lidocaine has been researched along with Necrosis in 74 studies
Lidocaine: A local anesthetic and cardiac depressant used as an antiarrhythmia agent. Its actions are more intense and its effects more prolonged than those of PROCAINE but its duration of action is shorter than that of BUPIVACAINE or PRILOCAINE.
lidocaine : The monocarboxylic acid amide resulting from the formal condensation of N,N-diethylglycine with 2,6-dimethylaniline.
Necrosis: The death of cells in an organ or tissue due to disease, injury or failure of the blood supply.
| Excerpt | Relevance | Reference |
|---|---|---|
| "A clinical dose of lidocaine greater than 5 mM destroys the cell membrane and induces both necrosis and apoptosis in an identified Lymnaea neuron." | 7.78 | Clinical dose of lidocaine destroys the cell membrane and induces both necrosis and apoptosis in an identified Lymnaea neuron. ( Kawasaki, Y; Oda, N; Onizuka, S; Shiraishi, S; Shirasaka, T; Tamura, R; Tsuneyoshi, I; Yonaha, T, 2012) |
| "Four patients (two women aged 50 and 67 years, a 36-year-old man, and a 5-year-old child) presented with necrosis of the eyelid after local anesthesia using 2% lidocaine with epinephrine." | 7.78 | [Eyelid necrosis after injection of lidocaine with epinephrine]. ( Ben Hadj Hamida, F; Ben Rayana, N; Ghorbel, M; Knani, L; Krifa, F; Mahjoub, H; Touzani, F; Yakoubi, S, 2012) |
| "During this experiment the authors investigated whether prolonged local use of verapamil or lidocaine prevents vasoconstriction and establishes better blood supply to the rat epigastric skin flap, hence reducing the necrosis that occurs otherwise." | 7.70 | Prolonged perivascular use of verapamil or lidocaine decreases skin flap necrosis. ( Buncke, HJ; Chen, SG; Dogan, T; Komorowska-Timek, E; Lineaweaver, WC; Zhang, F, 1999) |
| " When infected mice were treated with different amounts of lidocaine (a local anesthetic, chemically defined as a tertiary amide compound), reduction in intensity of the pancreatic necrosis and in the number of PMN were observed." | 7.69 | Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis. ( González, PH; Portiansky, EL, 1995) |
| "Epinephrine significantly increases lidocaine-induced skeletal muscle necrosis, even in low concentrations that elicit no damage by themselves." | 7.66 | Mechanism of epinephrine enhancement of lidocaine-induced skeletal muscle necrosis. ( Benoit, PW; Fort, NF; Yagiela, JA, 1982) |
| "Phentolamine rescue was not performed." | 5.46 | Digital Necrosis After Lidocaine and Epinephrine Injection in the Flexor Tendon Sheath Without Phentolamine Rescue. ( Carr, N; Gray, J; Lalonde, DH; Zhang, JX, 2017) |
| "Lidocaine inhibited the increase in MDA level associated with IR injury while showing no influence over increases in number of neutrophils and tissue MPO level, and it elevated the flap survival rate." | 5.37 | The impact of lidocaine on flap survival following reperfusion injury. ( Canoz, O; Eskitascioglu, T; Gunay, GK; Karaci, S; Kılıc, E, 2011) |
| "Labetalol was found to be less effective in preventing tissue necrosis." | 5.28 | Treatment of peripheral ischemia secondary to lidocaine containing epinephrine. ( Aycock, BG; Hawtof, DB; Moody, SB, 1989) |
| "Lidocaine has been shown to protect ischemic myocardium, but the degree of its effectiveness is not yet well established." | 5.27 | Effects of lidocaine and droxicainide on myocardial necrosis: a comparative study. ( Cheung, WM; Faria, DB; Maroko, PR; Ribeiro, LG, 1983) |
| " The injection of these agents is often associated with pain, and it is not uncommon for sclerotherapists to include lidocaine with the sclerosants in an attempt to reduce the pain associated with treatment." | 5.09 | Evaluation of lidocaine as an analgesic when added to hypertonic saline for sclerotherapy. ( Bukhari, RH; Cranley, RD; Hearn, AT; Lohr, JM; Paget, DS, 1999) |
| "Five review articles on finger necrosis following local anaesthesia concluded that lidocaine with adrenaline does not entail a risk of ischaemic injury." | 4.89 | [Necrosis in fingers and toes following local anaesthesia with adrenaline--an urban legend?]. ( Finsen, V, 2013) |
