Any EC 1.14.18.* (oxidoreductase acting on paired donors, miscellaneous compound as one donor, incorporating 1 atom of oxygen) inhibitor that interferes with the action of tyrosinase (monophenol monooxygenase), EC 1.14.18.1, an enzyme that catalyses the oxidation of phenols (such as tyrosine) and is widespread in plants and animals.
| Member | Definition | Class |
|---|
| (E)-2-methoxycinnamic acid | A member of the class of cinnamic acids that is trans-cinnamic acid carrying a methoxy substituent at position 2 on the benzene ring. | (E)-2-methoxycinnamic acid |
| 2,3,4-trihydroxbenzophenone | A benzenetriol that is benzophenone in which one of the phenyl groups is substituted by hydroxy groups at positions 2, 3, and 4. It is a redox mediator. | 2,3,4-trihydroxbenzophenone |
| 3-methylquercetin | A monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group. | isorhamnetin |
| 6,7,4'-trihydroxyisoflavone | A hydroxyisoflavone that is daidzein bearing an additional hydroxy substituent at position 6. | 4',6,7-trihydroxyisoflavone |
| acrovestone | A polyphenol that is isolated from Acronychia pedunculata and exhibits moderate antioxidant and antityrosinase activities. | acrovestone |
| alloin | A diastereoisomeric mixture of aloin A (barbaloin) and aloin B (isobarbaloin), which have similar properties. It is a bitter-tasting, yellow-brown colored compound found in the exudate of at least 68 Aloe species at levels of up to 6.6% of leaf dry weight (making between 3% and 35% of the total exudate), and in another 17 species at indeterminate levels. It is used as a stimulant-laxative, treating constipation by inducing bowel movements. | aloin |
| cefodizime | A cephalosporin compound having 5-(carboxymethyl)-4-methyl-1,3-thiazol-2-yl]sulfanyl}methyl and [2-(2-amino-1,3-thiazol-4-yl)-2-(methoxyimino)acetyl]amino side groups located at positions 3 and 7 respectively. | cefodizime |
| decaprenoic acid | A polyunsaturated fatty acid that is octa-2,6-dienoic acid bearing two methyl substituents at positions 3 and 7 (the 2E-isomer). | geranic acid |
| dihydropinosylvin | A member of the class of resorcinols carrying an additional 2-phenylethyl substituent at position 5. | dihydropinosylvin |
| dioscin | A spirostanyl glycoside that consists of the trisaccharide alpha-L-Rha-(1->4)-[alpha-L-Rha-(1->2)]-beta-D-Glc attached to position 3 of diosgenin via a glycosidic linkage. | dioscin |
| ellagic acid | An organic heterotetracyclic compound resulting from the formal dimerisation of gallic acid by oxidative aromatic coupling with intramolecular lactonisation of both carboxylic acid groups of the resulting biaryl. It is found in many fruits and vegetables, including raspberries, strawberries, cranberries, and pomegranates. | ellagic acid |
| isoliquiritigenin | A member of the class of chalcones that is trans-chalcone hydroxylated at C-2', -4 and -4'. | isoliquiritigenin |
| kojic acid | A pyranone that is 4H-pyran substituted by a hydroxy group at position 5, a hydroxymethyl group at position 2 and an oxo group at position 4. It has been isolated from the fungus Aspergillus oryzae. | kojic acid |
| mimosine | An L-alpha-amino acid that is propionic acid substituted by an amino group at position 2 and a 3-hydroxy-4-oxopyridin-1(4H)-yl group at position 3 (the 2S-stereoisomer). It a non-protein plant amino acid isolated from Mimosa pudica. | L-mimosine zwitterion; L-mimosine |
| papyriflavonol a | A pentahydroxyflavone that is flavone substituted with hydroxy groups at positions 3, 5, 7, 3' and 4' and prenyl groups at positions 6 and 5'. Isolated from Broussonetia papyrifera, it exhibits inhibitory activity against phospholipase A2 and tyrosinase. | papyriflavonol A |
| phenylthiourea | A member of the class of thioureas that is thiourea in which one of the hydrogens is replaced by a phenyl group. Depending on their genetic makeup, humans find it either very bitter-tasting or tasteless. This unusual property resulted in N-phenylthiourea being used in paternity testing prior to the advent of DNA testing. | N-phenylthiourea |
| quercitrin | A quercetin O-glycoside that is quercetin substituted by a alpha-L-rhamnosyl moiety at position 3 via a glycosidic linkage. | quercitrin |
