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delta-lactam

A lactam in which the amide bond is contained within a six-membered ring, which includes the amide nitrogen and the carbonyl carbon.

ChEBI ID: 77727

Members (8)

MemberDefinitionRole
2-piperidoneA delta-lactam that is piperidine which is substituted by an oxo group at position 2.piperidin-2-one
6-oxopiperidine-2-carboxylateA delta-lactam that is piperidine-2-carboxylic acid substituted at position 6 by an oxo group.6-ketopiperidine-2-carboxylic acid
aripiprazoleAn N-arylpiperazine that is piperazine substituted by a 4-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butyl group at position 1 and by a 2,3-dichlorophenyl group at position 4. It is an antipsychotic drug used for the treatment of Schizophrenia, and other mood disorders.aripiprazole
aripiprazole lauroxilA dodecanoate ester obtained by formal condensation of the carboxy group of dodecanoic acid with the hydroxy group of 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-2-oxo-3,4-dihydroquinolin-1(2H)-yl]methanol. A prodrug for aripiprazole, it is used for treatment of schizophrenia.aripiprazole lauroxil
dutasterideAn aza-steroid that is inasteride in which the tert-butyl group is replaced by a 2,5-bis(trifluoromethyl)phenyl group. A synthetic 4-azasteroid, dutasteride is a selective inhibitor of both the type 1 and type 2 isoforms of steroid 5alpha-reductase, an intracellular enzyme that converts testosterone to 5alpha-dihydrotestosterone. Dutasteride is used for the treatment of symptomatic benign prostatic hyperplasia in men with an enlarged prostate gland.dutasteride
finasterideAn aza-steroid that is a synthetic drug for the treatment of benign prostatic hyperplasia.finasteride
lupanineThe delta-lactam obtained by formal oxidation at the 2-position of sparteine. The major alkaloid from the seeds of Lupinus exaltatus, L. mexicanus and L. rotundiflorus, it is among the most important of the tetracyclic quinolizidine alkaloids.lupanine
palonosetronAn organic heterotricyclic compound that is an antiemetic used (as its hydrochloride salt) in combination with netupitant (under the trade name Akynzeo) to treat nausea and vomiting in patients undergoing cancer chemotherapy.palonosetron

Research

Studies (7,276)

TimeframeStudies, Drugs in This Class (%)All Drugs %
pre-1990308 (4.23)18.7374
1990's694 (9.54)18.2507
2000's2,035 (27.97)29.6817
2010's3,295 (45.29)24.3611
2020's944 (12.97)2.80

Study Types

Publication TypeStudies, Drugs in This Class (%)All Drugs (%)
Trials1,382 (17.09%)5.53%
Reviews1,183 (14.63%)6.00%
Case Studies911 (11.26%)4.05%
Observational60 (0.74%)0.25%
Other4,552 (56.28%)84.16%