An EC 3.1.3.* (phosphoric monoester hydrolase) inhibitor that interferes with the action of alkaline phosphatase (EC 3.1.3.1).
| Member | Definition | Class |
|---|
| adenosine monophosphate | A purine ribonucleoside 5'-monophosphate having adenine as the nucleobase. | adenosine 5'-monophosphate |
| aspartame | A dipeptide obtained by formal condensation of the alpha-carboxy group of L-aspartic acid with the amino group of methyl L-phenylalaninate. Commonly used as an artificial sweetener. | aspartame zwitterion; aspartame |
| homoarginine | An L-lysine derivative that is the L-enantiomer of homoarginine. | L-homoarginine |
| levamisole | A 6-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazole that has S configuration. It is used (generally as the monohydrochloride salt) to treat parasitic worm infections in pigs, sheep and cattle and was formerly used in humans as an adjuvant to chemotherapy for the treatment of various cancers. It is also widely used as an adulterant to coccaine. | levamisole |
| phenylalanine | The L-enantiomer of phenylalanine. | L-phenylalanine zwitterion; L-phenylalanine |
| vanadates | A vanadium oxoanion that is a trianion with formula VO4 in which the vanadium is in the +5 oxidation state and is attached to four oxygen atoms. | vanadate(3-) |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 2-dehydropantoate 2-reductase | Escherichia coli K-12 | Ki | 6,300.0000 | 1 | 1 |
| 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | Homo sapiens (human) | Ki | 19.2000 | 1 | 1 |
| 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 | Rattus norvegicus (Norway rat) | Ki | 40.0000 | 1 | 1 |
| 5'-nucleotidase | Rattus norvegicus (Norway rat) | IC50 | 50.2000 | 1 | 2 |
| Adenylate kinase 2, mitochondrial | Rattus norvegicus (Norway rat) | Ki | 80.0000 | 1 | 1 |
| Adenylate kinase isoenzyme 1 | Rattus norvegicus (Norway rat) | Ki | 580.0000 | 1 | 1 |
| Alcohol dehydrogenase E chain | Equus caballus (horse) | Ki | 38.0000 | 1 | 1 |
| Alcohol dehydrogenase S chain | Equus caballus (horse) | Ki | 38.0000 | 1 | 1 |
| Alkaline phosphatase, placental type | Homo sapiens (human) | IC50 | 400.0000 | 4 | 4 |
| Alkaline phosphatase, tissue-nonspecific isozyme | Homo sapiens (human) | IC50 | 46.8388 | 5 | 8 |
| Alkaline phosphatase, tissue-nonspecific isozyme | Homo sapiens (human) | Ki | 16.0000 | 1 | 1 |
| Alkaline phosphatase, tissue-nonspecific isozyme | Bos taurus (cattle) | IC50 | 42.2050 | 5 | 8 |
| Alkaline phosphatase, tissue-nonspecific isozyme | Bos taurus (cattle) | Ki | 1.8100 | 1 | 1 |
| Amine oxidase [flavin-containing] B | Rattus norvegicus (Norway rat) | IC50 | 0.4400 | 1 | 1 |
| Bile salt export pump | Homo sapiens (human) | IC50 | 1,000.0000 | 1 | 2 |
| Chain A, ADP-dependent glucokinase | Pyrococcus furiosus | Ki | 60.0000 | 1 | 1 |
| Chain A, AMINOPEPTIDASE | Streptomyces griseus | Ki | 12,700.0000 | 1 | 2 |