| "A literature review failed to provide evidence to support the dogma that block or infiltrative anesthesia with lidocaine and epinephrine produces digital necrosis." | 4.82 | Digital anesthesia with epinephrine: an old myth revisited. ( Krunic, AL; Soltani, K; Taylor, RS; Wang, LC; Weitzul, S, 2004) |
| " Preoperative application of anhydrous ethanol, hypertonic saline, lidocaine and the mixed solution (groups B, C, D and E, respectively) resulted in larger coagulation necrosis areas than in group A (p<0." | 3.80 | In vivo experimental study on the effects of fluid in increasing the efficiency of radiofrequency ablation. ( Cheng, W; Han, X; Liu, Z; Shao, H; Sun, YX; Wang, QC, 2014) |
| " Preadipocyte cell death induced by lidocaine is not caused by apoptosis but by necrosis, which cannot be prevented by coenzyme Q10." | 3.78 | Coenzyme Q10 does not enhance preadipocyte viability in an in vitro lipotransfer model. ( Burjak, S; Frey, M; Kamolz, LP; Keck, M; Selig, H; Stulnig, TM; Zeyda, M, 2012) |
| "Four patients (two women aged 50 and 67 years, a 36-year-old man, and a 5-year-old child) presented with necrosis of the eyelid after local anesthesia using 2% lidocaine with epinephrine." | 3.78 | [Eyelid necrosis after injection of lidocaine with epinephrine]. ( Ben Hadj Hamida, F; Ben Rayana, N; Ghorbel, M; Knani, L; Krifa, F; Mahjoub, H; Touzani, F; Yakoubi, S, 2012) |
| " We evaluated the effect of lidocaine on tissue necrosis after electrical burn injuries." | 3.78 | Effect of lidocaine on reducing injury in a rat electrical burn model. ( Aygit, AC; Benlier, E; Eskiocak, S; Kandulu, H; Omurlu, IK; Puyan, FO; Sikar, EY; Top, H, 2012) |
| "5% bupivacaine caused minimal chondrocyte necrosis when used in pain pumps for a maximum of 48 hours." | 3.74 | The effect of local anesthetics administered via pain pump on chondrocyte viability. ( Dragoo, JL; Kanwar, R; Korotkova, T; Wood, B, 2008) |
| "Lidocaine can directly inhibit the apoptosis and necrosis induced by LPS in cultured AT-II cells." | 3.73 | [Protective effect of lidocaine on injury alveolar Type II cells induced by LPS in adult rats]. ( Chen, SX; Ming, GF; Wu, XY; Xu, DM, 2006) |
| " When infected mice were treated with different amounts of lidocaine (a local anesthetic, chemically defined as a tertiary amide compound), reduction in intensity of the pancreatic necrosis and in the number of PMN were observed." | 3.69 | Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis. ( González, PH; Portiansky, EL, 1995) |
| "The effects of the antiarrhythmic drugs lidocaine and bretylium tosylate on myocardial necrosis were studied in anesthetized pigs subjected to 60-min coronary occlusion followed by 3-h reperfusion." | 3.68 | Differences in infarct size with lidocaine as compared with bretylium tosylate in acute myocardial ischemia and reperfusion in pigs. ( Corday, E; Drury, JK; Fishbein, MC; Hatori, N; Roberts, RL; Ryden, L; Satomura, K; Stiehm, ER; Tadokoro, H, 1991) |
| "The experiments on rats with a 3-day myocardial infarction caused by the left coronary artery ligation have shown that multiple lidocaine and pyromecaine injections according to a given scheme decrease the size of the necrosis area." | 3.67 | [Effect of lidocaine and pyromecaine on the size of an experimental myocardial infarct]. ( Chichkanov, GG; Goldshteĭne, GKh; Tsorin, IB, 1986) |
| "Epinephrine significantly increases lidocaine-induced skeletal muscle necrosis, even in low concentrations that elicit no damage by themselves." | 3.66 | Mechanism of epinephrine enhancement of lidocaine-induced skeletal muscle necrosis. ( Benoit, PW; Fort, NF; Yagiela, JA, 1982) |
| "A 45-year-old man with an internal carotid artery occlusion, cerebral hemispheric infarction, and an ipsilateral central retinal artery occlusion developed anterior segment necrosis after retrobulbar injection of lidocaine hydrochloride (Xylocaine) for treatment of an occlusion of the central retinal artery." | 3.66 | Anterior segment necrosis following treatment of central retinal artery occlusion: a clinicopathologic case report. ( Marcus, DF; Reeser, FH; Weidaw, CD, 1978) |
