Page last updated: 2024-09-27

Ankylosis of Teeth

Solid fixation of a tooth resulting from fusion of the cementum and alveolar bone, with obliteration of the periodontal ligament. It is uncommon in the deciduous dentition and very rare in permanent teeth. (Jablonski's Dictionary of Dentistry, 1992)

Synonyms(6)

Synonym
Ankylosis, Tooth
Ankylosis of Teeth
Dentoalveolar Ankylosis
Dental Ankylosis
Tooth Ankylosis
Ankylosis, Dentoalveolar

Research

Studies (61)

TimeframeStudies, This Condition (%)All Conditions %
pre-19900 (0.00)23.3326
1990's4 (6.56)12.5806
2000's33 (54.10)18.1394
2010's19 (31.15)28.8240
2020's5 (8.20)9.53
DrugIndicatedRelationship StrengthStudiesTrials
lactic acid0low10
nickel0low20
acetaminophen0low10
acetazolamide0low10
alendronate0low30
cimetidine0low10
etidronate0low10
sodium fluoride0low50
thyroxine0low10
prednisone0low10
edetic acid0low20
triamcinolone acetonide0medium11
limestone0low20
zinc oxide0low10
titanium0low70
calcium phosphate, dibasic, anhydrous0low10
calcium phosphate, monobasic, anhydrous0low10
tricalcium phosphate0low50
fluorides0low20
gallium nitrate0low10
zoledronic acid0low10
htr composite0low10
calcium pyrophosphate0low10
osteoprotegerin0low20
misoprostol0low10
phenylephrine hydrochloride0low10
gallium0low10
chlorhexidine0low10
acid phosphatase0low40
jaw0low20
vendex0low10
sodium hypochlorite0low20
ascorbic acid0low10
tetracycline0low20
oxytetracycline, anhydrous0low10
salicylates0low10
demeclocycline0medium11
ledermix0medium11
epidermal growth factor0low10
transforming growth factor beta0low120
guanine0low10

Protein Targets (505)

