Proteins > Multidrug resistance-associated protein 1
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Multidrug resistance-associated protein 1
A multidrug resistance-associated protein 1 that is encoded in the genome of human. [PRO:DNx, UniProtKB:P33527]
Synonyms
EC 7.6.2.2;
ATP-binding cassette sub-family C member 1;
Glutathione-S-conjugate-translocating ATPase ABCC1;
7.6.2.3;
Leukotriene C(4) transporter;
LTC4 transporter
Research
Bioassay Publications (57)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 11 (19.30) | 18.2507 |
| 2000's | 13 (22.81) | 29.6817 |
| 2010's | 27 (47.37) | 24.3611 |
| 2020's | 6 (10.53) | 2.80 |
Compounds (54)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| benzbromarone | Homo sapiens (human) | IC50 | 4.0000 | 1 | 1 |
| benzbromarone | Homo sapiens (human) | Ki | 0.1900 | 1 | 1 |
| verapamil | Homo sapiens (human) | IC50 | 5.5980 | 5 | 5 |
| verapamil | Homo sapiens (human) | Ki | 13.3000 | 2 | 2 |
| indomethacin | Homo sapiens (human) | IC50 | 12.3000 | 2 | 2 |
| mitoxantrone | Homo sapiens (human) | IC50 | 0.0081 | 4 | 4 |
| vincristine | Homo sapiens (human) | IC50 | 70.0000 | 1 | 1 |
| alpha-naphthoflavone | Homo sapiens (human) | IC50 | 11.3000 | 1 | 1 |
| vinblastine | Homo sapiens (human) | IC50 | 30.0000 | 1 | 1 |
| daunorubicin | Homo sapiens (human) | IC50 | 8.0000 | 1 | 1 |
| daunorubicin | Homo sapiens (human) | Ki | 0.5100 | 2 | 2 |
| estradiol-3-sulfate | Homo sapiens (human) | Ki | 0.3800 | 1 | 1 |
| sulfolithocholylglycine | Homo sapiens (human) | Ki | 1.4000 | 1 | 1 |
| hernandezine | Homo sapiens (human) | IC50 | 38.3200 | 1 | 1 |
| 3,5,7,3',4'-pentamethoxyflavone | Homo sapiens (human) | IC50 | 26.3500 | 1 | 1 |
| sr141716 | Homo sapiens (human) | Ki | 1.4000 | 1 | 1 |
| elacridar | Homo sapiens (human) | IC50 | 4.1280 | 1 | 1 |
| tariquidar | Homo sapiens (human) | IC50 | 23.7800 | 1 | 1 |
| etravirine | Homo sapiens (human) | IC50 | 8.5000 | 1 | 1 |
| 3',4'-dimethoxy-alpha-naphthoflavone | Homo sapiens (human) | IC50 | 1.7600 | 1 | 1 |
| naringenin | Homo sapiens (human) | Ki | 11.6000 | 2 | 2 |
| reversan | Homo sapiens (human) | IC50 | 4.3000 | 1 | 1 |
| estrone sulfate | Homo sapiens (human) | Ki | 0.4500 | 1 | 1 |
| biricodar | Homo sapiens (human) | IC50 | 5.1800 | 1 | 1 |
| quercetin | Homo sapiens (human) | Ki | 5.2500 | 2 | 2 |
| apigenin | Homo sapiens (human) | Ki | 3.6500 | 2 | 2 |
| chrysoeriol | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| ayanin | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| kaempferol | Homo sapiens (human) | Ki | 2.4000 | 2 | 2 |
| diosmetin | Homo sapiens (human) | IC50 | 3.0000 | 1 | 1 |
| myricetin | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| myricetin | Homo sapiens (human) | Ki | 7.8500 | 2 | 2 |
| robinetin | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
| sdz psc 833 | Homo sapiens (human) | Ki | 27.0000 | 1 | 1 |
| estradiol-17 beta-glucuronide | Homo sapiens (human) | Ki | 22.0000 | 1 | 1 |
| l 660,711 | Homo sapiens (human) | IC50 | 5.1975 | 4 | 4 |
| l 660,711 | Homo sapiens (human) | Ki | 55.2200 | 5 | 5 |
| cyclosporine | Homo sapiens (human) | IC50 | 3.5082 | 10 | 10 |
| cyclosporine | Homo sapiens (human) | Ki | 5.0000 | 1 | 1 |
| licochalcone a | Homo sapiens (human) | IC50 | 56.4875 | 4 | 4 |
| 5-hydroxy-3,3',4',7-tetramethoxyflavone | Homo sapiens (human) | IC50 | 50.0000 | 1 | 1 |
| 2,3-dehydrosilybin | Homo sapiens (human) | IC50 | 1.1000 | 1 | 1 |
| verlukast | Homo sapiens (human) | IC50 | 2.8000 | 1 | 1 |
| ko 143 | Homo sapiens (human) | IC50 | 5.5500 | 3 | 3 |
| wk-x-34 | Homo sapiens (human) | IC50 | 20.0000 | 1 | 1 |
| mk 0571 | Homo sapiens (human) | IC50 | 18.7850 | 2 | 2 |
| bms 754807 | Homo sapiens (human) | IC50 | 36.3000 | 1 | 1 |
| gs-9451 | Homo sapiens (human) | IC50 | 14.9000 | 1 | 1 |
Drugs with Activation Measurements
Drugs with Other Measurements
Modulation of the spacer in N,N-bis(alkanol)amine aryl ester heterodimers led to the discovery of a series of highly potent P-glycoprotein-based multidrug resistance (MDR) modulators.European journal of medicinal chemistry, , Jun-15, Volume: 172, 2019
Design, synthesis and biological evaluation of stereo- and regioisomers of amino aryl esters as multidrug resistance (MDR) reversers.European journal of medicinal chemistry, , Nov-15, Volume: 182, 2019
