Protoporphyria, Erythropoietic

An autosomal dominant porphyria that is due to a deficiency of FERROCHELATASE (heme synthetase) in both the LIVER and the BONE MARROW, the last enzyme in the 8-enzyme biosynthetic pathway of HEME. Clinical features include mainly neurological symptoms, rarely cutaneous lesions, and elevated levels of protoporphyrin and COPROPORPHYRINS in the feces.

Synonym
Protoporphyria, Erythropoietic

Excerpt	Reference
"Erythropoietic protoporphyria is a genetic disease characterized by sensitivity to sunlight caused by the accumulation of protoporphyrin IX."	( Asano, H; Kamide, R; Kawada, A; Kawara, S; Mizuno, M; Naru, E; Teramura, T, 2018)
"Erythropoietic protoporphyria is a rare disorder which represents an important health problem in children, causing painful photosensitivity."	( Berti, I; Burlo, F; De Martino, E; Marchini, S; Pastore, S; Severini, GM; Tommasini, A; Tumminelli, C; Zanon, D, 2023)

Timeframe	Studies, This Condition (%)	All Conditions %
pre-1990	21 (14.58)	23.3326
1990's	9 (6.25)	12.5806
2000's	35 (24.31)	18.1394
2010's	59 (40.97)	28.8240
2020's	20 (13.89)	9.53

Drug	Relationship Strength	Studies	Trials
aminolevulinic acid	low	10	0
1-butanol	low	1	0
cytosine	low	1	0
dihydroxyacetone	medium	1	1
glycine	low	1	0
hydroxymethylbilane	low	1	0
methanol	low	1	0
niacin	low	1	0
porphobilinogen	low	4	0
pyridoxal phosphate	low	1	0
pyridoxine	low	1	0
thymine	low	1	0
uroporphyrinogen iii	low	1	0
1-anilino-8-naphthalenesulfonate	low	1	0
acetaminophen	low	1	0
busulfan	low	1	0
carmustine	low	1	0
deferoxamine	low	2	0
fentanyl	low	1	0
hydroxychloroquine	low	1	0
isoflurane	low	2	0
isoniazid	low	2	0
o(6)-benzylguanine	low	1	0
phenobarbital	low	1	0
protoporphyrin ix	medium	45	3
sucrose	low	2	0
edetic acid	low	2	0
cytarabine	low	1	0
arginine	low	1	0
isobutyl alcohol	low	1	0
dehydrocholic acid	low	1	0
thiophenes	low	1	0
thiazoles	low	1	0
azacitidine	low	3	0
chenodeoxycholic acid	low	1	0
malondialdehyde	medium	1	1
acetylcysteine	low	1	0
zinc sulfate	medium	1	1
urobilinogen	low	1	0
daunorubicin	low	1	0
ursodeoxycholic acid	low	5	0
transferrin	low	1	0
glucaric acid	low	1	0
colestipol	medium	1	1
triazoles	low	1	0
coproporphyrin i	low	1	0
succinyl-coenzyme a	low	1	0
cobalt	low	1	0
vitamin b 6	low	1	0
zinc coproporphyrin iii	low	1	0
n-methylprotoporphyrin ix	low	1	0
methotrexate	low	1	0
deferasirox	low	1	0
deoxycholic acid	low	1	0
griseofulvin	low	6	0
tacrolimus	low	1	0
mycophenolic acid	low	1	0
cobaltous chloride	low	1	0
orlistat	low	1	0
zinc protoporphyrin ix	low	2	0
bilirubin	low	2	0
beta carotene	low	8	0
cysteine	low	1	0
akr 501	low	1	0
lactulose	low	1	0
losartan potassium	low	1	0
oligonucleotides	low	1	0
heme	medium	37	1
ascorbic acid	low	1	0
warfarin	low	2	0
epidermal growth factor	low	1	0
ferric oxide, saccharated	low	1	0
transforming growth factor alpha	low	1	0
cyclosporine	low	2	0
guanine	low	1	0
guanosine tetraphosphate	low	1	0
inosine	low	1	0
heme arginate	low	1	0
cholestyramine resin	low	6	0

Protein Targets (637)