ProteinPotency MeasurementsInhibition MeasurementsActivation MeasurementsDrugs
RAR-related orphan receptor gamma7007
ATAD5 protein, partial4004
GLS protein3003
Microtubule-associated protein tau3003
Smad31001
aldehyde dehydrogenase 1 family, member A14004
thyroid stimulating hormone receptor3003
nuclear receptor subfamily 1, group I, member 36006
progesterone receptor6006
EWS/FLI fusion protein4004
retinoic acid nuclear receptor alpha variant 19009
retinoid X nuclear receptor alpha4004
estrogen-related nuclear receptor alpha120012
estrogen nuclear receptor alpha120012
peroxisome proliferator activated receptor gamma5005
aryl hydrocarbon receptor6006
chromobox protein homolog 16006
thyroid hormone receptor beta isoform 25005
peripheral myelin protein 227007
cytochrome P450 3A4 isoform 13003
Gamma-aminobutyric acid receptor subunit pi3104
ATP-binding cassette sub-family C member 30606
Multidrug resistance-associated protein 40606
Solute carrier family 22 member 60404
Carbonic anhydrase 120417
UDP-glucuronosyltransferase 1A90001
Bile salt export pump0101
Voltage-dependent calcium channel gamma-2 subunit4004
Bile salt export pump0707
Cytochrome P450 2B10001
Cytochrome P450 1A10001
Carbonic anhydrase 106111
Carbonic anhydrase 206110
Myoglobin0101
Cytochrome P450 1A10012
Cytochrome P450 1A20102
Prostaglandin G/H synthase 10101
Carbonic anhydrase 30316
Cytochrome P450 3A40303
Cytochrome P450 2D60303
Cytochrome P450 2C9 0303
Polyunsaturated fatty acid lipoxygenase ALOX150101
Gamma-aminobutyric acid receptor subunit beta-13104
Sulfotransferase 1A1 0001
Gamma-aminobutyric acid receptor subunit delta3104
Gamma-aminobutyric acid receptor subunit gamma-23104
UDP-glucuronosyltransferase 1-60001
Glutamate receptor 24004
Gamma-aminobutyric acid receptor subunit alpha-53104
Gamma-aminobutyric acid receptor subunit alpha-33104
Arachidonate 5-lipoxygenase-activating protein0202
UDP-glucuronosyltransferase 1A1 0102
Carbonic anhydrase 40416
Prostaglandin G/H synthase 10101
Carbonic anhydrase 60315
Gamma-aminobutyric acid receptor subunit gamma-13104
Gamma-aminobutyric acid receptor subunit alpha-23104
Gamma-aminobutyric acid receptor subunit alpha-43104
Gamma-aminobutyric acid receptor subunit gamma-33104
Gamma-aminobutyric acid receptor subunit alpha-63104
Carbonic anhydrase 5A, mitochondrial0316
Prostaglandin G/H synthase 20001
Carbonic anhydrase 70315
Nuclear receptor ROR-gamma4004
Cytochrome P450 2J20202
Gamma-aminobutyric acid receptor subunit alpha-13104
Gamma-aminobutyric acid receptor subunit beta-33104
Gamma-aminobutyric acid receptor subunit beta-23104
Carbonic anhydrase 90417
GABA theta subunit3104
Canalicular multispecific organic anion transporter 10606
Carbonic anhydrase 150304
Carbonic anhydrase 130304
Gamma-aminobutyric acid receptor subunit epsilon3104
Carbonic anhydrase 140417
Carbonic anhydrase 5B, mitochondrial0316
toxin B0001
Chain A, TYROSYL-DNA PHOSPHODIESTERASE4004
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, CARBONIC ANHYDRASE II0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Carbonic Anhydrase Ii0011
Chain A, Beta-lactamase3003
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Endochitinase0101
Chain A, Class Iii Chitinase Chia10101
Chain A, Carbonic anhydrase 130101
Chain A, Carbonic anhydrase II0101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase 20101
Chain A, Carbonic anhydrase0101
Chain B, Carbonic anhydrase0101
Chain A, Carbonic anhydrase 20101
Carbonic anhydrase 0001
Carbonic anhydrase 0202
thioredoxin reductase5005
GALC protein2002
GLI family zinc finger 37007
cytochrome P450 family 3 subfamily A polypeptide 48008
glucocorticoid receptor [Homo sapiens]7007
Carbonic anhydrase 0101
Carbonic anhydrase 0101
arylsulfatase A3003
Carbonic anhydrase0101
euchromatic histone-lysine N-methyltransferase 2120012
Bloom syndrome protein isoform 12002
thyroid hormone receptor beta isoform a4004
nuclear factor erythroid 2-related factor 2 isoform 18008
geminin8008
survival motor neuron protein isoform d2002
muscleblind-like protein 1 isoform 12002
Carbonic anhydrase0101
Prolyl endopeptidase0101
Carbonic anhydrase-related protein 110102
Glycogen phosphorylase, muscle form0101
Renin0202
Carbonic anhydrase 20202
Cathepsin B0101
Steryl-sulfatase0101
5-hydroxytryptamine receptor 2C0101