| "Potassium chloride (KCl) given subcutaneously in high concentrations causes necrosis of skin, possibly from vasoconstriction around the injection site." | 3.65 | Lidocaine treatment of experimental cutaneous lesions from potassium chloride injection. ( Behnia, R; Wilkinson, CJ, 1977) |
| "Uvular necrosis is an extremely rare complication of gastroscopy." | 1.46 | Uvular necrosis following diagnostic gastroscopy. ( Digby-Bell, J; Zeki, S, 2017) |
| "Phentolamine rescue was not performed." | 1.46 | Digital Necrosis After Lidocaine and Epinephrine Injection in the Flexor Tendon Sheath Without Phentolamine Rescue. ( Carr, N; Gray, J; Lalonde, DH; Zhang, JX, 2017) |
| "Lidocaine was injected in the lidocaine group, and the same concentration of saline was injected in the control group." | 1.42 | Effects of lidocaine on random skin flap survival in rats. ( Cai, L; Cao, B; Gao, W; Lin, D; Wang, L, 2015) |
| "Lidocaine inhibited the increase in MDA level associated with IR injury while showing no influence over increases in number of neutrophils and tissue MPO level, and it elevated the flap survival rate." | 1.37 | The impact of lidocaine on flap survival following reperfusion injury. ( Canoz, O; Eskitascioglu, T; Gunay, GK; Karaci, S; Kılıc, E, 2011) |
| "Bupivacaine and lower concentrations of lidocaine transiently alter Ca2+(cyt) homeostasis for several minutes, but without an immediate neurotoxic effect within 60 min." | 1.31 | Effect of local anesthetic on neuronal cytoplasmic calcium and plasma membrane lysis (necrosis) in a cell culture model. ( DaSilva, AD; Gores, GJ; Johnson, ME; Saenz, JA; Uhl, CB, 2002) |
| "Lidocaine is a sodium channel blocker that also inhibits several neutrophil functions." | 1.30 | Reduction of myocardial infarct size in rabbits and inhibition of activation of rabbit and human neutrophils by lidocaine. ( Atkinson, JB; Forman, MB; Holsinger, JP; Murray, JJ; Vitola, JV, 1997) |
| "Labetalol was found to be less effective in preventing tissue necrosis." | 1.28 | Treatment of peripheral ischemia secondary to lidocaine containing epinephrine. ( Aycock, BG; Hawtof, DB; Moody, SB, 1989) |
| "Lidocaine has been shown to protect ischemic myocardium, but the degree of its effectiveness is not yet well established." | 1.27 | Effects of lidocaine and droxicainide on myocardial necrosis: a comparative study. ( Cheung, WM; Faria, DB; Maroko, PR; Ribeiro, LG, 1983) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 25 (33.78) | 18.7374 |
| 1990's | 11 (14.86) | 18.2507 |
| 2000's | 17 (22.97) | 29.6817 |
| 2010's | 20 (27.03) | 24.3611 |
| 2020's | 1 (1.35) | 2.80 |
| Authors | Studies |
|---|---|
| Fang, CL | 1 |
| Tsai, CB | 1 |
| Chen, MS | 1 |
| Yang, HY | 1 |
| Fang, KJ | 1 |
| Digby-Bell, J | 1 |
| Zeki, S | 1 |
| Chatigny, F | 1 |
| Groman, DB | 1 |
| Martinson, SA | 1 |
| Stevens, ED | 1 |
| Finsen, V | 1 |
| Sun, YX | 1 |
| Cheng, W | 1 |
| Han, X | 1 |
| Liu, Z | 1 |
| Wang, QC | 1 |
| Shao, H | 1 |
| Cao, B | 1 |
| Wang, L | 1 |
| Lin, D | 1 |
| Cai, L | 1 |
| Gao, W | 1 |
| Ji, Y | 1 |
| Guo, L | 1 |
| Zhang, Y | 1 |
| Liu, Y | 1 |
| Gogna, N | 1 |
| Hussain, S | 1 |
| Al-Rawi, S | 1 |
| Zhang, JX | 1 |
| Gray, J | 1 |
| Lalonde, DH | 1 |
| Carr, N | 1 |
| Rose, G | 1 |
| Costa, V | 1 |
| Drake, A | 1 |
| Siadecki, SD | 1 |
| Saul, T | 1 |
| Dragoo, JL | 1 |
| Korotkova, T | 1 |
| Kanwar, R | 1 |
| Wood, B | 1 |
| Patrizi, A | 1 |
| Gurioli, C | 1 |
| Neri, I | 1 |
| D'Acunto, C | 1 |
| Eskitascioglu, T | 1 |
| Karaci, S | 1 |
| Canoz, O | 1 |
| Kılıc, E | 1 |
| Gunay, GK | 1 |
| Sliti, N | 1 |
| Zaraa, I | 1 |
| Daoud, L | 1 |
| Trojett, S | 1 |
| Letaief, I | 1 |
| Mokni, M | 1 |
| Jeddi, A | 1 |
| Ben Osman, A | 1 |
| Mili-Boussen, I | 1 |
| Errais, K | 1 |
| Chebil, A | 1 |
| Daghfous, R | 1 |
| Belkahia, C | 1 |
| Quertani, A | 1 |
| Bruce, AM | 1 |
| Spencer, JM | 1 |
| Hormozi, AK | 1 |
| Zendehnam, H | 1 |
| Hosseini, SN | 1 |
| Rasti, M | 1 |
| Rostami, K | 1 |
| Hamraz, H | 1 |
| Farkas, B | 1 |
| Kvell, K | 1 |
| Czömpöly, T | 1 |
| Illés, T | 1 |
| Bárdos, T | 1 |
| García-Vilanova-Comas, A | 1 |
| Fuster-Diana, C | 1 |
| Cubells-Parrilla, M | 1 |
| Pérez-Ferriols, MD | 1 |
| Pérez-Valles, A | 1 |
| Roig-Vila, JV | 1 |
| Keck, M | 1 |
| Zeyda, M | 1 |
| Burjak, S | 1 |
| Kamolz, LP | 1 |
| Selig, H | 1 |
