Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism.
| Member | Definition | Role |
|---|
| aldosterone | A pregnane-based steroidal hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney. | aldosterone |
| deoxycortone pivalate | | 11-deoxycorticosterone pivalate |
| desoxycorticosterone | A mineralocorticoid that is progesterone substituted at position 21 by a hydroxy group. | 11-deoxycorticosterone |
| fludrocortisone | | fludrocortisone |
| fludrocortisone acetate | An acetate ester resulting from the formal condensation of the primary hydroxy group of fludrocortisone with acetic acid. A synthetic corticosteroid, it has glucocorticoid actions about 10 times as potent as hydrocortisone, while its mineralocorticoid actions are over 100 times as potent. It is used in partial replacement therapy for primary and secondary adrenocortical insufficiency in Addison's disease and for the treatment of salt-losing adrenal hyperplasia. | fludrocortisone acetate |