An EC 3.5.1.* (non-peptide linear amide C-N hydrolase) inhibitor that interferes with the action of amidase (EC 3.5.1.4).
ChEBI ID: 77941
| Member | Definition | Class |
|---|---|---|
| acetaldehyde | The aldehyde formed from acetic acid by reduction of the carboxy group. It is the most abundant carcinogen in tobacco smoke. | acetaldehyde |
| acetone | A methyl ketone that consists of propane bearing an oxo group at C2. | acetone |
| acetonitrile | A nitrile that is hydrogen cyanide in which the hydrogen has been replaced by a methyl group. | acetonitrile |
| ammonium hydroxide | An azane that consists of a single nitrogen atom covelently bonded to three hydrogen atoms. | ammonia |
| dimethyl sulfide | A methyl sulfide in which the sulfur atom is substituted by two methyl groups. It is produced naturally by some marine algae. | dimethyl sulfide |
| formaldehyde | An aldehyde resulting from the formal oxidation of methanol. | formaldehyde |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 23,184 (35.53) | 18.7374 |
| 1990's | 8,188 (12.55) | 18.2507 |
| 2000's | 12,266 (18.80) | 29.6817 |
| 2010's | 16,081 (24.65) | 24.3611 |
| 2020's | 5,527 (8.47) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 1,025 (1.46%) | 5.53% |
| Reviews | 3,064 (4.36%) | 6.00% |
| Case Studies | 1,815 (2.58%) | 4.05% |
| Observational | 44 (0.06%) | 0.25% |
| Other | 64,372 (91.54%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| acetylcholinesterase | Homo sapiens (human) | Potency | 47.4771 | 3 | 3 |
| activating transcription factor 6 | Homo sapiens (human) | Potency | 7.2412 | 1 | 1 |
| AR protein | Homo sapiens (human) | Potency | 0.8820 | 7 | 7 |
| Ataxin-2 | Homo sapiens (human) | Potency | 0.6394 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 0.6394 | 1 | 1 |
| caspase 7, apoptosis-related cysteine protease | Homo sapiens (human) | Potency | 71.7403 | 1 | 1 |
| caspase-3 | Cricetulus griseus (Chinese hamster) | Potency | 71.7403 | 1 | 1 |
| caspase-3 | Homo sapiens (human) | Potency | 71.7403 | 1 | 1 |
| Caspase-7 | Cricetulus griseus (Chinese hamster) | Potency | 71.7403 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 63.0124 | 2 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 5.0788 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 4.0238 | 9 | 9 |
| estrogen receptor 2 (ER beta) | Homo sapiens (human) | Potency | 80.4940 | 1 | 1 |
| estrogen-related nuclear receptor alpha | Homo sapiens (human) | Potency | 2.8857 | 6 | 7 |
| farnesoid X nuclear receptor | Homo sapiens (human) | Potency | 62.1976 | 3 | 3 |
| GLI family zinc finger 3 | Homo sapiens (human) | Potency | 0.1305 | 2 | 2 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 37.4450 | 3 | 4 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | Potency | 0.4034 | 1 | 1 |
| heat shock protein beta-1 | Homo sapiens (human) | Potency | 57.5187 | 2 | 2 |
| Histone H2A.x | Cricetulus griseus (Chinese hamster) | Potency | 118.2580 | 1 | 1 |
| hypoxia-inducible factor 1 alpha subunit | Homo sapiens (human) | Potency | 48.0366 | 2 | 2 |
| lamin isoform A-delta10 | Homo sapiens (human) | Potency | 0.1000 | 1 | 1 |
| nuclear factor erythroid 2-related factor 2 isoform 1 | Homo sapiens (human) | Potency | 37.1134 | 3 | 3 |
| nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a | Homo sapiens (human) | Potency | 64.5370 | 1 | 1 |
| nuclear receptor subfamily 1, group I, member 3 | Homo sapiens (human) | Potency | 33.3970 | 2 | 2 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 27.8622 | 4 | 4 |
| peroxisome proliferator-activated receptor delta | Homo sapiens (human) | Potency | 49.4845 | 3 | 3 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 4.5265 | 1 | 1 |
| pregnane X receptor | Rattus norvegicus (Norway rat) | Potency | 89.1251 | 1 | 1 |
| progesterone receptor | Homo sapiens (human) | Potency | 28.5603 | 1 | 1 |
| RAR-related orphan receptor gamma | Mus musculus (house mouse) | Potency | 2.1896 | 2 | 2 |
| retinoic acid nuclear receptor alpha variant 1 | Homo sapiens (human) | Potency | 16.0666 | 3 | 4 |
| retinoid X nuclear receptor alpha | Homo sapiens (human) | Potency | 29.2422 | 2 | 2 |
| SMAD family member 2 | Homo sapiens (human) | Potency | 21.9408 | 2 | 2 |
| SMAD family member 3 | Homo sapiens (human) | Potency | 21.9408 | 2 | 2 |
| TDP1 protein | Homo sapiens (human) | Potency | 18.0796 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 2.5808 | 3 | 4 |
| thyroid stimulating hormone receptor | Homo sapiens (human) | Potency | 48.1090 | 4 | 4 |
| thyrotropin-releasing hormone receptor | Homo sapiens (human) | Potency | 42.6993 | 2 | 2 |
| v-jun sarcoma virus 17 oncogene homolog (avian) | Homo sapiens (human) | Potency | 64.5370 | 1 | 1 |
| vitamin D (1,25- dihydroxyvitamin D3) receptor | Homo sapiens (human) | Potency | 30.7460 | 2 | 2 |
| Voltage-dependent calcium channel gamma-2 subunit | Mus musculus (house mouse) | Potency | 0.4034 | 1 | 1 |