| Stulnig, TM | 1 |
| Frey, M | 1 |
| Onizuka, S | 1 |
| Tamura, R | 1 |
| Yonaha, T | 1 |
| Oda, N | 1 |
| Kawasaki, Y | 1 |
| Shirasaka, T | 1 |
| Shiraishi, S | 1 |
| Tsuneyoshi, I | 1 |
| Yakoubi, S | 1 |
| Knani, L | 1 |
| Touzani, F | 1 |
| Ben Rayana, N | 1 |
| Krifa, F | 1 |
| Mahjoub, H | 1 |
| Ghorbel, M | 1 |
| Ben Hadj Hamida, F | 1 |
| Benlier, E | 1 |
| Eskiocak, S | 1 |
| Puyan, FO | 1 |
| Sikar, EY | 1 |
| Kandulu, H | 1 |
| Omurlu, IK | 1 |
| Top, H | 1 |
| Aygit, AC | 1 |
| Johnson, ME | 2 |
| Saenz, JA | 1 |
| DaSilva, AD | 1 |
| Uhl, CB | 2 |
| Gores, GJ | 2 |
| Sharma, A | 1 |
| Gupta, A | 2 |
| Bandyopadhyay, S | 1 |
| Vinekar, AS | 1 |
| Ram, J | 1 |
| Dogra, MR | 1 |
| FLINN, RB | 1 |
| Lee, HT | 1 |
| Krichevsky, IE | 1 |
| Xu, H | 1 |
| Ota-Setlik, A | 1 |
| D'Agati, VD | 1 |
| Emala, CW | 1 |
| Atabey, A | 1 |
| Galdino, G | 2 |
| El-Shahat, A | 1 |
| Ramirez, OM | 2 |
| Spittler, KH | 1 |
| Wang, H | 1 |
| Krunic, AL | 1 |
| Wang, LC | 1 |
| Soltani, K | 1 |
| Weitzul, S | 1 |
| Taylor, RS | 1 |
| Karaçal, N | 1 |
| Ambarcioğlu, O | 1 |
| Topal, U | 1 |
| Mamedov, T | 1 |
| Kutlu, N | 1 |
| Salmi, AM | 1 |
| Kamiya, Y | 1 |
| Ohta, K | 1 |
| Kaneko, Y | 1 |
| Xu, DM | 1 |
| Ming, GF | 1 |
| Wu, XY | 1 |
| Chen, SX | 1 |
| Stahl, M | 1 |
| Meyer, C | 1 |
| Haas, E | 1 |
| Glaenz, T | 1 |
| Zutt, M | 1 |
| Yan, M | 1 |
| Chen, C | 1 |
| Zhang, F | 2 |
| Chen, G | 1 |
| Riberti, C | 1 |
| Costa, P | 1 |
| Lefèvre, JC | 1 |
| Chassagne, JF | 1 |
| Faria, DB | 1 |
| Cheung, WM | 1 |
| Ribeiro, LG | 1 |
| Maroko, PR | 1 |
| Carroll, MJ | 1 |
| Yagiela, JA | 1 |
| Benoit, PW | 2 |
| Fort, NF | 1 |
| Portiansky, EL | 1 |
| González, PH | 1 |
| Fazio, MJ | 1 |
| Zitelli, JA | 1 |
| Cave, AC | 1 |
| Horowitz, GL | 1 |
| Apstein, CS | 1 |
| Dire, DJ | 1 |
| Hogan, DE | 1 |
| Olivencia, JA | 1 |
| Vitola, JV | 1 |
| Forman, MB | 1 |
| Holsinger, JP | 1 |
| Atkinson, JB | 1 |
| Murray, JJ | 1 |
| Bukhari, RH | 1 |
| Lohr, JM | 1 |
| Paget, DS | 1 |
| Hearn, AT | 1 |
| Cranley, RD | 1 |
| Komorowska-Timek, E | 1 |
| Chen, SG | 1 |
| Dogan, T | 1 |
| Lineaweaver, WC | 1 |
| Buncke, HJ | 1 |
| Millard, TP | 1 |
| James, MP | 1 |
| De Monaco, D | 1 |
| De Monaco, A | 1 |
| Kammer, E | 1 |
| Noever, G | 1 |
| Dong, H | 1 |
| Kerl, H | 1 |
| Cerroni, L | 1 |
| Steiness, E | 2 |
| Rasmussen, F | 2 |
| Svendsen, O | 2 |
| Nielsen, P | 1 |
| Weidaw, CD | 1 |
| Marcus, DF | 1 |
| Reeser, FH | 1 |
| Behnia, R | 1 |
| Wilkinson, CJ | 1 |
| Bazex, A | 1 |
| Montastruc, P | 1 |
| Bazex, J | 1 |
| Darnaud, J | 1 |
| Zemb, JP | 1 |
| Goussaud, C | 1 |
| Hatori, N | 1 |
| Roberts, RL | 1 |
| Tadokoro, H | 1 |
| Ryden, L | 1 |
| Satomura, K | 1 |
| Fishbein, MC | 1 |
| Stiehm, ER | 1 |
| Corday, E | 1 |
| Drury, JK | 1 |
| Wałaszewski, J | 1 |
| Rowiński, W | 1 |
| Pacholczyk, M | 1 |
| Lagiewska, B | 1 |
| Cajzner, S | 1 |
| Chmura, A | 1 |
| Lao, M | 1 |
| Aycock, BG | 1 |
| Hawtof, DB | 1 |
| Moody, SB | 1 |
| Warner, DS | 1 |
| Godersky, JC | 1 |
| Smith, ML | 1 |
| Grøntved, A | 1 |
| Eriksen, S | 1 |
| Goldshteĭne, GKh | 1 |
| Tsorin, IB | 1 |
| Chichkanov, GG | 1 |
| Reinisch, J | 1 |
| Myers, B | 1 |
| Sörensen, SE | 1 |
| Nilsson, K | 1 |
| Eichbaum, FW | 1 |
| Yasaka, WJ | 1 |
| Sapsford, RN | 1 |
| Blackstone, EH | 1 |
| Kirklin, JW | 1 |
| Karp, RB | 1 |
| Kouchoukos, NT | 1 |
| Pacifico, AD | 1 |
| Roe, CR | 1 |
| Bradley, EL | 1 |
| Joseph, AA | 1 |
| Kincl, FA | 1 |
| Porciello, PI | 1 |
| Zanini, S | 1 |
| Poppi, A | 1 |
| Goudaert, M | 1 |
| Carlier, C | 1 |
| Urquhart-Hay, D | 1 |
| Danielsson, B | 1 |
| Kronberg, L | 1 |
| Klingenström, P | 1 |
| Nylén, B | 1 |
| Westermark, L | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Double-blind Randomized Clinical Trial to Evaluate the Reduction of Pain in the Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo, in the Outpatients Area.[NCT03676556] | Phase 3 | 46 participants (Anticipated) | Interventional | 2021-06-16 | Recruiting | ||
| Randomised, Double-blind Clinical Trial to Evaluate the Reduction of Pain in the Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo[NCT02584335] | Phase 4 | 7 participants (Actual) | Interventional | 2015-07-31 | Terminated (stopped due to Difficulties with the recruitment) | ||