| Chain A, phosphodiesterase-nucleotide pyrophosphatase | Xanthomonas citri pv. citri str. 306 | Ki | 260.0000 | 1 | 1 |
| Chain A, Ribonuclease pancreatic | Bos taurus (cattle) | Ki | 46.0000 | 1 | 2 |
| Choline O-acetyltransferase | Homo sapiens (human) | IC50 | 1,800,000,000.0000 | 1 | 1 |
| Cytochrome P450 2C9 | Homo sapiens (human) | IC50 | 2.6000 | 1 | 1 |
| E3 ubiquitin-protein ligase XIAP | Homo sapiens (human) | IC50 | 80.2000 | 1 | 1 |
| Fructose-1,6-bisphosphatase 1 | Homo sapiens (human) | IC50 | 2.6436 | 11 | 11 |
| Fructose-1,6-bisphosphatase 1 | Sus scrofa (pig) | IC50 | 1.3000 | 2 | 2 |
| Glycine--tRNA ligase | Bombyx mori (domestic silkworm) | Ki | 80.0000 | 1 | 1 |
| Histamine H3 receptor | Rattus norvegicus (Norway rat) | IC50 | 0.8000 | 1 | 2 |
| Inosine-5'-monophosphate dehydrogenase | Escherichia coli K-12 | Ki | 450.0000 | 1 | 1 |
| Intestinal-type alkaline phosphatase | Bos taurus (cattle) | IC50 | 125.9640 | 7 | 10 |
| Intestinal-type alkaline phosphatase | Homo sapiens (human) | IC50 | 135.0456 | 6 | 9 |
| L-lactate dehydrogenase A chain | Homo sapiens (human) | IC50 | 500.0000 | 1 | 1 |
| Large neutral amino acids transporter small subunit 1 | Homo sapiens (human) | IC50 | 69.0000 | 2 | 2 |
| Large neutral amino acids transporter small subunit 1 | Rattus norvegicus (Norway rat) | Ki | 55.0000 | 1 | 1 |
| Phospholipase A-2-activating protein | Homo sapiens (human) | IC50 | 5.0000 | 1 | 3 |
| Protease | Human immunodeficiency virus 1 | Ki | 0.0002 | 1 | 1 |
| Proto-oncogene tyrosine-protein kinase Src | Homo sapiens (human) | IC50 | 0.1000 | 1 | 1 |
| Receptor-type tyrosine-protein phosphatase F | Homo sapiens (human) | IC50 | 22.5633 | 1 | 3 |
| Transient receptor potential cation channel subfamily M member 2 | Homo sapiens (human) | IC50 | 70.0000 | 2 | 2 |
| Tyrosine-protein phosphatase non-receptor type 1 | Homo sapiens (human) | IC50 | 16.9288 | 2 | 4 |
| Tyrosine-protein phosphatase non-receptor type 11 | Homo sapiens (human) | IC50 | 22.5633 | 1 | 3 |
| Tyrosine-protein phosphatase non-receptor type 2 | Homo sapiens (human) | IC50 | 22.5633 | 1 | 3 |
| Tyrosine-protein phosphatase non-receptor type 6 | Homo sapiens (human) | IC50 | 22.5633 | 1 | 3 |
| Voltage-dependent calcium channel subunit alpha-2/delta-1 | Mus musculus (house mouse) | Ki | 0.9786 | 1 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|
| 5'-nucleotidase | Homo sapiens (human) | Km | 14.0000 | 1 | 1 |
| Adenosine deaminase-like protein | Homo sapiens (human) | Km | 32.8000 | 1 | 1 |
| Adenosine receptor A1 | Rattus norvegicus (Norway rat) | KA | 0.0130 | 1 | 1 |
| Adenosine receptor A2a | Rattus norvegicus (Norway rat) | KA | 0.0130 | 1 | 2 |
| Adenylate kinase 2, mitochondrial | Homo sapiens (human) | Km | 380.0000 | 1 | 1 |
| Adenylate kinase 2, mitochondrial | Rattus norvegicus (Norway rat) | Km | 85.0000 | 2 | 2 |
| Adenylate kinase isoenzyme 1 | Homo sapiens (human) | Km | 175.0000 | 1 | 1 |