Protein	Potency Measurements	Inhibition Measurements	Activation Measurements	Drugs
Chain B, pheromone binding protein	0	0	1	1
Chain A, pheromone binding protein	0	0	1	1
Chain A, JmjC domain-containing histone demethylation protein 3A	5	0	0	5
Chain A, RNA-directed RNA polymerase NS5	0	2	0	2
acid sphingomyelinase	2	0	0	2
thioredoxin reductase	7	0	0	7
USP1 protein, partial	9	0	0	9
TDP1 protein	21	0	0	21
vitamin D3 receptor isoform VDRA	5	0	0	5
importin subunit beta-1 isoform 1	3	0	0	3
flap endonuclease 1	5	0	0	5
serine/threonine-protein kinase PLK1	2	0	0	2
snurportin-1	3	0	0	3
peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	5	0	0	5
GTP-binding nuclear protein Ran isoform 1	1	0	0	1
DNA polymerase eta isoform 1	4	0	0	4
DNA polymerase iota isoform a (long)	8	0	0	8
urokinase-type plasminogen activator precursor	5	0	0	5
plasminogen precursor	5	0	0	5
urokinase plasminogen activator surface receptor precursor	5	0	0	5
geminin	26	0	0	26
DNA polymerase kappa isoform 1	8	0	0	8
fibroblast growth factor 22 isoform 1 precursor	0	0	0	1
Mitogen-activated protein kinase 13	0	1	0	1
Beta-lactamase	0	1	0	1
Transthyretin	0	1	1	2
Fatty acid-binding protein, intestinal	0	1	1	2
Fatty acid-binding protein, adipocyte	0	1	1	2
Cyclin-A2	0	2	0	2
Cannabinoid receptor 1	0	0	1	1
Cyclin-dependent kinase 2	0	2	2	4
Choline O-acetyltransferase	0	1	0	1
Mitogen-activated protein kinase 12	0	1	0	1
Guanine nucleotide-binding protein G	5	0	0	5
Fatty acid-binding protein 5	0	0	1	1
Fatty acid-binding protein 5	0	0	1	1
Mitogen-activated protein kinase 11	0	1	0	1
Mitogen-activated protein kinase 14	0	1	0	1
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE	10	0	0	10
aldehyde dehydrogenase 1 family, member A1	14	0	0	14
glucocorticoid receptor [Homo sapiens]	17	0	0	17
farnesoid X nuclear receptor	9	0	0	9
estrogen nuclear receptor alpha	25	0	0	25
Voltage-dependent calcium channel gamma-2 subunit	8	0	0	8
Cellular tumor antigen p53	18	0	0	18
Glutamate receptor 2	9	1	0	10
Choline O-acetyltransferase	0	1	0	2
RAR-related orphan receptor gamma	18	0	0	18
ATAD5 protein, partial	6	0	0	6
GLS protein	4	0	0	4
Microtubule-associated protein tau	7	0	0	7
Smad3	5	0	0	5
thyroid stimulating hormone receptor	9	0	0	9
nuclear receptor subfamily 1, group I, member 3	11	0	0	11
progesterone receptor	12	0	0	12
EWS/FLI fusion protein	10	0	0	10
retinoic acid nuclear receptor alpha variant 1	16	0	0	16
retinoid X nuclear receptor alpha	11	0	0	11
estrogen-related nuclear receptor alpha	19	0	0	19
peroxisome proliferator activated receptor gamma	13	0	0	13
aryl hydrocarbon receptor	7	0	0	7
chromobox protein homolog 1	14	0	0	14
thyroid hormone receptor beta isoform 2	17	0	0	17
peripheral myelin protein 22	14	0	0	14
cytochrome P450 3A4 isoform 1	7	0	0	7
Gamma-aminobutyric acid receptor subunit pi	7	0	0	7
ATP-binding cassette sub-family C member 3	0	11	0	11
Multidrug resistance-associated protein 4	0	11	0	12
Solute carrier family 22 member 6	0	4	0	4
Carbonic anhydrase 12	0	1	0	1
UDP-glucuronosyltransferase 1A9	0	0	0	2
Bile salt export pump	0	5	0	5
Bile salt export pump	0	17	0	17
Cytochrome P450 2B1	0	0	0	1
Cytochrome P450 1A1	0	0	0	1
Carbonic anhydrase 1	0	1	0	1
Carbonic anhydrase 2	0	2	2	4
Myoglobin	0	1	0	1
Cytochrome P450 1A1	0	0	1	2
Cytochrome P450 1A2	0	1	0	2
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 3	0	1	0	1
Cytochrome P450 3A4	0	6	0	7
Cytochrome P450 2D6	0	2	0	2
Cytochrome P450 2C9	0	4	1	5
Polyunsaturated fatty acid lipoxygenase ALOX15	0	1	0	1
Gamma-aminobutyric acid receptor subunit beta-1	7	0	0	7
Sulfotransferase 1A1	0	0	0	1
Gamma-aminobutyric acid receptor subunit delta	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-2	7	0	0	7
