Page last updated: 2024-08-07 16:22:06
Dipeptidyl peptidase 4
A dipeptidyl peptidase 4 that is encoded in the genome of mouse. [OMA:P28843, PRO:DNx]
Synonyms
EC 3.4.14.5;
Dipeptidyl peptidase IV;
DPP IV;
T-cell activation antigen CD26;
Thymocyte-activating molecule;
THAM
Research
Bioassay Publications (6)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 4 (66.67) | 29.6817 |
| 2010's | 2 (33.33) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (7)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| quinpirole | Mus musculus (house mouse) | EC50 | 0.0034 | 1 | 1 |
Approaches towards the development of chimeric DPP4/ACE inhibitors for treating metabolic syndrome.Bioorganic & medicinal chemistry letters, , 06-01, Volume: 27, Issue:11, 2017
Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin.Bioorganic & medicinal chemistry letters, , Jun-15, Volume: 17, Issue:12, 2007
2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.Journal of medicinal chemistry, , Jan-12, Volume: 49, Issue:1, 2006
2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.Journal of medicinal chemistry, , Jan-12, Volume: 49, Issue:1, 2006