Polyunsaturated fatty acid 5-lipoxygenase0101
Cytochrome P450 2C80101
Cytochrome P450 2A60101
5-hydroxytryptamine receptor 2A0101
Androgen receptor0101
Translocator protein0101
Cannabinoid receptor 10101
Cytochrome P450 2B60101
Carbonic anhydrase 5A, mitochondrial0101
Adenosine receptor A10101
Serum paraoxonase/arylesterase 10202
Dipeptidyl peptidase 40001
Endochitinase0101
Adenosine receptor A2a0101
5-hydroxytryptamine receptor 2B0101
Sodium-dependent serotonin transporter0101
Delta-type opioid receptor0101
Cytochrome P450 2C190101
Delta-type opioid receptor0101
Mu-type opioid receptor0202
Carbonic anhydrase0303
Kappa-type opioid receptor0101
Carbonic anhydrase0101
D(1A) dopamine receptor0101
Corticosteroid 11-beta-dehydrogenase isozyme 10101
Carbonic anhydrase0101
D(2) dopamine receptor0101
Cholinesterase0101
Carbonic anhydrase 0101
Mu-type opioid receptor0101
Fatty-acid amide hydrolase 10101
Beta-carbonic anhydrase 10101
Carbonic anhydrase 20101
Glutamate receptor ionotropic, NMDA 2B0101
Squalene synthase0101
Neuronal acetylcholine receptor subunit alpha-70101
Carbonic anhydrase0101
Carbonic anhydrase, alpha family 0101
Carbonic anhydrase 0101
Carbonic anhydrase 30101
Carbonic anhydrase0102
Carbonic anhydrase0102
Carbonic anhydrase 0101
Sigma intracellular receptor 20101
Delta carbonic anhydrase0101
Sigma non-opioid intracellular receptor 10101
Renin0101
Carbonic anhydrase 0101
Endochitinase A10101
Multidrug resistance-associated protein 10101
Carbonic anhydrase 130214
Carbonic anhydrase 40202
Acidic mammalian chitinase0101
Carbonic anhydrase 70101
Carbonic anhydrase 0202
Carbonic anhydrase 0101
Carbonic anhydrase 2, isoform A 0101
Chain A, farnesyl pyrophosphate synthase0101
Geranylgeranyl pyrophosphate synthase0304
Farnesyl pyrophosphate synthase0404
Acetylcholinesterase0101
Hypoxanthine-guanine phosphoribosyltransferase0101
Farnesyl pyrophosphate synthase 0303
Farnesyl pyrophosphate synthase 0202
Chain A, Hyaluronidase, phage associated0101
acetylcholinesterase3003
AR protein9009
thioredoxin glutathione reductase4004
vitamin D (1,25- dihydroxyvitamin D3) receptor5005
IDH15005
nuclear factor erythroid 2-related factor 2 isoform 24004
lethal(3)malignant brain tumor-like protein 1 isoform I1001
lethal factor (plasmid)2002
lamin isoform A-delta109009
Polyphenol oxidase 20101
Pancreatic alpha-amylase0202
Albumin0101
Urease0101
Prolyl 4-hydroxylase subunit alpha-10001
Tyrosinase0101
Alpha-2B adrenergic receptor0011
Spike glycoprotein3003
Hyaluronate lyase0101
Prolyl hydroxylase EGLN20001
Egl nine homolog 10001
Prolyl hydroxylase EGLN30001
Hypoxia-inducible factor 1-alpha inhibitor0001
Solute carrier family 23 member 10101
Chain A, JmjC domain-containing histone demethylation protein 3A3003
Chain A, BCL-2-RELATED PROTEIN A10011
Chain A, Cruzipain2002
Luciferase2002
acid sphingomyelinase2002
interleukin 82002
PAX80001
glp-1 receptor, partial2002
15-lipoxygenase, partial1001
pregnane X receptor2002
phosphopantetheinyl transferase4004
hypoxia-inducible factor 1 alpha subunit3003
SMAD family member 22002
USP1 protein, partial3003
SMAD family member 32002
TDP1 protein5005
caspase 7, apoptosis-related cysteine protease1001
hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor)5005
PINK11001
estrogen receptor 2 (ER beta)3003
farnesoid X nuclear receptor2002
pregnane X nuclear receptor5005
G4004
cytochrome P450 2D66006
67.9K protein1001
glucocerebrosidase1001
Parkin1001
peroxisome proliferator-activated receptor delta3003
heat shock protein 900011
caspase-31001
calcineurin A1, putative0011
cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a4004
thyroid stimulating hormone receptor4004
activating transcription factor 61001
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105), isoform CRA_a2002
v-jun sarcoma virus 17 oncogene homolog (avian)6006
Histone H2A.x4004
cytochrome P450 2D6 isoform 11001
hepatocyte nuclear factor 4-alpha isoform 20101
cellular tumor antigen p53 isoform a2002
cytochrome P450 2C19 precursor2002
cytochrome P450 2C9 precursor1001
perilipin-50101
perilipin-10101
potassium voltage-gated channel subfamily H member 2 isoform d2002
transcriptional regulator ERG isoform 32002
heat shock protein beta-12002
huntingtin isoform 21001
importin subunit beta-1 isoform 12002