1,2,3,4-Tetrahydroisoquinoline/2H-chromen-2-one conjugates as nanomolar P-glycoprotein inhibitors: Molecular determinants for affinity and selectivity over multidrug resistance associated protein 1.European journal of medicinal chemistry, , Jan-01, Volume: 161, 2019
Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with "Click Chemistry".Journal of medicinal chemistry, , 11-21, Volume: 61, Issue:22, 2018
Design, synthesis, biological evaluation, NMR and DFT studies of structurally simplified trimethoxy benzamides as selective P-glycoprotein inhibitors: the role of molecular flatness.Chemical biology & drug design, , Volume: 88, Issue:6, 2016
Trimethoxybenzanilide-based P-glycoprotein modulators: an interesting case of lipophilicity tuning by intramolecular hydrogen bonding.Journal of medicinal chemistry, , Aug-14, Volume: 57, Issue:15, 2014
Thieno[2,3-b]pyridines--a new class of multidrug resistance (MDR) modulators.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Potent galloyl-based selective modulators targeting multidrug resistance associated protein 1 and P-glycoprotein.Journal of medicinal chemistry, , Jan-12, Volume: 55, Issue:1, 2012
Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives.Journal of medicinal chemistry, , Sep-10, Volume: 52, Issue:17, 2009
A 4-aminobenzoic acid derivative as novel lead for selective inhibitors of multidrug resistance-associated proteins.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 18, Issue:17, 2008
Structure-activity relationships of flavonoids as inhibitors of breast cancer resistance protein (BCRP).Bioorganic & medicinal chemistry, , Mar-15, Volume: 19, Issue:6, 2011
A 4-aminobenzoic acid derivative as novel lead for selective inhibitors of multidrug resistance-associated proteins.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 18, Issue:17, 2008
Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.Journal of medicinal chemistry, , 09-26, Volume: 62, Issue:18, 2019
Multidrug resistance protein 1 (MRP1, ABCC1) mediates resistance to mitoxantrone via glutathione-dependent drug efflux.Molecular pharmacology, , Volume: 69, Issue:4, 2006
Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump.Biochemical and biophysical research communications, , Jun-29, Volume: 247, Issue:3, 1998
Anthracyclines modulate multidrug resistance protein (MRP) mediated organic anion transport.Biochimica et biophysica acta, , May-22, Volume: 1326, Issue:1, 1997
ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids.The Journal of biological chemistry, , Apr-19, Volume: 271, Issue:16, 1996
Competitive inhibition by genistein and ATP dependence of daunorubicin transport in intact MRP overexpressing human small cell lung cancer cells.Biochemical pharmacology, , Sep-15, Volume: 48, Issue:6, 1994
Multidrug resistance protein (MRP) 1 and MRP3 attenuate cytotoxic and transactivating effects of the cyclopentenone prostaglandin, 15-deoxy-Delta(12,14)prostaglandin J2 in MCF7 breast cancer cells.Biochemistry, , May-13, Volume: 42, Issue:18, 2003
Transport of methotrexate (MTX) and folates by multidrug resistance protein (MRP) 3 and MRP1: effect of polyglutamylation on MTX transport.Cancer research, , Oct-01, Volume: 61, Issue:19, 2001
Flavonoid derivatives as selective ABCC1 modulators: Synthesis and functional characterization.European journal of medicinal chemistry, , Feb-15, Volume: 109, 2016
Thieno[2,3-b]pyridines--a new class of multidrug resistance (MDR) modulators.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Pharmacological characterization of the murine and human orthologs of multidrug-resistance protein in transfected human embryonic kidney cells.Molecular pharmacology, , Volume: 52, Issue:3, 1997
Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.Cancer research, , Mar-01, Volume: 56, Issue:5, 1996
ATP-dependent 17 beta-estradiol 17-(beta-D-glucuronide) transport by multidrug resistance protein (MRP). Inhibition by cholestatic steroids.The Journal of biological chemistry, , Apr-19, Volume: 271, Issue:16, 1996
Licochalcone A Selectively Resensitizes ABCG2-Overexpressing Multidrug-Resistant Cancer Cells to Chemotherapeutic Drugs.Journal of natural products, , 05-22, Volume: 83, Issue:5, 2020