| rubrofusarin | A member of the class of benzochromenones that is benzo[g]chromen-4-one carrying two additional hydroxy substituents at positions 5 and 6 as well as methyl and methoxy substituents at positions 2 and 8 respectively. An orange polyketide pigment that is a common intermediate in many different fungal biosynthetic pathways. | rubrofusarin |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 1 | Homo sapiens (human) | Potency | 7.5231 | 1 | 4 |
| 15-lipoxygenase, partial | Homo sapiens (human) | Potency | 5.0119 | 1 | 1 |
| 2,3-bisphosphoglycerate-independent phosphoglycerate mutase | Leishmania major strain Friedlin | Potency | 37.9330 | 1 | 1 |
| 67.9K protein | Vaccinia virus | Potency | 16.8037 | 2 | 2 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 62.6947 | 1 | 1 |
| aldehyde dehydrogenase 1 family, member A1 | Homo sapiens (human) | Potency | 39.8107 | 1 | 1 |
| Alpha-synuclein | Homo sapiens (human) | Potency | 34.0620 | 1 | 2 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Potency | 16.3601 | 1 | 1 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 6.6918 | 1 | 2 |
| AR protein | Homo sapiens (human) | Potency | 40.4971 | 4 | 7 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 62.0371 | 2 | 2 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 10.9845 | 4 | 4 |
| Ataxin-2 | Homo sapiens (human) | Potency | 51.7992 | 2 | 3 |
| ATP-dependent phosphofructokinase | Trypanosoma brucei brucei TREU927 | Potency | 20.2964 | 2 | 3 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 65.1393 | 1 | 2 |
| atrial natriuretic peptide receptor 1 precursor | Homo sapiens (human) | Potency | 30.1313 | 1 | 1 |
| atrial natriuretic peptide receptor 2 precursor | Homo sapiens (human) | Potency | 26.1216 | 1 | 1 |
| Bloom syndrome protein isoform 1 | Homo sapiens (human) | Potency | 23.8407 | 2 | 5 |
| bromodomain adjacent to zinc finger domain 2B | Homo sapiens (human) | Potency | 0.7943 | 1 | 1 |
| cellular tumor antigen p53 isoform a | Homo sapiens (human) | Potency | 14.7506 | 2 | 3 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 12.7377 | 1 | 5 |
| Chain A, ATP-DEPENDENT DNA HELICASE Q1 | Homo sapiens (human) | Potency | 1.2233 | 2 | 4 |
| Chain A, Beta-lactamase | Escherichia coli K-12 | Potency | 84.2180 | 1 | 2 |
| Chain A, HADH2 protein | Homo sapiens (human) | Potency | 7.5293 | 2 | 4 |
| Chain A, JmjC domain-containing histone demethylation protein 3A | Homo sapiens (human) | Potency | 18.0035 | 1 | 3 |
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 13.2092 | 3 | 8 |
| Chain A, Putative fructose-1,6-bisphosphate aldolase | Giardia intestinalis | Potency | 9.9982 | 2 | 4 |
| Chain A, TYROSYL-DNA PHOSPHODIESTERASE | Homo sapiens (human) | Potency | 0.0562 | 2 | 4 |
| Chain B, HADH2 protein | Homo sapiens (human) | Potency | 7.5293 | 2 | 4 |
| chromobox protein homolog 1 | Homo sapiens (human) | Potency | 40.4000 | 2 | 4 |
| core-binding factor subunit beta isoform 2 | Homo sapiens (human) | Potency | 0.3604 | 2 | 2 |
| cytochrome P450 2C19 precursor | Homo sapiens (human) | Potency | 17.8020 | 1 | 2 |
| cytochrome P450 2C9 precursor | Homo sapiens (human) | Potency | 23.8770 | 1 | 2 |
| cytochrome P450 3A4 isoform 1 | Homo sapiens (human) | Potency | 6.9906 | 2 | 4 |
| cytochrome P450 family 3 subfamily A polypeptide 4 | Homo sapiens (human) | Potency | 2.1317 | 1 | 1 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 5.4926 | 1 | 1 |
| D(1A) dopamine receptor | Homo sapiens (human) | Potency | 15.8489 | 1 | 1 |
| DNA polymerase beta | Homo sapiens (human) | Potency | 0.1585 | 1 | 1 |
| DNA polymerase eta isoform 1 | Homo sapiens (human) | Potency | 16.5058 | 1 | 3 |
| DNA polymerase iota isoform a (long) | Homo sapiens (human) | Potency | 43.4628 | 1 | 7 |
| DNA polymerase kappa isoform 1 | Homo sapiens (human) | Potency | 26.7553 | 1 | 7 |
| endonuclease IV | Escherichia coli | Potency | 10.2918 | 2 | 2 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 43.7940 | 8 | 15 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 18.2462 | 2 | 5 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 45.9029 | 5 | 7 |
