinal cord primarily conducts sensory and motor nerve impulses between the brain and the peripheral nervous tissues. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] |
| cerebral cortex development | biological process | The progression of the cerebral cortex over time from its initial formation until its mature state. The cerebral cortex is the outer layered region of the telencephalon. [GO_REF:0000021, GOC:cls, GOC:dgh, GOC:dph, GOC:jid] |
| receptor internalization | biological process | A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane. [GOC:bf, GOC:mah, GOC:signaling, PMID:15006537, PMID:19643732] |
| response to estradiol | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen. [GOC:mah, ISBN:0911910123] |
| monoatomic ion transmembrane transport | biological process | A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. [GOC:mah] |
| ionotropic glutamate receptor signaling pathway | biological process | The series of molecular signals initiated by glutamate binding to a glutamate receptor on the surface of the target cell, followed by the movement of ions through a channel in the receptor complex, and ending with the regulation of a downstream cellular process, e.g. transcription. [GOC:signaling, ISBN:0198506732] |
| response to cocaine | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant. [GOC:ef, GOC:jl] |
| positive regulation of membrane potential | biological process | Any process that activates or increases the frequency, rate or extent of establishment or extent of a membrane potential, the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane. [GOC:go_curators] |
| response to arsenic-containing substance | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an arsenic stimulus from compounds containing arsenic, including arsenates, arsenites, and arsenides. [GOC:hjd, ISBN:0721662544] |
| response to electrical stimulus | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an electrical stimulus. [GOC:ai] |
| regulation of postsynaptic membrane potential | biological process | Any process that modulates the potential difference across a post-synaptic membrane. [GOC:dph, GOC:ef] |
| long-term synaptic potentiation | biological process | A process that modulates synaptic plasticity such that synapses are changed resulting in the increase in the rate, or frequency of synaptic transmission at the synapse. [GOC:dgh, GOC:dph] |
| long-term synaptic depression | biological process | A process that modulates synaptic plasticity such that synapses are changed resulting in the decrease in the rate, or frequency of synaptic transmission at the synapse. [GOC:dgh, GOC:dph] |
| response to fungicide | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fungicide stimulus. Fungicides are chemicals used to kill fungi. [GOC:dph] |
| cellular response to amino acid stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amino acid stimulus. An amino acid is a carboxylic acids containing one or more amino groups. [GOC:mah] |
| cellular response to ammonium ion | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ammonium stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23509267] |
| cellular response to dsRNA | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a double-stranded RNA stimulus. [GOC:mah] |
| cellular response to peptide hormone stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptide hormone stimulus. A peptide hormone is any of a class of peptides that are secreted into the blood stream and have endocrine functions in living animals. [GOC:mah] |
| cellular response to amine stimulus | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amine stimulus. An amine is a compound formally derived from ammonia by replacing one, two or three hydrogen atoms by hydrocarbyl groups. [GOC:mah] |
| regulation of presynaptic membrane potential | biological process | Any process that modulates the potential difference across a presynaptic membrane. [GOC:dph, GOC:ef] |
| regulation of postsynaptic cytosolic calcium ion concentration | biological process | Any process that regulates the concentration of calcium in the postsynaptic cytosol. [GOC:dos] |
| cellular response to brain-derived neurotrophic factor stimulus | biological process | A process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brain-derived neurotrophic factor stimulus. [PMID:21958434] |
| modulation of chemical synaptic transmission | biological process | Any process that modulates the frequency or amplitude of synaptic transmission, the process of communication from a neuron to a target (neuron, muscle, or secretory cell) across a synapse. Amplitude, in this case, refers to the change in postsynaptic membrane potential due to a single instance of synaptic transmission. [GOC:ai] |
| synaptic transmission, glutamatergic | biological process | The vesicular release of glutamate from a presynapse, across a chemical synapse, the subsequent activation of glutamate receptors at the postsynapse of a target cell (neuron, muscle, or secretory cell) and the effects of this activation on the postsynaptic membrane potential and ionic composition of the postsynaptic cytosol. This process encompasses both spontaneous and evoked release of neurotransmitter and all parts of synaptic vesicle exocytosis. Evoked transmission starts with the arrival of an action potential at the presynapse. [GOC:dos] |