Proteins > Acetylcholinesterase
Page last updated: 2024-08-07 16:14:52
Acetylcholinesterase
[no definition available]
Synonyms
AChE;
EC 3.1.1.7
Research
Bioassay Publications (38)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (2.63) | 18.7374 |
| 1990's | 4 (10.53) | 18.2507 |
| 2000's | 19 (50.00) | 29.6817 |
| 2010's | 12 (31.58) | 24.3611 |
| 2020's | 2 (5.26) | 2.80 |
Compounds (31)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| melatonin | Bos taurus (cattle) | IC50 | 0.1000 | 2 | 3 |
| bw 284 c 51 | Bos taurus (cattle) | IC50 | 0.0080 | 1 | 1 |
| tacrine | Bos taurus (cattle) | IC50 | 0.1848 | 22 | 30 |
| tacrine | Bos taurus (cattle) | Ki | 0.0400 | 3 | 3 |
| ambenonium | Bos taurus (cattle) | IC50 | 0.0001 | 1 | 1 |
| donepezil | Bos taurus (cattle) | IC50 | 0.1644 | 5 | 6 |
| donepezil | Bos taurus (cattle) | Ki | 0.0029 | 2 | 2 |
| profenamine | Bos taurus (cattle) | Ki | 173.2000 | 2 | 2 |
| gallamine triethiodide | Bos taurus (cattle) | IC50 | 8,760.0000 | 1 | 1 |
| huprine x | Bos taurus (cattle) | IC50 | 0.0020 | 2 | 2 |
| periciazine | Bos taurus (cattle) | IC50 | 7.0000 | 1 | 1 |
| procainamide | Bos taurus (cattle) | IC50 | 0.5000 | 1 | 1 |
| propidium | Bos taurus (cattle) | IC50 | 17.2630 | 1 | 3 |
| pyridostigmine | Bos taurus (cattle) | IC50 | 0.0500 | 1 | 1 |
| pyridostigmine | Bos taurus (cattle) | Ki | 19.7000 | 1 | 1 |
| trigonelline | Bos taurus (cattle) | IC50 | 233.0000 | 1 | 1 |
| donepezil hydrochloride | Bos taurus (cattle) | IC50 | 0.0081 | 1 | 1 |
| physostigmine | Bos taurus (cattle) | IC50 | 0.7197 | 4 | 4 |
| edrophonium chloride | Bos taurus (cattle) | IC50 | 0.0500 | 1 | 1 |
| edrophonium bromide | Bos taurus (cattle) | IC50 | 5.3600 | 1 | 1 |
| galantamine | Bos taurus (cattle) | IC50 | 4.5300 | 2 | 2 |
| benzenaminium, 4,4'-(3-oxo-1,5-pentanediyl)bis(n,n-dimethyl-n-2-propenyl-), dibromide | Bos taurus (cattle) | Ki | 0.0571 | 1 | 1 |
| rivastigmine | Bos taurus (cattle) | IC50 | 0.6200 | 1 | 1 |
| propidium iodide | Bos taurus (cattle) | IC50 | 20.4445 | 2 | 2 |
| tv3326 | Bos taurus (cattle) | IC50 | 30.3000 | 1 | 1 |
| huperzine a | Bos taurus (cattle) | IC50 | 0.1000 | 1 | 1 |
| tacrine hydrochloride | Bos taurus (cattle) | IC50 | 0.1300 | 3 | 3 |
| huperzine b | Bos taurus (cattle) | Ki | 0.7940 | 1 | 1 |
| ith 4012 | Bos taurus (cattle) | IC50 | 0.8200 | 1 | 1 |
| bis(7)-tacrine | Bos taurus (cattle) | Ki | 0.0013 | 4 | 4 |
| huprine y | Bos taurus (cattle) | IC50 | 0.0093 | 6 | 14 |
| 6-chlorotacrine | Bos taurus (cattle) | IC50 | 0.3100 | 1 | 3 |
| asoxime chloride | Bos taurus (cattle) | IC50 | 126.0000 | 1 | 1 |
| pralidoxime chloride | Bos taurus (cattle) | IC50 | 346.0000 | 1 | 1 |
Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.
