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Acetylcholinesterase
[no definition available]
Synonyms
AChE;
EC 3.1.1.7
Research
Bioassay Publications (38)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 1 (2.63) | 18.7374 |
| 1990's | 4 (10.53) | 18.2507 |
| 2000's | 19 (50.00) | 29.6817 |
| 2010's | 12 (31.58) | 24.3611 |
| 2020's | 2 (5.26) | 2.80 |
Compounds (31)
Drugs with Inhibition Measurements
Tacrines for Alzheimer's disease therapy. III. The PyridoTacrines.European journal of medicinal chemistry, , Mar-15, Volume: 166, 2019
New tacrine-4-oxo-4H-chromene hybrids as multifunctional agents for the treatment of Alzheimer's disease, with cholinergic, antioxidant, and β-amyloid-reducing properties.Journal of medicinal chemistry, , Feb-09, Volume: 55, Issue:3, 2012
N-acylaminophenothiazines: neuroprotective agents displaying multifunctional activities for a potential treatment of Alzheimer's disease.European journal of medicinal chemistry, , Volume: 46, Issue:6, 2011
Cholinergic and neuroprotective drugs for the treatment of Alzheimer and neuronal vascular diseases. II. Synthesis, biological assessment, and molecular modelling of new tacrine analogues from highly substituted 2-aminopyridine-3-carbonitriles.Bioorganic & medicinal chemistry, , Jan-01, Volume: 19, Issue:1, 2011
Novel tacrine-8-hydroxyquinoline hybrids as multifunctional agents for the treatment of Alzheimer's disease, with neuroprotective, cholinergic, antioxidant, and copper-complexing properties.Journal of medicinal chemistry, , Jul-08, Volume: 53, Issue:13, 2010
Synthesis, inhibitory activity of cholinesterases, and neuroprotective profile of novel 1,8-naphthyridine derivatives.Journal of medicinal chemistry, , Jul-22, Volume: 53, Issue:14, 2010
Old phenothiazine and dibenzothiadiazepine derivatives for tomorrow's neuroprotective therapies against neurodegenerative diseases.European journal of medicinal chemistry, , Volume: 45, Issue:12, 2010
Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Neuroprotective and cholinergic properties of multifunctional glutamic acid derivatives for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Nov-26, Volume: 52, Issue:22, 2009
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Homo- and hetero-bivalent edrophonium-like ammonium salts as highly potent, dual binding site AChE inhibitors.Bioorganic & medicinal chemistry, , Aug-01, Volume: 16, Issue:15, 2008
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
Novel tacrine-melatonin hybrids as dual-acting drugs for Alzheimer disease, with improved acetylcholinesterase inhibitory and antioxidant properties.Journal of medicinal chemistry, , Jan-26, Volume: 49, Issue:2, 2006
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.Journal of medicinal chemistry, , Nov-16, Volume: 49, Issue:23, 2006
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.Bioorganic & medicinal chemistry, , Dec-15, Volume: 13, Issue:24, 2005
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Design, synthesis, and biological evaluation of dual binding site acetylcholinesterase inhibitors: new disease-modifying agents for Alzheimer's disease.Journal of medicinal chemistry, , Nov-17, Volume: 48, Issue:23, 2005
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000
Synthesis, in vitro pharmacology, and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Aug-26, Volume: 42, Issue:17, 1999
Design, synthesis and biological evaluation of coumarin alkylamines as potent and selective dual binding site inhibitors of acetylcholinesterase.Bioorganic & medicinal chemistry, , Jan-01, Volume: 21, Issue:1, 2013
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Donepezil-tacrine hybrid related derivatives as new dual binding site inhibitors of AChE.Bioorganic & medicinal chemistry, , Dec-15, Volume: 13, Issue:24, 2005
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003
Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Mar-17, Volume: 8, Issue:6, 1998