| euchromatic histone-lysine N-methyltransferase 2 | Homo sapiens (human) | Potency | 28.7927 | 1 | 5 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 0.0063 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | Potency | 19.9526 | 1 | 1 |
| flap endonuclease 1 | Homo sapiens (human) | Potency | 36.1120 | 1 | 6 |
| fructose-bisphosphate aldolase A | Oryctolagus cuniculus (rabbit) | Potency | 63.0957 | 1 | 1 |
| GABA theta subunit | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-1 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-2 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-3 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-4 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-5 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit alpha-6 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-1 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-2 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit beta-3 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit delta | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit epsilon | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-1 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-2 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit gamma-3 | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| Gamma-aminobutyric acid receptor subunit pi | Rattus norvegicus (Norway rat) | Potency | 6.9906 | 1 | 2 |
| geminin | Homo sapiens (human) | Potency | 13.8985 | 4 | 6 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 59.2476 | 2 | 4 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| GLS protein | Homo sapiens (human) | Potency | 14.8297 | 2 | 5 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 11.2637 | 6 | 9 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 4.6609 | 2 | 3 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | Potency | 0.0141 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 13.8825 | 2 | 2 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | Potency | 0.0141 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | Potency | 0.0141 | 1 | 1 |
| glyceraldehyde-3-phosphate dehydrogenase isoform 1 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| Guanine nucleotide-binding protein G | Homo sapiens (human) | Potency | 56.2341 | 1 | 1 |
| heat shock 70kDa protein 5 (glucose-regulated protein, 78kDa) | Homo sapiens (human) | Potency | 23.3288 | 1 | 3 |
| hemoglobin subunit beta | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Histamine H2 receptor | Cavia porcellus (domestic guinea pig) | Potency | 15.8399 | 2 | 10 |
| histone acetyltransferase KAT2A isoform 1 | Homo sapiens (human) | Potency | 25.1189 | 1 | 1 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 63.9030 | 1 | 3 |
| histone-lysine N-methyltransferase 2A isoform 2 precursor | Homo sapiens (human) | Potency | 21.4215 | 1 | 2 |
| IDH1 | Homo sapiens (human) | Potency | 13.0295 | 1 | 2 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 32.9838 | 1 | 2 |
| Inositol monophosphatase 1 | Rattus norvegicus (Norway rat) | Potency | 15.8489 | 1 | 1 |
| Integrin alpha-IIb | Homo sapiens (human) | Potency | 0.0398 | 1 | 1 |
| Integrin beta-3 | Homo sapiens (human) | Potency | 0.0398 | 1 | 1 |
| Interferon beta | Homo sapiens (human) | Potency | 34.9872 | 1 | 6 |
| interleukin 8 | Homo sapiens (human) | Potency | 74.9780 | 1 | 1 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 7.6267 | 1 | 3 |
| lethal factor (plasmid) | Bacillus anthracis str. A2012 | Potency | 16.3114 | 1 | 2 |
| lethal(3)malignant brain tumor-like protein 1 isoform I | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 35.9698 | 3 | 7 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 4.4668 | 1 | 1 |
| M-phase phosphoprotein 8 | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 18.5979 | 2 | 11 |
| mitogen-activated protein kinase 1 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| muscleblind-like protein 1 isoform 1 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| neuropeptide S receptor isoform A | Homo sapiens (human) | Potency | 31.6228 | 1 | 1 |
| nonstructural protein 1 | Influenza A virus (A/WSN/1933(H1N1)) | Potency | 15.8489 | 1 | 1 |