| A Single Center, Randomized, Double-Blind Controlled Study of Topical Endoluminal Pancreatic Duct Lidocaine for Prevention of Post-ERCP Pancreatitis[NCT00953199] | 506 participants (Actual) | Interventional | 2010-03-31 | Completed | |||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
The primary outcome of interest will be development of acute pancreatitis defined as new or worsening abdominal pain post-ERCP associated with an increase in serum amylase at least 3 times the upper limit of normal. (NCT00953199)
Timeframe: 24-48 hours post-procedure
| Intervention | participants (Number) |
|---|---|
| Lidocaine | 26 |
| Normal Saline | 20 |
serum amylase levels are measure by a blood draw (NCT00953199)
Timeframe: measurement is taken 2 hrs after ERCP
| Intervention | units/liter (Mean) |
|---|---|
| Lidocaine | 130 |
| Normal Saline | 128 |
5 reviews available for lidocaine and Necrosis
| Article | Year |
|---|---|
[Necrosis in fingers and toes following local anaesthesia with adrenaline--an urban legend?].
Topics: Anesthesia, Local; Anesthetics, Local; Epinephrine; Fingers; Humans; Lidocaine; Necrosis; Toes; Vaso | 2013 |
Digital anesthesia with epinephrine: an old myth revisited.
Topics: Anesthesia, Local; Anesthetics, Local; Epinephrine; Fingers; Humans; Lidocaine; Necrosis; Nerve Bloc | 2004 |
Ambulatory phlebectomy. A rare complication of local anesthetic: case report and literature review.
Topics: Adult; Ambulatory Surgical Procedures; Anesthetics, Local; Epinephrine; Female; Humans; Lidocaine; N | 1996 |
Avoidance of adrenaline in peripheral local anaesthesia: a perpetuated medical myth?
Topics: Anesthesia, Local; Anesthetics, Combined; Contraindications; Epinephrine; Humans; Lidocaine; Necrosi | 2001 |
[Digital nerve block anaesthesia: historical development and two cases of finger-tip necrosis, a rare complication].
Topics: Adult; Aged; Anesthesia, Local; Epinephrine; Female; Fingers; History, 19th Century; History, 20th C | 2002 |
4 trials available for lidocaine and Necrosis
| Article | Year |
|---|---|
Full-thickness skin grafts. Clinical observations on the impact of using epinephrine in local anesthesia of the donor site.
Topics: Aged; Anesthesia, Local; Dermatologic Surgical Procedures; Epinephrine; Esthetics; Facial Neoplasms; | 1995 |
Double-blinded comparison of diphenhydramine versus lidocaine as a local anesthetic.
Topics: Adult; Anesthetics, Local; Diphenhydramine; Double-Blind Method; Drug Hypersensitivity; Humans; Inje | 1993 |
Evaluation of lidocaine as an analgesic when added to hypertonic saline for sclerotherapy.
Topics: Analgesics; Anesthetics, Local; Double-Blind Method; Follow-Up Studies; Humans; Incidence; Injection | 1999 |
Coronary perfusion versus cold ischemic arrest during aortic valve surgery. A randomized study.
Topics: Adult; Aged; Aortic Valve; Arrhythmias, Cardiac; Cardiac Catheterization; Cardiac Output; Creatine K | 1974 |
65 other studies available for lidocaine and Necrosis
| Article | Year |
|---|---|
Factors Affecting the Efficacy of Suction Curettage Using an Arthroscopic Shaver for Bromhidrosis.
Topics: Anesthesia, Local; Anesthetics, Local; Axilla; Curettage; Debridement; Epinephrine; Female; Hematoma | 2021 |
Uvular necrosis following diagnostic gastroscopy.
Topics: Analgesia; Anesthetics, Local; Anti-Bacterial Agents; Gastroscopy; Humans; Iatrogenic Disease; Lidoc | 2017 |
Evaluation of tissue changes following intramuscular infiltration of lidocaine in rainbow trout Oncorhynchus mykiss.
Topics: Animals; Connective Tissue; Hemorrhage; Inflammation; Lidocaine; Muscle, Skeletal; Necrosis; Oncorhy | 2018 |
In vivo experimental study on the effects of fluid in increasing the efficiency of radiofrequency ablation.
Topics: Anesthetics, Local; Animals; Catheter Ablation; Drug Combinations; Ethanol; Lidocaine; Liver; Liver | 2014 |
Effects of lidocaine on random skin flap survival in rats.
Topics: Anesthetics, Local; Animals; Dermatitis; Enzyme Activation; Graft Survival; Lidocaine; Male; Malondi | 2015 |
Comparison of topical anesthesia and subcutaneous infiltration anesthesia with regard to effect of plasma skin regeneration system.
