| Member | Definition | Role |
|---|
| 1-methyluric acid | An oxopurine that is 7,9-dihydro-1H-purine-2,6,8(3H)-trione substituted by a methyl group at N-1. It is one of the metabolites of caffeine found in human urine. | 1-methyluric acid |
| 1,3-dimethyl-8-(3-methyl-1-piperidinyl)-7-[2-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]ethyl]purine-2,6-dione | | 1,3-dimethyl-8-(3-methyl-1-piperidinyl)-7-[2-[(5-methyl-1,3,4-thiadiazol-2-yl)thio]ethyl]purine-2,6-dione |
| 1,3-dimethyl-8-[[methyl-(phenylmethyl)amino]methyl]-7-(2-methylpropyl)purine-2,6-dione | | 1,3-dimethyl-8-[[methyl-(phenylmethyl)amino]methyl]-7-(2-methylpropyl)purine-2,6-dione |
| 1,3-dimethyl-8-[2-(1-pyrrolidinyl)ethylthio]-6-sulfanylidene-7H-purin-2-one | | 1,3-dimethyl-8-[2-(1-pyrrolidinyl)ethylthio]-6-sulfanylidene-7H-purin-2-one |
| 1,3-dimethyl-8-[methyl-(phenylmethyl)amino]-7-[2-(2-pyrimidinylthio)ethyl]purine-2,6-dione | | 1,3-dimethyl-8-[methyl-(phenylmethyl)amino]-7-[2-(2-pyrimidinylthio)ethyl]purine-2,6-dione |
| 1,3-dimethyluric acid | An oxopurine that is 7,9-dihydro-1H-purine-2,6,8(3H)-trionesubstituted by methyl groups at N-1 and N-3. | 1,3-dimethyluric acid |
| 1,3-dipropyl-8-cyclopentylxanthine | An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group. | DPCPX |
| 1,3-dipropyl-8-phenylxanthine | | 8-phenyl-1,3-dipropyl-7H-purine-2,6-dione |
| 1,3,7-trimethyl-8-(phenylmethyl)purine-2,6-dione | | 1,3,7-trimethyl-8-(phenylmethyl)purine-2,6-dione |
| 1,3,7-trimethylurate | An oxopurine in which the purine ring is substituted by oxo groups at positions 2, 6, and 8, and the nitrogens at positions 1, 3, and 7 are substituted by methyl groups. It is a metabolite of caffeine. | 1,3,7-trimethyluric acid |
| 1,3,7,9-tetramethyluric acid | An oxopurine that is uric acid in which the hydrogens at positions 1,3,7 and 9 are replaced by methyl groups. It is a purine alkaloid that is found in Chinese tea known as kucha (Camellia assamica var. kucha) and exhibits anti-inflammatory and analgesic properties. | 1,3,7,9-tetramethyluric acid |
| 1,7-dimethyluric acid | An oxopurine that is 7,9-dihydro-1H-purine-2,6,8(3H)-trione substituted by methyl groups at N-1 and N-7. It is a metabolite of caffeine and is often found in human urine samples. | 1,7-dimethyluric acid |
| 1',3'-dimethylspiro[1H-indole-3,8'-7,9-dihydropurine]-2,2',6'-trione | | 1',3'-dimethylspiro[1H-indole-3,8'-7,9-dihydropurine]-2,2',6'-trione |
| 2-(1,3-dimethyl-2,6-dioxo-7-purinyl)-N-(phenylmethyl)-N-(2-pyridinyl)acetamide | | 2-(1,3-dimethyl-2,6-dioxo-7-purinyl)-N-(phenylmethyl)-N-(2-pyridinyl)acetamide |
| 2-(1,3-dimethyl-2,6-dioxo-7-purinyl)-N-[3-[(4-methoxyphenyl)sulfamoyl]-4-methylphenyl]acetamide | | 2-(1,3-dimethyl-2,6-dioxo-7-purinyl)-N-[3-[(4-methoxyphenyl)sulfamoyl]-4-methylphenyl]acetamide |
| 2-(1,3-dimethyl-2,6-dioxo-7-purinyl)-N'-[2-(2-ethoxyphenoxy)-1-oxoethyl]acetohydrazide | | 2-(1,3-dimethyl-2,6-dioxo-7-purinyl)-N'-[2-(2-ethoxyphenoxy)-1-oxoethyl]acetohydrazide |