mitogen-activated protein kinase 12002
ubiquitin-conjugating enzyme E2 N0101
nuclear factor NF-kappa-B p105 subunit isoform 11001
flap endonuclease 13003
protein AF-9 isoform a0001
snurportin-12002
melanocortin receptor 40101
CAAX prenyl protease0001
urokinase-type plasminogen activator precursor1001
plasminogen precursor1001
bcl-2-related protein A10101
urokinase plasminogen activator surface receptor precursor1001
nuclear receptor ROR-gamma isoform 14004
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 isoform a0101
DNA polymerase kappa isoform 16006
glycogen synthase kinase-3 alpha0001
hexokinase HKDC10101
DNA repair protein RAD52 homolog isoform a0001
bcl-2-like protein 11 isoform 10011
Synaptojanin-20101
Solute carrier family 22 member 20304
Solute carrier family 22 member 1 0303
Polyunsaturated fatty acid lipoxygenase ALOX15B2002
Synaptojanin-10101
Solute carrier family 22 member 30101
Glutathione reductase, mitochondrial0102
Interferon beta4004
HLA class I histocompatibility antigen, B alpha chain 4004
Cellular tumor antigen p538008
Integrin beta-32002
72 kDa type IV collagenase0303
Integrin alpha-IIb2002
Matrix metalloproteinase-90202
Trypanothione reductase0101
Alpha-synuclein1102
Histamine H2 receptor2215
TAR DNA-binding protein 432002
Peroxisomal N(1)-acetyl-spermine/spermidine oxidase0101
Multidrug and toxin extrusion protein 20202
Rap guanine nucleotide exchange factor 41001
Inositol hexakisphosphate kinase 14004
Multidrug and toxin extrusion protein 10202
ATPase family AAA domain-containing protein 53003
Ataxin-23003
Spermine oxidase0101
cytochrome P450 2C9, partial4004
Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE2002
alpha-galactosidase1001
M-phase phosphoprotein 82002
muscarinic acetylcholine receptor M11001
Solute carrier family 22 member 10101
Solute carrier family 22 member 20101
cGMP-specific 3',5'-cyclic phosphodiesterase0101
ATP-dependent translocase ABCB10101
ATP-dependent translocase ABCB10101
Potassium-transporting ATPase alpha chain 10101
ATP-dependent translocase ABCB10101
Histamine H2 receptor0202
Histamine H1 receptor0011
Potassium-transporting ATPase subunit beta0101
Aldehyde oxidase0101
Solute carrier family 22 member 60101
Solute carrier family 22 member 10202
Solute carrier family 22 member 80204
Histamine H4 receptor0101
Solute carrier family 22 member 110102
Solute carrier family 22 member 20202
Solute carrier family 22 member 40101
Solute carrier family 22 member 80202
ATP-dependent phosphofructokinase3003
dopamine D1 receptor1001
regulator of G-protein signaling 42002
hexokinase-4 isoform 11001
vitamin D3 receptor isoform VDRA5005
glucokinase regulatory protein1001
peptidyl-prolyl cis-trans isomerase NIMA-interacting 13003
Eyes absent homolog 20202
Amyloid-beta precursor protein0101
Angiotensin-converting enzyme 0101
Metallo-beta-lactamase VIM-130101
Beta-lactamase 0101
Beta-lactamase 0101
Beta-lactamase VIM-1 0101
apical membrane antigen 1, AMA13003
Type IV secretion-like conjugative transfer relaxase protein TraI 0101
DNA polymerase iota isoform a (long)2002
histone acetyltransferase KAT2A isoform 12002
Purine nucleoside phosphorylase0202
Hypoxanthine-guanine phosphoribosyltransferase0001
Ricin0101
2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase0011
Purine nucleoside phosphorylase 0012
Shiga toxin subunit A0101
Guanine deaminase0001
Chymotrypsinogen A0101
DNA polymerase beta2002
neuropeptide S receptor isoform A1001
Chain A, Putative fructose-1,6-bisphosphate aldolase1001
Chain A, 2-oxoglutarate Oxygenase2002
Chain A, ATP-DEPENDENT DNA HELICASE Q11001
WRN1001
Valosin-containing protein0101
bromodomain adjacent to zinc finger domain 2B1001
lysosomal alpha-glucosidase preproprotein2002
15-hydroxyprostaglandin dehydrogenase [NAD(+)] isoform 11001
microphthalmia-associated transcription factor isoform 90101
ubiquitin carboxyl-terminal hydrolase 2 isoform a1001
eukaryotic translation initiation factor 4 gamma 1 isoform 40101
serine/threonine-protein kinase PLK12002
DNA polymerase eta isoform 12002
eukaryotic translation initiation factor 4E isoform 10101
DNA dC->dU-editing enzyme APOBEC-3G isoform 11001
Rap guanine nucleotide exchange factor 32002
Neuronal acetylcholine receptor subunit alpha-42002
Neuronal acetylcholine receptor subunit beta-22002
