An agonist that binds to and activates cannabinoid receptors.
ChEBI ID: 67072
| Member | Definition | Class |
|---|---|---|
| am 694 | A member of the class of indoles that is 1H-indole which is substituted at position 1 by a 5-fluoropentyl group and a position 3 by an o-fluorobenzoyl group. It is a selective agonist for the CB1 cannabinoid receptor; Ki values for the CB1 and CB2 receptors are 0.08 and 1.44 nM, respectively. | 1-(5-fluoropentyl)-3-(2-iodobenzoyl)indole |
| arachidonoyl amine | A primary fatty amide resulting from the formal condensation of the carboxy group of arachidonic acid with ammonia. | arachidonoyl amine |
| cannabigerol | A member of the class of resorcinols that is resorcinol which is substituted by a (2E)-3,7-dimethylocta-2,6-dien-1-yl group at position 2 and by a pentyl group at position 5. It is a natural product found in Cannabis sativa and Helichrysum species. | cannabigerol |
| dronabinol | A diterpenoid that is 6a,7,8,10a-tetrahydro-6H-benzo[c]chromene substituted at position 1 by a hydroxy group, positions 6, 6 and 9 by methyl groups and at position 3 by a pentyl group. The principal psychoactive constituent of the cannabis plant, it is used for treatment of anorexia associated with AIDS as well as nausea and vomiting associated with cancer chemotherapy. | Delta(9)-tetrahydrocannabinol |
| n-arachidonoyl l-serine | An N-acyl-amino acid resulting from the formal condensation of the carboxy group of arachidonic acid with the amino group of L-serine. It is an endocannabinoid-like lipid isolated from bovine brains. | N-arachidonoyl-L-serine |
| Timeframe | Studies, Drugs with This Role(%) | All Drugs % |
|---|---|---|
| pre-1990 | 2,254 (28.55) | 18.7374 |
| 1990's | 842 (10.66) | 18.2507 |
| 2000's | 1,437 (18.20) | 29.6817 |
| 2010's | 2,041 (25.85) | 24.3611 |
| 2020's | 1,322 (16.74) | 2.80 |
| Publication Type | Studies, Drugs with this Role (%) | All Drugs (%) |
|---|---|---|
| Trials | 788 (9.34%) | 5.53% |
| Reviews | 836 (9.91%) | 6.00% |
| Case Studies | 202 (2.40%) | 4.05% |
| Observational | 47 (0.56%) | 0.25% |
| Other | 6,561 (77.79%) | 84.16% |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| AR protein | Homo sapiens (human) | Potency | 23.2880 | 2 | 2 |
| aryl hydrocarbon receptor | Homo sapiens (human) | Potency | 8.6906 | 2 | 2 |
| Ataxin-2 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| ATPase family AAA domain-containing protein 5 | Homo sapiens (human) | Potency | 33.4915 | 1 | 1 |
| Cellular tumor antigen p53 | Homo sapiens (human) | Potency | 28.6008 | 2 | 2 |
| cytochrome P450, family 19, subfamily A, polypeptide 1, isoform CRA_a | Homo sapiens (human) | Potency | 23.7101 | 1 | 1 |
| estrogen nuclear receptor alpha | Homo sapiens (human) | Potency | 17.9644 | 3 | 3 |
| glucocorticoid receptor [Homo sapiens] | Homo sapiens (human) | Potency | 24.7866 | 3 | 3 |
| peroxisome proliferator activated receptor gamma | Homo sapiens (human) | Potency | 30.1065 | 1 | 1 |
| potassium voltage-gated channel subfamily H member 2 isoform d | Homo sapiens (human) | Potency | 35.4813 | 1 | 1 |
| pregnane X nuclear receptor | Homo sapiens (human) | Potency | 7.9433 | 1 | 1 |
| TDP1 protein | Homo sapiens (human) | Potency | 23.8723 | 2 | 2 |
| thyroid hormone receptor beta isoform 2 | Rattus norvegicus (Norway rat) | Potency | 14.5668 | 2 | 2 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cannabinoid receptor 1 | Homo sapiens (human) | IC50 | 1.6564 | 2 | 2 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | IC50 | 0.2180 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Ki | 1.0603 | 23 | 23 |
| Cannabinoid receptor 1 | Mus musculus (house mouse) | Ki | 0.0405 | 2 | 2 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | Ki | 1.5077 | 13 | 14 |
| Cannabinoid receptor 2 | Rattus norvegicus (Norway rat) | IC50 | 0.2180 | 1 | 1 |
| Cannabinoid receptor 2 | Mus musculus (house mouse) | Ki | 0.0303 | 3 | 4 |
| Cannabinoid receptor 2 | Rattus norvegicus (Norway rat) | Ki | 0.0460 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | IC50 | 1.7348 | 2 | 2 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Ki | 0.5836 | 27 | 27 |