UDP-glucuronosyltransferase 1-6	0	0	0	1
Gamma-aminobutyric acid receptor subunit alpha-5	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-3	7	0	0	7
Arachidonate 5-lipoxygenase-activating protein	0	1	0	1
UDP-glucuronosyltransferase 1A1	0	0	0	2
Carbonic anhydrase 4	0	1	0	1
Prostaglandin G/H synthase 1	0	1	0	1
Carbonic anhydrase 6	0	1	0	1
Gamma-aminobutyric acid receptor subunit gamma-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-2	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-4	7	0	0	7
Gamma-aminobutyric acid receptor subunit gamma-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit alpha-6	7	0	0	7
Carbonic anhydrase 5A, mitochondrial	0	1	0	1
Prostaglandin G/H synthase 2	0	0	0	1
Carbonic anhydrase 7	0	1	0	1
Nuclear receptor ROR-gamma	3	0	0	3
Cytochrome P450 2J2	0	2	0	2
Gamma-aminobutyric acid receptor subunit alpha-1	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-3	7	0	0	7
Gamma-aminobutyric acid receptor subunit beta-2	7	0	0	7
Carbonic anhydrase 9	0	2	1	3
GABA theta subunit	7	0	0	7
Canalicular multispecific organic anion transporter 1	0	11	0	11
Carbonic anhydrase 15	0	1	0	1
Carbonic anhydrase 13	0	1	0	1
Gamma-aminobutyric acid receptor subunit epsilon	7	0	0	7
Carbonic anhydrase 14	0	1	0	1
Carbonic anhydrase 5B, mitochondrial	0	1	0	1
toxin B	0	0	0	1
Chain A, 2-oxoglutarate Oxygenase	11	0	0	11
Chain A, ATP-DEPENDENT DNA HELICASE Q1	3	0	0	3
acetylcholinesterase	5	0	0	5
dopamine D1 receptor	2	0	0	2
15-lipoxygenase, partial	4	0	0	4
pregnane X receptor	3	0	0	3
phosphopantetheinyl transferase	9	0	0	9
NFKB1 protein, partial	5	0	0	5
Thrombopoietin	2	0	0	2
AR protein	24	0	0	24
regulator of G-protein signaling 4	2	0	0	2
vitamin D (1,25- dihydroxyvitamin D3) receptor	11	0	0	11
arylsulfatase A	6	0	0	6
euchromatic histone-lysine N-methyltransferase 2	17	0	0	17
Bloom syndrome protein isoform 1	7	0	0	7
D(1A) dopamine receptor	1	0	0	1
thyroid hormone receptor beta isoform a	6	0	0	6
heat shock protein beta-1	2	0	0	2
survival motor neuron protein isoform d	6	0	0	6
muscarinic acetylcholine receptor M1	5	0	0	5
Histone deacetylase 3	0	1	0	1
Histone deacetylase 4	0	1	0	1
Histone deacetylase 1	0	2	0	2
Histone deacetylase 7	0	1	0	1
Histone deacetylase 2	0	1	0	1
Polyamine deacetylase HDAC10	0	1	0	1
Histone deacetylase 11	0	1	0	1
Ataxin-2	8	0	0	8
Histone deacetylase 8	0	2	0	2
Histone deacetylase 6	0	2	0	2
Histone deacetylase 9	0	1	0	1
Histone deacetylase 5	0	1	0	1
ATP-dependent phosphofructokinase	11	0	0	11
Chain A, Beta-lactamase	4	0	0	4
bromodomain adjacent to zinc finger domain 2B	5	0	0	5
Gamma-aminobutyric acid receptor subunit rho-1	0	1	0	1
Glutamate receptor 1	0	1	0	1
Glutamate receptor 2	0	1	0	1
Glutamate receptor 3	0	1	0	1
Glutamate receptor ionotropic, kainate 3	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Glutamate receptor 4	0	1	0	1
Solute carrier family 15 member 1	0	1	0	1
Solute carrier family 15 member 2	0	1	0	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
Chain E, LYSINE, ARGININE, ORNITHINE-BINDING PROTEIN	0	0	1	1
alpha-galactosidase	3	0	0	3
cytochrome P450 2C19 precursor	4	0	0	4
lethal factor (plasmid)	5	0	0	5
Nitric oxide synthase, endothelial	0	0	0	2
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, brain	0	0	0	1
Nitric oxide synthase, inducible	0	0	0	1
Nitric oxide synthase, inducible	0	0	1	3
Cationic amino acid transporter 3	0	1	0	1
Chain A, Hyaluronidase, phage associated	0	1	0	1
GLI family zinc finger 3	11	0	0	11
thioredoxin glutathione reductase	1	0	0	1
cytochrome P450 family 3 subfamily A polypeptide 4	12	0	0	12
IDH1	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 2	8	0	0	8
