Page last updated: 2024-09-26

dehydrocrotonin

Description

dehydrocrotonin: a 19-nor-clerodane diterpene; isolated from the bark of Croton cajucara; structure given in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

FloraRankFlora DefinitionFamilyFamily Definition
CrotongenusA plant genus of the family EUPHORBIACEAE. The common name of dragon's blood is also used for DRACAENA and Daemonorops (ARECACEAE). Croton tiglium is the source of CROTON OIL.[MeSH]EuphorbiaceaeThe spurge family of flowering plants in the order Malpighiales. The family consists of annual and perennial herbs and woody shrubs or trees. Members contain securinine.[MeSH]

Cross-References

ID SourceID
PubMed CID156089
MeSH IDM0269557

Synonyms (6)

Synonym
spiro(furan-3(2h),1'(7'h)-napthalene)-2,7'-dione, 2',3',4,4',4'a,5,8',8'a-octahydro-2',5'-dimethyl-5-(3-furanyl)-, (1'r-(1'-alpha(r*),2'-alpha,4'a-alpha,8'a-beta))-
dehydrocrotonin
(5'r,7r,8r,8as)-5'-(furan-3-yl)-4,7-dimethylspiro[1,4a,5,6,7,8a-hexahydronaphthalene-8,3'-oxolane]-2,2'-dione
72548-29-9
DTXSID90993396
5'-(furan-3-yl)-2,5-dimethyl-2,3,4,4a,8,8a-hexahydro-7h-spiro[naphthalene-1,3'-oxolane]-2',7-dione

Research Excerpts

Overview

ExcerptReference
"Dehydrocrotonin (DHC) is a diterpene lactone obtained from Croton cajucara (Sacaca). "( Anazetti, MC; DurĂ¡n, N; Haun, M; Melo, PS, 2003)

Research

Studies (36)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's8 (22.22)18.2507
2000's22 (61.11)29.6817
2010's4 (11.11)24.3611
2020's2 (5.56)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other36 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research Highlights

Safety/Toxicity (9)

ArticleYear
New derivative of trans-dehydrocrotonin isolated from Croton cajucara shows reduced cytotoxic and genotoxic effects in hepatocellular carcinoma (HepG2) cell line.
Toxicon : official journal of the International Society on Toxinology, Volume: 220
2022
Dehydrocrotonin and its beta-cyclodextrin complex: cytotoxicity in V79 fibroblasts and rat cultured hepatocytes.
European journal of pharmacology, Mar-07, Volume: 510, Issue: 1-2
2005
Antiulcer activity and subacute toxicity of trans-dehydrocrotonin from Croton cajucara.
Human & experimental toxicology, Volume: 23, Issue: 9
2004
Comparative cytotoxicity of dimethylamide-crotonin in the promyelocytic leukemia cell line (HL60) and human peripheral blood mononuclear cells.
Toxicology, Jun-30, Volume: 188, Issue: 2-3
2003
Cytotoxic effect of the diterpene lactone dehydrocrotonin from Croton cajucara on human promyelocytic leukemia cells.
Planta medica, Volume: 69, Issue: 1
2003
Derivatives of dehydrocrotonin, a diterpene lactone isolated from Croton cajucara: cytotoxicity in rat cultured hepatocytes and in V79 cells.
Human & experimental toxicology, Volume: 21, Issue: 5
2002
Antigenotoxicity of trans-dehydrocrotonin, a clerodane diterpene from Croton cajucara.
Planta medica, Volume: 67, Issue: 9
2001
Cytotoxicity of derivatives from dehydrocrotonin on V79 cells and Escherichia coli.
Toxicology, Feb-28, Volume: 159, Issue: 3
2001
Cytotoxicity of trans-dehydrocrotonin from Croton cajucara on V79 cells and rat hepatocytes.
Planta medica, Volume: 65, Issue: 6
1999
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Long-term Use (1)

ArticleYear
Antiulcer activity and subacute toxicity of trans-dehydrocrotonin from Croton cajucara.
Human & experimental toxicology, Volume: 23, Issue: 9
2004
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]