Topics: Administration, Topical; Anesthetics, Local; Animals; Collagen; Injections, Subcutaneous; Lidocaine; | 2015 |
Case reports: Palatal mucosal necrosis after administration of a palatal infiltration.
Topics: Amoxicillin; Epinephrine; Female; Humans; Lidocaine; Middle Aged; Mouth Mucosa; Necrosis; Nortriptyl | 2015 |
Digital Necrosis After Lidocaine and Epinephrine Injection in the Flexor Tendon Sheath Without Phentolamine Rescue.
Topics: Amputation, Surgical; Anesthetics, Local; Epinephrine; Female; Finger Injuries; Humans; Lidocaine; M | 2017 |
Ultrasound-guided dorsal penile nerve block performed in a case of zipper entrapment injury.
Topics: Adult; Anesthetics, Local; Anti-Bacterial Agents; Bacitracin; Foreskin; Humans; Lidocaine; Male; Nec | 2017 |
The effect of local anesthetics administered via pain pump on chondrocyte viability.
Topics: Anesthetics, Local; Bioreactors; Bupivacaine; Cells, Cultured; Chondrocytes; Epinephrine; Humans; In | 2008 |
Necrosis of the eyebrow after local injection of lidocaine 2% on the lower eyelid: is a thrombus-embolic mechanism involved?
Topics: Aged, 80 and over; Anesthetics, Local; Eyebrows; Female; Humans; Lidocaine; Necrosis; Thromboembolis | 2009 |
The impact of lidocaine on flap survival following reperfusion injury.
Topics: Animals; Anti-Inflammatory Agents; Dose-Response Relationship, Drug; Lidocaine; Malondialdehyde; Mod | 2011 |
[Acute bilateral palpebral necrosis: a rare complication of local anaesthesia].
Topics: Acute Disease; Adolescent; Anesthetics, Local; Chalazion; Corneal Ulcer; Epinephrine; Eyelid Disease | 2010 |
[Acute bilateral palpebral necrosis: a rare complication of local anaesthesia].
Topics: Acute Disease; Adolescent; Anesthetics, Local; Chalazion; Corneal Ulcer; Epinephrine; Eyelid Disease | 2010 |
[Acute bilateral palpebral necrosis: a rare complication of local anaesthesia].
Topics: Acute Disease; Adolescent; Anesthetics, Local; Chalazion; Corneal Ulcer; Epinephrine; Eyelid Disease | 2010 |
[Acute bilateral palpebral necrosis: a rare complication of local anaesthesia].
Topics: Acute Disease; Adolescent; Anesthetics, Local; Chalazion; Corneal Ulcer; Epinephrine; Eyelid Disease | 2010 |
Eyelid necrosis after local anaesthesia for lacrimal sac surgery.
Topics: Adrenal Cortex Hormones; Aged; Aged, 80 and over; Anesthetics, Local; Anti-Bacterial Agents; Eyelids | 2010 |
Surgical myths in dermatology.
Topics: Adult; Clinical Trials as Topic; Dermatology; Drug Interactions; Ear; Epinephrine; Evidence-Based Me | 2010 |
Epinephrine's effect in varying concentrations on the end artery organ in an animal model.
Topics: Anesthetics, Local; Animals; Arteries; Double-Blind Method; Ear; Epinephrine; Ischemia; Lidocaine; M | 2010 |
Increased chondrocyte death after steroid and local anesthetic combination.
Topics: Amides; Anesthetics, Local; Apoptosis; Betamethasone; Bupivacaine; Cell Survival; Cells, Cultured; C | 2010 |
Nicolau syndrome after lidocaine injection and cold application: a rare complication of breast core needle biopsy.
Topics: Amoxicillin; Anesthetics, Local; Anti-Bacterial Agents; Anti-Inflammatory Agents, Non-Steroidal; Bac | 2011 |
Coenzyme Q10 does not enhance preadipocyte viability in an in vitro lipotransfer model.
Topics: Adipocytes; Adipose Tissue; Anesthetics, Local; Apoptosis; Cell Survival; Humans; Lidocaine; Necrosi | 2012 |
Clinical dose of lidocaine destroys the cell membrane and induces both necrosis and apoptosis in an identified Lymnaea neuron.
Topics: Anesthetics, Local; Animals; Annexin A5; Apoptosis; Cell Membrane; Electric Capacitance; Lidocaine; | 2012 |
[Eyelid necrosis after injection of lidocaine with epinephrine].
Topics: Adult; Aged; Child, Preschool; Drug Combinations; Epinephrine; Eyelid Diseases; Eyelids; Female; Hum | 2012 |
Effect of lidocaine on reducing injury in a rat electrical burn model.
Topics: Anesthetics, Local; Animals; Burns, Electric; Drug Administration Schedule; Edema; Infusions, Intrav | 2012 |
Effect of local anesthetic on neuronal cytoplasmic calcium and plasma membrane lysis (necrosis) in a cell culture model.
Topics: Anesthetics, Local; Animals; Bupivacaine; Calcium; Cell Membrane; Cells, Cultured; Dose-Response Rel | 2002 |
Necrosis of the eyelids and sclera after retrobulbar anesthesia.
Topics: Anesthesia, Local; Anesthetics, Local; Arterial Occlusive Diseases; Epinephrine; Eyelid Diseases; Ey | 2003 |
THE PREVENTION OF ACTIVE TUBULAR NECROSIS IN HEMORRHAGIC SHOCK.