| 2-[(7-ethyl-1,3-dimethyl-2,6-dioxo-8-purinyl)thio]-N-(6-methyl-2-pyridinyl)acetamide | | 2-[(7-ethyl-1,3-dimethyl-2,6-dioxo-8-purinyl)thio]-N-(6-methyl-2-pyridinyl)acetamide |
| 2-[[3-methyl-7-(3-methylbutyl)-2,6-dioxo-8-purinyl]thio]propanoic acid methyl ester | | 2-[[3-methyl-7-(3-methylbutyl)-2,6-dioxo-8-purinyl]thio]propanoic acid methyl ester |
| 2,8-dihydroxyadenine | An oxopurine that is adenine bearing two oxo substituents at positions 2 and 8. | 2,8-dihydroxyadenine; 2,8-dioxoadenine |
| 3-butyl-8-(2-fluorophenyl)-7-(phenylmethyl)purine-2,6-dione | | 3-butyl-8-(2-fluorophenyl)-7-(phenylmethyl)purine-2,6-dione |
| 3-methyl-7-(2-phenylethyl)-8-(propylamino)purine-2,6-dione | | 3-methyl-7-(2-phenylethyl)-8-(propylamino)purine-2,6-dione |
| 3-methyl-7-(phenylmethyl)-8-(propan-2-ylthio)purine-2,6-dione | | 3-methyl-7-(phenylmethyl)-8-(propan-2-ylthio)purine-2,6-dione |
| 3-methyl-7-[(4-methylphenyl)methyl]-8-[2-(1-piperidinyl)ethylthio]purine-2,6-dione | | 3-methyl-7-[(4-methylphenyl)methyl]-8-[2-(1-piperidinyl)ethylthio]purine-2,6-dione |
| 3-methyl-7-pentyl-8-(2-phenylethylthio)purine-2,6-dione | | 3-methyl-7-pentyl-8-(2-phenylethylthio)purine-2,6-dione |
| 3,5-dimethyl-4-isoxazolecarboxylic acid (3-butyl-2,6-dioxo-7-propyl-8-purinyl)methyl ester | | 3,5-dimethyl-4-isoxazolecarboxylic acid (3-butyl-2,6-dioxo-7-propyl-8-purinyl)methyl ester |
| 3,7-dimethyl-1-(phenylmethyl)-8-[(phenylmethyl)amino]purine-2,6-dione | | 3,7-dimethyl-1-(phenylmethyl)-8-[(phenylmethyl)amino]purine-2,6-dione |
| 3,7-dimethyluric acid | An oxopurine that is 7,9-dihydro-1H-purine-2,6,8(3H)-trione substituted by methyl groups at N-3 and N-7. | 3,7-dimethyluric acid |
| 4-[(1,3-dimethyl-2,6-dioxo-7H-purin-8-yl)methylamino]benzoic acid | | 4-[(1,3-dimethyl-2,6-dioxo-7H-purin-8-yl)methylamino]benzoic acid |
| 4-[[7-[(4-fluorophenyl)methyl]-1,3-dimethyl-2,6-dioxo-8-purinyl]methyl]-1-piperazinecarboxylic acid ethyl ester | | 4-[[7-[(4-fluorophenyl)methyl]-1,3-dimethyl-2,6-dioxo-8-purinyl]methyl]-1-piperazinecarboxylic acid ethyl ester |
| 4-[7-(2-methoxyethyl)-2,6-dioxo-3-(phenylmethyl)-8-purinyl]benzonitrile | | 4-[7-(2-methoxyethyl)-2,6-dioxo-3-(phenylmethyl)-8-purinyl]benzonitrile |
| 5-hydroxyisourate | An oxopurine that is 5,7-dihydro-1H-purine-2,6,8(9H)-trione in which the hydrogen at position 5 is substituted by a hydroxy group. | 5-hydroxyisouric acid |
| 6-thiouric acid | | 6-Thiourate |
| 7-(2-chloroethyl)theophylline | | 7-(2-chloroethyl)-1,3-dimethylpurine-2,6-dione |
| 7-(2-methoxyethyl)-3-methyl-8-(phenylthio)purine-2,6-dione | | 7-(2-methoxyethyl)-3-methyl-8-(phenylthio)purine-2,6-dione |
| 7-(3-methoxypropyl)-3-(phenylmethyl)-8-(3-thiophenyl)purine-2,6-dione | | 7-(3-methoxypropyl)-3-(phenylmethyl)-8-(3-thiophenyl)purine-2,6-dione |
| 7-[(2-chloro-6-fluorophenyl)methyl]-1,3-dimethyl-8-(1-piperidinylmethyl)purine-2,6-dione | | 7-[(2-chloro-6-fluorophenyl)methyl]-1,3-dimethyl-8-(1-piperidinylmethyl)purine-2,6-dione |
| 7-[(2-chloro-6-fluorophenyl)methyl]-1,3-dimethyl-8-[(3-methyl-1-piperidinyl)methyl]purine-2,6-dione | | 7-[(2-chloro-6-fluorophenyl)methyl]-1,3-dimethyl-8-[(3-methyl-1-piperidinyl)methyl]purine-2,6-dione |