nuclear factor erythroid 2-related factor 2 isoform 1	15	0	0	15
lethal(3)malignant brain tumor-like protein 1 isoform I	1	0	0	1
lamin isoform A-delta10	14	0	0	14
Polyphenol oxidase 2	0	3	0	3
Pancreatic alpha-amylase	0	2	0	2
Albumin	0	1	0	1
Urease	0	1	0	1
Prolyl 4-hydroxylase subunit alpha-1	0	0	0	1
Tyrosinase	0	1	0	1
Alpha-2B adrenergic receptor	0	1	2	3
Spike glycoprotein	7	0	1	8
Hyaluronate lyase	0	1	0	1
Prolyl hydroxylase EGLN2	0	0	0	1
Egl nine homolog 1	0	0	0	1
Prolyl hydroxylase EGLN3	0	0	0	1
Hypoxia-inducible factor 1-alpha inhibitor	0	0	0	1
Solute carrier family 23 member 1	0	1	0	1
interleukin 8	2	0	0	2
glp-1 receptor, partial	5	0	0	5
Fumarate hydratase	2	0	0	2
PPM1D protein	3	0	0	3
estrogen receptor 2 (ER beta)	7	0	0	7
pregnane X nuclear receptor	7	0	0	7
polyprotein	2	0	0	2
67.9K protein	7	0	0	7
Parkin	1	0	0	1
peroxisome proliferator-activated receptor delta	8	0	0	8
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a	7	0	0	7
thyroid stimulating hormone receptor	5	0	0	5
activating transcription factor 6	6	0	0	6
peripheral myelin protein 22 isoform 1	3	0	0	3
hemoglobin subunit beta	1	0	0	1
cellular tumor antigen p53 isoform a	3	0	0	3
huntingtin isoform 2	3	0	0	3
ras-related protein Rab-9A	1	0	0	1
serine/threonine-protein kinase mTOR isoform 1	2	0	0	2
histone acetyltransferase KAT2A isoform 1	5	0	0	5
Interferon beta	6	0	0	6
Integrin beta-3	3	0	0	3
Integrin alpha-IIb	3	0	0	3
Adenosine receptor A3	0	1	0	1
DNA (cytosine-5)-methyltransferase 1	0	1	0	1
Adenosine receptor A2a	0	1	0	1
Adenosine receptor A1	0	1	0	1
D(1A) dopamine receptor	2	0	0	2
Multidrug and toxin extrusion protein 1	0	3	0	3
Histone-lysine N-methyltransferase EHMT2	0	1	0	1
ATPase family AAA domain-containing protein 5	6	0	0	6
core protein, partial	0	1	0	1
Solute carrier organic anion transporter family member 1B3	0	4	0	6
Solute carrier organic anion transporter family member 1B1	0	5	0	6
Chain A, TYROSYL-DNA PHOSPHODIESTERASE	5	0	0	5
Chain A, Putative fructose-1,6-bisphosphate aldolase	4	0	0	4
Chain A, HADH2 protein	8	0	0	8
Chain B, HADH2 protein	8	0	0	8
Chain A, Cruzipain	3	0	0	3
caspase-1 isoform alpha precursor	2	0	0	2
Caspase-7	2	0	0	2
Inositol monophosphatase 1	2	0	0	2
apical membrane antigen 1, AMA1	3	0	0	3
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a	6	0	0	6
ubiquitin carboxyl-terminal hydrolase 2 isoform a	2	0	0	2
Matrix metalloproteinase-9	0	1	0	1
Disintegrin and metalloproteinase domain-containing protein 17	1	0	0	1
endonuclease IV	2	0	0	2
cytochrome P450 2D6	3	0	0	3
nuclear receptor ROR-gamma isoform 1	5	0	0	5
Glutathione reductase, mitochondrial	0	1	0	1
Alpha-synuclein	3	0	0	3
Glutathione reductase	0	1	0	1
Luciferase	5	0	0	5
SMAD family member 2	4	0	0	4
SMAD family member 3	4	0	0	4
caspase 7, apoptosis-related cysteine protease	3	0	0	3
caspase-3	3	0	0	3
v-jun sarcoma virus 17 oncogene homolog (avian)	5	0	0	5
Caspase-7	2	0	0	2
caspase-3	2	0	0	2
Alpha-2A adrenergic receptor	0	1	1	2
Vitamin D3 receptor	0	3	3	6
Alpha-2C adrenergic receptor	0	1	1	2
Retinoic acid receptor RXR-alpha	0	0	1	1
Ileal sodium/bile acid cotransporter	0	3	0	3
TAR DNA-binding protein 43	5	0	0	5
Bile acid receptor	0	0	1	1
G-protein coupled bile acid receptor 1	0	0	3	3
Bile acid receptor	0	0	3	3
G	3	0	0	3
M-phase phosphoprotein 8	3	0	0	3
Solute carrier family 22 member 1	0	1	0	1
Solute carrier family 22 member 2	0	2	0	3
Solute carrier family 22 member 1	0	4	0	4
Solute carrier family 22 member 2	0	1	0	1
cGMP-specific 3',5'-cyclic phosphodiesterase	0	1	0	1
HLA class I histocompatibility antigen, B alpha chain	3	0	0	3
ATP-dependent translocase ABCB1	0	1	0	1
ATP-dependent translocase ABCB1	0	3	0	4
Potassium-transporting ATPase alpha chain 1	0	1	0	1
