A neutral cholesterol ester hydrolase 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q6PIU2]
NCEH;
EC 3.1.1.-;
Arylacetamide deacetylase-like 1
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 1,6-bis(cyclohexyloximinocarbonyl)hexane | Homo sapiens (human) | IC50 | 10.0000 | 1 | 1 |
| orlistat | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| ol-135 | Homo sapiens (human) | IC50 | 100.0000 | 4 | 4 |
This protein enables 4 target(s):
| Target | Category | Definition |
|---|---|---|
| sterol esterase activity | molecular function | Catalysis of the reaction: a steryl ester + H2O = a sterol + a fatty acid. [EC:3.1.1.13] |
| phosphate ion binding | molecular function | Binding to a phosphate ion. [GOC:jl] |
| acetylalkylglycerol acetylhydrolase activity | molecular function | Catalysis of the reaction: 2-acetyl-1-alkyl-sn-glycerol + H2O = 1-alkyl-sn-glycerol + acetate + H+. [EC:3.1.1.71, RHEA:11552] |
| serine hydrolase activity | molecular function | Catalysis of the hydrolysis of a substrate by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). [Wikipedia:Serine_hydrolase] |
This protein is located in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| endoplasmic reticulum membrane | cellular component | The lipid bilayer surrounding the endoplasmic reticulum. [GOC:mah] |
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
This protein is involved in 4 target(s):
| Target | Category | Definition |
|---|---|---|
| xenobiotic metabolic process | biological process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc] |
| lipid catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. [GOC:go_curators] |
| low-density lipoprotein particle clearance | biological process | The process in which a low-density lipoprotein particle is removed from the blood via receptor-mediated endocytosis and its constituent parts degraded. [GOC:BHF, GOC:mah] |
| ether lipid metabolic process | biological process | The chemical reactions and pathways involving ether lipids, lipids that contain (normally) one lipid alcohol in ether linkage to one of the carbon atoms (normally C-1) of glycerol. [ISBN:0198506732, PMID:15337120] |