Page last updated: 2024-08-07 16:32:13
Type-1 angiotensin II receptor
An angiotensin II receptor 1 that is encoded in the genome of rabbit. [OMA:P34976, PRO:DNx]
Synonyms
Angiotensin II type-1 receptor;
AT1
Research
Bioassay Publications (18)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 6 (33.33) | 18.2507 |
| 2000's | 5 (27.78) | 29.6817 |
| 2010's | 6 (33.33) | 24.3611 |
| 2020's | 1 (5.56) | 2.80 |
Compounds (23)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| candesartan cilexetil | Oryctolagus cuniculus (rabbit) | IC50 | 0.2000 | 1 | 1 |
| candesartan | Oryctolagus cuniculus (rabbit) | Ki | 0.0006 | 1 | 1 |
| ketoconazole | Oryctolagus cuniculus (rabbit) | IC50 | 0.0078 | 1 | 1 |
| losartan | Oryctolagus cuniculus (rabbit) | IC50 | 0.0250 | 2 | 2 |
| 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one | Oryctolagus cuniculus (rabbit) | IC50 | 0.5000 | 1 | 1 |
| prazosin | Oryctolagus cuniculus (rabbit) | Ki | 0.0020 | 2 | 3 |
| valsartan | Oryctolagus cuniculus (rabbit) | Ki | 4.7000 | 1 | 2 |
| secoisolariciresinol | Oryctolagus cuniculus (rabbit) | IC50 | 47.3000 | 1 | 1 |
| gefitinib | Oryctolagus cuniculus (rabbit) | IC50 | 0.0073 | 1 | 1 |
| bibs 39 | Oryctolagus cuniculus (rabbit) | Ki | 0.2545 | 2 | 2 |
| bibs 222 | Oryctolagus cuniculus (rabbit) | Ki | 0.7300 | 1 | 1 |
| mk 996 | Oryctolagus cuniculus (rabbit) | IC50 | 0.0002 | 1 | 1 |
| isolariciresinol | Oryctolagus cuniculus (rabbit) | IC50 | 100.0000 | 1 | 1 |
| l 158809 | Oryctolagus cuniculus (rabbit) | IC50 | 0.0003 | 2 | 2 |
| lariciresinol | Oryctolagus cuniculus (rabbit) | IC50 | 25.6000 | 1 | 1 |
| conidendrin | Oryctolagus cuniculus (rabbit) | IC50 | 0.2000 | 1 | 1 |
| cv 11194 | Oryctolagus cuniculus (rabbit) | IC50 | 0.0001 | 1 | 1 |
| hetacillin | Oryctolagus cuniculus (rabbit) | IC50 | 85.6000 | 1 | 1 |
| nu 7441 | Oryctolagus cuniculus (rabbit) | IC50 | 0.1300 | 1 | 1 |
Drugs with Activation Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| losartan | Oryctolagus cuniculus (rabbit) | Kd | 0.0426 | 5 | 6 |
| bexarotene | Oryctolagus cuniculus (rabbit) | Kd | 0.0360 | 1 | 1 |
| a 81988 | Oryctolagus cuniculus (rabbit) | Kd | 0.0001 | 1 | 1 |
| alitretinoin | Oryctolagus cuniculus (rabbit) | Kd | 0.0500 | 1 | 1 |
| fty 720p | Oryctolagus cuniculus (rabbit) | EC50 | 0.0003 | 1 | 1 |