Topics: Dextrans; Kidney Function Tests; Kidney Tubules; Lidocaine; Mannitol; Necrosis; Phenoxybenzamine; Pr | 1964 |
Local anesthetics worsen renal function after ischemia-reperfusion injury in rats.
Topics: Anesthetics, Local; Animals; Apoptosis; Blood Pressure; Bupivacaine; Gene Expression; Heart Rate; In | 2004 |
The effects of tumescent solutions containing lidocaine and epinephrine on skin flap survival in rats.
Topics: Animals; Epinephrine; Graft Survival; Lidocaine; Male; Necrosis; Rats; Rats, Sprague-Dawley; Skin; S | 2004 |
Mitochondrial injury and caspase activation by the local anesthetic lidocaine.
Topics: Anesthetics, Local; Animals; Apoptosis; Buffers; Caspases; Cells, Cultured; Cytochromes c; Enzyme Ac | 2004 |
Enhancement of dorsal random-pattern skin flap survival in rats with topical lidocaine and prilocaine (EMLA): enhancement of flap survival by EMLA.
Topics: Administration, Topical; Animals; Graft Survival; Ischemia; Lidocaine; Lidocaine, Prilocaine Drug Co | 2005 |
Breast reconstruction with free transverse rectus abdominis myocutaneous flaps in hospitals unaccustomed to microsurgery: original retrospective study.
Topics: Blood Loss, Surgical; Clinical Competence; Epinephrine; Female; Humans; Lidocaine; Mammaplasty; Micr | 2005 |
Lidocaine-induced apoptosis and necrosis in U937 cells depending on its dosage.
Topics: Anesthetics, Local; Caspase 3; Caspase Inhibitors; Caspases; Cell Survival; Cyclosporine; DNA Fragme | 2005 |
[Protective effect of lidocaine on injury alveolar Type II cells induced by LPS in adult rats].
Topics: Animals; Apoptosis; Cells, Cultured; Epithelial Cells; Flow Cytometry; Lactate Dehydrogenases; Lidoc | 2006 |
Leg ulcer progression caused by topical anesthesia with EMLA cream.
Topics: Anesthetics, Local; Debridement; Diagnosis, Differential; Disease Progression; Drug Eruptions; Femal | 2008 |
Leg ulcer progression caused by topical anesthesia with EMLA cream.
Topics: Anesthetics, Local; Debridement; Diagnosis, Differential; Disease Progression; Drug Eruptions; Femal | 2008 |
Leg ulcer progression caused by topical anesthesia with EMLA cream.
Topics: Anesthetics, Local; Debridement; Diagnosis, Differential; Disease Progression; Drug Eruptions; Femal | 2008 |
Leg ulcer progression caused by topical anesthesia with EMLA cream.
Topics: Anesthetics, Local; Debridement; Diagnosis, Differential; Disease Progression; Drug Eruptions; Femal | 2008 |
Lidocaine abolishes the myocardial protective effect of sevoflurane post-conditioning.
Topics: Animals; Biomarkers; Cardiotonic Agents; Heart; Heart Ventricles; In Vitro Techniques; KATP Channels | 2008 |
[Clinical experience with the combination of dextran 40, dihydroergotoxine, lidocaine in intravenous perfusion in the prevention of postoperative ischemia of skin flaps].
Topics: Dextrans; Dihydroergotoxine; Drug Therapy, Combination; Humans; Ischemia; Lidocaine; Necrosis; Surgi | 1984 |
Effects of lidocaine and droxicainide on myocardial necrosis: a comparative study.
Topics: Anilides; Animals; Anti-Arrhythmia Agents; Blood Pressure; Coronary Disease; Dogs; Heart Rate; Lidoc | 1983 |
Tissue necrosis following a buccal infiltration.
Topics: Anesthesia, Dental; Anesthesia, Local; Female; Gingival Diseases; Humans; Injections; Lidocaine; Mid | 1980 |
Mechanism of epinephrine enhancement of lidocaine-induced skeletal muscle necrosis.
Topics: Animals; Drug Synergism; Epinephrine; Lidocaine; Male; Muscular Diseases; Necrosis; Phenylephrine; R | 1982 |
Protective effect of lidocaine in the experimental foot-and-mouth disease pancreatitis.
Topics: Animals; Aphthovirus; Edema; Foot-and-Mouth Disease; Lidocaine; Male; Mice; Necrosis; Neutrophils; P | 1995 |
Can ischemic preconditioning protect against hypoxia-induced damage? Studies of contractile function in isolated perfused rat hearts.
Topics: Animals; Arrhythmias, Cardiac; Coronary Circulation; Energy Metabolism; Heart; Hypoxia; Lidocaine; M | 1994 |
Reduction of myocardial infarct size in rabbits and inhibition of activation of rabbit and human neutrophils by lidocaine.
Topics: Animals; Anti-Arrhythmia Agents; Heart; Hemodynamics; Humans; Lidocaine; Luminescent Measurements; M | 1997 |
Prolonged perivascular use of verapamil or lidocaine decreases skin flap necrosis.
Topics: Administration, Topical; Animals; Lidocaine; Necrosis; Postoperative Period; Rats; Rats, Sprague-Daw | 1999 |
Does tumescent infiltration have a deleterious effect on undermined skin flaps?
Topics: Anesthetics, Local; Epinephrine; Female; Humans; Hydrostatic Pressure; Injections, Subcutaneous; Lid | 1999 |
EMLA cream-induced irritant contact dermatitis.