Discovery of Novel Flavonoid Dimers To Reverse Multidrug Resistance Protein 1 (MRP1, ABCC1) Mediated Drug Resistance in Cancers Using a High Throughput Platform with "Click Chemistry".Journal of medicinal chemistry, , 11-21, Volume: 61, Issue:22, 2018
Hernandezine, a Bisbenzylisoquinoline Alkaloid with Selective Inhibitory Activity against Multidrug-Resistance-Linked ATP-Binding Cassette Drug Transporter ABCB1.Journal of natural products, , 08-26, Volume: 79, Issue:8, 2016
Thieno[2,3-b]pyridines--a new class of multidrug resistance (MDR) modulators.Bioorganic & medicinal chemistry, , Nov-01, Volume: 22, Issue:21, 2014
Phenylsulfonylfuroxans as modulators of multidrug-resistance-associated protein-1 and P-glycoprotein.Journal of medicinal chemistry, , Aug-12, Volume: 53, Issue:15, 2010
Modulation of multidrug resistance protein 1 (MRP1/ABCC1)-mediated multidrug resistance by bivalent apigenin homodimers and their derivatives.Journal of medicinal chemistry, , Sep-10, Volume: 52, Issue:17, 2009
Aromatic 2-(thio)ureidocarboxylic acids as a new family of modulators of multidrug resistance-associated protein 1: synthesis, biological evaluation, and structure-activity relationships.Journal of medicinal chemistry, , Aug-13, Volume: 52, Issue:15, 2009
ATP- and glutathione-dependent transport of chemotherapeutic drugs by the multidrug resistance protein MRP1.British journal of pharmacology, , Volume: 126, Issue:3, 1999
Transport of glutathione, glucuronate, and sulfate conjugates by the MRP gene-encoded conjugate export pump.Cancer research, , Mar-01, Volume: 56, Issue:5, 1996
ATP-dependent glutathione disulphide transport mediated by the MRP gene-encoded conjugate export pump.The Biochemical journal, , Mar-01, Volume: 314 ( Pt 2), 1996
Discovery of Encequidar, First-in-Class Intestine Specific P-glycoprotein Inhibitor.Journal of medicinal chemistry, , 04-08, Volume: 64, Issue:7, 2021
Rational drug design of 6-substituted 4-anilino-2-phenylpyrimidines for exploration of novel ABCG2 binding site.European journal of medicinal chemistry, , Feb-15, Volume: 212, 2021
[no title available]Journal of medicinal chemistry, , 09-24, Volume: 63, Issue:18, 2020
Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.Journal of medicinal chemistry, , 09-26, Volume: 62, Issue:18, 2019
Synthesis and biological evaluation of quinazoline derivatives - A SAR study of novel inhibitors of ABCG2.European journal of medicinal chemistry, , Jan-01, Volume: 161, 2019
Synthesis and biological investigation of 2,4-substituted quinazolines as highly potent inhibitors of breast cancer resistance protein (ABCG2).European journal of medicinal chemistry, , Oct-20, Volume: 139, 2017
4-Anilino-2-pyridylquinazolines and -pyrimidines as Highly Potent and Nontoxic Inhibitors of Breast Cancer Resistance Protein (ABCG2).Journal of medicinal chemistry, , 05-25, Volume: 60, Issue:10, 2017
Synthesis and Biological Evaluation of 4-Anilino-quinazolines and -quinolines as Inhibitors of Breast Cancer Resistance Protein (ABCG2).Journal of medicinal chemistry, , 06-09, Volume: 59, Issue:11, 2016
Investigation of quinazolines as inhibitors of breast cancer resistance protein (ABCG2).Bioorganic & medicinal chemistry, , Dec-15, Volume: 21, Issue:24, 2013
Synthesis and biological evaluation of flavones and benzoflavones as inhibitors of BCRP/ABCG2.European journal of medicinal chemistry, , Volume: 67, 2013
A 4-aminobenzoic acid derivative as novel lead for selective inhibitors of multidrug resistance-associated proteins.Bioorganic & medicinal chemistry letters, , Sep-01, Volume: 18, Issue:17, 2008
The MRP gene encodes an ATP-dependent export pump for leukotriene C4 and structurally related conjugates.The Journal of biological chemistry, , Nov-11, Volume: 269, Issue:45, 1994
[no title available]European journal of medicinal chemistry, , Jun-05, Volume: 218, 2021
Tariquidar-related triazoles as potent, selective and stable inhibitors of ABCG2 (BCRP).European journal of medicinal chemistry, , Apr-01, Volume: 191, 2020
Triazole Bridged Flavonoid Dimers as Potent, Nontoxic, and Highly Selective Breast Cancer Resistance Protein (BCRP/ABCG2) Inhibitors.Journal of medicinal chemistry, , 09-26, Volume: 62, Issue:18, 2019
