Page last updated: 2024-08-07 16:22:11
Protein kinase C delta type
A protein kinase C delta type that is encoded in the genome of mouse. [OMA:P28867, PRO:DNx]
Synonyms
EC 2.7.11.13;
Tyrosine-protein kinase PRKCD;
2.7.10.2;
nPKC-delta
Research
Bioassay Publications (5)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 3 (60.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (4)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| phorbol 12,13-dibutyrate | Mus musculus (house mouse) | Kd | 0.1284 | 3 | 3 |
Diacylglycerol lactones targeting the structural features that distinguish the atypical C1 domains of protein kinase C ζ and ι from typical C1 domains.Journal of medicinal chemistry, , May-08, Volume: 57, Issue:9, 2014
Conformationally constrained analogues of diacylglycerol (DAG). 28. DAG-dioxolanones reveal a new additional interaction site in the C1b domain of PKC delta.Journal of medicinal chemistry, , Jul-26, Volume: 50, Issue:15, 2007
Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method and evaluation by site-directed mutagenesis.Journal of medicinal chemistry, , May-24, Volume: 44, Issue:11, 2001
Structural basis of RasGRP binding to high-affinity PKC ligands.Journal of medicinal chemistry, , Feb-14, Volume: 45, Issue:4, 2002
Structural basis of binding of high-affinity ligands to protein kinase C: prediction of the binding modes through a new molecular dynamics method and evaluation by site-directed mutagenesis.Journal of medicinal chemistry, , May-24, Volume: 44, Issue:11, 2001
Probing the binding of indolactam-V to protein kinase C through site-directed mutagenesis and computational docking simulations.Journal of medicinal chemistry, , Sep-09, Volume: 42, Issue:18, 1999