Topics: Acrodermatitis; Administration, Topical; Anesthetics, Local; Child; Dermatitis, Contact; Diagnosis, | 2002 |
Reversible skeletal muscle damage after administration of local anesthetics with and without epinephrine.
Topics: Animals; Epinephrine; Injections, Intramuscular; Lidocaine; Male; Muscles; Necrosis; Prilocaine; Rat | 1978 |
A comparative study of serum creatine phosphokinase (CPK) activity in rabbits, pigs and humans after intramuscular injection of local damaging drugs.
Topics: Animals; Creatine Kinase; Diazepam; Digoxin; Female; Humans; Injections, Intramuscular; Lidocaine; M | 1978 |
Anterior segment necrosis following treatment of central retinal artery occlusion: a clinicopathologic case report.
Topics: Arterial Occlusive Diseases; Epinephrine; Eye; Eye Diseases; Humans; Ischemia; Lidocaine; Male; Midd | 1978 |
Lidocaine treatment of experimental cutaneous lesions from potassium chloride injection.
Topics: Animals; Guinea Pigs; Ischemia; Lidocaine; Necrosis; Potassium Chloride; Skin; Skin Diseases; Vasoco | 1977 |
[Local necrosis following intramuscular injection].
Topics: Animals; Creatine Kinase; Diazepam; Humans; Injections, Intramuscular; Isotonic Solutions; Lidocaine | 1976 |
[Letter: Mechanism of ulcero-mutilating acropathies].
Topics: Acrodermatitis; Arteriovenous Anastomosis; Bone Diseases; Carbon Dioxide; Extremities; Humans; Injec | 1975 |
Differences in infarct size with lidocaine as compared with bretylium tosylate in acute myocardial ischemia and reperfusion in pigs.
Topics: Animals; Arterial Occlusive Diseases; Bretylium Tosylate; Coronary Circulation; Coronary Disease; Gr | 1991 |
Multiple risk factor analysis of delayed graft function (ATN) after cadaveric transplantation: positive effect of lidocaine donor pretreatment.
Topics: Analysis of Variance; Humans; Immunosuppression Therapy; Kidney Transplantation; Kidney Tubules; Lid | 1991 |
Treatment of peripheral ischemia secondary to lidocaine containing epinephrine.
Topics: Animals; Epinephrine; Foot; Ischemia; Labetalol; Lidocaine; Models, Biological; Necrosis; Phentolami | 1989 |
Failure of pre-ischemic lidocaine administration to ameliorate global ischemic brain damage in the rat.
Topics: Animals; Brain; Brain Edema; Brain Ischemia; Lidocaine; Male; Necrosis; Premedication; Rats | 1988 |
[Local anesthetics with added adrenaline during halothane anesthesia. Assessment of the risk of necrosis and systemic side effects when these preparations are employed peripherally].
Topics: Anesthesia, Inhalation; Anesthetics, Local; Epinephrine; Halothane; Humans; Lidocaine; Necrosis; Ris | 1987 |
[Effect of lidocaine and pyromecaine on the size of an experimental myocardial infarct].
Topics: Animals; Anti-Arrhythmia Agents; Coronary Circulation; Dogs; Drug Evaluation, Preclinical; Electroca | 1986 |
The effect of local anesthesia with epinephrine on skin flap survival.
Topics: Anesthesia, Local; Animals; Drug Hypersensitivity; Epinephrine; Lidocaine; Necrosis; Skin; Skin Tran | 1974 |
Thermography and microangiography in the investigation of local toxic effects of contrast media and anaesthetics.
Topics: Anesthetics, Local; Angiography; Animals; Capillary Permeability; Contrast Media; Dextrans; Diatrizo | 1972 |
Local anaesthetic effect of oxyfedrin in animals.
Topics: Administration, Topical; Anesthesia, Conduction; Anesthesia, Local; Anesthetics, Local; Animals; Con | 1973 |
Toxic and antifertility effects of quinacrine hydrochloride in rats.
Topics: Animals; Atrophy; Autopsy; Colonic Diseases; Dose-Response Relationship, Drug; Drug Synergism; Embry | 1974 |
[Comparison of 2 modern antiarrhythmic drugs: lidocaine and diphenylhydantoin].
Topics: Arrhythmias, Cardiac; Brain; Chronic Disease; Hemodynamics; Humans; Hypotension; Lidocaine; Necrosis | 1972 |
[3 cases of necrosis of the palatine mucosa after local anesthesia].
Topics: Adult; Anesthesia, Dental; Humans; Lidocaine; Male; Mouth Mucosa; Necrosis; Palate; Stomatitis | 1968 |
Paraplegia following epidural analgesia.
Topics: Anesthesia, Spinal; Epinephrine; Humans; Ischemia; Lidocaine; Male; Middle Aged; Necrosis; Neurologi | 1969 |
Studies on the medicinal chemistry of oxoquinazolines. II. Synthesis and local anaesthetic activity of homologous derivatives of 1,2,3,4-tetrahydro-2,4-dioxoquinazoline and 3,4-dihydro-4-oxoquinazoline.
Topics: Anesthetics, Local; Animals; Anura; Chemical Phenomena; Chemistry; Cornea; Guinea Pigs; In Vitro Tec | 1969 |
Vasoconstrictors and experimental flaps.
Topics: Animals; Epinephrine; Lidocaine; Necrosis; Rats; Skin; Sodium Chloride; Vasopressins | 1966 |