Proteins > Type-1 angiotensin II receptor
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Type-1 angiotensin II receptor
An angiotensin II receptor 1 that is encoded in the genome of rabbit. [OMA:P34976, PRO:DNx]
Synonyms
Angiotensin II type-1 receptor;
AT1
Research
Bioassay Publications (18)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
Compounds (23)
Drugs with Inhibition Measurements
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|
| losartan | Oryctolagus cuniculus (rabbit) | Kd | 0.0426 | 5 | 6 |
| bexarotene | Oryctolagus cuniculus (rabbit) | Kd | 0.0360 | 1 | 1 |
| a 81988 | Oryctolagus cuniculus (rabbit) | Kd | 0.0001 | 1 | 1 |
| alitretinoin | Oryctolagus cuniculus (rabbit) | Kd | 0.0500 | 1 | 1 |
| fty 720p | Oryctolagus cuniculus (rabbit) | EC50 | 0.0003 | 1 | 1 |
Pyrazole-containing pharmaceuticals: target, pharmacological activity, and their SAR studies.RSC medicinal chemistry, , Nov-16, Volume: 13, Issue:11, 2022
Discovery of novel, potent and low-toxicity angiotensin II receptor type 1 (AT1) blockers: Design, synthesis and biological evaluation of 6-substituted aminocarbonyl benzimidazoles with a chiral center.European journal of medicinal chemistry, , Oct-20, Volume: 103, 2015
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.Bioorganic & medicinal chemistry, , Dec-15, Volume: 18, Issue:24, 2010
Design, synthesis, and biological evaluation of AT1 angiotensin II receptor antagonists based on the pyrazolo[3,4-b]pyridine and related heteroaromatic bicyclic systems.Journal of medicinal chemistry, , Apr-10, Volume: 51, Issue:7, 2008
Synthesis and biological activity of 2-alkylbenzimidazoles bearing a N-phenylpyrrole moiety as novel angiotensin II AT1 receptor antagonists.Bioorganic & medicinal chemistry letters, , May-15, Volume: 17, Issue:10, 2007
Further studies on imidazo[4,5-b]pyridine AT1 angiotensin II receptor antagonists. Effects of the transformation of the 4-phenylquinoline backbone into 4-phenylisoquinolinone or 1-phenylindene scaffolds.Journal of medicinal chemistry, , Nov-02, Volume: 49, Issue:22, 2006
Discovery of a novel class of orally active, non-peptide angiotensin II antagonists.Journal of medicinal chemistry, , Oct-02, Volume: 35, Issue:20, 1992
A series of 6- and 7-piperazinyl- and -piperidinylmethylbenzoxazinones with dopamine D4 antagonist activity: discovery of a potential atypical antipsychotic agent.Journal of medicinal chemistry, , Dec-16, Volume: 42, Issue:25, 1999
1'-Benzyl-3,4-dihydrospiro[2H-1- benzothiopyran-2,4'-piperidine] (spipethiane), a potent and highly selective sigma1 ligand.Journal of medicinal chemistry, , May-07, Volume: 41, Issue:10, 1998
Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy.Journal of medicinal chemistry, , Feb-02, Volume: 39, Issue:3, 1996
Triazolinone biphenylsulfonamides as angiotensin II receptor antagonists with high affinity for both the AT1 and AT2 subtypes.Journal of medicinal chemistry, , Dec-23, Volume: 37, Issue:26, 1994
Angiotensin II receptor type 1 (AT1) selective nonpeptidic antagonists--a perspective.Bioorganic & medicinal chemistry, , Dec-15, Volume: 18, Issue:24, 2010
Excursions in drug discovery.Journal of medicinal chemistry, , Jul-23, Volume: 36, Issue:15, 1993