| Nrf2 | Homo sapiens (human) | Potency | 16.5928 | 2 | 2 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 36.6996 | 3 | 7 |
| Nuclear receptor ROR-gamma | Homo sapiens (human) | Potency | 4.3080 | 1 | 2 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 15.8637 | 2 | 7 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 28.2312 | 3 | 8 |
| P53 | Homo sapiens (human) | Potency | 50.1187 | 1 | 1 |
| peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Homo sapiens (human) | Potency | 11.2951 | 2 | 2 |
| peripheral myelin protein 22 | Rattus norvegicus (Norway rat) | Potency | 16.1366 | 1 | 1 |
| peripheral myelin protein 22 isoform 1 | Homo sapiens (human) | Potency | 15.1014 | 1 | 1 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 38.6455 | 1 | 2 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 31.0212 | 2 | 2 |
| phosphoglycerate kinase | Trypanosoma brucei brucei TREU927 | Potency | 6.9385 | 2 | 3 |
| phosphopantetheinyl transferase | Bacillus subtilis | Potency | 79.4328 | 1 | 2 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | Potency | 3.7842 | 1 | 2 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 3.9811 | 1 | 1 |
| PPM1D protein | Homo sapiens (human) | Potency | 34.9873 | 1 | 4 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 49.4523 | 2 | 4 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 39.8107 | 1 | 1 |
| Rap guanine nucleotide exchange factor 3 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| Rap guanine nucleotide exchange factor 4 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 16.1241 | 2 | 6 |
| regulator of G-protein signaling 4 | Homo sapiens (human) | Potency | 79.4328 | 1 | 1 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 49.0291 | 3 | 9 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 40.6713 | 2 | 3 |
| runt-related transcription factor 1 isoform AML1b | Homo sapiens (human) | Potency | 0.3604 | 2 | 2 |
| serine-protein kinase ATM isoform a | Homo sapiens (human) | Potency | 29.8816 | 1 | 2 |
| serine/threonine-protein kinase mTOR isoform 1 | Homo sapiens (human) | Potency | 26.1216 | 1 | 1 |
| serine/threonine-protein kinase PLK1 | Homo sapiens (human) | Potency | 8.4368 | 1 | 1 |
| Smad3 | Homo sapiens (human) | Potency | 19.9526 | 1 | 1 |
| snurportin-1 | Homo sapiens (human) | Potency | 32.9838 | 1 | 2 |
| Spike glycoprotein | Severe acute respiratory syndrome-related coronavirus | Potency | 19.9526 | 1 | 1 |
| TAR DNA-binding protein 43 | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 20.9226 | 2 | 5 |
| thioredoxin glutathione reductase | Schistosoma mansoni | Potency | 56.2341 | 1 | 1 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 17.6150 | 3 | 4 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 51.3689 | 2 | 7 |
| thyroid hormone receptor beta isoform a | Homo sapiens (human) | Potency | 32.4648 | 1 | 2 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 32.2285 | 3 | 5 |
| transcriptional regulator ERG isoform 3 | Homo sapiens (human) | Potency | 10.0000 | 1 | 1 |
| ubiquitin carboxyl-terminal hydrolase 2 isoform a | Homo sapiens (human) | Potency | 1.1220 | 1 | 1 |
| USP1 protein, partial | Homo sapiens (human) | Potency | 56.2509 | 2 | 4 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 17.6698 | 1 | 1 |
| vitamin D3 receptor isoform VDRA | Homo sapiens (human) | Potency | 60.0392 | 1 | 4 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 27.7509 | 1 | 1 |
| WRN | Homo sapiens (human) | Potency | 28.1838 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 17-beta-hydroxysteroid dehydrogenase type 1 | Homo sapiens (human) | IC50 | 2.8300 | 1 | 1 |
| 17-beta-hydroxysteroid dehydrogenase type 2 | Homo sapiens (human) | IC50 | 0.3600 | 1 | 1 |
| 3-oxoacyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 8.3000 | 1 | 1 |
| 5-lipoxygenase | Bos taurus (cattle) | IC50 | 30.0000 | 1 | 1 |
| 5'-nucleotidase | Homo sapiens (human) | IC50 | 1.8500 | 1 | 1 |
| 5'-nucleotidase | Mus musculus (house mouse) | IC50 | 0.0400 | 1 | 1 |
| 72 kDa type IV collagenase | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