ATP-dependent translocase ABCB1	0	1	0	1
Histamine H2 receptor	0	2	0	2
Histamine H1 receptor	0	0	1	1
Histamine H2 receptor	4	2	1	7
Potassium-transporting ATPase subunit beta	0	1	0	1
Aldehyde oxidase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	2
Solute carrier family 22 member 1	0	2	0	2
Multidrug and toxin extrusion protein 2	0	1	0	1
Solute carrier family 22 member 8	0	2	0	4
Inositol hexakisphosphate kinase 1	3	0	0	3
Histamine H4 receptor	0	1	0	1
Solute carrier family 22 member 11	0	1	0	2
Solute carrier family 22 member 2	0	2	0	2
Solute carrier family 22 member 4	0	1	0	1
Solute carrier family 22 member 8	0	2	0	2
cytochrome P450 2C9, partial	3	0	0	3
LMP1 [Human herpesvirus 4]	0	0	0	2
Histone H2A.x	7	0	0	7
nuclear receptor coactivator 1 isoform 1 [Homo sapiens]	0	2	0	2
transactivating tegument protein VP16 [Human herpesvirus 1]	0	2	0	2
nuclear receptor coactivator 3 isoform a	0	2	0	2
Thymidine kinase 2, mitochondrial	0	1	0	1
Thymidine kinase, cytosolic	0	1	0	1
Thymidine kinase	0	1	0	1
Thymidylate synthase	0	2	0	3
Thymidine kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Probable deoxycytidylate deaminase	0	0	0	1
Cytidine deaminase	0	1	0	2
E3 ubiquitin-protein ligase Mdm2	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	1
Thymidine kinase	0	1	0	1
Deoxynucleoside kinase	0	1	0	1
Deoxycytidine kinase	0	0	0	1
Chain A, Breast cancer type 1 susceptibility protein	1	0	0	1
Chain A, Ferritin light chain	6	0	0	6
hypoxia-inducible factor 1 alpha subunit	3	0	0	3
runt-related transcription factor 1 isoform AML1b	1	0	0	1
core-binding factor subunit beta isoform 2	1	0	0	1
mitogen-activated protein kinase 1	2	0	0	2
histone-lysine N-methyltransferase 2A isoform 2 precursor	2	0	0	2
Polyunsaturated fatty acid lipoxygenase ALOX15B	3	0	0	3
NADH-ubiquinone oxidoreductase chain 4	0	0	0	1
72 kDa type IV collagenase	0	1	0	1
DNA topoisomerase 2-alpha	0	0	0	1
Carbonyl reductase [NADPH] 1	0	0	0	1
Glutamate receptor 1	2	1	0	3
Glutamate receptor 3	2	1	0	3
Glutamate receptor 4	2	1	0	3
Platelet-activating factor receptor	1	0	0	1
Multidrug resistance-associated protein 1	0	2	0	4
Reverse transcriptase/RNaseH	0	1	0	1
Broad substrate specificity ATP-binding cassette transporter ABCG2	0	1	0	3
Lysine-specific demethylase 6B	0	1	0	1
Lysine-specific demethylase 4A	0	2	1	3
Lysine-specific demethylase 5A	0	1	0	1
Flavin reductase (NADPH)	0	0	1	1
Potassium voltage-gated channel subfamily H member 2	0	4	0	4
Voltage-dependent L-type calcium channel subunit alpha-1C	0	1	0	1
Sodium channel protein type 5 subunit alpha	0	1	0	1
Potassium voltage-gated channel subfamily D member 3	0	1	0	1
Hypoxia-inducible factor 1-alpha	0	0	1	1
Methylcytosine dioxygenase TET2	0	1	0	1
Deoxyhypusine hydroxylase	0	1	0	1
Chain A, STEROID DELTA-ISOMERASE	0	0	1	1
Steroid Delta-isomerase	0	0	1	1
Eyes absent homolog 2	0	1	0	1
Amyloid-beta precursor protein	0	2	0	2
Angiotensin-converting enzyme	0	1	0	1
Metallo-beta-lactamase VIM-13	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase	0	1	0	1
Beta-lactamase VIM-1	0	1	0	1
potassium voltage-gated channel subfamily H member 2 isoform d	3	0	0	3
Nuclear receptor subfamily 1 group I member 2	0	0	3	3
D(2) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] A	0	1	0	1
D(4) dopamine receptor	0	1	0	1
Amine oxidase [flavin-containing] B	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Delta-type opioid receptor	0	3	0	3
Mu-type opioid receptor	0	3	1	4
Kappa-type opioid receptor	0	2	0	2
Histamine H1 receptor	0	1	0	1
Mu-type opioid receptor	0	2	1	3
D(3) dopamine receptor	0	1	0	1
Delta-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Kappa-type opioid receptor	0	2	0	2