| Diacylglycerol lipase-alpha | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Fatty acid-binding protein, liver | Mus musculus (house mouse) | Ki | 1.0000 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Homo sapiens (human) | IC50 | 43.6000 | 1 | 1 |
| G-protein coupled receptor 55 | Homo sapiens (human) | IC50 | 14.2000 | 1 | 1 |
| Inhibin alpha chain | Homo sapiens (human) | IC50 | 5.2000 | 1 | 1 |
| L-lactate dehydrogenase A chain | Homo sapiens (human) | Ki | 14.0000 | 1 | 1 |
| Lysophosphatidylserine lipase ABHD12 | Homo sapiens (human) | IC50 | 11.6000 | 1 | 1 |
| Monoacylglycerol lipase ABHD6 | Homo sapiens (human) | IC50 | 48.2000 | 1 | 1 |
| Monoglyceride lipase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| N-acylethanolamine-hydrolyzing acid amidase | Homo sapiens (human) | IC50 | 100.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | IC50 | 13.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Rattus norvegicus (Norway rat) | IC50 | 13.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily M member 8 | Homo sapiens (human) | IC50 | 0.1600 | 1 | 1 |
| Transient receptor potential cation channel subfamily M member 8 | Rattus norvegicus (Norway rat) | IC50 | 0.1600 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | IC50 | 2.6000 | 2 | 2 |
| Transient receptor potential cation channel subfamily V member 2 | Homo sapiens (human) | IC50 | 1.5000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 2 | Rattus norvegicus (Norway rat) | IC50 | 1.5000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 3 | Homo sapiens (human) | IC50 | 66.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 4 | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Cannabinoid receptor 1 | Homo sapiens (human) | EC50 | 0.0458 | 3 | 3 |
| Cannabinoid receptor 1 | Rattus norvegicus (Norway rat) | EC50 | 0.0738 | 2 | 3 |
| Cannabinoid receptor 2 | Mus musculus (house mouse) | EC50 | 0.0073 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | EC50 | 0.0086 | 3 | 3 |
| D(3) dopamine receptor | Homo sapiens (human) | EC50 | 0.0102 | 1 | 1 |
| G-protein coupled receptor 55 | Homo sapiens (human) | EC50 | 10.0000 | 1 | 1 |
| Glutamate receptor 1 | Rattus norvegicus (Norway rat) | EC50 | 0.1995 | 1 | 1 |
| Glutamate receptor 2 | Rattus norvegicus (Norway rat) | EC50 | 0.1995 | 1 | 1 |
| Glutamate receptor 3 | Rattus norvegicus (Norway rat) | EC50 | 0.1995 | 1 | 1 |
| Glutamate receptor 4 | Rattus norvegicus (Norway rat) | EC50 | 0.1995 | 1 | 1 |
| Glycine receptor subunit alpha-1 | Homo sapiens (human) | EC50 | 1.3000 | 1 | 1 |
| N-arachidonyl glycine receptor | Homo sapiens (human) | EC50 | 4.6100 | 1 | 1 |
| Nuclear receptor subfamily 1 group I member 2 | Homo sapiens (human) | EC50 | 18.9333 | 3 | 3 |
| Peroxisome proliferator-activated receptor gamma | Homo sapiens (human) | EC50 | 15.7000 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | EC50 | 0.7000 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Rattus norvegicus (Norway rat) | EC50 | 1.4433 | 2 | 3 |
| Transient receptor potential cation channel subfamily V member 1 | Homo sapiens (human) | EC50 | 1.3000 | 2 | 2 |
| Transient receptor potential cation channel subfamily V member 2 | Homo sapiens (human) | EC50 | 1.7000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 2 | Rattus norvegicus (Norway rat) | EC50 | 1.7000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 3 | Homo sapiens (human) | EC50 | 1.0000 | 1 | 1 |
| Transient receptor potential cation channel subfamily V member 4 | Homo sapiens (human) | EC50 | 5.1000 | 1 | 1 |
| Protein | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Drugs |
|---|---|---|---|---|---|
| Alpha-2A adrenergic receptor | Homo sapiens (human) | EC5 | 0.0020 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | K | 1.0400 | 1 | 1 |
| Cannabinoid receptor 1 | Mus musculus (house mouse) | K | 0.3800 | 1 | 1 |
| Cannabinoid receptor 1 | Homo sapiens (human) | Log Ki | 0.0016 | 1 | 1 |
| Cannabinoid receptor 2 | Homo sapiens (human) | Log Ki | 0.0016 | 1 | 1 |
| Fatty-acid amide hydrolase 1 | Rattus norvegicus (Norway rat) | Km | 2.3400 | 1 | 1 |
| Transient receptor potential cation channel subfamily A member 1 | Homo sapiens (human) | Activity | 10.0000 | 1 | 1 |