Substituted chromones as highly potent nontoxic inhibitors, specific for the breast cancer resistance protein.Journal of medicinal chemistry, , Jan-26, Volume: 55, Issue:2, 2012
Enables
This protein enables 14 target(s):
| Target | Category | Definition |
|---|
| ATP binding | molecular function | Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. [ISBN:0198506732] |
| ABC-type vitamin B12 transporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin. [GOC:pz, RHEA:17873] |
| ABC-type glutathione S-conjugate transporter activity | molecular function | Catalysis of the reaction: ATP + H2O + glutathione S-conjugate(in) -> ADP + phosphate + glutathione S-conjugate(out). [GOC:jl, PMID:1455517, RHEA:19121] |
| efflux transmembrane transporter activity | molecular function | Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. [GOC:ai, GOC:mtg_transport, ISBN:0815340729] |
| ATP hydrolysis activity | molecular function | Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. [RHEA:13065] |
| ATPase-coupled lipid transmembrane transporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + lipid(in) = ADP + phosphate + lipid(out). [GOC:BHF, GOC:rl] |
| glutathione transmembrane transporter activity | molecular function | Enables the transfer of glutathione, the tripeptide glutamylcysteinylglycine, from one side of a membrane to the other. [GOC:mah] |
| ATPase-coupled transmembrane transporter activity | molecular function | Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. [GOC:mtg_transport, ISBN:0815340729] |
| xenobiotic transmembrane transporter activity | molecular function | Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc] |
| ATPase-coupled inorganic anion transmembrane transporter activity | molecular function | Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + inorganic anion(out) = ADP + phosphate + inorganic anion(in). [GOC:mlg] |
| sphingolipid transporter activity | molecular function | Enables the directed movement of sphingolipids into, out of or within a cell, or between cells. Sphingolipids are a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:ai, ISBN:0198506732] |
| carboxylic acid transmembrane transporter activity | molecular function | Enables the transfer of carboxylic acids from one side of a membrane to the other. Carboxylic acids are organic acids containing one or more carboxyl (COOH) groups or anions (COO-). [GOC:ai] |
| ABC-type transporter activity | molecular function | Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. [PMID:26517899] |
| ABC-type xenobiotic transporter activity | molecular function | Catalysis of the reaction: ATP + H2O + xenobiotic(in) = ADP + phosphate + xenobiotic(out). [EC:7.6.2.2] |
Located In
This protein is located in 7 target(s):
| Target | Category | Definition |
|---|
| plasma membrane | cellular component | The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. [ISBN:0716731363] |
| basal plasma membrane | cellular component | The region of the plasma membrane located at the basal end of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| membrane | cellular component | A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. [GOC:dos, GOC:mah, ISBN:0815316194] |
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
| apical plasma membrane | cellular component | The region of the plasma membrane located at the apical end of the cell. [GOC:curators] |
| lateral plasma membrane | cellular component | The portion of the plasma membrane at the lateral side of the cell. In epithelial cells, lateral plasma membranes are on the sides of cells which lie at the interface of adjacent cells. [GOC:hb, GOC:mah, GOC:pr] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Active In
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|
| basolateral plasma membrane | cellular component | The region of the plasma membrane that includes the basal end and sides of the cell. Often used in reference to animal polarized epithelial membranes, where the basal membrane is the part attached to the extracellular matrix, or in plant cells, where the basal membrane is defined with respect to the zygotic axis. [GOC:go_curators] |
Involved In
This protein is involved in 23 target(s):