| acetyl-CoA acetyltransferase/HMG-CoA reductase | Enterococcus faecalis | IC50 | 1,265.3900 | 1 | 1 |
| Acetylcholinesterase | Electrophorus electricus (electric eel) | IC50 | 132.9200 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | IC50 | 2,000.0000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | Ki | 10.5700 | 3 | 3 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | IC50 | 2,000.0000 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | Ki | 7.6150 | 2 | 2 |
| Aldehyde oxidase 1 | Cavia porcellus (domestic guinea pig) | Ki | 4.5300 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Bos taurus (cattle) | IC50 | 10.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member B1 | Homo sapiens (human) | IC50 | 0.6675 | 2 | 4 |
| Aldo-keto reductase family 1 member B1 | Rattus norvegicus (Norway rat) | IC50 | 0.1200 | 2 | 3 |
| Aldo-keto reductase family 1 member B1 | Sus scrofa (pig) | IC50 | 95.0000 | 1 | 1 |
| Aldo-keto reductase family 1 member C21 | Mus musculus (house mouse) | IC50 | 33.3000 | 1 | 1 |
| ALK tyrosine kinase receptor | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Alpha-1A adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| Alpha-1B adrenergic receptor | Homo sapiens (human) | IC50 | 8.3300 | 1 | 1 |
| Alpha-1B adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| Alpha-1D adrenergic receptor | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| Amine oxidase [flavin-containing] A | Rattus norvegicus (Norway rat) | IC50 | 15.6000 | 2 | 2 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | IC50 | 47.2000 | 1 | 1 |
| Amyloid-beta precursor protein | Homo sapiens (human) | IC50 | 139.9000 | 3 | 3 |
| Angiopoietin-1 receptor | Homo sapiens (human) | IC50 | 0.2600 | 1 | 1 |
| Angiotensin-converting enzyme | Homo sapiens (human) | IC50 | 5,000.0000 | 1 | 1 |
| Arginase | Leishmania amazonensis | IC50 | 12.2000 | 1 | 1 |
| Arginase | Leishmania amazonensis | Ki | 7.9000 | 1 | 1 |
| Aromatase | Homo sapiens (human) | IC50 | 3.8000 | 1 | 1 |
| Aurora kinase A | Homo sapiens (human) | IC50 | 2.4800 | 1 | 1 |
| Aurora kinase B | Homo sapiens (human) | IC50 | 3.4200 | 2 | 2 |
| Autoinducer 2-binding periplasmic protein LuxP | Vibrio harveyi | IC50 | 4.0000 | 1 | 1 |
| Beta-secretase 1 | Homo sapiens (human) | IC50 | 29.4667 | 3 | 3 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | IC50 | 23.3000 | 3 | 3 |
| Bifunctional epoxide hydrolase 2 | Homo sapiens (human) | Ki | 48.4500 | 2 | 2 |
| cAMP-dependent protein kinase catalytic subunit alpha | Bos taurus (cattle) | IC50 | 0.6000 | 1 | 1 |
| cAMP-dependent protein kinase catalytic subunit alpha | Homo sapiens (human) | IC50 | 2.0500 | 2 | 2 |
| cAMP-dependent protein kinase catalytic subunit beta | Homo sapiens (human) | IC50 | 2.0500 | 2 | 2 |
| cAMP-dependent protein kinase catalytic subunit gamma | Homo sapiens (human) | IC50 | 2.0500 | 2 | 2 |
| Canalicular multispecific organic anion transporter 1 | Rattus norvegicus (Norway rat) | Ki | 10.0000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | Ki | 73.9200 | 5 | 6 |
| Carbonic anhydrase 12 | Homo sapiens (human) | Ki | 4.6312 | 4 | 4 |
| Carbonic anhydrase 13 | Homo sapiens (human) | Ki | 4.2400 | 1 | 1 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | Ki | 10.3000 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | Ki | 8.9100 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | Ki | 77.6033 | 5 | 6 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ki | 10.5000 | 1 | 1 |
| Carbonic anhydrase 4 | Homo sapiens (human) | Ki | 4.6464 | 2 | 2 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | Ki | 7.5900 | 1 | 1 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | Ki | 12.7000 | 1 | 1 |
| Carbonic anhydrase 6 | Homo sapiens (human) | Ki | 7.0600 | 1 | 1 |
| Carbonic anhydrase 7 | Homo sapiens (human) | Ki | 5.0381 | 3 | 3 |
| Carbonic anhydrase 9 | Homo sapiens (human) | Ki | 44.5850 | 2 | 2 |
| Casein kinase II subunit alpha | Homo sapiens (human) | IC50 | 0.0400 | 3 | 3 |
| Casein kinase II subunit alpha | Homo sapiens (human) | Ki | 0.0200 | 1 | 1 |
| Casein kinase II subunit alpha | Rattus norvegicus (Norway rat) | IC50 | 0.0400 | 1 | 1 |