Mu-type opioid receptor	0	1	0	1
Mu-type opioid receptor	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	2	0	2
Sigma non-opioid intracellular receptor 1	0	3	0	3
Sigma non-opioid intracellular receptor 1	0	1	0	1
Glycine receptor subunit alpha-1	0	0	1	1
Sodium- and chloride-dependent GABA transporter 2	0	1	0	1
Sodium- and chloride-dependent GABA transporter 3	0	1	0	1
Glutamate receptor ionotropic, NMDA 1	0	2	1	3
Sodium- and chloride-dependent glycine transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2A	0	2	1	3
Glutamate receptor ionotropic, NMDA 2B	0	2	1	3
Glutamate receptor ionotropic, NMDA 2C	0	2	1	3
Large neutral amino acids transporter small subunit 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 2D	0	2	1	3
Proton-coupled amino acid transporter 1	0	1	0	1
Glutamate receptor ionotropic, NMDA 3B	0	2	1	3
Serine racemase	0	1	0	1
Olfactory receptor 51E2	0	0	1	1
Glutamate receptor ionotropic, NMDA 3A	0	2	1	3
Sodium- and chloride-dependent glycine transporter 2	0	1	0	1
nuclear receptor subfamily 1, group I, member 2	1	0	0	1
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1	5	0	0	5
DNA dC->dU-editing enzyme APOBEC-3G isoform 1	1	0	0	1
Heme oxygenase 1	0	1	0	1
Heme oxygenase 2	0	1	0	1
Lanosterol 14-alpha demethylase	0	1	0	1
Purine nucleoside phosphorylase	0	2	0	3
Hypoxanthine-guanine phosphoribosyltransferase	0	0	0	1
Ricin	0	1	0	1
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase	0	0	1	1
Purine nucleoside phosphorylase	0	0	1	2
Shiga toxin subunit A	0	1	0	1
Guanine deaminase	0	0	0	1
Genome polyprotein	0	1	0	1
Spike glycoprotein	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Transmembrane protease serine 2	0	0	1	1
Procathepsin L	0	0	1	1
Muscarinic acetylcholine receptor M2	0	2	0	2
Muscarinic acetylcholine receptor M4	0	1	0	1
Muscarinic acetylcholine receptor M5	0	1	0	1
Replicase polyprotein 1a	0	0	1	1
Replicase polyprotein 1ab	0	0	1	1
Replicase polyprotein 1ab	0	2	1	3
Replicase polyprotein 1ab	0	2	1	3
Muscarinic acetylcholine receptor M1	0	1	0	1
Muscarinic acetylcholine receptor M3	0	1	0	1
Alpha-1D adrenergic receptor	0	2	0	2
Sigma intracellular receptor 2	0	1	0	1
Cyclic GMP-AMP synthase	0	1	0	1
Angiotensin-converting enzyme 2	0	0	1	1
Toll-like receptor 9	0	1	0	1
Toll-like receptor 7	0	1	0	1
Chain A, ADENOSINE DEAMINASE	0	1	0	1
Chain A, ADENOSINE DEAMINASE	0	1	0	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
Chain A, Membrane lipoprotein tmpC	0	0	1	1
glycogen synthase kinase-3 beta isoform 1	0	0	1	1
muscleblind-like protein 1 isoform 1	3	0	0	3
Adenosylhomocysteinase	0	1	0	2
Adenosine deaminase	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	0	1	0	1
Neuronal acetylcholine receptor subunit alpha-7	0	1	0	1
3-oxoacyl-[acyl-carrier-protein] synthase 3	0	1	0	1
cytochrome P450 2D6 isoform 1	3	0	0	3
N-glycosylase/DNA lyase	0	1	0	1
Myeloperoxidase	0	2	0	2
Formamidopyrimidine-DNA glycosylase	0	1	0	1
DNA gyrase subunit A	0	1	0	1
DNA gyrase subunit B	0	1	0	1
Cytochrome P450 2C8	0	1	0	1
Cytochrome P450 2A6	0	1	0	1
Macrophage migration inhibitory factor	0	2	0	2
Cytochrome P450 2C19	0	2	0	2
Endonuclease III-like protein 1	0	1	0	1
DNA gyrase subunit B	0	1	0	1
DNA gyrase subunit A	0	1	0	1
Enoyl-[acyl-carrier-protein] reductase [NADH]	0	1	0	2
Pantothenate synthetase	0	1	0	1
Isocitrate lyase	0	1	0	1
Putative FAD-containing monooxygenase MymA	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Endonuclease 8-like 1	0	1	0	1
Type-1A angiotensin II receptor	0	1	0	1
Type-1B angiotensin II receptor	0	2	0	2
Type-2 angiotensin II receptor	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase B	0	1	0	1
cGMP-inhibited 3',5'-cyclic phosphodiesterase A	0	1	0	1