phosphoglycerate kinase1001
beta-2 adrenergic receptor1001
mu-type opioid receptor isoform MOR-10011
Vpr1001
5-hydroxytryptamine receptor 2A0011
Chain A, HADH2 protein1001
Chain B, HADH2 protein1001
Glucocorticoid receptor0415
Glycine receptor subunit alpha-10404
Glycine receptor subunit beta0404
Glycine receptor subunit alpha-20404
Glycine receptor subunit alpha-30404
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, Lysr-type Regulatory Protein0011
Chain A, 146aa long hypothetical transcriptional regulator0011
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Chain B, Anthranilate phosphoribosyltransferase0101
Chain C, Anthranilate phosphoribosyltransferase0101
Chain A, Anthranilate phosphoribosyltransferase0101
Anthranilate phosphoribosyltransferase0101
90-kda heat shock protein beta HSP90 beta, partial0101
estrogen receptor beta isoform 10101
heat shock protein HSP 90-alpha isoform 20101
tyrosine-protein phosphatase non-receptor type 7 isoform 20101
Dihydroxyacetone phosphate acyltransferase0001
30S ribosomal protein S60101
30S ribosomal protein S70101
50S ribosomal protein L150101
Tetracycline resistance protein, class B0001
Muscarinic acetylcholine receptor M20101
Stromelysin-10101
50S ribosomal protein L100101
50S ribosomal protein L110101
50S ribosomal protein L7/L120101
50S ribosomal protein L190101
50S ribosomal protein L10101
50S ribosomal protein L200101
50S ribosomal protein L270101
50S ribosomal protein L280101
50S ribosomal protein L290101
50S ribosomal protein L310101
50S ribosomal protein L31 type B0101
50S ribosomal protein L320101
50S ribosomal protein L330101
50S ribosomal protein L340101
50S ribosomal protein L350101
50S ribosomal protein L360101
30S ribosomal protein S100101
30S ribosomal protein S110101
30S ribosomal protein S120101
30S ribosomal protein S130101
30S ribosomal protein S160101
30S ribosomal protein S180101
30S ribosomal protein S190101
30S ribosomal protein S200101
30S ribosomal protein S20101
30S ribosomal protein S30101
30S ribosomal protein S40101
30S ribosomal protein S50101
30S ribosomal protein S80101
30S ribosomal protein S90101
50S ribosomal protein L130101
50S ribosomal protein L140101
50S ribosomal protein L160101
50S ribosomal protein L230101
30S ribosomal protein S150101
Multidrug transporter MdfA0101
50S ribosomal protein L170101
50S ribosomal protein L210101
50S ribosomal protein L300101
50S ribosomal protein L60101
30S ribosomal protein S140101
30S ribosomal protein S170101
30S ribosomal protein S10101
50S ribosomal protein L180101
Alpha-1B adrenergic receptor0101
Neutrophil collagenase0202
Alpha-1D adrenergic receptor0101
Alpha-1A adrenergic receptor0101
Collagenase 30101
Cannabinoid receptor 10101
50S ribosomal protein L20101
50S ribosomal protein L30101
50S ribosomal protein L240101
50S ribosomal protein L40101
50S ribosomal protein L220101
50S ribosomal protein L50101
30S ribosomal protein S210101
50S ribosomal protein L250101
50S ribosomal protein L36 20101
Integrase 0101
P2Y purinoceptor 120101
Protein-arginine deiminase type-40101
Solute carrier family 22 member 70001
Chain X, Thyroid hormone receptor beta-10011
Chain X, Thyroid hormone receptor beta-10011
Solute carrier organic anion transporter family member 1A40001
Nuclear receptor subfamily 1 group I member 20011
Solute carrier organic anion transporter family member 1A50001
Transthyretin0102
Thyroid hormone receptor alpha0011
Thyroid hormone receptor beta0011
Proliferating cell nuclear antigen0101
Retinoic acid receptor RXR-alpha0022
Peroxisome proliferator-activated receptor gamma0022
Malate dehydrogenase, mitochondrial0101
Solute carrier organic anion transporter family member 1A20001
Solute carrier organic anion transporter family member 1A30001
Solute carrier organic anion transporter family member 4C10101
Monocarboxylate transporter 80001
Bile acid receptor0101
Solute carrier organic anion transporter family member 1C10001
Solute carrier organic anion transporter family member 1B10001
nuclear receptor subfamily 1, group I, member 21001
Fumarate hydratase1001
polyprotein1001
Butyrophilin subfamily 3 member A10012
Farnesyl diphosphate synthase0101
Matrix metalloproteinase-140101
Geranylgeranyl pyrophosphate synthase0202
H0101
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]