| Target | Category | Definition |
|---|
| leukotriene metabolic process | biological process | The chemical reactions and pathways involving leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid. [GOC:ma] |
| xenobiotic metabolic process | biological process | The chemical reactions and pathways involving a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:cab2, GOC:krc] |
| response to xenobiotic stimulus | biological process | Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a xenobiotic, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:jl, GOC:krc] |
| cobalamin transport | biological process | The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. [GOC:ai] |
| sphingolipid biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid). [GOC:mah, ISBN:0198506732] |
| cellular response to oxidative stress | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. [GOC:mah] |
| heme catabolic process | biological process | The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring. [GOC:jl] |
| xenobiotic transport | biological process | The directed movement of a xenobiotic into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A xenobiotic is a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. [GOC:go_curators, GOC:krc] |
| phospholipid translocation | biological process | The movement of a phospholipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. [ISBN:0815316194, PMID:16452632, PMID:20043909, PMID:20302864] |
| positive regulation of inflammatory response | biological process | Any process that activates or increases the frequency, rate or extent of the inflammatory response. [GOC:ai] |
| transmembrane transport | biological process | The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. [GOC:dph, GOC:jid] |
| cell chemotaxis | biological process | The directed movement of a motile cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). [GOC:dph] |
| transepithelial transport | biological process | The directed movement of a substance from one side of an epithelium to the other. [GOC:mah, GOC:yaf, ISBN:0716731363] |
| cyclic nucleotide transport | biological process | The directed movement of a cyclic nucleotide, any nucleotide in which phosphate group is in diester linkage to two positions on the sugar residue, into, out of or within a cell. [GOC:mah, ISBN:0198506732] |
| leukotriene transport | biological process | The directed movement of leukotrienes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Leukotrienes are linear C20 endogenous metabolites of arachidonic acid (icosa-5,8,11,14-tetraenoic acid) containing a terminal carboxy function and four or more double bonds (three or more of which are conjugated) as well as other functional groups. [GOC:mah] |
| monoatomic anion transmembrane transport | biological process | The process in which a monoatomic anion is transported across a membrane. Monatomic anions (also called simple anions) are negatively charged ions consisting of exactly one atom. [GOC:dos, GOC:vw] |
| sphingolipid translocation | biological process | The movement of a sphingolipid molecule from one leaflet of a membrane bilayer to the opposite leaflet. [GOC:BHF, GOC:rl] |
| export across plasma membrane | biological process | The directed movement of some substance from inside of a cell, across the plasma membrane and into the extracellular region. [GOC:pg] |
| transport across blood-brain barrier | biological process | The directed movement of substances (e.g. macromolecules, small molecules, ions) through the blood-brain barrier. [GOC:aruk, GOC:bc, PMID:29377008] |
| cellular response to amyloid-beta | biological process | Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a amyloid-beta stimulus. [GO_REF:0000071, GOC:TermGenie, PMID:23555824] |
| carboxylic acid transmembrane transport | biological process | The process in which carboxylic acid is transported across a membrane. [GO_REF:0000069, GOC:TermGenie, PMID:10869563] |
| xenobiotic transport across blood-brain barrier | biological process | The directed movement of a xenobiotic through the blood-brain barrier. [PMID:25053619] |
| glutathione transmembrane transport | biological process | A process in which glutathione is transported across a membrane. [GOC:mah] |