5-hydroxytryptamine receptor 1A	0	1	0	1
Type-1 angiotensin II receptor	0	1	0	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
Chain B, DIHYDROFOLATE REDUCTASE	0	0	1	1
ClpP	1	0	0	1
Thymidylate synthase	0	1	0	1
Thymidylate synthase	0	1	0	1
polyunsaturated fatty acid lipoxygenase ALOX12	1	0	0	1
transcriptional regulator ERG isoform 3	2	0	0	2
DNA polymerase beta	2	0	0	2
Toll-like receptor 4	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
ATP-binding cassette sub-family C member 3	0	1	0	2
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	2	0	3
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Dihydrofolate reductase	0	2	0	3
Thymidylate synthase	0	1	0	1
Tyrosine-protein kinase ABL1	0	0	1	1
Thymidylate synthase	0	2	0	2
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
5-hydroxytryptamine receptor 2C	0	1	0	2
High mobility group protein B1	0	0	1	1
Dihydrofolate reductase	0	1	0	1
Thymidylate synthase	0	1	0	1
Dihydrofolate reductase	0	2	2	4
Glucose-6-phosphate 1-dehydrogenase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Folate receptor beta	0	1	0	1
5-hydroxytryptamine receptor 2A	0	1	0	1
Cytochrome P450 11B1, mitochondrial	0	1	0	1
Folate receptor alpha	0	1	0	1
Dihydrofolate reductase	0	2	0	2
Histidine decarboxylase	0	1	0	1
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Bifunctional purine biosynthesis protein ATIC	0	2	0	2
Reduced folate transporter	0	2	0	2
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
6-phosphogluconate dehydrogenase, decarboxylating	0	1	0	1
Solute carrier organic anion transporter family member 1A3	0	0	0	1
Pteridine reductase 1	0	1	0	1
Folylpolyglutamate synthase, mitochondrial	0	1	0	3
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Bifunctional dihydrofolate reductase-thymidylate synthase	0	1	0	1
Canalicular multispecific organic anion transporter 1	0	1	0	2
Trifunctional purine biosynthetic protein adenosine-3	0	1	0	1
Solute carrier family 22 member 20	0	1	0	1
Dihydrofolate reductase	0	1	0	1
Solute carrier family 22 member 6	0	1	0	1
Dihydrofolate reductase	0	1	0	1
ATP-binding cassette sub-family C member 11	0	0	0	1
Proton-coupled folate transporter	0	1	0	1
Multidrug resistance associated protein	0	1	0	2
Protein-arginine deiminase type-4	0	1	0	1
Chain A, Inosine-5'-Monophosphate Dehydrogenase 2	0	1	0	1
Inosine-5'-monophosphate dehydrogenase 2	0	2	0	2
Inosine-5'-monophosphate dehydrogenase 1	0	2	0	2
Sodium-dependent serotonin transporter	0	1	0	1
Peroxisome proliferator-activated receptor gamma	0	0	1	1
Inosine-5'-monophosphate dehydrogenase	0	1	0	2
UDP-glucuronosyltransferase 1A7	0	0	0	1
UDP-glucuronosyltransferase 1A10	0	0	0	1
UDP-glucuronosyltransferase 1A8	0	0	0	1
thyrotropin-releasing hormone receptor	1	0	0	1
lysosomal alpha-glucosidase preproprotein	2	0	0	2
Neuronal acetylcholine receptor subunit alpha-4	2	0	0	2
Cholesteryl ester transfer protein	0	1	0	1
Neuronal acetylcholine receptor subunit beta-2	2	0	0	2
D-amino-acid oxidase	0	1	0	1
Xanthine dehydrogenase/oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 3	0	0	1	1
Nicotinamidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	0	1	1
Hydroxycarboxylic acid receptor 2	0	2	1	3
D-aspartate oxidase	0	1	0	1
Hydroxycarboxylic acid receptor 2	0	1	1	2
cytochrome P450 2C9 precursor	2	0	0	2
dual specificity tyrosine-phosphorylation-regulated kinase 1A	0	0	0	1
Cyclin-dependent kinase 1	0	1	0	1
G2/mitotic-specific cyclin-B1	0	1	0	1
G2/mitotic-specific cyclin-B	0	1	0	1
Methylated-DNA--protein-cysteine methyltransferase	0	1	0	2
Cyclin-A1	0	1	0	1
Cyclin-dependent kinase 1	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Rap guanine nucleotide exchange factor 3	1	0	0	1