| 7-[(3-bromophenyl)methyl]-1,3-dimethyl-8-(2-methylpropylamino)purine-2,6-dione | | 7-[(3-bromophenyl)methyl]-1,3-dimethyl-8-(2-methylpropylamino)purine-2,6-dione |
| 7-[(4-fluorophenyl)methyl]-1,3-dimethyl-8-[(2-oxo-2-thiophen-2-ylethyl)thio]purine-2,6-dione | | 7-[(4-fluorophenyl)methyl]-1,3-dimethyl-8-[(2-oxo-2-thiophen-2-ylethyl)thio]purine-2,6-dione |
| 7-[2-(1,3-benzothiazol-2-ylthio)ethyl]-1,3-dimethyl-8-(3-methyl-1-piperidinyl)purine-2,6-dione | | 7-[2-(1,3-benzothiazol-2-ylthio)ethyl]-1,3-dimethyl-8-(3-methyl-1-piperidinyl)purine-2,6-dione |
| 7-[2-hydroxy-3-(2-methylphenoxy)propyl]-3-methyl-8-(propan-2-ylthio)purine-2,6-dione | | 7-[2-hydroxy-3-(2-methylphenoxy)propyl]-3-methyl-8-(propan-2-ylthio)purine-2,6-dione |
| 7-ethylguanine | | 7-Ethylguanine |
| 7-methylxanthine | An oxopurine that is xanthine in which the hydrogen attached to the nitrogen at position 7 is replaced by a methyl group. It is an intermediate metabolite in the synthesis of caffeine. | 7-methylxanthine |
| 8-(1,3-benzothiazol-2-ylthio)-3-methyl-7-pentylpurine-2,6-dione | | 8-(1,3-benzothiazol-2-ylthio)-3-methyl-7-pentylpurine-2,6-dione |
| 8-(2,5-dimethylphenoxy)-1,3-dimethyl-7-prop-2-enylpurine-2,6-dione | | 8-(2,5-dimethylphenoxy)-1,3-dimethyl-7-prop-2-enylpurine-2,6-dione |
| 8-(3-ethoxypropylamino)-1,3-dimethyl-7H-purine-2,6-dione | | 8-(3-ethoxypropylamino)-1,3-dimethyl-7H-purine-2,6-dione |
| 8-(4-methoxyphenyl)-7-methyl-3-(phenylmethyl)purine-2,6-dione | | 8-(4-methoxyphenyl)-7-methyl-3-(phenylmethyl)purine-2,6-dione |
| 8-(butan-2-ylthio)-7-[(4-chlorophenyl)methyl]-3-methylpurine-2,6-dione | | 8-(butan-2-ylthio)-7-[(4-chlorophenyl)methyl]-3-methylpurine-2,6-dione |
| 8-[(1-ethyl-3-piperidinyl)thio]-1,3-dimethyl-6-sulfanylidene-7H-purin-2-one | | 8-[(1-ethyl-3-piperidinyl)thio]-1,3-dimethyl-6-sulfanylidene-7H-purin-2-one |
| 8-[[4-[2-furanyl(oxo)methyl]-1-piperazinyl]methyl]-1,3-dimethyl-7-[(2-methylphenyl)methyl]purine-2,6-dione | | 8-[[4-[2-furanyl(oxo)methyl]-1-piperazinyl]methyl]-1,3-dimethyl-7-[(2-methylphenyl)methyl]purine-2,6-dione |
| 8-[[4-[2-furanyl(oxo)methyl]-1-piperazinyl]methyl]-1,3-dimethyl-7-propylpurine-2,6-dione | | 8-[[4-[2-furanyl(oxo)methyl]-1-piperazinyl]methyl]-1,3-dimethyl-7-propylpurine-2,6-dione |
| 8-anilino-1,3-dimethyl-7H-purine-2,6-dione | | 8-anilino-1,3-dimethyl-7H-purine-2,6-dione |
| 8-cyclopentyl-1,3-dimethylxanthine | | 8-cyclopentyl-1,3-dimethyl-7H-purine-2,6-dione |
| 8-hydroxyadenine | An oxopurine that is adenine bearing a single oxo substituent at position 8. | 8-hydroxyadenine; 8-oxoadenine |
| 8-hydroxyguanine | An oxopurine that is guanine in which the hydrogen at position 8 is replaced by an oxo group and in which the nitrogens at positions 7 and 9 each bear a hydrogen. | 7,8-dihydro-8-oxoguanine |
| 8-methoxymethyl-3-isobutyl-1-methylxanthine | | 8-(methoxymethyl)-1-methyl-3-(2-methylpropyl)-7H-purine-2,6-dione |
| 8-nitroguanine | | 8-Nitroguanine |