| Casein kinase II subunit alpha' | Homo sapiens (human) | IC50 | 0.0400 | 2 | 2 |
| Casein kinase II subunit beta | Homo sapiens (human) | IC50 | 0.0400 | 2 | 2 |
| Casein kinase II subunit beta | Rattus norvegicus (Norway rat) | IC50 | 0.0400 | 1 | 1 |
| Chain A, Casein kinase II subunit alpha | Homo sapiens (human) | Ki | 0.0200 | 1 | 1 |
| Chain A, PROTEIN (CATECHOL OXIDASE) | Ipomoea batatas (sweet potato) | IC50 | 43.0000 | 1 | 1 |
| Chain A, RNA-directed RNA polymerase NS5 | Dengue virus 2 16681-PDK53 | IC50 | 57.6600 | 1 | 1 |
| Collagenase 3 | Homo sapiens (human) | IC50 | 0.0140 | 1 | 1 |
| Cruzipain | Trypanosoma cruzi | IC50 | 142.0000 | 2 | 2 |
| Cyclin-A1 | Homo sapiens (human) | IC50 | 3.3900 | 1 | 1 |
| Cyclin-A2 | Homo sapiens (human) | IC50 | 3.3900 | 1 | 1 |
| Cyclin-dependent kinase 2 | Homo sapiens (human) | IC50 | 3.3900 | 1 | 1 |
| Cyclin-dependent kinase 4 | Homo sapiens (human) | IC50 | 1.0900 | 1 | 1 |
| Cysteine protease ATG4B | Homo sapiens (human) | IC50 | 4.2500 | 2 | 2 |
| Cytochrome P450 1A1 | Homo sapiens (human) | IC50 | 0.0560 | 1 | 1 |
| Cytochrome P450 1A2 | Homo sapiens (human) | IC50 | 0.7650 | 2 | 2 |
| Cytochrome P450 1B1 | Homo sapiens (human) | IC50 | 0.0170 | 1 | 1 |
| Cytochrome P450 2C19 | Homo sapiens (human) | IC50 | 12.4446 | 1 | 2 |
| Cytochrome P450 2D6 | Homo sapiens (human) | IC50 | 2.5195 | 2 | 2 |
| Cytochrome P450 2D6 | Homo sapiens (human) | Ki | 1.9500 | 1 | 1 |
| Cytochrome P450 3A4 | Homo sapiens (human) | IC50 | 0.2690 | 1 | 1 |
| D-amino-acid oxidase | Homo sapiens (human) | IC50 | 2.0000 | 1 | 1 |
| D-amino-acid oxidase | Sus scrofa (pig) | IC50 | 2.0000 | 1 | 1 |
| Deoxyhypusine hydroxylase | Homo sapiens (human) | IC50 | 5.0000 | 1 | 1 |
| DNA dC->dU-editing enzyme APOBEC-3G isoform 1 | Homo sapiens (human) | IC50 | 0.4500 | 1 | 1 |
| DNA polymerase eta | Homo sapiens (human) | IC50 | 0.0620 | 1 | 1 |
| DNA polymerase iota | Homo sapiens (human) | IC50 | 0.0620 | 1 | 1 |
| DNA primase | Mycobacterium tuberculosis CDC1551 | IC50 | 100.0000 | 1 | 1 |
| dual specificity protein phosphatase 3 | Homo sapiens (human) | IC50 | 1.1050 | 2 | 2 |
| dual specificity protein phosphatase 6 | Rattus norvegicus (Norway rat) | IC50 | 39.5000 | 1 | 1 |
| Dual specificity tyrosine-phosphorylation-regulated kinase 1A | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Ectonucleoside triphosphate diphosphohydrolase 1 | Mus musculus (house mouse) | IC50 | 0.5000 | 1 | 1 |
| ELAV-like protein 3 | Homo sapiens (human) | IC50 | 0.6000 | 1 | 1 |
| Enoyl-acyl-carrier protein reductase | Plasmodium falciparum (malaria parasite P. falciparum) | IC50 | 5.0000 | 1 | 1 |
| Ephrin type-B receptor 4 | Homo sapiens (human) | IC50 | 1.8300 | 1 | 1 |
| Epidermal growth factor receptor | Homo sapiens (human) | IC50 | 0.6900 | 1 | 1 |
| Estrogen receptor | Homo sapiens (human) | IC50 | 1.8700 | 1 | 1 |
| Estrogen receptor beta | Homo sapiens (human) | IC50 | 0.2690 | 1 | 1 |
| eukaryotic translation initiation factor 4 gamma 1 isoform 4 | Homo sapiens (human) | IC50 | 47.6714 | 1 | 1 |
| eukaryotic translation initiation factor 4E isoform 1 | Mus musculus (house mouse) | IC50 | 47.6714 | 1 | 1 |
| Focal adhesion kinase 1 | Homo sapiens (human) | IC50 | 3.1100 | 1 | 1 |
| G-protein coupled receptor 35 | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| G1/S-specific cyclin-D1 | Homo sapiens (human) | IC50 | 1.0900 | 1 | 1 |
| Glutathione reductase, mitochondrial | Homo sapiens (human) | IC50 | 22.8000 | 1 | 1 |
| Glutathione S-transferase | Plasmodium falciparum 3D7 | IC50 | 74.4000 | 1 | 1 |
| Glutathione S-transferase Mu 1 | Mus musculus (house mouse) | IC50 | 100.0000 | 1 | 1 |
| Glutathione S-transferase P | Homo sapiens (human) | IC50 | 63.5500 | 2 | 2 |
| Glycogen synthase kinase-3 beta | Homo sapiens (human) | IC50 | 7.5000 | 1 | 1 |
| heat shock 70kDa protein 1A | Homo sapiens (human) | IC50 | 66.9200 | 3 | 3 |
| heat shock cognate 71 kDa protein isoform 1 | Homo sapiens (human) | IC50 | 99.6000 | 2 | 2 |
| heat shock cognate 71 kDa protein isoform 2 | Homo sapiens (human) | IC50 | 99.6000 | 2 | 2 |
| Hepatocyte growth factor receptor | Homo sapiens (human) | IC50 | 0.5800 | 1 | 1 |