Phosphatidylserine lipase ABHD16A	0	1	0	1
Pancreatic triacylglycerol lipase	0	2	0	3
Lipoprotein lipase	0	1	0	1
Hepatic triacylglycerol lipase	0	1	0	1
Pancreatic triacylglycerol lipase	0	1	0	1
Translocator protein	0	1	0	1
Proteasome subunit beta type-1	0	1	0	1
Cannabinoid receptor 1	0	2	0	2
Proteasome subunit beta type-5	0	1	0	1
Kappa-type opioid receptor	0	1	0	1
Cannabinoid receptor 2	0	1	0	1
Fatty acid synthase	0	2	0	2
Proteasome subunit beta type-2	0	1	0	1
Fatty-acid amide hydrolase 1	0	1	0	1
Platelet-activating factor acetylhydrolase	0	1	0	1
Neutral cholesterol ester hydrolase 1	0	1	0	1
Diacylglycerol lipase-alpha	0	1	0	1
Lysophosphatidylserine lipase ABHD12	0	1	0	1
Diacylglycerol lipase-beta	0	1	0	1
Monoacylglycerol lipase ABHD6	0	1	0	1
Acyl-protein thioesterase 2	0	1	0	1
Diacylglycerol lipase-alpha	0	1	0	1
Endothelial lipase	0	1	0	1
Sodium channel protein type 1 subunit alpha	0	1	0	1
Sodium channel protein type 2 subunit alpha	0	1	0	1
Sodium channel protein type 3 subunit alpha	0	1	0	1
GALC protein	1	0	0	1
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)	1	0	0	1
beta-2 adrenergic receptor	1	0	0	1
mu-type opioid receptor isoform MOR-1	0	0	1	1
Vpr	1	0	0	1
5-hydroxytryptamine receptor 2A	0	0	1	1
SUMO-1	0	1	0	1
WRN	1	0	0	1
isocitrate dehydrogenase 1, partial	1	0	0	1
pyruvate kinase	1	0	0	1
parathyroid hormone/parathyroid hormone-related peptide receptor precursor	3	0	0	3
atrial natriuretic peptide receptor 2 precursor	1	0	0	1
tumor susceptibility gene 101 protein	1	0	0	1
POsterior Segregation	0	0	1	1
chaperonin GroEL	1	0	0	1
neuropeptide S receptor isoform A	1	0	0	1
60 kDa chaperonin	0	1	0	1
60 kDa heat shock protein, mitochondrial	0	1	0	1
Sodium-dependent noradrenaline transporter	0	0	1	1
10 kDa heat shock protein, mitochondrial	0	1	0	1
Exoribonuclease H	0	1	0	1
Thiosulfate sulfurtransferase	0	1	0	1
Coproheme decarboxylase	0	0	1	1
60 kDa chaperonin	0	1	0	1
Protease	0	2	0	2
10 kDa chaperonin	0	1	0	1
Single-stranded DNA cytosine deaminase	1	0	0	1
Zinc finger protein mex-5	0	0	1	1
phosphoglycerate kinase	1	0	0	1
Receptor-type tyrosine-protein phosphatase beta	0	0	0	1
Low molecular weight phosphotyrosine protein phosphatase	0	1	0	1
P2X purinoceptor 1	0	0	1	1
P2X purinoceptor 1	0	1	0	1
P2X purinoceptor 4	0	0	1	1
Trans-sialidase	0	1	0	1
Trans-sialidase	0	1	0	1
P2X purinoceptor 2	0	0	1	1
Pyridoxal kinase	0	0	0	1
Chain A, MALTOPORIN	0	0	1	1
Chain B, MALTOPORIN	0	0	1	1
UDP-glucuronosyltransferase 2B7	0	0	0	1
Cytochrome P450 3A5	0	1	0	1
UDP-glucuronosyltransferase 1A4	0	0	0	1
Serine/threonine-protein kinase mTOR	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP1A	0	2	1	3
Peptidyl-prolyl cis-trans isomerase FKBP1B	0	0	1	1
Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	0	1	0	1
Peptidyl-prolyl cis-trans isomerase FKBP5	0	1	0	1
Splicing factor 3B subunit 3	0	1	0	1
Thymidine phosphorylase	0	1	0	1
Ubiquitin carboxyl-terminal hydrolase 2	0	1	0	1
Glucocorticoid receptor	0	0	1	1
Sodium/bile acid cotransporter	0	1	0	1
CDGSH iron-sulfur domain-containing protein 1	0	2	0	2
M1-family alanyl aminopeptidase	0	1	0	1
Albumin	0	0	1	1
Albumin	0	0	1	1
Proprotein convertase subtilisin/kexin type 7	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1-like protein 1	0	1	0	1
Vitamin K epoxide reductase complex subunit 1	0	2	0	2
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protoporphyria, Erythropoietic

Synonyms(1)

Research Excerpts

Overview

Research

Studies (144)

Protein Targets (637)

Protoporphyria, Erythropoietic

Synonyms(1)

Research Excerpts

Overview

Research

Studies (144)

Drugs Studied (90)

Protein Targets (637)