| 8-oxyguanine | An oxopurine that is guanine which is substituted by an oxo group at position 8. | 8-oxoguanine |
| 9-carboxymethoxymethylguanine | | 9-Carboxymethoxymethylguanine |
| acefylline | | 2-(1,3-dimethyl-2,6-dioxo-7-purinyl)acetic acid |
| acyclovir | An oxopurine that is guanine substituted by a (2-hydroxyethoxy)methyl substituent at position 9. Used in the treatment of viral infections. | acyclovir |
| bamifylline | | bamifylline |
| cafedrine | | cafedrine |
| cipamfylline | | cipamfylline |
| denbufylline | | 1,3-dibutyl-7-(2-oxopropyl)purine-2,6-dione |
| doxofylline | An oxopurine that is a derivative of xanthine, methylated at N-1 and N-3 and carrying a 1,3-dioxolan-2-ylmethyl group at N-7, used in the treatment of asthma. | doxofylline |
| dyphylline | An oxopurine that is theophylline bearing a 2,3-dihydroxypropyl group at the 7 position. It has broncho- and vasodilator properties, and is used in the treatment of asthma, cardiac dyspnea, and bronchitis. It is also an ingredient in preparations that have been promoted for coughs. | dyphylline |
| enprofylline | Xanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. | enprofylline |
| entecavir | Guanine substituted at the 9 position by a 4-hydroxy-3-(hydroxymethyl)-2-methylidenecyclopentyl group. A synthetic analogue of 2'-deoxyguanosine, it is a nucleoside reverse transcriptase inhibitor with selective antiviral activity against hepatitis B virus. Entecavir is phosphorylated intracellularly to the active triphosphate form, which competes with deoxyguanosine triphosphate, the natural substrate of hepatitis B virus reverse transcriptase, inhibiting every stage of the enzyme's activity, although it has no activity against HIV. It is used for the treatment of chronic hepatitis B. | entecavir (anhydrous) |
| etamiphylline | | etamiphylline |
| etofylline | | 7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione |
| etofylline clofibrate | | etofylline clofibrate |
| fenethylline | | fenetylline |
| furafylline | | Furafylline |
| ganciclovir | An oxopurine that is guanine substituted by a [(1,3-dihydroxypropan-2-yl)oxy]methyl group at position 9. Ganciclovir is an antiviral drug used to treat or prevent AIDS-related cytomegalovirus infections. | ganciclovir |
| guanine | A 2-aminopurine carrying a 6-oxo substituent. | guanine |
| hypoxanthine | A purine nucleobase that consists of purine bearing an oxo substituent at position 6. | hypoxanthine |
| isoguanine | An oxopurine that is 3,7-dihydro-purin-2-one in which the hydrogen at position 6 is substituted by an amino group. | isoguanine |
| istradefylline | | istradefylline |
| mrs 1754 | | N-(4-cyanophenyl)-2-[4-(2,6-dioxo-1,3-dipropyl-7H-purin-8-yl)phenoxy]acetamide |
| pentifylline | | pentifylline |
| pentoxifylline | | Pentoxifylline |
| propentofylline | | Propentofylline |
| proxyphylline | | Proxyphylline |
| psb 1115 | | 4-(2,6-dioxo-1-propyl-3,7-dihydropurin-8-yl)benzenesulfonic acid |
| psb 36 | | LSM-1748 |
| reproterol | | reproterol |
| rolofylline | | Rolofylline |
| theodrenaline | | theodrenaline |