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.Journal of medicinal chemistry, , Nov-16, Volume: 49, Issue:23, 2006
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.Journal of medicinal chemistry, , Aug-26, Volume: 47, Issue:18, 2004
Pyridophens: binary pyridostigmine-aprophen prodrugs with differential inhibition of acetylcholinesterase, butyrylcholinesterase, and muscarinic receptors.Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
Structure-activity studies on a potent antagonist to organophosphate-induced toxicity.Journal of medicinal chemistry, , Volume: 34, Issue:5, 1991
Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
Synthesis and activity studies of N-[omega-N'-(adamant-1'-yl)aminoalkyl]- 2-(4'-dimethylaminophenyl)acetamides: in the search of selective inhibitors for the different molecular forms of acetylcholinesterase.Bioorganic & medicinal chemistry letters, , Mar-17, Volume: 8, Issue:6, 1998
Structure-activity studies on a potent antagonist to organophosphate-induced toxicity.Journal of medicinal chemistry, , Volume: 34, Issue:5, 1991
Acetylcholinesterase inhibitors from the toadstool Cortinarius infractus.Bioorganic & medicinal chemistry, , Mar-15, Volume: 18, Issue:6, 2010
New potent acetylcholinesterase inhibitors in the tetracyclic triterpene series.Journal of medicinal chemistry, , Nov-01, Volume: 50, Issue:22, 2007
Pyrano[3,2-c]quinoline-6-chlorotacrine hybrids as a novel family of acetylcholinesterase- and beta-amyloid-directed anti-Alzheimer compounds.Journal of medicinal chemistry, , Sep-10, Volume: 52, Issue:17, 2009
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Novel donepezil-based inhibitors of acetyl- and butyrylcholinesterase and acetylcholinesterase-induced beta-amyloid aggregation.Journal of medicinal chemistry, , Jun-26, Volume: 51, Issue:12, 2008
Synthesis and pharmacological evaluation of huprine-tacrine heterodimers: subnanomolar dual binding site acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Synthesis, in vitro pharmacology, and molecular modeling of syn-huprines as acetylcholinesterase inhibitors.Journal of medicinal chemistry, , Dec-20, Volume: 44, Issue:26, 2001
Exploiting protein fluctuations at the active-site gorge of human cholinesterases: further optimization of the design strategy to develop extremely potent inhibitors.Journal of medicinal chemistry, , Jun-12, Volume: 51, Issue:11, 2008
Development of molecular probes for the identification of extra interaction sites in the mid-gorge and peripheral sites of butyrylcholinesterase (BuChE). Rational design of novel, selective, and highly potent BuChE inhibitors.Journal of medicinal chemistry, , Mar-24, Volume: 48, Issue:6, 2005
Specific targeting of acetylcholinesterase and butyrylcholinesterase recognition sites. Rational design of novel, selective, and highly potent cholinesterase inhibitors.Journal of medicinal chemistry, , Jan-02, Volume: 46, Issue:1, 2003
Novel and potent tacrine-related hetero- and homobivalent ligands for acetylcholinesterase and butyrylcholinesterase.Bioorganic & medicinal chemistry letters, , Jul-09, Volume: 11, Issue:13, 2001
Anti-cholinesterase hybrids as multi-target-directed ligands against Alzheimer's disease (1998-2018).Bioorganic & medicinal chemistry, , 03-15, Volume: 27, Issue:6, 2019
Binding of 13-amidohuprines to acetylcholinesterase: exploring the ligand-induced conformational change of the gly117-gly118 peptide bond in the oxyanion hole.Journal of medicinal chemistry, , Nov-16, Volume: 49, Issue:23, 2006
Modulation of binding strength in several classes of active site inhibitors of acetylcholinesterase studied by comparative binding energy analysis.Journal of medicinal chemistry, , Aug-26, Volume: 47, Issue:18, 2004
New tacrine-huperzine A hybrids (huprines): highly potent tight-binding acetylcholinesterase inhibitors of interest for the treatment of Alzheimer's disease.Journal of medicinal chemistry, , Nov-30, Volume: 43, Issue:24, 2000