| Inhibitor of nuclear factor kappa-B kinase subunit beta | Homo sapiens (human) | IC50 | 1.9800 | 1 | 1 |
| Inositol hexakisphosphate kinase 2 | Homo sapiens (human) | IC50 | 0.5000 | 1 | 1 |
| Inositol polyphosphate multikinase | Homo sapiens (human) | IC50 | 2.2000 | 1 | 1 |
| Insulin receptor | Homo sapiens (human) | IC50 | 0.3400 | 1 | 1 |
| Insulin-like growth factor 1 receptor | Homo sapiens (human) | IC50 | 0.2500 | 1 | 1 |
| Integrase | Human immunodeficiency virus 1 | IC50 | 52.5500 | 4 | 4 |
| integrase, partial | Human immunodeficiency virus 1 | IC50 | 8.2720 | 2 | 2 |
| Interstitial collagenase | Homo sapiens (human) | IC50 | 0.0160 | 1 | 1 |
| lens epithelium-derived growth factor p75 | Homo sapiens (human) | IC50 | 8.2720 | 2 | 2 |
| likely tRNA 2'-phosphotransferase | Candida albicans SC5314 | IC50 | 0.2913 | 2 | 2 |
| M17 leucyl aminopeptidase | Plasmodium falciparum 3D7 | IC50 | 138.0800 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | IC50 | 4.7700 | 1 | 1 |
| Macrophage migration inhibitory factor | Homo sapiens (human) | Ki | 1.9500 | 1 | 1 |
| Maltase-glucoamylase, intestinal | Homo sapiens (human) | Ki | 2.3000 | 1 | 1 |
| Matrilysin | Homo sapiens (human) | IC50 | 0.0080 | 1 | 1 |
| Matrix metalloproteinase-9 | Homo sapiens (human) | IC50 | 0.0100 | 1 | 1 |
| Mcl-1 | Homo sapiens (human) | IC50 | 27.2850 | 2 | 2 |
| Mitogen-activated protein kinase 10 | Homo sapiens (human) | IC50 | 18.6750 | 1 | 4 |
| Mitogen-activated protein kinase 14 | Homo sapiens (human) | IC50 | 18.6750 | 1 | 4 |
| Mitogen-activated protein kinase kinase kinase 8 | Homo sapiens (human) | IC50 | 2.3700 | 1 | 1 |
| mothers against decapentaplegic homolog 3 isoform 1 | Homo sapiens (human) | IC50 | 0.1420 | 1 | 1 |
| Muscarinic acetylcholine receptor M1 | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 4 |
| Muscarinic acetylcholine receptor M2 | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 3 |
| Muscarinic acetylcholine receptor M3 | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 3 |
| Muscarinic acetylcholine receptor M4 | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 3 |
| Muscarinic acetylcholine receptor M5 | Rattus norvegicus (Norway rat) | IC50 | 0.5700 | 1 | 3 |
| NACHT, LRR and PYD domains-containing protein 3 | Homo sapiens (human) | IC50 | 5.8200 | 2 | 2 |
| Neuraminidase | Influenza A virus (A/USSR/90/1977(H1N1)) | IC50 | 115.1000 | 2 | 2 |
| Non-structural protein 1 | Dengue virus | IC50 | 1.7000 | 1 | 1 |
| NUAK family SNF1-like kinase 1 | Homo sapiens (human) | IC50 | 0.5100 | 1 | 1 |
| Nuclear factor NF-kappa-B p100 subunit | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| Nuclear factor NF-kappa-B p105 subunit | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| Nucleophosmin | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Oligo-1,6-glucosidase IMA1 | Saccharomyces cerevisiae S288C | IC50 | 160.0000 | 1 | 1 |
| P2Y purinoceptor 12 | Homo sapiens (human) | Ki | 10.0000 | 1 | 1 |
| Pancreatic triacylglycerol lipase | Sus scrofa (pig) | IC50 | 70.0000 | 1 | 1 |
| Platelet-derived growth factor receptor beta | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| Polymerase acidic protein | Influenza A virus (A/Puerto Rico/8/1934(H1N1)) | IC50 | 12.4446 | 1 | 2 |
| Polypeptide N-acetylgalactosaminyltransferase 2 | Homo sapiens (human) | IC50 | 1.7200 | 2 | 2 |
| Polyphenol oxidase 1 | Agaricus bisporus | IC50 | 13.6125 | 3 | 4 |
| Polyphenol oxidase 1 | Agaricus bisporus | Ki | 12.2000 | 1 | 1 |
| Polyphenol oxidase 2 | Agaricus bisporus | IC50 | 61.1832 | 110 | 116 |
| Polyphenol oxidase 2 | Agaricus bisporus | Ki | 74.1250 | 10 | 10 |
| Polyunsaturated fatty acid 5-lipoxygenase | Homo sapiens (human) | IC50 | 36.2500 | 3 | 4 |
| Polyunsaturated fatty acid 5-lipoxygenase | Rattus norvegicus (Norway rat) | IC50 | 35.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX12 | Homo sapiens (human) | IC50 | 8.7000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15 | Homo sapiens (human) | IC50 | 49.0000 | 1 | 1 |
| Polyunsaturated fatty acid lipoxygenase ALOX15B | Homo sapiens (human) | IC50 | 80.0000 | 2 | 3 |