Journal of medicinal chemistry, , Jan-26, Volume: 49, Issue:2, 2006
Journal of medicinal chemistry, , Jan-26, Volume: 49, Issue:2, 2006
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.
Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines.
European journal of medicinal chemistry, , Mar-15, Volume: 166, 2019
New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.
Journal of medicinal chemistry, , Feb-09, Volume: 55, Issue:3, 2012
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.
Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.
Journal of medicinal chemistry, , Jul-08, Volume: 53, Issue:13, 2010
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010
Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases.
European journal of medicinal chemistry, , Volume: 45, Issue:12, 2010
Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.
Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.
Journal of medicinal chemistry, , Nov-26, Volume: 52, Issue:22, 2009
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.
Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.
Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.
Journal of medicinal chemistry, , Jan-26, Volume: 49, Issue:2, 2006
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
Journal of medicinal chemistry, , Nov-16, Volume: 49, Issue:23, 2006
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.
Bioorganic & medicinal chemistry, , Dec-15, Volume: 13, Issue:24, 2005
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.
Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.
Journal of medicinal chemistry, , Nov-17, Volume: 48, Issue:23, 2005
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.
Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.
Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.
Journal of medicinal chemistry, , Aug-26, Volume: 42, Issue:17, 1999
European journal of medicinal chemistry, , Mar-15, Volume: 166, 2019
New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.
Journal of medicinal chemistry, , Feb-09, Volume: 55, Issue:3, 2012
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.
Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.
Journal of medicinal chemistry, , Jul-08, Volume: 53, Issue:13, 2010
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.
Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010
Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases.
European journal of medicinal chemistry, , Volume: 45, Issue:12, 2010
Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.
Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.
Journal of medicinal chemistry, , Nov-26, Volume: 52, Issue:22, 2009
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.
Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.
Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.
Journal of medicinal chemistry, , Jan-26, Volume: 49, Issue:2, 2006
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
Journal of medicinal chemistry, , Nov-16, Volume: 49, Issue:23, 2006
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.
Bioorganic & medicinal chemistry, , Dec-15, Volume: 13, Issue:24, 2005
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.
Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.
Journal of medicinal chemistry, , Nov-17, Volume: 48, Issue:23, 2005
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.
Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.
Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.
Journal of medicinal chemistry, , Aug-26, Volume: 42, Issue:17, 1999
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.
Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.
Bioorganic & medicinal chemistry, , Jan-01, Volume: 21, Issue:1, 2013
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.
Bioorganic & medicinal chemistry, , Dec-15, Volume: 13, Issue:24, 2005
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.
Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.
Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003
Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.
Bioorganic & medicinal chemistry letters, , Mar-17, Volume: 8, Issue:6, 1998
Bioorganic & medicinal chemistry, , Jan-01, Volume: 21, Issue:1, 2013
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.
Bioorganic & medicinal chemistry, , Dec-15, Volume: 13, Issue:24, 2005
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.
Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.
Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003
Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.
Bioorganic & medicinal chemistry letters, , Mar-17, Volume: 8, Issue:6, 1998
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.
Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.
Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003
Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.
Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
Journal of medicinal chemistry, , Nov-16, Volume: 49, Issue:23, 2006
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.
Journal of medicinal chemistry, , Aug-26, Volume: 47, Issue:18, 2004
Journal of medicinal chemistry, , Nov-16, Volume: 49, Issue:23, 2006
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.
Journal of medicinal chemistry, , Aug-26, Volume: 47, Issue:18, 2004
Quinolizidinyl derivatives of bi- and tricyclic systems as potent inhibitors of acetyl- and butyrylcholinesterase with potential in Alzheimer's disease.
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase.
Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.
Journal of medicinal chemistry, , Sep-10, Volume: 52, Issue:17, 2009
Journal of medicinal chemistry, , Sep-10, Volume: 52, Issue:17, 2009
Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors.
Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
Structure-activity studies on a potent antagonist to organophosphate-induced toxicity.
Journal of medicinal chemistry, , Volume: 34, Issue:5, 1991
Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
Structure-activity studies on a potent antagonist to organophosphate-induced toxicity.
Journal of medicinal chemistry, , Volume: 34, Issue:5, 1991
Pyridine alkaloids with activity in the central nervous system.
Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
Bioorganic & medicinal chemistry, , 12-15, Volume: 28, Issue:24, 2020
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.
Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.
Bioorganic & medicinal chemistry letters, , Mar-17, Volume: 8, Issue:6, 1998
Structure-activity studies on a potent antagonist to organophosphate-induced toxicity.
Journal of medicinal chemistry, , Volume: 34, Issue:5, 1991
Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.
Bioorganic & medicinal chemistry letters, , Mar-17, Volume: 8, Issue:6, 1998
Structure-activity studies on a potent antagonist to organophosphate-induced toxicity.
Journal of medicinal chemistry, , Volume: 34, Issue:5, 1991
Synthesis and study of thiocarbonate derivatives of choline as potential inhibitors of acetylcholinesterase.
Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
Journal of medicinal chemistry, , Sep-12, Volume: 40, Issue:19, 1997
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.
Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.
Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.
Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease.
Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.
Journal of medicinal chemistry, , Sep-10, Volume: 52, Issue:17, 2009
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Journal of medicinal chemistry, , Sep-10, Volume: 52, Issue:17, 2009
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Carbamate derivatives of indolines as cholinesterase inhibitors and antioxidants for the treatment of Alzheimer's disease.
Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
Journal of medicinal chemistry, , Dec-13, Volume: 55, Issue:23, 2012
[no title available]
Journal of natural products, , 10-23, Volume: 83, Issue:10, 2020
Journal of natural products, , 10-23, Volume: 83, Issue:10, 2020
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.
Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors.
Journal of medicinal chemistry, , Dec-20, Volume: 44, Issue:26, 2001
Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.
Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors.
Journal of medicinal chemistry, , Dec-20, Volume: 44, Issue:26, 2001
Synthesis of more potent analogues of the acetylcholinesterase inhibitor, huperzine B.
Bioorganic & medicinal chemistry letters, , Jun-03, Volume: 12, Issue:11, 2002
Bioorganic & medicinal chemistry letters, , Jun-03, Volume: 12, Issue:11, 2002
Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines.
European journal of medicinal chemistry, , Mar-15, Volume: 166, 2019
European journal of medicinal chemistry, , Mar-15, Volume: 166, 2019
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.
Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.
Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.
Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.
Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001
Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.
Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.
Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.
Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).
Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
Journal of medicinal chemistry, , Nov-16, Volume: 49, Issue:23, 2006
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.
Journal of medicinal chemistry, , Aug-26, Volume: 47, Issue:18, 2004
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.
Journal of medicinal chemistry, , Nov-16, Volume: 49, Issue:23, 2006
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.
Journal of medicinal chemistry, , Aug-26, Volume: 47, Issue:18, 2004
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.
Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.
Journal of medicinal chemistry, , Sep-10, Volume: 52, Issue:17, 2009
Journal of medicinal chemistry, , Sep-10, Volume: 52, Issue:17, 2009
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.
Journal of medicinal chemistry, , Volume: 32, Issue:2, 1989
Journal of medicinal chemistry, , Volume: 32, Issue:2, 1989
Quaternary salts of 2-[(hydroxyimino)methyl]imidazole. 2. Preparation and in vitro and in vivo evaluation of 1-(alkoxymethyl)-2-[(hydroxyimino)methyl]-3-methylimida zolium halides for reactivation of organophosphorus-inhibited acetylcholinesterases.
Journal of medicinal chemistry, , Volume: 32, Issue:2, 1989
Journal of medicinal chemistry, , Volume: 32, Issue:2, 1989