| Adenylate kinase isoenzyme 1 | Rattus norvegicus (Norway rat) | Km | 580.0000 | 1 | 1 |
| Alkaline phosphatase, tissue-nonspecific isozyme | Homo sapiens (human) | Km | 441.0000 | 1 | 1 |
| Carbonic anhydrase | Candida albicans SC5314 | KA | 15.5000 | 1 | 1 |
| Carbonic anhydrase | Methanosarcina thermophila | KA | 68.0000 | 1 | 1 |
| Carbonic anhydrase | Methanothermobacter thermautotrophicus str. Delta H | Ka | 70.0000 | 1 | 1 |
| Carbonic anhydrase | Saccharomyces cerevisiae S288C | Ka | 86.0000 | 2 | 2 |
| Carbonic anhydrase | Cryptococcus neoformans var. grubii | KA | 44.1000 | 1 | 1 |
| Carbonic anhydrase | Nakaseomyces glabratus CBS 138 | Ka | 24.1000 | 1 | 1 |
| Carbonic anhydrase 1 | Homo sapiens (human) | KA | 0.0700 | 12 | 12 |
| Carbonic anhydrase 12 | Homo sapiens (human) | KA | 1.3900 | 2 | 2 |
| Carbonic anhydrase 13 | Homo sapiens (human) | KA | 1.0000 | 1 | 1 |
| Carbonic anhydrase 13 | Mus musculus (house mouse) | KA | 1.0200 | 1 | 1 |
| Carbonic anhydrase 14 | Homo sapiens (human) | KA | 0.2400 | 2 | 2 |
| Carbonic anhydrase 15 | Mus musculus (house mouse) | KA | 33.4000 | 1 | 1 |
| Carbonic anhydrase 2 | Homo sapiens (human) | KA | 0.0130 | 14 | 14 |
| Carbonic anhydrase 3 | Homo sapiens (human) | Ka | 34.8000 | 3 | 3 |
| Carbonic anhydrase 4 | Homo sapiens (human) | KA | 28.3000 | 4 | 4 |
| Carbonic anhydrase 5A, mitochondrial | Homo sapiens (human) | KA | 9.8050 | 2 | 2 |
| Carbonic anhydrase 5B, mitochondrial | Homo sapiens (human) | KA | 10.2250 | 2 | 2 |
| Carbonic anhydrase 6 | Homo sapiens (human) | KA | 1.2200 | 3 | 3 |
| Carbonic anhydrase 7 | Homo sapiens (human) | KA | 10.4650 | 2 | 2 |
| Carbonic anhydrase 9 | Homo sapiens (human) | KA | 16.1500 | 2 | 2 |
| Carbonic anhydrase-like protein, putative | Trypanosoma cruzi strain CL Brener | KA | 12.1000 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 1 | Rattus norvegicus (Norway rat) | KA | 10.9300 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2A | Rattus norvegicus (Norway rat) | KA | 10.9300 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2B | Rattus norvegicus (Norway rat) | KA | 10.9300 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2C | Rattus norvegicus (Norway rat) | KA | 10.9300 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 2D | Rattus norvegicus (Norway rat) | KA | 10.9300 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3A | Rattus norvegicus (Norway rat) | KA | 10.9300 | 1 | 1 |
| Glutamate receptor ionotropic, NMDA 3B | Rattus norvegicus (Norway rat) | KA | 10.9300 | 1 | 1 |
| GTP:AMP phosphotransferase AK3, mitochondrial | Rattus norvegicus (Norway rat) | Km | 85.0000 | 2 | 2 |
| Large neutral amino acids transporter small subunit 1 | Homo sapiens (human) | Km | 12.6000 | 2 | 2 |
| Monocarboxylate transporter 10 | Rattus norvegicus (Norway rat) | Km | 7,020.0000 | 1 | 1 |
| Plasma kallikrein | Homo sapiens (human) | KA | 10.4500 | 1 | 1 |
| SLC16A10 protein | Homo sapiens (human) | Km | 740.5000 | 1 | 1 |