| Prostaglandin E synthase | Homo sapiens (human) | IC50 | 1.1000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Homo sapiens (human) | IC50 | 46.7000 | 1 | 1 |
| Prostaglandin G/H synthase 1 | Bos taurus (cattle) | IC50 | 2,000.0000 | 3 | 3 |
| Prostaglandin G/H synthase 2 | Homo sapiens (human) | IC50 | 46.7000 | 1 | 1 |
| Prostaglandin G/H synthase 2 | Ovis aries (sheep) | IC50 | 2,000.0000 | 2 | 2 |
| Proteasome subunit beta type-5 | Homo sapiens (human) | IC50 | 4.8800 | 1 | 1 |
| Protein disulfide-isomerase | Homo sapiens (human) | Ki | 36.1000 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase receptor Ret | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | IC50 | 0.4667 | 3 | 3 |
| RAC-alpha serine/threonine-protein kinase | Homo sapiens (human) | IC50 | 3.3400 | 1 | 1 |
| Receptor tyrosine-protein kinase erbB-2 | Homo sapiens (human) | IC50 | 3.5400 | 1 | 1 |
| Receptor-type tyrosine-protein kinase FLT3 | Homo sapiens (human) | IC50 | 40.0000 | 1 | 1 |
| Renin | Homo sapiens (human) | IC50 | 0.9800 | 1 | 1 |
| Serine/threonine-protein kinase B-raf | Homo sapiens (human) | IC50 | 1.7600 | 1 | 1 |
| Serine/threonine-protein kinase pim-2 | Homo sapiens (human) | IC50 | 25.0000 | 1 | 1 |
| Serine/threonine-protein kinase PLK1 | Homo sapiens (human) | IC50 | 3.3400 | 1 | 1 |
| Serine/threonine-protein kinase PLK4 | Homo sapiens (human) | IC50 | 2.9700 | 1 | 1 |
| Solute carrier family 15 member 1 | Homo sapiens (human) | Ki | 22,000.0000 | 2 | 2 |
| Solute carrier family 15 member 2 | Homo sapiens (human) | Ki | 8,956.2550 | 1 | 2 |
| Solute carrier family 15 member 2 | Rattus norvegicus (Norway rat) | Ki | 9,000.0000 | 1 | 1 |
| Solute carrier family 22 member 6 | Homo sapiens (human) | IC50 | 0.2700 | 1 | 1 |
| Solute carrier organic anion transporter family member 1B3 | Homo sapiens (human) | Ki | 3.8250 | 4 | 4 |
| Squalene monooxygenase | Rattus norvegicus (Norway rat) | IC50 | 2.0000 | 1 | 1 |
| Stromelysin-1 | Homo sapiens (human) | IC50 | 0.0810 | 1 | 1 |
| Succinyl-diaminopimelate desuccinylase | Haemophilus influenzae Rd KW20 | IC50 | 100.0000 | 1 | 1 |
| Tat | Human immunodeficiency virus 1 | IC50 | 1.6690 | 1 | 1 |
| Thioredoxin reductase 1, cytoplasmic | Homo sapiens (human) | IC50 | 176.8000 | 2 | 2 |
| Thioredoxin reductase 1, cytoplasmic | Rattus norvegicus (Norway rat) | IC50 | 200.0000 | 1 | 1 |
| Thioredoxin reductase 2, mitochondrial | Homo sapiens (human) | IC50 | 176.8000 | 2 | 2 |
| Thioredoxin reductase 2, mitochondrial | Rattus norvegicus (Norway rat) | IC50 | 200.0000 | 1 | 1 |
| Thioredoxin reductase 3 | Homo sapiens (human) | IC50 | 176.8000 | 2 | 2 |
| Tissue alpha-L-fucosidase | Bos taurus (cattle) | IC50 | 89.0000 | 1 | 1 |
| Transcription factor p65 | Homo sapiens (human) | IC50 | 32.0000 | 1 | 1 |
| Translin-associated protein X | Homo sapiens (human) | IC50 | 3.5000 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | IC50 | 922.7414 | 20 | 22 |
| Tyrosinase | Mus musculus (house mouse) | IC50 | 530.5000 | 5 | 5 |
| Tyrosinase | Priestia megaterium | IC50 | 52.0000 | 1 | 1 |
| Tyrosinase | Homo sapiens (human) | Ki | 120.6667 | 3 | 3 |
| Tyrosinase | Mus musculus (house mouse) | Ki | 5,500.0000 | 1 | 1 |
| Tyrosinase | Danio rerio (zebrafish) | IC50 | 12,550.0000 | 2 | 2 |
| Tyrosine-protein kinase Fgr | Rattus norvegicus (Norway rat) | IC50 | 3.5000 | 1 | 1 |
| Tyrosine-protein kinase Lyn | Rattus norvegicus (Norway rat) | IC50 | 7.5000 | 1 | 1 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 55.0000 | 2 | 2 |
| Tyrosyl-DNA phosphodiesterase 1 | Homo sapiens (human) | IC50 | 55.0000 | 1 | 1 |
| Uncharacterized protein YOR062C | Saccharomyces cerevisiae S288C | IC50 | 19.0000 | 1 | 1 |
| unnamed protein product | Aspergillus oryzae RIB40 | IC50 | 52.7195 | 2 | 2 |
| Vascular endothelial growth factor receptor 2 | Homo sapiens (human) | IC50 | 0.7900 | 1 | 1 |
| Vascular endothelial growth factor receptor 3 | Homo sapiens (human) | IC50 | 1.5400 | 1 | 1 |
| Vif | Human immunodeficiency virus 1 | IC50 | 0.4500 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Bos taurus (cattle) | IC50 | 47.3000 | 1 | 1 |
| Xanthine dehydrogenase/oxidase | Homo sapiens (human) | IC50 | 423.4500 | 4 | 5 |